{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:53:09Z","timestamp":1752360789198,"version":"3.37.3"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130056"],"award-info":[{"award-number":["82130056"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-74623-x","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T08:02:47Z","timestamp":1728460967000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serum metabolomics analysis reveals potential biomarkers of penicillins-induced fatal anaphylactic shock in rats"],"prefix":"10.1038","volume":"14","author":[{"given":"Qianwen","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gege","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaili","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cairong","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanlin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keming","family":"Yun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,9]]},"reference":[{"key":"74623_CR1","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1136\/archdischild-2015-309068","volume":"102","author":"CI Barker","year":"2017","unstructured":"Barker, C. I., Germovsek, E. & Sharland, M. What do I need to know about penicillin antibiotics? Arch. Dis. Child. Educ. Pract. Ed. 102, 44\u201350 (2017).","journal-title":"Arch. Dis. Child. Educ. Pract. Ed."},{"key":"74623_CR2","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1056\/NEJMra1807761","volume":"381","author":"M Castells","year":"2019","unstructured":"Castells, M., Khan, D. A. & Phillips, E. J. Penicillin allergy. N Engl. J. Med. 381, 2338\u20132351 (2019).","journal-title":"N Engl. J. Med."},{"key":"74623_CR3","doi-asserted-by":"publisher","first-page":"903161","DOI":"10.3389\/falgy.2022.903161","volume":"3","author":"A Ramsey","year":"2022","unstructured":"Ramsey, A. Penicillin allergy and Perioperative Anaphylaxis. Front. Allergy. 3, 903161 (2022).","journal-title":"Front. Allergy"},{"key":"74623_CR4","doi-asserted-by":"crossref","unstructured":"Park, M. A. & Li, J. T. Diagnosis and management of penicillin allergy. Mayo Clin Proc. 80, 405\u2013410 (2005).","DOI":"10.4065\/80.3.405"},{"key":"74623_CR5","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.jaip.2018.06.010","volume":"7","author":"N Dhopeshwarkar","year":"2019","unstructured":"Dhopeshwarkar, N. et al. Drug-Induced Anaphylaxis Documented in Electronic Health Records. J. Allergy Clin. Immunol. Pract. 7, 103\u2013111 (2019).","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"74623_CR6","doi-asserted-by":"crossref","unstructured":"Jerschow, E., Lin, R. Y., Scaperotti, M. M. & McGinn, A. P. Fatal anaphylaxis in the United States, 1999\u20132010: temporal patterns and demographic associations. J Allergy Clin Immunol. 134, 1318\u20131328 e1317 (2014).","DOI":"10.1016\/j.jaci.2014.08.018"},{"key":"74623_CR7","first-page":"206","volume":"31","author":"ZD Li","year":"2015","unstructured":"Li, Z. D., Liu, W. G., Zhao, Z. Q., Shen, Y. W. & Chen, Y. J. [Analysis of 59 anaphylactic death cases]. Fa Yi Xue Za Zhi. 31, 206\u2013210 (2015).","journal-title":"Fa Yi Xue Za Zhi"},{"key":"74623_CR8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/PAF.0b013e3181c0e7bb","volume":"30","author":"R Yilmaz","year":"2009","unstructured":"Yilmaz, R., Yuksekbas, O., Erkol, Z., Bulut, E. R. & Arslan, M. N. Postmortem findings after anaphylactic reactions to drugs in Turkey. Am. J. Forensic Med. Pathol. 30, 346\u2013349 (2009).","journal-title":"Am. J. Forensic Med. Pathol."},{"key":"74623_CR9","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/s12016-011-8279-6","volume":"43","author":"C Chang","year":"2012","unstructured":"Chang, C., Mahmood, M. M., Teuber, S. S. & Gershwin, M. E. Overview of penicillin allergy. Clin. Rev. Allergy Immunol. 43, 84\u201397 (2012).","journal-title":"Clin. Rev. Allergy Immunol."},{"key":"74623_CR10","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/j.jaci.2021.02.013","volume":"147","author":"P Bruhns","year":"2021","unstructured":"Bruhns, P. & Chollet-Martin, S. Mechanisms of human drug-induced anaphylaxis. J. Allergy Clin. Immunol. 147, 1133\u20131142 (2021).","journal-title":"J. Allergy Clin. Immunol."},{"key":"74623_CR11","doi-asserted-by":"publisher","first-page":"110814","DOI":"10.1016\/j.forsciint.2021.110814","volume":"323","author":"N Heldring","year":"2021","unstructured":"Heldring, N., Kahn, L. & Zilg, B. Fatal anaphylactic shock: a review of postmortem biomarkers and diagnostics. Forensic Sci. Int. 323, 110814 (2021).","journal-title":"Forensic Sci. Int."},{"key":"74623_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.forsciint.2010.04.039","volume":"204","author":"U Da Broi","year":"2011","unstructured":"Da Broi, U. & Moreschi, C. Post-mortem diagnosis of anaphylaxis: a difficult task in forensic medicine. Forensic Sci. Int. 204, 1\u20135 (2011).","journal-title":"Forensic Sci. Int."},{"key":"74623_CR13","doi-asserted-by":"crossref","unstructured":"Del Duca, F. et al. Death due to anaphylactic reaction: the role of the forensic pathologist in an accurate Postmortem diagnosis. Med. (Kaunas) 59, 2184 (2023).","DOI":"10.3390\/medicina59122184"},{"key":"74623_CR14","first-page":"102","volume":"64","author":"M Kobek","year":"2014","unstructured":"Kobek, M. et al. Possibilities of post-mortem diagnostics, including immunodiagnostics, in cases of sudden death due to anaphylactic and anaphylactoid reactions. Arch. Med. Sadowej Kryminol. 64, 102\u2013110 (2014).","journal-title":"Arch. Med. Sadowej Kryminol"},{"key":"74623_CR15","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1080\/004982599238047","volume":"29","author":"JK Nicholson","year":"1999","unstructured":"Nicholson, J. K., Lindon, J. C. & Holmes, E. J. x. \u2018Metabonomics\u2019: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica. 29, 1181\u20131189 (1999).","journal-title":"Xenobiotica"},{"key":"74623_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nrm3314","volume":"13","author":"GJ Patti","year":"2012","unstructured":"Patti, G. J., Yanes, O., Siuzdak, G. & Innovation Metabolomics: the apogee of the omics trilogy. Nat. Rev. Mol. Cell. Biol. 13, 263\u2013269 (2012).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"74623_CR17","doi-asserted-by":"publisher","first-page":"616157","DOI":"10.3389\/fphar.2020.616157","volume":"11","author":"SM Aleidi","year":"2020","unstructured":"Aleidi, S. M. et al. Obesity connected metabolic changes in type 2 Diabetic patients treated with metformin. Front. Pharmacol. 11, 616157 (2020).","journal-title":"Front. Pharmacol."},{"key":"74623_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1002\/mas.21455","volume":"36","author":"MM Khamis","year":"2017","unstructured":"Khamis, M. M., Adamko, D. J. & El-Aneed, A. Mass spectrometric based approaches in urine metabolomics and biomarker discovery. Mass Spectrom. Rev. 36, 115\u2013134 (2017).","journal-title":"Mass Spectrom. Rev."},{"key":"74623_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12986-019-0335-x","volume":"16","author":"F Qiu","year":"2019","unstructured":"Qiu, F. & Zhang, Y. Q. Metabolic effects of mulberry branch bark powder on diabetic mice based on GC-MS metabolomics approach. Nutr. Metab. (Lond). 16, 10 (2019).","journal-title":"Nutr. Metab. (Lond)"},{"key":"74623_CR20","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s40495-016-0074-x","volume":"2","author":"X Wang","year":"2016","unstructured":"Wang, X., Chen, S. & Jia, W. J. C. P. R. Metabolomics in cancer biomarker research. Curr. Pharmacol. Rep. 2, 293\u2013298 (2016).","journal-title":"Curr. Pharmacol. Rep."},{"key":"74623_CR21","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1007\/s00414-021-02532-z","volume":"135","author":"Z Wei","year":"2021","unstructured":"Wei, Z. et al. Application of Q-TOF\u2013MS based metabonomics techniques to analyze the plasma metabolic profile changes on rats following death due to acute intoxication of phorate. Int. J. Legal Med. 135, 1437\u20131447 (2021).","journal-title":"Int. J. Legal Med."},{"key":"74623_CR22","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1007\/s00216-012-6129-x","volume":"404","author":"X Hu","year":"2012","unstructured":"Hu, X. et al. GC\u2013MS-based metabolic profiling reveals metabolic changes in anaphylaxis animal models. Anal. Bioanal Chem. 404, 887\u2013893 (2012).","journal-title":"Anal. Bioanal Chem."},{"key":"74623_CR23","first-page":"628","volume":"16","author":"YY Gu","year":"2018","unstructured":"Gu, Y. Y., Shi, L., Zhang, D. D., Huang, X. & Chen, D. Z. Metabonomics delineates allergic reactions induced by Shuang-Huang-Lian injection in rats using ultra performance liquid chromatography-mass spectrometry. Chin. J. Nat. Med. 16, 628\u2013640 (2018).","journal-title":"Chin. J. Nat. Med."},{"key":"74623_CR24","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.jep.2018.07.013","volume":"225","author":"X Gao","year":"2018","unstructured":"Gao, X. et al. Deciphering biochemical basis of Qingkailing injection-induced anaphylaxis in a rat model by time-dependent metabolomic profiling based on metabolite polarity-oriented analysis. J. Ethnopharmacol. 225, 287\u2013296 (2018).","journal-title":"J. Ethnopharmacol."},{"key":"74623_CR25","doi-asserted-by":"publisher","first-page":"2100","DOI":"10.1021\/acsomega.0c05178","volume":"6","author":"K Zhang","year":"2021","unstructured":"Zhang, K. et al. The Use of Gas Chromatography coupled with high-resolution Mass Spectrometry-based untargeted metabolomics to Discover metabolic changes and help in the determination of Complex causes of death: a preliminary study. ACS Omega. 6, 2100\u20132109 (2021).","journal-title":"ACS Omega"},{"key":"74623_CR26","doi-asserted-by":"publisher","first-page":"dlac116","DOI":"10.1093\/jacamr\/dlac116","volume":"4","author":"C Mabilat","year":"2022","unstructured":"Mabilat, C. et al. Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs. JAC Antimicrob. Resist. 4, dlac116 (2022).","journal-title":"JAC Antimicrob. Resist."},{"key":"74623_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1111\/cea.14434","volume":"54","author":"G Pouessel","year":"2024","unstructured":"Pouessel, G. et al. Anaphylaxis mortality in the perioperative setting: Epidemiology, elicitors, risk factors and knowledge gaps. Clin. Exp. Allergy. 54, 11\u201320 (2024).","journal-title":"Clin. Exp. Allergy"},{"key":"74623_CR28","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1016\/j.jaip.2017.06.031","volume":"5","author":"PJ Turner","year":"2017","unstructured":"Turner, P. J. et al. Fatal anaphylaxis: Mortality Rate and Risk factors. J. Allergy Clin. Immunol. Pract. 5, 1169\u20131178 (2017).","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"74623_CR29","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1056\/NEJM198706253162603","volume":"316","author":"LB Schwartz","year":"1987","unstructured":"Schwartz, L. B., Metcalfe, D. D., Miller, J. S., Earl, H. & Sullivan, T. J. N. E. J. o. M. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. N Engl. J. Med. 316, 1622\u20131626 (1987).","journal-title":"N Engl. J. Med."},{"key":"74623_CR30","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.jpba.2018.06.038","volume":"158","author":"KL Khoo","year":"2018","unstructured":"Khoo, K. L. et al. Plasma and urine metabolite profiling reveals the protective effect of Clinacanthus nutans in an ovalbumin-induced anaphylaxis model: 1H-NMR metabolomics approach. J. Pharm. Biomed. Anal. 158, 438\u2013450 (2018).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"74623_CR31","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.4049\/jimmunol.158.10.5002","volume":"158","author":"JS Park","year":"1997","unstructured":"Park, J. S. et al. Anti-IL-4 monoclonal antibody prevents antibiotics-induced active fatal anaphylaxis. J. Immunol. 158, 5002\u20135006 (1997).","journal-title":"J. Immunol."},{"key":"74623_CR32","doi-asserted-by":"publisher","first-page":"674","DOI":"10.3181\/0711-MR-311","volume":"233","author":"AP Simopoulos","year":"2008","unstructured":"Simopoulos, A. P. The importance of the omega-6\/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. (Maywood). 233, 674\u2013688 (2008).","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"74623_CR33","doi-asserted-by":"publisher","first-page":"311","DOI":"10.3945\/an.113.003772","volume":"4","author":"J Whelan","year":"2013","unstructured":"Whelan, J. & Fritsche, K. Linoleic acid. Adv. Nutr. 4, 311\u2013312 (2013).","journal-title":"Adv. Nutr."},{"key":"74623_CR34","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1080\/13543784.2019.1555237","volume":"28","author":"G Marone","year":"2019","unstructured":"Marone, G. et al. Prostaglandin D(2) receptor antagonists in allergic disorders: safety, efficacy, and future perspectives. Expert Opin. Investig. Drugs. 28, 73\u201384 (2019).","journal-title":"Expert Opin. Investig. Drugs"},{"issue":"Suppl 1","key":"74623_CR35","first-page":"S191","volume":"153","author":"R Pettipher","year":"2008","unstructured":"Pettipher, R. The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses. Br. J. Pharmacol. 153 (Suppl 1), S191\u2013199 (2008).","journal-title":"Br. J. Pharmacol."},{"key":"74623_CR36","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1159\/000313836","volume":"85","author":"R Schuligoi","year":"2010","unstructured":"Schuligoi, R. et al. CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases. Pharmacology. 85, 372\u2013382 (2010).","journal-title":"Pharmacology"},{"key":"74623_CR37","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1084\/jem.193.2.255","volume":"193","author":"H Hirai","year":"2001","unstructured":"Hirai, H. et al. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193, 255\u2013261 (2001).","journal-title":"J. Exp. Med."},{"key":"74623_CR38","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/S0952-3278(03)00080-2","volume":"69","author":"K Kabashima","year":"2003","unstructured":"Kabashima, K. & Narumiya, S. The DP receptor, allergic inflammation and asthma. Prostaglandins Leukot. Essent. Fat. Acids. 69, 187\u2013194 (2003).","journal-title":"Prostaglandins Leukot. Essent. Fat. Acids"},{"key":"74623_CR39","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1093\/intimm\/dxh096","volume":"16","author":"K Takeshita","year":"2004","unstructured":"Takeshita, K. et al. CRTH2 is a prominent effector in contact hypersensitivity-induced neutrophil inflammation. Int. Immunol. 16, 947\u2013959 (2004).","journal-title":"Int. Immunol."},{"key":"74623_CR40","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1111\/j.1365-2222.2004.02027.x","volume":"34","author":"C Yoshimura-Uchiyama","year":"2004","unstructured":"Yoshimura-Uchiyama, C. et al. Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells\/DP2. Clin. Exp. Allergy. 34, 1283\u20131290 (2004).","journal-title":"Clin. Exp. Allergy"},{"key":"74623_CR41","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1161\/ATVBAHA.112.300993","volume":"33","author":"K Kobayashi","year":"2013","unstructured":"Kobayashi, K. et al. Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP\/PKA\/Tiam1\/Rac1 pathway. Arterioscler. Thromb. Vasc Biol. 33, 565\u2013571 (2013).","journal-title":"Arterioscler. Thromb. Vasc Biol."},{"key":"74623_CR42","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.jaci.2017.02.030","volume":"140","author":"T Nakamura","year":"2017","unstructured":"Nakamura, T. et al. Mast cell-derived prostaglandin D(2) attenuates anaphylactic reactions in mice. J. Allergy Clin. Immunol. 140, 630\u2013632e639 (2017).","journal-title":"J. Allergy Clin. Immunol."},{"key":"74623_CR43","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1080\/07315724.2007.10719612","volume":"26","author":"Y Miyake","year":"2007","unstructured":"Miyake, Y. et al. Fish and fat intake and prevalence of allergic rhinitis in Japanese females: the Osaka Maternal and Child Health Study. J. Am. Coll. Nutr. 26, 279\u2013287 (2007).","journal-title":"J. Am. Coll. Nutr."},{"key":"74623_CR44","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.4049\/jimmunol.0902257","volume":"184","author":"G Perez-Chacon","year":"2010","unstructured":"Perez-Chacon, G., Astudillo, A. M., Ruiperez, V., Balboa, M. A. & Balsinde, J. Signaling role for lysophosphatidylcholine acyltransferase 3 in receptor-regulated arachidonic acid reacylation reactions in human monocytes. J. Immunol. 184, 1071\u20131078 (2010).","journal-title":"J. Immunol."},{"key":"74623_CR45","doi-asserted-by":"crossref","unstructured":"Knuplez, E. & Marsche, G. An updated review of Pro- and Anti-inflammatory properties of plasma lysophosphatidylcholines in the Vascular System. Int. J. Mol. Sci. 21, 4501 (2020).","DOI":"10.3390\/ijms21124501"},{"key":"74623_CR46","doi-asserted-by":"publisher","first-page":"117203","DOI":"10.1016\/j.jep.2023.117203","volume":"319","author":"BH Wang","year":"2024","unstructured":"Wang, B. H. et al. Qufeng Xuanbi Formula inhibited benzo[a]pyrene-induced aggravated asthma airway mucus secretion by AhR\/ROS\/ERK pathway. J. Ethnopharmacol. 319, 117203 (2024).","journal-title":"J. Ethnopharmacol."},{"key":"74623_CR47","doi-asserted-by":"publisher","first-page":"1135701","DOI":"10.3389\/fimmu.2023.1135701","volume":"14","author":"S Jiang","year":"2023","unstructured":"Jiang, S. et al. The immediate adverse drug reactions induced by ShenMai Injection are mediated by thymus-derived T cells and associated with RhoA\/ROCK signaling pathway. Front. Immunol. 14, 1135701 (2023).","journal-title":"Front. Immunol."},{"key":"74623_CR48","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/nrm1128","volume":"4","author":"K Riento","year":"2003","unstructured":"Riento, K. & Ridley, A. J. Rocks: multifunctional kinases in cell behaviour. Nat. Rev. Mol. Cell. Biol. 4, 446\u2013456 (2003).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"74623_CR49","doi-asserted-by":"crossref","unstructured":"Wang, D. et al. Penilloic acid is the chief culprit involved in non-IgE mediated, immediate penicillin-induced hypersensitivity reactions in mice. Front. Pharmacol. 13, 874486 (2022).","DOI":"10.3389\/fphar.2022.874486"},{"key":"74623_CR50","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4168\/aair.2014.6.1.61","volume":"6","author":"M Yoder","year":"2014","unstructured":"Yoder, M. et al. Bioactive lysophosphatidylcholine 16:0 and 18:0 are elevated in lungs of asthmatic subjects. Allergy Asthma Immunol. Res. 6, 61\u201365 (2014).","journal-title":"Allergy Asthma Immunol. Res."},{"key":"74623_CR51","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.it.2015.10.005","volume":"36","author":"A Baeyens","year":"2015","unstructured":"Baeyens, A., Fang, V., Chen, C. & Schwab, S. R. Exit strategies: S1P Signaling and T Cell Migration. Trends Immunol. 36, 778\u2013787 (2015).","journal-title":"Trends Immunol."},{"key":"74623_CR52","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.coph.2009.02.002","volume":"9","author":"LY Lee","year":"2009","unstructured":"Lee, L. Y. & Gu, Q. Role of TRPV1 in inflammation-induced airway hypersensitivity. Curr. Opin. Pharmacol. 9, 243\u2013249 (2009).","journal-title":"Curr. Opin. Pharmacol."},{"key":"74623_CR53","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.jaci.2013.09.016","volume":"133","author":"LP McGarvey","year":"2014","unstructured":"McGarvey, L. P. et al. Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma. J. Allergy Clin. Immunol. 133, 704\u2013712e704 (2014).","journal-title":"J. Allergy Clin. Immunol."},{"key":"74623_CR54","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/978-1-4419-9533-9_8","volume":"716","author":"A Olivera","year":"2011","unstructured":"Olivera, A. & Rivera, J. An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease. Adv. Exp. Med. Biol. 716, 123\u2013142 (2011).","journal-title":"Adv. Exp. Med. Biol."},{"key":"74623_CR55","doi-asserted-by":"publisher","first-page":"e37","DOI":"10.5415\/apallergy.2019.9.e37","volume":"9","author":"D Barber","year":"2019","unstructured":"Barber, D., Villasenor, A. & Escribese, M. M. Metabolomics strategies to discover new biomarkers associated to severe allergic phenotypes. Asia Pac. Allergy. 9, e37 (2019).","journal-title":"Asia Pac. Allergy"},{"key":"74623_CR56","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1097\/00000542-199112000-00004","volume":"75","author":"D Laroche","year":"1991","unstructured":"Laroche, D., Vergnaud, M. C., Sillard, B., Soufarapis, H. & Bricard, H. Biochemical markers of anaphylactoid reactions to drugs. Comparison of plasma histamine and tryptase. Anesthesiology. 75, 945\u2013949 (1991).","journal-title":"Anesthesiology"},{"key":"74623_CR57","first-page":"575","volume":"16","author":"K Onodera","year":"1994","unstructured":"Onodera, K., Shinoda, H., Imaizumi, M., Hiraki-Sakurai, E. & Yamatodani, A. Effects of intracerebroventricular administration of N-acetylhistamine on body temperature in mice. Methods Find. Exp. Clin. Pharmacol. 16, 575\u2013581 (1994).","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"74623_CR58","first-page":"224","volume":"35","author":"Y Xu","year":"2017","unstructured":"Xu, Y., Guo, N., Dou, D., Ran, X. & Liu, C. Metabolomics analysis of anaphylactoid reaction reveals its mechanism in a rat model. Asian Pac. J. Allergy Immunol. 35, 224\u2013232 (2017).","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"74623_CR59","doi-asserted-by":"publisher","first-page":"19528","DOI":"10.1074\/jbc.M112.364471","volume":"287","author":"M Hebecker","year":"2012","unstructured":"Hebecker, M. & Jozsi, M. Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. J. Biol. Chem. 287, 19528\u201319536 (2012).","journal-title":"J. Biol. Chem."},{"key":"74623_CR60","doi-asserted-by":"publisher","first-page":"117","DOI":"10.2147\/JAA.S334752","volume":"15","author":"J Zhen","year":"2022","unstructured":"Zhen, J. et al. The multiomics analyses of gut microbiota, urine metabolome and plasma Proteome revealed significant changes in Allergy featured with Indole Derivatives of Tryptophan. J. Asthma Allergy. 15, 117\u2013131 (2022).","journal-title":"J. Asthma Allergy"},{"key":"74623_CR61","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1084\/jem.114.6.875","volume":"114","author":"BB Levine","year":"1961","unstructured":"Levine, B. B. & Ovary, Z. Studies on the mechanism of the formation of the penicillin antigen. III. The N-(D-alpha-benzylpenicilloyl) group as an antigenic determinant responsible for hypersensitivity to penicillin G. J. Exp. Med. 114, 875\u2013904 (1961).","journal-title":"J. Exp. Med."},{"key":"74623_CR62","doi-asserted-by":"publisher","first-page":"21","DOI":"10.4049\/jimmunol.1900225","volume":"203","author":"PE Deak","year":"2019","unstructured":"Deak, P. E. et al. Covalent heterobivalent inhibitor design for inhibition of IgE-Dependent penicillin allergy in a murine model. J. Immunol. 203, 21\u201330 (2019).","journal-title":"J. Immunol."},{"key":"74623_CR63","unstructured":"Paget, G. E. & Barnase, J. M. In Evaluation of Drug Activities: Pharmaocometrics. Vol. 1 (eds Laurence, D. R. & Bocharach, A. L.) 3\u201322  (Academic, 1964)."},{"key":"74623_CR64","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. K. E. G. G. Kyoto Encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"74623_CR65","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951 (2019).","journal-title":"Protein Sci."},{"key":"74623_CR66","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013D592 (2023).","journal-title":"Nucleic Acids Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74623-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74623-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74623-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T09:04:57Z","timestamp":1728464697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74623-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,9]]},"references-count":66,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["74623"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-74623-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2024,10,9]]},"assertion":[{"value":"17 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23534"}}