{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:56:58Z","timestamp":1787763418516,"version":"build-2784847793"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:00:00Z","timestamp":1727654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-74253-3","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T02:02:33Z","timestamp":1727661753000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Different effects of migraine associated features on headache impact, pain intensity, and psychiatric conditions in patients with migraine"],"prefix":"10.1038","volume":"14","author":[{"given":"Noboru","family":"Imai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiko","family":"Matsumori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"74253_CR1","doi-asserted-by":"crossref","unstructured":"Villar-Martinez, M. D. & Goadsby, P. J. Pathophysiology and therapy of associated features of migraine. Cells11 (2022).","DOI":"10.3390\/cells11172767"},{"key":"74253_CR2","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/j.1468-2982.2006.01075.x","volume":"26","author":"L Kelman","year":"2006","unstructured":"Kelman, L. & Tanis, D. The relationship between migraine pain and other associated symptoms. Cephalalgia. 26, 548\u2013553 (2006).","journal-title":"Cephalalgia"},{"key":"74253_CR3","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1097\/AJP.0000000000000301","volume":"32","author":"B Baykan","year":"2016","unstructured":"Baykan, B. et al. Characterization of migraineurs having allodynia: results of a large population-based study. Clin. J. Pain. 32, 631\u2013635 (2016).","journal-title":"Clin. J. Pain"},{"key":"74253_CR4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s10194-016-0616-y","volume":"17","author":"O\u00d6 Yal\u0131n","year":"2016","unstructured":"Yal\u0131n, O. \u00d6. et al. Phenotypic features of chronic migraine. J. Headache Pain. 17, 26 (2016).","journal-title":"J. Headache Pain"},{"key":"74253_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s10194-017-0742-1","volume":"18","author":"MFP Peres","year":"2017","unstructured":"Peres, M. F. P., Mercante, J. P. P., Tobo, P. R., Kamei, H. & Bigal, M. E. Anxiety and depression symptoms and migraine: a symptom-based approach research. J. Headache Pain. 18, 37 (2017).","journal-title":"J. Headache Pain"},{"key":"74253_CR6","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/head.13708","volume":"60","author":"S Munjal","year":"2020","unstructured":"Munjal, S. et al. Most bothersome symptom in persons with migraine: results from the migraine in America symptoms and treatment (MAST) study. Headache. 60, 416\u2013429 (2020).","journal-title":"Headache"},{"key":"74253_CR7","doi-asserted-by":"crossref","unstructured":"Hirata, K. et al. OVERCOME, Japan,. Comprehensive population-based survey of migraine in Japan: Results of the ObserVational Survey of the Epidemiology, tReatment, and Care of MigrainE (OVERCOME [Japan]) study. Curr. Med. Res. Opin. Study 37, 1945\u20131955. (2021).","DOI":"10.1080\/03007995.2021.1971179"},{"key":"74253_CR8","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s10194-021-01243-5","volume":"22","author":"T Shimizu","year":"2021","unstructured":"Shimizu, T. et al. Disability, quality of life, productivity impairment and employer costs of migraine in the workplace. J. Headache Pain. 22, 29 (2021).","journal-title":"J. Headache Pain"},{"key":"74253_CR9","doi-asserted-by":"crossref","unstructured":"Matsumori, Y. et al. OVERCOME, Japan,. Burden of migraine in Japan: Results of the ObserVational survey of the epidemiology, tReatment, and care of MigrainE (OVERCOME [Japan]) Study. Neurol. Ther. Study 11, 205\u2013222. (2022).","DOI":"10.1007\/s40120-021-00305-9"},{"key":"74253_CR10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1186\/s10194-022-01529-2","volume":"23","author":"F Sakai","year":"2022","unstructured":"Sakai, F. et al. Correction: a study to investigate the prevalence of headache disorders and migraine among people registered in a health insurance association in Japan. J. Headache Pain. 23, 164 (2022).","journal-title":"J. Headache Pain"},{"key":"74253_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1186\/s10194-022-01439-3","volume":"23","author":"F Sakai","year":"2022","unstructured":"Sakai, F. et al. A study to investigate the prevalence of headache disorders and migraine among people registered in a health insurance association in Japan. J. Headache Pain. 23, 70 (2022).","journal-title":"J. Headache Pain"},{"key":"74253_CR12","doi-asserted-by":"publisher","first-page":"5176","DOI":"10.1007\/s12325-022-02289-w","volume":"39","author":"T Takeshima","year":"2022","unstructured":"Takeshima, T. et al. Potential unmet needs in acute treatment of migraine in Japan: results of the OVERCOME (Japan) study. Adv. Ther.39, 5176\u20135190 (2022).","journal-title":"Adv. Ther."},{"key":"74253_CR13","doi-asserted-by":"crossref","unstructured":"Hirata, K. et al. OVERCOME, Japan,. Outcomes and Factors Associated with Insufficient Effectiveness of Acute Treatments of Migraine in Japan: Results of the ObserVational survey of the Epidemiology, tReatment, and Care of MigrainE (OVERCOME [Japan]) Study. Drugs Real World Outcomes Study 10, 415\u2013428. (2023).","DOI":"10.1007\/s40801-023-00368-0"},{"key":"74253_CR14","doi-asserted-by":"publisher","first-page":"333102423116568","DOI":"10.1177\/03331024231165682","volume":"43","author":"F Sakai","year":"2023","unstructured":"Sakai, F. et al. Diagnosis, knowledge, perception, and productivity impact of headache education and clinical evaluation program in the workplace at an information technology company of more than 70,000 employees. Cephalalgia. 43, 3331024231165682 (2023).","journal-title":"Cephalalgia"},{"key":"74253_CR15","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/head.13745","volume":"60","author":"TA Pearl","year":"2020","unstructured":"Pearl, T. A., Dumkrieger, G., Chong, C. D., Dodick, D. W. & Schwedt, T. J. Sensory hypersensitivity symptoms in migraine with vs without aura: results from the American registry for migraine research. Headache. 60, 506\u2013514 (2020).","journal-title":"Headache"},{"issue":"Suppl 2","key":"74253_CR16","doi-asserted-by":"publisher","first-page":"S220","DOI":"10.1007\/s10072-007-0781-5","volume":"28","author":"C Lovati","year":"2007","unstructured":"Lovati, C. et al. Allodynia in different forms of migraine. Neurol. Sci.28 (Suppl 2), S220\u2013S221 (2007).","journal-title":"Neurol. Sci."},{"key":"74253_CR17","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1111\/head.13806","volume":"60","author":"O Alban\u00eas","year":"2020","unstructured":"Alban\u00eas, O., Bernardo, A., Lys Medeiros, F. & Sampaio Rocha-Filho, P. A. Osmophobia and odor-triggered headaches in children and adolescents: prevalence, associated factors, and importance in the diagnosis of migraine. Headache. 60, 954\u2013966 (2020).","journal-title":"Headache"},{"key":"74253_CR18","first-page":"776","volume":"17","author":"PAS Rocha-Filho","year":"2016","unstructured":"Rocha-Filho, P. A. S., Marques, K. S., Torres, R. C. S. & Leal, K. N. R. Migraine, osmophobia, and anxiety. Pain Med.17, 776\u2013780 (2016).","journal-title":"Pain Med."},{"key":"74253_CR19","doi-asserted-by":"publisher","first-page":"6619","DOI":"10.1523\/JNEUROSCI.0373-15.2015","volume":"35","author":"R Burstein","year":"2015","unstructured":"Burstein, R., Noseda, R., Borsook, D. & Migraine Multiple processes, complex pathophysiology. J. Neurosci.35, 6619\u20136629 (2015).","journal-title":"J. Neurosci."},{"key":"74253_CR20","doi-asserted-by":"publisher","first-page":"831035","DOI":"10.3389\/fneur.2021.831035","volume":"12","author":"A M\u00ednguez-Olaondo","year":"2021","unstructured":"M\u00ednguez-Olaondo, A. et al. Cutaneous allodynia in migraine: a narrative review. Front. Neurol.12, 831035 (2021).","journal-title":"Front. Neurol."},{"issue":"3rd edition","key":"74253_CR21","first-page":"1","volume":"38","author":"Headache Classification Committee o","year":"2018","unstructured":"Headache Classification Committee of the International Headache Society (IHS) The International classification of Headache disorders, 3rd edition. Cephalalgia. 38 (3rd edition), 1\u2013211 (2018).","journal-title":"Cephalalgia"},{"key":"74253_CR22","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1212\/01.wnl.0000183358.53939.38","volume":"65","author":"M Jakubowski","year":"2005","unstructured":"Jakubowski, M., Silberstein, S., Ashkenazi, A. & Burstein, R. Can allodynic migraine patients be identified interictally using a questionnaire? Neurology. 65, 1419\u20131422 (2005).","journal-title":"Neurology"},{"key":"74253_CR23","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1177\/0333102410379890","volume":"31","author":"M Yang","year":"2011","unstructured":"Yang, M., Rendas-Baum, R., Varon, S. F. & Kosinski, M. Validation of the Headache Impact Test (HIT-6\u2122) across episodic and chronic migraine. Cephalalgia. 31, 357\u2013367 (2011).","journal-title":"Cephalalgia"},{"key":"74253_CR24","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.3389\/fpsyg.2018.01741","volume":"9","author":"S Doi","year":"2018","unstructured":"Doi, S., Ito, M., Takebayashi, Y., Muramatsu, K. & Horikoshi, M. Factorial validity and invariance of the 7-item generalized anxiety disorder scale (GAD-7) among populations with and without self-reported psychiatric diagnostic status. Front. Psychol.9, 1741 (2018).","journal-title":"Front. Psychol."},{"key":"74253_CR25","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.genhosppsych.2018.03.007","volume":"52","author":"K Muramatsu","year":"2018","unstructured":"Muramatsu, K. et al. Performance of the Japanese version of the Patient Health Questionnaire-9 (J-PHQ-9) for depression in primary care. Gen. Hosp. Psychiatry. 52, 64\u201369 (2018).","journal-title":"Gen. Hosp. Psychiatry"},{"key":"74253_CR26","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s10194-020-1084-y","volume":"21","author":"DC Buse","year":"2020","unstructured":"Buse, D. C. et al. Comorbid and co-occurring conditions in migraine and associated risk of increasing headache pain intensity and headache frequency: results of the migraine in America symptoms and treatment (MAST) study. J. Headache Pain. 21, 23 (2020).","journal-title":"J. Headache Pain"},{"key":"74253_CR27","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1111\/head.14106","volume":"61","author":"JH Yin","year":"2021","unstructured":"Yin, J. H. et al. Prevalence and association of lifestyle and medical-, psychiatric-, and pain-related comorbidities in patients with migraine: a cross-sectional study. Headache. 61, 715\u2013726 (2021).","journal-title":"Headache"},{"key":"74253_CR28","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1111\/j.1526-4610.2009.01521.x","volume":"49","author":"GE Tietjen","year":"2009","unstructured":"Tietjen, G. E. et al. Allodynia in migraine: Association with comorbid pain conditions. Headache. 49, 1333\u20131344 (2009).","journal-title":"Headache"},{"key":"74253_CR29","first-page":"104589","volume":"82","author":"F Athar","year":"2022","unstructured":"Athar, F. et al. Frequency of migraine according to the ICHD-3 criteria and its association with sociodemographic and triggering factors in Pakistan: a cross-sectional study. Ann. Med. Surg. (Lond). 82, 104589 (2022).","journal-title":"Ann. Med. Surg. (Lond)"},{"key":"74253_CR30","doi-asserted-by":"publisher","first-page":"e0289729","DOI":"10.1371\/journal.pone.0289729","volume":"18","author":"SJ Kim","year":"2023","unstructured":"Kim, S. J. et al. Most bothersome symptom in migraine and probable migraine: a population-based study. PLOS ONE. 18, e0289729 (2023).","journal-title":"PLOS ONE"},{"key":"74253_CR31","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1111\/head.14308","volume":"62","author":"YH Tu","year":"2022","unstructured":"Tu, Y. H. et al. Most bothersome symptoms in patients with migraine: a hospital-based study in Taiwan. Headache. 62, 596\u2013603 (2022).","journal-title":"Headache"},{"key":"74253_CR32","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s11916-016-0538-z","volume":"20","author":"A \u00d6zge","year":"2016","unstructured":"\u00d6zge, A. & Yalin, O. \u00d6. Chronic migraine in children and adolescents. Curr. Pain Headache Rep.20, 14 (2016).","journal-title":"Curr. Pain Headache Rep."},{"key":"74253_CR33","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1001\/jamapediatrics.2022.3940","volume":"176","author":"K Falla","year":"2022","unstructured":"Falla, K. et al. Anxiety and depressive symptoms and disorders in children and adolescents with migraine: a systematic review and meta-analysis. JAMA Pediatr.176, 1176\u20131187 (2022).","journal-title":"JAMA Pediatr."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74253-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74253-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74253-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T02:06:25Z","timestamp":1727661985000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74253-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":33,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["74253"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-74253-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4096243\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,30]]},"assertion":[{"value":"13 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare the following potential conflicts of interest with respect to the research, authorship, and\/or publication of this article. NI reports being an advisor for Sawai and receiving speaker fees from Daiichi Sankyo, Eli Lilly, Otsuka, and Amgen; however, these companies were not related to the study. YM reports personal consultancy fees from Amgen Astellas BioPharma K.K., Daiichi Sankyo Company Limited, Eli Lilly Japan K.K., and Otsuka Pharmaceutical Co., Ltd. during the conduct of the study; however, no company had any relation to the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was conducted at two accredited headache education facilities endorsed by the Japanese Headache Society: the Japanese Red Cross Shizuoka Hospital and the Sendai Headache and Neurology Clinic. This was a two-center prospective investigation of patients with headache disorders. The participants provided informed consent in accordance with the Ethical Guidelines for Medical and Health Research Involving Human Subjects issued by the Japanese Ministry of Health, Labor, and Welfare. This study was approved by the Ethics Committee of the Japanese Red Cross Shizuoka Hospital (reference number: 2018\u201321).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"22611"}}