{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:50:07Z","timestamp":1792785007404,"version":"4.5.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Youth Research Fund Project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-74251-5","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T06:02:36Z","timestamp":1727935356000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Predicting the severity of mycoplasma pneumoniae pneumonia in pediatric and adult patients: a multicenter study"],"prefix":"10.1038","volume":"14","author":[{"given":"Li-Yong","family":"Zhuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Wei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Da","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Mei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Mei","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Jing","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"74251_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/cid\/ciy419","volume":"68","author":"PK Kutty","year":"2019","unstructured":"Kutty, P. K. et al. Mycoplasma pneumoniae among children hospitalized with community-acquired Pneumonia. Clin. Infect. Dis.68, 5\u201312. https:\/\/doi.org\/10.1093\/cid\/ciy419 (2019).","journal-title":"Clin. Infect. Dis."},{"key":"74251_CR2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1186\/s12931-019-1152-5","volume":"20","author":"YJ Choi","year":"2019","unstructured":"Choi, Y. J., Jeon, J. H. & Oh, J. W. Critical combination of initial markers for predicting refractory Mycoplasma pneumoniae pneumonia in children: a case control study. Respir Res.20, 193. https:\/\/doi.org\/10.1186\/s12931-019-1152-5 (2019).","journal-title":"Respir Res."},{"key":"74251_CR3","doi-asserted-by":"crossref","unstructured":"Gadsby, N. J. et al. Increased reports of Mycoplasma pneumoniae from laboratories in Scotland in 2010 and 2011 - impact of the epidemic in infants. Euro. Surveill17 (2012).","DOI":"10.2807\/ese.17.10.20110-en"},{"key":"74251_CR4","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1002\/ppul.24327","volume":"54","author":"C Yan","year":"2019","unstructured":"Yan, C. et al. Molecular and clinical characteristics of severe Mycoplasma pneumoniae pneumonia in children. Pediatr. Pulmonol.54, 1012\u20131021. https:\/\/doi.org\/10.1002\/ppul.24327 (2019).","journal-title":"Pediatr. Pulmonol."},{"key":"74251_CR5","doi-asserted-by":"publisher","unstructured":"Liu, J. et al. Mycoplasma pneumoniae pneumonia associated thrombosis at Beijing Children\u2019s hospital. BMC Infect. Dis.20https:\/\/doi.org\/10.1186\/s12879-020-4774-9 (2020).","DOI":"10.1186\/s12879-020-4774-9"},{"key":"74251_CR6","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s12519-018-0162-6","volume":"14","author":"X Wang","year":"2018","unstructured":"Wang, X. et al. Necrotizing pneumonia caused by refractory Mycoplasma pneumonia pneumonia in children. World J. Pediatr.14, 344\u2013349. https:\/\/doi.org\/10.1007\/s12519-018-0162-6 (2018).","journal-title":"World J. Pediatr."},{"key":"74251_CR7","doi-asserted-by":"publisher","DOI":"10.5603\/ARM.a2018.0049","author":"I San Martin","year":"2018","unstructured":"San Martin, I., Zarikian, S. E., Herranz, M. & Moreno-Galarraga, L. Necrotizing pneumonia due to Mycoplasma in children: an uncommon presentation of a common disease. Adv. Respir Med.https:\/\/doi.org\/10.5603\/ARM.a2018.0049 (2018).","journal-title":"Adv. Respir Med."},{"key":"74251_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3389\/fmicb.2016.00023","volume":"7","author":"M Narita","year":"2016","unstructured":"Narita, M. Classification of Extrapulmonary manifestations due to Mycoplasma pneumoniae infection on the basis of possible pathogenesis. Front. Microbiol.7, 23. https:\/\/doi.org\/10.3389\/fmicb.2016.00023 (2016).","journal-title":"Front. Microbiol."},{"key":"74251_CR9","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1001\/jamadermatol.2019.3602","volume":"156","author":"PM Meyer Sauteur","year":"2020","unstructured":"Meyer Sauteur, P. M. et al. Frequency and clinical presentation of Mucocutaneous Disease due to Mycoplasma pneumoniae infection in Children with Community-Acquired Pneumonia. JAMA Dermatol.156, 144\u2013150. https:\/\/doi.org\/10.1001\/jamadermatol.2019.3602 (2020).","journal-title":"JAMA Dermatol."},{"key":"74251_CR10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.5546\/aap.2018.eng.179","volume":"116","author":"E Kassisse","year":"2018","unstructured":"Kassisse, E., Garc\u00eda, H., Prada, L., Salazar, I. & Kassisse, J. Prevalence of Mycoplasma pneumoniae infection in pediatric patients with acute asthma exacerbation. Arch. Argent. Pediatr.116, 179\u2013185. https:\/\/doi.org\/10.5546\/aap.2018.eng.179 (2018).","journal-title":"Arch. Argent. Pediatr."},{"key":"74251_CR11","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1128\/cmr.00114-16","volume":"30","author":"KB Waites","year":"2017","unstructured":"Waites, K. B., Xiao, L., Liu, Y., Balish, M. F. & Atkinson, T. P. Mycoplasma pneumoniae from the respiratory tract and Beyond. Clin. Microbiol. Rev.30, 747\u2013809. https:\/\/doi.org\/10.1128\/cmr.00114-16 (2017).","journal-title":"Clin. Microbiol. Rev."},{"key":"74251_CR12","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1016\/j.jaci.2018.07.021","volume":"143","author":"AH Totten","year":"2019","unstructured":"Totten, A. H. et al. Allergic airway sensitization impairs antibacterial IgG antibody responses during bacterial respiratory tract infections. J. Allergy Clin. Immunol.143, 1183\u20131197e1187. https:\/\/doi.org\/10.1016\/j.jaci.2018.07.021 (2019).","journal-title":"J. Allergy Clin. Immunol."},{"key":"74251_CR13","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1093\/cid\/cix378","volume":"65","author":"T B\u00e9net","year":"2017","unstructured":"B\u00e9net, T. et al. Microorganisms Associated with Pneumonia in Children\u2009<\u20095 years of age in developing and emerging countries: the GABRIEL Pneumonia Multicenter, prospective, case-control study. Clin. Infect. Dis.65, 604\u2013612. https:\/\/doi.org\/10.1093\/cid\/cix378 (2017).","journal-title":"Clin. Infect. Dis."},{"key":"74251_CR14","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1186\/s12879-017-2614-3","volume":"17","author":"L Wang","year":"2017","unstructured":"Wang, L. et al. A comparison study between GeXP-based multiplex-PCR and serology assay for Mycoplasma pneumoniae detection in children with community acquired pneumonia. BMC Infect. Dis.17, 518. https:\/\/doi.org\/10.1186\/s12879-017-2614-3 (2017).","journal-title":"BMC Infect. Dis."},{"key":"74251_CR15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.jpha.2020.03.004","volume":"10","author":"C Shen","year":"2020","unstructured":"Shen, C. et al. Quantitative computed tomography analysis for stratifying the severity of Coronavirus Disease 2019. J. Pharm. Anal.10, 123\u2013129. https:\/\/doi.org\/10.1016\/j.jpha.2020.03.004 (2020).","journal-title":"J. Pharm. Anal."},{"key":"74251_CR16","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s41747-018-0068-z","volume":"2","author":"S Rizzo","year":"2018","unstructured":"Rizzo, S. et al. Radiomics: the facts and the challenges of image analysis. Eur. Radiol. Exp.2, 36. https:\/\/doi.org\/10.1186\/s41747-018-0068-z (2018).","journal-title":"Eur. Radiol. Exp."},{"key":"74251_CR17","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/brain\/awab340","volume":"145","author":"G Li","year":"2022","unstructured":"Li, G. et al. An MRI radiomics approach to predict survival and tumour-infiltrating macrophages in gliomas. Brain145, 1151\u20131161. https:\/\/doi.org\/10.1093\/brain\/awab340 (2022).","journal-title":"Brain"},{"key":"74251_CR18","doi-asserted-by":"publisher","first-page":"5852","DOI":"10.1007\/s00330-022-08704-8","volume":"32","author":"Q Chen","year":"2022","unstructured":"Chen, Q. et al. Radiomics in precision medicine for gastric cancer: opportunities and challenges. Eur. Radiol.32, 5852\u20135868. https:\/\/doi.org\/10.1007\/s00330-022-08704-8 (2022).","journal-title":"Eur. Radiol."},{"key":"74251_CR19","first-page":"16","volume":"20","author":"NHC China","year":"2023","unstructured":"China, N. H. C. o. t. P. s. R. o. guidelines for the diagnosis and treatment of Mycoplasma pneumoniae pneumonia in children (2023 version). Ration. drug use Explor. China20, 16\u201324 (2023).","journal-title":"Ration. drug use Explor. China"},{"key":"74251_CR20","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1148\/radiol.2020200370","volume":"295","author":"F Pan","year":"2020","unstructured":"Pan, F. et al. Time Course of Lung Changes at chest CT during recovery from Coronavirus Disease 2019 (COVID-19). Radiology295, 715\u2013721. https:\/\/doi.org\/10.1148\/radiol.2020200370 (2020).","journal-title":"Radiology"},{"key":"74251_CR21","doi-asserted-by":"publisher","first-page":"1153784","DOI":"10.3389\/fradi.2023.1153784","volume":"3","author":"J Wu","year":"2023","unstructured":"Wu, J. et al. uRP: an integrated research platform for one-stop analysis of medical images. Front. Radiol.3, 1153784. https:\/\/doi.org\/10.3389\/fradi.2023.1153784 (2023).","journal-title":"Front. Radiol."},{"key":"74251_CR22","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/mp.14609","volume":"48","author":"F Shan","year":"2021","unstructured":"Shan, F. et al. Abnormal lung quantification in chest CT images of COVID-19 patients with deep learning and its application to severity prediction. Med. Phys.48, 1633\u20131645. https:\/\/doi.org\/10.1002\/mp.14609 (2021).","journal-title":"Med. Phys."},{"key":"74251_CR23","doi-asserted-by":"publisher","first-page":"e104","DOI":"10.1158\/0008-5472.Can-17-0339","volume":"77","author":"JJM van Griethuysen","year":"2017","unstructured":"van Griethuysen, J. J. M. et al. Computational Radiomics System to Decode the Radiographic phenotype. Cancer Res.77, e104\u2013e107. https:\/\/doi.org\/10.1158\/0008-5472.Can-17-0339 (2017).","journal-title":"Cancer Res."},{"key":"74251_CR24","doi-asserted-by":"publisher","first-page":"9747","DOI":"10.1038\/s41598-020-66466-z","volume":"10","author":"L Jiang","year":"2020","unstructured":"Jiang, L., Greenwood, C. M. T., Yao, W. & Li, L. Bayesian Hyper-LASSO classification for feature selection with application to Endometrial Cancer RNA-seq data. Sci. Rep.10, 9747. https:\/\/doi.org\/10.1038\/s41598-020-66466-z (2020).","journal-title":"Sci. Rep."},{"key":"74251_CR25","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1002\/ppul.23095","volume":"50","author":"L Guo","year":"2015","unstructured":"Guo, L., Liu, F., Lu, M. P., Zheng, Q. & Chen, Z. M. Increased T cell activation in BALF from children with Mycoplasma pneumoniae pneumonia. Pediatr. Pulmonol.50, 814\u2013819. https:\/\/doi.org\/10.1002\/ppul.23095 (2015).","journal-title":"Pediatr. Pulmonol."},{"key":"74251_CR26","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.jmii.2020.03.030","volume":"54","author":"YC Lee","year":"2021","unstructured":"Lee, Y. C. et al. Altered chemokine profile in Refractory Mycoplasma pneumoniae pneumonia infected children. J. Microbiol. Immunol. Infect.54, 673\u2013679. https:\/\/doi.org\/10.1016\/j.jmii.2020.03.030 (2021).","journal-title":"J. Microbiol. Immunol. Infect."},{"key":"74251_CR27","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1038\/s41598-021-81853-w","volume":"11","author":"P Chen","year":"2021","unstructured":"Chen, P. et al. The relationships between LncRNA NNT-AS1, CRP, PCT and their interactions and the refractory mycoplasma pneumoniae pneumonia in children. Sci. Rep.11, 2059. https:\/\/doi.org\/10.1038\/s41598-021-81853-w (2021).","journal-title":"Sci. Rep."},{"key":"74251_CR28","doi-asserted-by":"publisher","first-page":"6595","DOI":"10.1038\/s41598-021-86086-5","volume":"11","author":"Y Bi","year":"2021","unstructured":"Bi, Y. et al. Development of a scale for early prediction of refractory Mycoplasma pneumoniae pneumonia in hospitalized children. Sci. Rep.11, 6595. https:\/\/doi.org\/10.1038\/s41598-021-86086-5 (2021).","journal-title":"Sci. Rep."},{"key":"74251_CR29","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/s10020-019-0105-2","volume":"25","author":"G Li","year":"2019","unstructured":"Li, G. et al. High co-expression of TNF-\u03b1 and CARDS toxin is a good predictor for refractory Mycoplasma pneumoniae pneumonia. Mol. Med.25, 38. https:\/\/doi.org\/10.1186\/s10020-019-0105-2 (2019).","journal-title":"Mol. Med."},{"key":"74251_CR30","doi-asserted-by":"publisher","first-page":"e24894","DOI":"10.1097\/md.0000000000024894","volume":"100","author":"H Gong","year":"2021","unstructured":"Gong, H., Sun, B., Chen, Y. & Chen, H. The risk factors of children acquiring refractory mycoplasma pneumoniae pneumonia: a meta-analysis. Med. (Baltim).100, e24894. https:\/\/doi.org\/10.1097\/md.0000000000024894 (2021).","journal-title":"Med. (Baltim)."},{"key":"74251_CR31","doi-asserted-by":"publisher","first-page":"897550","DOI":"10.3389\/fsurg.2022.897550","volume":"9","author":"C Fang","year":"2022","unstructured":"Fang, C., Mao, Y., Jiang, M. & Yin, W. Pediatric critical illness score, clinical characteristics and Comprehensive Treatment of children with severe Mycoplasma Pneumoniae Pneumonia. Front. Surg.9, 897550. https:\/\/doi.org\/10.3389\/fsurg.2022.897550 (2022).","journal-title":"Front. Surg."},{"key":"74251_CR32","doi-asserted-by":"publisher","first-page":"e192","DOI":"10.1017\/s0950268819000839","volume":"147","author":"LW Gao","year":"2019","unstructured":"Gao, L. W. et al. The epidemiology of paediatric Mycoplasma pneumoniae pneumonia in North China: 2006 to 2016. Epidemiol. Infect.147, e192. https:\/\/doi.org\/10.1017\/s0950268819000839 (2019).","journal-title":"Epidemiol. Infect."},{"key":"74251_CR33","doi-asserted-by":"publisher","unstructured":"Song, L. et al. Clinical, conventional CT and Radiomic feature-based machine learning models for Predicting ALK Rearrangement Status in Lung Adenocarcinoma patients. Front. Oncol.10. https:\/\/doi.org\/10.3389\/fonc.2020.00369 (2020).","DOI":"10.3389\/fonc.2020.00369"},{"key":"74251_CR34","doi-asserted-by":"publisher","first-page":"813614","DOI":"10.3389\/fped.2022.813614","volume":"10","author":"F Shen","year":"2022","unstructured":"Shen, F. et al. Development of a Nomogram for Predicting Refractory Mycoplasma pneumoniae Pneumonia in Children. Front. Pediatr.10, 813614. https:\/\/doi.org\/10.3389\/fped.2022.813614 (2022).","journal-title":"Front. Pediatr."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74251-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74251-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74251-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T06:10:33Z","timestamp":1727935833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74251-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,3]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["74251"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-74251-5","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4366643\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,3]]},"assertion":[{"value":"4 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22978"}}