{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:23:44Z","timestamp":1792650224353,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["CC"],"award-info":[{"award-number":["CC"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["NC"],"award-info":[{"award-number":["NC"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004704","name":"National Research Council of Thailand","doi-asserted-by":"publisher","award":["N42A660301 (SC)"],"award-info":[{"award-number":["N42A660301 (SC)"]}],"id":[{"id":"10.13039\/501100004704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002842","name":"Chiang Mai University","doi-asserted-by":"publisher","award":["CMU Excellent Center award"],"award-info":[{"award-number":["CMU Excellent Center award"]}],"id":[{"id":"10.13039\/501100002842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","award":["AM"],"award-info":[{"award-number":["AM"]}],"id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-74353-0","type":"journal-article","created":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T11:11:40Z","timestamp":1727608300000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Alterations of senescence-associated markers in patients with non-syndromic cleft lip and palate"],"prefix":"10.1038","volume":"14","author":[{"given":"Chirakan","family":"Charoenvicha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirapan","family":"Thongsroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nattayaporn","family":"Apaijai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanawat","family":"Attachaipanich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wimon","family":"Sirimaharaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krit","family":"Khwanngern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nipon","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apiwat","family":"Mutirangura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siriporn C.","family":"Chattipakorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,29]]},"reference":[{"issue":"Spec 1","key":"74353_CR1","doi-asserted-by":"publisher","first-page":"R73","DOI":"10.1093\/hmg\/ddh052","volume":"13","author":"P Stanier","year":"2004","unstructured":"Stanier, P. & Moore, G. E. Genetics of cleft lip and palate: syndromic genes contribute to the incidence of non-syndromic clefts. Hum. Mol. Genet. 13 (Spec 1), R73\u201381. https:\/\/doi.org\/10.1093\/hmg\/ddh052 (2004).","journal-title":"Hum. Mol. Genet."},{"key":"74353_CR2","unstructured":"Anomalies, W. H. O. R. M. o. C., Mossey, P. A., Catilla, E. E., Programme, W. H. O. H. G. & Anomalies, W. H. O. M. o. I. C. R. o. C.\u00a0(World Health Organization, 2003)."},{"key":"74353_CR3","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1002\/bdr2.1802","volume":"112","author":"MA Garland","year":"2020","unstructured":"Garland, M. A. et al. Role of epigenetics and miRNAs in orofacial clefts. Birth Defects Res. 112, 1635\u20131659. https:\/\/doi.org\/10.1002\/bdr2.1802 (2020).","journal-title":"Birth Defects Res."},{"key":"74353_CR4","doi-asserted-by":"publisher","first-page":"12727","DOI":"10.3390\/ijms232112727","volume":"23","author":"C Charoenvicha","year":"2022","unstructured":"Charoenvicha, C., Sirimaharaj, W., Khwanngern, K., Chattipakorn, N. & Chattipakorn, S. C. Alterations in DNA methylation in Orofacial Clefts. Int. J. Mol. Sci. 23, 12727 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"74353_CR5","doi-asserted-by":"publisher","unstructured":"Luo, Y., Lu, X. & Xie, H. Dynamic Alu methylation during normal development, aging, and tumorigenesis. Biomed. Res. Int.\u00a0 2014 (784706). https:\/\/doi.org\/10.1155\/2014\/784706 (2014).","DOI":"10.1155\/2014\/784706"},{"key":"74353_CR6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.amjms.2020.03.002","volume":"359","author":"D Ye","year":"2020","unstructured":"Ye, D., Jiang, D., Zhang, X. & Mao, Y. Alu methylation and risk of Cancer: a Meta-analysis. Am. J. Med. Sci. 359, 271\u2013280. https:\/\/doi.org\/10.1016\/j.amjms.2020.03.002 (2020).","journal-title":"Am. J. Med. Sci."},{"key":"74353_CR7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1080\/15592294.2015.1130518","volume":"11","author":"A Bakshi","year":"2016","unstructured":"Bakshi, A., Herke, S. W., Batzer, M. A. & Kim, J. DNA methylation variation of human-specific Alu repeats. Epigenetics. 11, 163\u2013173. https:\/\/doi.org\/10.1080\/15592294.2015.1130518 (2016).","journal-title":"Epigenetics"},{"key":"74353_CR8","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2217\/epi-2017-0096","volume":"10","author":"M Patchsung","year":"2018","unstructured":"Patchsung, M. et al. Alu siRNA to increase Alu element methylation and prevent DNA damage. Epigenomics. 10, 175\u2013185. https:\/\/doi.org\/10.2217\/epi-2017-0096 (2018).","journal-title":"Epigenomics"},{"key":"74353_CR9","doi-asserted-by":"publisher","first-page":"649492","DOI":"10.3389\/fphys.2021.649492","volume":"12","author":"H Yamaguchi","year":"2021","unstructured":"Yamaguchi, H. et al. Alteration of DNA damage response causes cleft palate. Front. Physiol. 12, 649492. https:\/\/doi.org\/10.3389\/fphys.2021.649492 (2021).","journal-title":"Front. Physiol."},{"key":"74353_CR10","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/dgd.12305","volume":"58","author":"D Sakai","year":"2016","unstructured":"Sakai, D. & Trainor, P. A. Face off against ROS: Tcof1\/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development. Dev. Growth Differ. 58, 577\u2013585. https:\/\/doi.org\/10.1111\/dgd.12305 (2016).","journal-title":"Dev. Growth Differ."},{"key":"74353_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.bbrc.2019.06.031","volume":"516","author":"Y Zhang","year":"2019","unstructured":"Zhang, Y. et al. Protective effect of folic acid on vulnerability to oxidative stress in dental pulp stem cells of deciduous teeth from children with orofacial clefts. Biochem. Biophys. Res. Commun. 516, 127\u2013132. https:\/\/doi.org\/10.1016\/j.bbrc.2019.06.031 (2019).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"74353_CR12","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.biocel.2010.06.001","volume":"42","author":"KH Al-Gubory","year":"2010","unstructured":"Al-Gubory, K. H., Fowler, P. A. & Garrel, C. The roles of cellular reactive oxygen species, oxidative stress and antioxidants in pregnancy outcomes. Int. J. Biochem. Cell. Biol. 42, 1634\u20131650. https:\/\/doi.org\/10.1016\/j.biocel.2010.06.001 (2010).","journal-title":"Int. J. Biochem. Cell. Biol."},{"key":"74353_CR13","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1093\/toxsci\/kfn263","volume":"108","author":"PG Wells","year":"2009","unstructured":"Wells, P. G. et al. Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer. Toxicol. Sci. 108, 4\u201318. https:\/\/doi.org\/10.1093\/toxsci\/kfn263 (2009).","journal-title":"Toxicol. Sci."},{"key":"74353_CR14","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.freeradbiomed.2007.06.027","volume":"43","author":"MJ Hitchler","year":"2007","unstructured":"Hitchler, M. J. & Domann, F. E. An epigenetic perspective on the free radical theory of development. Free Radic Biol. Med. 43, 1023\u20131036. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.06.027 (2007).","journal-title":"Free Radic Biol. Med."},{"key":"74353_CR15","doi-asserted-by":"publisher","unstructured":"Luceri, C. et al. Analysis of Oxidative Stress-Related Markers in Crohn\u2019s Disease Patients at Surgery and Correlations with Clinical Findings. Antioxid. (Basel). 8. https:\/\/doi.org\/10.3390\/antiox8090378 (2019).","DOI":"10.3390\/antiox8090378"},{"key":"74353_CR16","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1007\/s11010-020-03928-y","volume":"476","author":"BN Waghela","year":"2021","unstructured":"Waghela, B. N. et al. AGE-RAGE synergy influences programmed cell death signaling to promote cancer. Mol. Cell. Biochem. 476, 585\u2013598. https:\/\/doi.org\/10.1007\/s11010-020-03928-y (2021).","journal-title":"Mol. Cell. Biochem."},{"key":"74353_CR17","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1002\/jcp.20919","volume":"210","author":"H Zhang","year":"2007","unstructured":"Zhang, H. Molecular signaling and genetic pathways of senescence: its role in tumorigenesis and aging. J. Cell. Physiol. 210, 567\u2013574. https:\/\/doi.org\/10.1002\/jcp.20919 (2007).","journal-title":"J. Cell. Physiol."},{"key":"74353_CR18","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1101\/gad.8.21.2540","volume":"8","author":"A Di Leonardo","year":"1994","unstructured":"Di Leonardo, A., Linke, S. P., Clarkin, K. & Wahl, G. M. DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev. 8, 2540\u20132551. https:\/\/doi.org\/10.1101\/gad.8.21.2540 (1994).","journal-title":"Genes Dev."},{"key":"74353_CR19","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","volume":"18","author":"W Huang","year":"2022","unstructured":"Huang, W., Hickson, L. J., Eirin, A., Kirkland, J. L. & Lerman, L. O. Cellular senescence: the good, the bad and the unknown. Nat. Rev. Nephrol. 18, 611\u2013627. https:\/\/doi.org\/10.1038\/s41581-022-00601-z (2022).","journal-title":"Nat. Rev. Nephrol."},{"key":"74353_CR20","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1093\/ije\/dyv042","volume":"44","author":"GC Sharp","year":"2015","unstructured":"Sharp, G. C. et al. Maternal pre-pregnancy BMI and gestational weight gain, offspring DNA methylation and later offspring adiposity: findings from the Avon Longitudinal Study of parents and children. Int. J. Epidemiol. 44, 1288\u20131304. https:\/\/doi.org\/10.1093\/ije\/dyv042 (2015).","journal-title":"Int. J. Epidemiol."},{"key":"74353_CR21","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1016\/j.ajhg.2016.02.019","volume":"98","author":"BR Joubert","year":"2016","unstructured":"Joubert, B. R. et al. DNA methylation in newborns and maternal smoking in pregnancy: genome-wide Consortium Meta-analysis. Am. J. Hum. Genet. 98, 680\u2013696. https:\/\/doi.org\/10.1016\/j.ajhg.2016.02.019 (2016).","journal-title":"Am. J. Hum. Genet."},{"key":"74353_CR22","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1093\/ije\/dyy032","volume":"47","author":"RC Richmond","year":"2018","unstructured":"Richmond, R. C. et al. The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST). Int. J. Epidemiol. 47, 928\u2013937. https:\/\/doi.org\/10.1093\/ije\/dyy032 (2018).","journal-title":"Int. J. Epidemiol."},{"key":"74353_CR23","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41390-018-0267-6","volume":"85","author":"Y L\u00f3pez-Gordillo","year":"2019","unstructured":"L\u00f3pez-Gordillo, Y. et al. Maternal folic acid supplementation reduces the severity of cleft palate in Tgf-\u03b2(3) null mutant mice. Pediatr. Res. 85, 566\u2013573. https:\/\/doi.org\/10.1038\/s41390-018-0267-6 (2019).","journal-title":"Pediatr. Res."},{"key":"74353_CR24","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1139\/o79-007","volume":"57","author":"DR Hoffman","year":"1979","unstructured":"Hoffman, D. R., Cornatzer, W. E. & Duerre, J. A. Relationship between tissue levels of S-adenosylmethionine, S-adenylhomocysteine, and transmethylation reactions. Can. J. Biochem. 57, 56\u201365. https:\/\/doi.org\/10.1139\/o79-007 (1979).","journal-title":"Can. J. Biochem."},{"key":"74353_CR25","doi-asserted-by":"publisher","first-page":"1384","DOI":"10.1097\/SCS.0b013e3181ec6992","volume":"21","author":"RP Erickson","year":"2010","unstructured":"Erickson, R. P. Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid. J. Craniofac. Surg. 21, 1384\u20131387. https:\/\/doi.org\/10.1097\/SCS.0b013e3181ec6992 (2010).","journal-title":"J. Craniofac. Surg."},{"key":"74353_CR26","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s43032-020-00161-2","volume":"27","author":"HY Liu","year":"2020","unstructured":"Liu, H. Y., Liu, S. M. & Zhang, Y. Z. Maternal folic acid supplementation mediates offspring health via DNA methylation. Reprod. Sci. 27, 963\u2013976. https:\/\/doi.org\/10.1007\/s43032-020-00161-2 (2020).","journal-title":"Reprod. Sci."},{"key":"74353_CR27","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1242\/dev.122.10.3195","volume":"122","author":"H Lei","year":"1996","unstructured":"Lei, H. et al. De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development. 122, 3195\u20133205. https:\/\/doi.org\/10.1242\/dev.122.10.3195 (1996).","journal-title":"Development"},{"key":"74353_CR28","first-page":"220","volume":"23","author":"GU Eleje","year":"2014","unstructured":"Eleje, G. U., lgwegbe, A. O., Okonkwo, J. E., Udigwe, G. O. & Eke, A. C. Elderly primigravidae versus young primigravidae: a review of pregnancy outcome in a low resource setting. Niger J. Med. 23, 220\u2013229 (2014).","journal-title":"Niger J. Med."},{"key":"74353_CR29","doi-asserted-by":"publisher","first-page":"2441","DOI":"10.1038\/s41598-017-02721-0","volume":"7","author":"L Alvizi","year":"2017","unstructured":"Alvizi, L. et al. Differential methylation is associated with non-syndromic cleft lip and palate and contributes to penetrance effects. Sci. Rep. 7, 2441. https:\/\/doi.org\/10.1038\/s41598-017-02721-0 (2017).","journal-title":"Sci. Rep."},{"key":"74353_CR30","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s13148-017-0362-2","volume":"9","author":"GC Sharp","year":"2017","unstructured":"Sharp, G. C. et al. Distinct DNA methylation profiles in subtypes of orofacial cleft. Clin. Epigenetics. 9, 63. https:\/\/doi.org\/10.1186\/s13148-017-0362-2 (2017).","journal-title":"Clin. Epigenetics"},{"key":"74353_CR31","doi-asserted-by":"publisher","first-page":"133","DOI":"10.2217\/epi-2018-0091","volume":"11","author":"LJ Howe","year":"2019","unstructured":"Howe, L. J. et al. Evidence for DNA methylation mediating genetic liability to non-syndromic cleft lip\/palate. Epigenomics. 11, 133\u2013145. https:\/\/doi.org\/10.2217\/epi-2018-0091 (2019).","journal-title":"Epigenomics"},{"key":"74353_CR32","doi-asserted-by":"publisher","first-page":"731","DOI":"10.21873\/cdp.10168","volume":"2","author":"S Denariyakoon","year":"2022","unstructured":"Denariyakoon, S., Puttipanyalears, C., Chatamra, K. & Mutirangura, A. Breast Cancer Sera changes in alu element methylation predict metastatic Disease Progression. Cancer Diagn. Progn. 2, 731\u2013738. https:\/\/doi.org\/10.21873\/cdp.10168 (2022).","journal-title":"Cancer Diagn. Progn"},{"key":"74353_CR33","doi-asserted-by":"publisher","first-page":"4469","DOI":"10.7314\/apjcp.2012.13.9.4469","volume":"13","author":"N Kitkumthorn","year":"2012","unstructured":"Kitkumthorn, N., Keelawat, S., Rattanatanyong, P. & Mutirangura, A. LINE-1 and Alu methylation patterns in lymph node metastases of head and neck cancers. Asian Pac. J. Cancer Prev. 13, 4469\u20134475. https:\/\/doi.org\/10.7314\/apjcp.2012.13.9.4469 (2012).","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"74353_CR34","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/3-540-31181-5_12","volume":"310","author":"M Ehrlich","year":"2006","unstructured":"Ehrlich, M. Cancer-linked DNA hypomethylation and its relationship to hypermethylation. Curr. Top. Microbiol. Immunol. 310, 251\u2013274. https:\/\/doi.org\/10.1007\/3-540-31181-5_12 (2006).","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"74353_CR35","doi-asserted-by":"publisher","first-page":"577","DOI":"10.2217\/epi-2019-0064","volume":"11","author":"A Mutirangura","year":"2019","unstructured":"Mutirangura, A. Is global hypomethylation a nidus for molecular pathogenesis of age-related noncommunicable diseases? Epigenomics. 11, 577\u2013579. https:\/\/doi.org\/10.2217\/epi-2019-0064 (2019).","journal-title":"Epigenomics"},{"key":"74353_CR36","doi-asserted-by":"publisher","first-page":"e0120032","DOI":"10.1371\/journal.pone.0120032","volume":"10","author":"K Rerkasem","year":"2015","unstructured":"Rerkasem, K. et al. Higher Alu methylation levels in catch-up growth in twenty-year-old offsprings. PLoS One. 10, e0120032. https:\/\/doi.org\/10.1371\/journal.pone.0120032 (2015).","journal-title":"PLoS One"},{"key":"74353_CR37","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13148-017-0395-6","volume":"9","author":"J Thongsroy","year":"2017","unstructured":"Thongsroy, J., Patchsung, M. & Mutirangura, A. The association between Alu hypomethylation and severity of type 2 diabetes mellitus. Clin. Epigenetics. 9, 93. https:\/\/doi.org\/10.1186\/s13148-017-0395-6 (2017).","journal-title":"Clin. Epigenetics"},{"key":"74353_CR38","doi-asserted-by":"publisher","first-page":"e0270004","DOI":"10.1371\/journal.pone.0270004","volume":"17","author":"J Thongsroy","year":"2022","unstructured":"Thongsroy, J. & Mutirangura, A. The association between Alu hypomethylation and the severity of hypertension. PLoS One. 17, e0270004. https:\/\/doi.org\/10.1371\/journal.pone.0270004 (2022).","journal-title":"PLoS One"},{"key":"74353_CR39","doi-asserted-by":"publisher","first-page":"e65677","DOI":"10.1371\/journal.pone.0065677","volume":"8","author":"GS Kobayashi","year":"2013","unstructured":"Kobayashi, G. S. et al. Susceptibility to DNA damage as a molecular mechanism for non-syndromic cleft lip and palate. PLoS One. 8, e65677. https:\/\/doi.org\/10.1371\/journal.pone.0065677 (2013).","journal-title":"PLoS One"},{"key":"74353_CR40","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1002\/dvdy.637","volume":"252","author":"S Washausen","year":"2023","unstructured":"Washausen, S. & Knabe, W. Patterns of senescence and apoptosis during development of branchial arches, epibranchial placodes, and pharyngeal pouches. Dev. Dyn. 252, 1189\u20131223. https:\/\/doi.org\/10.1002\/dvdy.637 (2023).","journal-title":"Dev. Dyn."},{"key":"74353_CR41","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/jhg.2012.137","volume":"58","author":"A Peixoto","year":"2013","unstructured":"Peixoto, A. et al. Genomic characterization of two large Alu-mediated rearrangements of the BRCA1 gene. J. Hum. Genet. 58, 78\u201383. https:\/\/doi.org\/10.1038\/jhg.2012.137 (2013).","journal-title":"J. Hum. Genet."},{"key":"74353_CR42","doi-asserted-by":"publisher","first-page":"e100429","DOI":"10.1371\/journal.pone.0100429","volume":"9","author":"SY Park","year":"2014","unstructured":"Park, S. Y. et al. Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer. PLoS One. 9, e100429. https:\/\/doi.org\/10.1371\/journal.pone.0100429 (2014).","journal-title":"PLoS One"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74353-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74353-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74353-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T11:11:47Z","timestamp":1727608307000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74353-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,29]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["74353"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-74353-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,29]]},"assertion":[{"value":"15 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"22555"}}