{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:33:11Z","timestamp":1785882791812,"version":"3.56.0"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82274630"],"award-info":[{"award-number":["82274630"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the National Administration of Traditional Chinese Medicine","award":["GZY-KJS-2020-077"],"award-info":[{"award-number":["GZY-KJS-2020-077"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"the Peak Academic Talents in Jiangsu Province Hospital of Chinese Medicine","award":["y2018rc05"],"award-info":[{"award-number":["y2018rc05"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Youth Talent Project of Jiangsu Province Administration of Traditional Chinese Medicinegrant number","award":["QN202308"],"award-info":[{"award-number":["QN202308"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]},{"name":"Natural Science Youth Foundation of Jiangsu Province","award":["BK20240741"],"award-info":[{"award-number":["BK20240741"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-74717-6","type":"journal-article","created":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T02:01:39Z","timestamp":1728612099000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The mediating effect of circulating inflammatory proteins on the relationship between gut microbiota and FD: a bidirectional Mendelian randomization study"],"prefix":"10.1038","volume":"14","author":[{"given":"Li","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,11]]},"reference":[{"issue":"17","key":"74717_CR1","doi-asserted-by":"publisher","first-page":"2756","DOI":"10.3748\/wjg.v12.i17.2756","volume":"12","author":"JH Lee","year":"2006","unstructured":"Lee, J. H. et al. Efficacy and safety of ecabet sodium on functional dyspepsia: a prospective, double-blinded, randomized, multi-center controlled trial. World J. Gastroenterol. 12(17), 2756\u20132761 (2006).","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"74717_CR2","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1159\/000532082","volume":"105","author":"T Oshima","year":"2024","unstructured":"Oshima, T. Functional dyspepsia: current understanding and future perspective. Digestion 105(1), 26\u201333 (2024).","journal-title":"Digestion"},{"issue":"6","key":"74717_CR3","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1097\/MPG.0000000000001344","volume":"63","author":"C Romano","year":"2016","unstructured":"Romano, C. et al. Functional dyspepsia: an Enigma in a conundrum. J. Pediatr. Gastroenterol. Nutr. 63(6), 579\u2013584 (2016).","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"74717_CR4","doi-asserted-by":"publisher","first-page":"155481","DOI":"10.1016\/j.phymed.2024.155481","volume":"127","author":"J Zhang","year":"2024","unstructured":"Zhang, J. et al. Insights and future prospects of traditional Chinese medicine in the treatment of functional dyspepsia. Phytomedicine. 127, 155481 (2024).","journal-title":"Phytomedicine"},{"issue":"13","key":"74717_CR5","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1007\/s40265-020-01362-4","volume":"80","author":"GS Sayuk","year":"2020","unstructured":"Sayuk, G. S. et al. Functional dyspepsia: diagnostic and therapeutic approaches. Drugs 80(13), 1319\u20131336 (2020).","journal-title":"Drugs"},{"issue":"Pt 1","key":"74717_CR6","doi-asserted-by":"publisher","first-page":"131640","DOI":"10.1016\/j.ijbiomac.2024.131640","volume":"268","author":"T Liu","year":"2024","unstructured":"Liu, T. et al. Laminarin ameliorates iodoacetamide-induced functional dyspepsia via modulation of 5-HT(3) receptors and the gut microbiota. Int. J. Biol. Macromol. 268(Pt 1), 131640 (2024).","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"74717_CR7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1136\/gutjnl-2021-326158","volume":"72","author":"ER Shanahan","year":"2023","unstructured":"Shanahan, E. R. et al. Alterations to the duodenal microbiota are linked to gastric emptying and symptoms in functional dyspepsia. Gut. 72 (5), 929\u2013938 (2023).","journal-title":"Gut"},{"issue":"12","key":"74717_CR8","doi-asserted-by":"publisher","first-page":"e13666","DOI":"10.1111\/eci.13666","volume":"51","author":"R Vasapolli","year":"2021","unstructured":"Vasapolli, R. et al. Gut microbiota profiles and the role of anti-CdtB and anti-vinculin antibodies in patients with functional gastrointestinal disorders (FGID). Eur. J. Clin. Invest. 51(12), e13666 (2021).","journal-title":"Eur. J. Clin. Invest."},{"issue":"1","key":"74717_CR9","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1159\/000504090","volume":"101","author":"A Fukui","year":"2020","unstructured":"Fukui, A. et al. Higher levels of Streptococcus in upper gastrointestinal mucosa associated with symptoms in patients with functional dyspepsia. Digestion 101(1), 38\u201345 (2020).","journal-title":"Digestion"},{"issue":"3","key":"74717_CR10","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/19490976.2015.1044711","volume":"6","author":"Y Ringel","year":"2015","unstructured":"Ringel, Y. et al. High throughput sequencing reveals distinct microbial populations within the mucosal and luminal niches in healthy individuals. Gut Microbes 6(3), 173\u2013181 (2015).","journal-title":"Gut Microbes"},{"key":"74717_CR11","doi-asserted-by":"publisher","first-page":"110886","DOI":"10.1016\/j.jinorgbio.2019.110886","volume":"203","author":"PN Alexandrov","year":"2020","unstructured":"Alexandrov, P. N. et al. Aluminum-induced generation of lipopolysaccharide (LPS) from the human gastrointestinal (GI)-tract microbiome-resident Bacteroides fragilis. J. Inorg. Biochem. 203, 110886 (2020).","journal-title":"J. Inorg. Biochem."},{"issue":"6","key":"74717_CR12","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1038\/ajg.2010.512","volume":"106","author":"T Liebregts","year":"2011","unstructured":"Liebregts, T. et al. Small bowel homing T cells are associated with symptoms and delayed gastric emptying in functional dyspepsia. Am. J. Gastroenterol. 106(6), 1089\u20131098 (2011).","journal-title":"Am. J. Gastroenterol."},{"issue":"8","key":"74717_CR13","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1038\/ajg.2010.151","volume":"105","author":"S Futagami","year":"2010","unstructured":"Futagami, S. et al. Migration of eosinophils and CCR2-\/CD68-double positive cells into the duodenal mucosa of patients with postinfectious functional dyspepsia. Am. J. Gastroenterol. 105(8), 1835\u20131842 (2010).","journal-title":"Am. J. Gastroenterol."},{"key":"74717_CR14","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1471-2172-9-65","volume":"9","author":"T Hrncir","year":"2008","unstructured":"Hrncir, T. et al. Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice. BMC Immunol. 9, 65 (2008).","journal-title":"BMC Immunol."},{"issue":"1","key":"74717_CR15","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1001\/jamaneurol.2019.3419","volume":"77","author":"S Bandres-Ciga","year":"2020","unstructured":"Bandres-Ciga, S. et al. Mendelian randomization-a journey from obscurity to center stage with a few potholes along the way. JAMA Neurol. 77(1), 7\u20138 (2020).","journal-title":"JAMA Neurol."},{"key":"74717_CR16","doi-asserted-by":"publisher","first-page":"1363776","DOI":"10.3389\/fmicb.2024.1363776","volume":"15","author":"B Gao","year":"2024","unstructured":"Gao, B. et al. Relationships among gut microbiota, plasma metabolites, and juvenile idiopathic arthritis: a mediation mendelian randomization study. Front. Microbiol. 15, 1363776 (2024).","journal-title":"Front. Microbiol."},{"issue":"2","key":"74717_CR17","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41588-020-00763-1","volume":"53","author":"A Kurilshikov","year":"2021","unstructured":"Kurilshikov, A. et al. Large-scale association analyses identify host factors influencing human gut microbiome composition. Nat. Genet. 53(2), 156\u2013165 (2021).","journal-title":"Nat. Genet."},{"issue":"9","key":"74717_CR18","doi-asserted-by":"publisher","first-page":"1540","DOI":"10.1038\/s41590-023-01588-w","volume":"24","author":"JH Zhao","year":"2023","unstructured":"Zhao, J. H. et al. Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets. Nat. Immunol. 24(9), 1540\u20131551 (2023).","journal-title":"Nat. Immunol."},{"issue":"7944","key":"74717_CR19","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki, M. I. et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature 613(7944), 508\u2013518 (2023).","journal-title":"Nature"},{"issue":"4","key":"74717_CR20","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1038\/s41588-019-0350-x","volume":"51","author":"S Sanna","year":"2019","unstructured":"Sanna, S. et al. Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases. Nat. Genet. 51(4), 600\u2013605 (2019).","journal-title":"Nat. Genet."},{"issue":"3","key":"74717_CR21","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/hep.32728","volume":"77","author":"J Xie","year":"2023","unstructured":"Xie, J. et al. The associations between modifiable risk factors and nonalcoholic fatty liver disease: a comprehensive mendelian randomization study. Hepatology 77(3), 949\u2013964 (2023).","journal-title":"Hepatology"},{"issue":"7","key":"74717_CR22","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1002\/gepi.21758","volume":"37","author":"S Burgess","year":"2013","unstructured":"Burgess, S. et al. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet. Epidemiol. 37(7), 658\u2013665 (2013).","journal-title":"Genet. Epidemiol."},{"issue":"5","key":"74717_CR23","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck, M. et al. Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat. Genet. 50(5), 693\u2013698 (2018).","journal-title":"Nat. Genet."},{"issue":"3","key":"74717_CR24","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1093\/ije\/dyq151","volume":"40","author":"BL Pierce","year":"2011","unstructured":"Pierce, B. L. et al. Power and instrument strength requirements for mendelian randomization studies using multiple genetic variants. Int. J. Epidemiol. 40(3), 740\u2013752 (2011).","journal-title":"Int. J. Epidemiol."},{"key":"74717_CR25","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12874-015-0034-x","volume":"15","author":"E Kulinskaya","year":"2015","unstructured":"Kulinskaya, E. et al. An accurate test for homogeneity of odds ratios based on Cochran\u2019s Q-statistic. BMC Med. Res. Methodol. 15, 49 (2015).","journal-title":"BMC Med. Res. Methodol."},{"issue":"4","key":"74717_CR26","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","volume":"124","author":"S Akira","year":"2006","unstructured":"Akira, S. et al. Pathogen recognition and innate immunity. Cell 124(4), 783\u2013801 (2006).","journal-title":"Cell"},{"issue":"7","key":"74717_CR27","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1016\/j.cmet.2021.05.002","volume":"33","author":"D Borgmann","year":"2021","unstructured":"Borgmann, D. et al. Gut-brain communication by distinct sensory neurons differently controls feeding and glucose metabolism. Cell. Metab. 33(7), 1466-1482.e1467 (2021).","journal-title":"Cell. Metab."},{"issue":"2","key":"74717_CR28","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s13167-023-00321-9","volume":"14","author":"K Liu","year":"2023","unstructured":"Liu, K. et al. Clarifying the effect of gut microbiota on allergic conjunctivitis risk is instrumental for predictive, preventive, and personalized medicine: a mendelian randomization analysis. Epma j. 14(2), 235\u2013248 (2023).","journal-title":"Epma j."},{"issue":"1","key":"74717_CR29","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s13071-020-3897-6","volume":"13","author":"HL Chen","year":"2020","unstructured":"Chen, H. L. et al. Dissection of the cecal microbial community in chickens after Eimeria tenella infection. Parasit. Vectors 13(1), 56 (2020).","journal-title":"Parasit. Vectors"},{"issue":"1","key":"74717_CR30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s12906-022-03575-4","volume":"22","author":"Z Zhao","year":"2022","unstructured":"Zhao, Z. et al. Bacterial diversity in the intestinal mucosa of heart failure rats treated with Sini Decoction. BMC Complement. Med. Ther. 22(1), 93 (2022).","journal-title":"BMC Complement. Med. Ther."},{"issue":"23","key":"74717_CR31","doi-asserted-by":"publisher","first-page":"e1801187","DOI":"10.1002\/mnfr.201801187","volume":"63","author":"M Zhuang","year":"2019","unstructured":"Zhuang, M. et al. Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion. Mol. Nutr. Food Res. 63(23), e1801187 (2019).","journal-title":"Mol. Nutr. Food Res."},{"key":"74717_CR32","doi-asserted-by":"publisher","first-page":"12693","DOI":"10.1038\/srep12693","volume":"5","author":"M Pozuelo","year":"2015","unstructured":"Pozuelo, M. et al. Reduction of butyrate- and methane-producing microorganisms in patients with irritable bowel syndrome. Sci. Rep. 5, 12693 (2015).","journal-title":"Sci. Rep."},{"key":"74717_CR33","doi-asserted-by":"crossref","unstructured":"Moustafa, A. et al. Genetic risk, dysbiosis, and treatment stratification using host genome and gut microbiome in inflammatory bowel disease. Clin. Transl Gastroenterol. 9(1), e132 (2018).","DOI":"10.1038\/ctg.2017.58"},{"issue":"3","key":"74717_CR34","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S2213-8587(14)70134-2","volume":"3","author":"AJ Cox","year":"2015","unstructured":"Cox, A. J. et al. Obesity, inflammation, and the gut microbiota. Lancet Diabetes Endocrinol. 3(3), 207\u2013215 (2015).","journal-title":"Lancet Diabetes Endocrinol."},{"key":"74717_CR35","doi-asserted-by":"crossref","unstructured":"Jia, W. et al.\u00a0Integrated network pharmacology and gut microbiota analysis to explore the mechanism of sijunzi decoction involved in alleviating airway inflammation in a mouse model of asthma. Evid Based Complement Alternat Med. 2023, 1130893 (2023).","DOI":"10.1155\/2023\/1130893"},{"issue":"1","key":"74717_CR36","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12934-021-01568-5","volume":"20","author":"A Li","year":"2021","unstructured":"Li, A. et al. Microbiome analysis reveals gut microbiota alteration of early-weaned Yimeng black goats with the effect of milk replacer and age. Microb. Cell. Fact. 20(1), 78 (2021).","journal-title":"Microb. Cell. Fact."},{"issue":"1","key":"74717_CR37","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/s41398-021-01620-3","volume":"11","author":"E Medawar","year":"2021","unstructured":"Medawar, E. et al. Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior. Transl Psychiatry. 11 (1), 500 (2021).","journal-title":"Transl Psychiatry"},{"issue":"5","key":"74717_CR38","first-page":"361","volume":"82","author":"G Tomasello","year":"2011","unstructured":"Tomasello, G. et al. From gut microflora imbalance to mycobacteria infection: is there a relationship with chronic intestinal inflammatory diseases?. Ann. Ital. Chir. 82(5), 361\u2013368 (2011).","journal-title":"Ann. Ital. Chir."},{"key":"74717_CR39","doi-asserted-by":"publisher","first-page":"122728","DOI":"10.1016\/j.jchromb.2021.122728","volume":"1174","author":"ZM Zhang","year":"2021","unstructured":"Zhang, Z. M. et al. Integrated gut microbiota and fecal metabolomics reveal the renoprotective effect of Rehmanniae Radix Preparata and Corni Fructus on adenine-induced CKD rats. J. Chromatogr. B Analyt Technol. Biomed. Life Sci. 1174, 122728 (2021).","journal-title":"J. Chromatogr. B Analyt Technol. Biomed. Life Sci."},{"issue":"10","key":"74717_CR40","doi-asserted-by":"publisher","first-page":"e13914","DOI":"10.1111\/nmo.13914","volume":"32","author":"S Facchin","year":"2020","unstructured":"Facchin, S. et al. Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease. Neurogastroenterol Motil. 32(10), e13914 (2020).","journal-title":"Neurogastroenterol Motil."},{"key":"74717_CR41","doi-asserted-by":"publisher","first-page":"942460","DOI":"10.3389\/fcimb.2022.942460","volume":"12","author":"L Chen","year":"2022","unstructured":"Chen, L. et al. A comparison of the composition and functions of the oral and gut microbiotas in Alzheimer\u2019s patients. Front. Cell. Infect. Microbiol. 12, 942460 (2022).","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"74717_CR42","doi-asserted-by":"publisher","first-page":"2162306","DOI":"10.1080\/19490976.2022.2162306","volume":"15","author":"S Malan-M\u00fcller","year":"2023","unstructured":"Malan-M\u00fcller, S. et al. The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles. Gut Microbes 15(1), 2162306 (2023).","journal-title":"Gut Microbes"},{"issue":"1","key":"74717_CR43","doi-asserted-by":"publisher","first-page":"19603","DOI":"10.1038\/s41598-019-56132-4","volume":"9","author":"T Nozu","year":"2019","unstructured":"Nozu, T. et al. Butyrate inhibits visceral allodynia and colonic hyperpermeability in rat models of irritable bowel syndrome. Sci. Rep. 9(1), 19603 (2019).","journal-title":"Sci. Rep."},{"key":"74717_CR44","doi-asserted-by":"publisher","first-page":"810462","DOI":"10.3389\/fnut.2022.810462","volume":"9","author":"Y Guo","year":"2022","unstructured":"Guo, Y. et al. Pine (Pinus massoniana Lamb.) needle extract supplementation improves performance, egg quality, serum parameters, and the gut microbiome in laying hens. Front. Nutr. 9, 810462 (2022).","journal-title":"Front. Nutr."},{"key":"74717_CR45","doi-asserted-by":"publisher","first-page":"798052","DOI":"10.3389\/fcimb.2021.798052","volume":"11","author":"F Wan","year":"2021","unstructured":"Wan, F. et al. Supplementation with Chinese medicinal plant extracts from Lonicera hypoglauca and scutellaria baicalensis mitigates colonic inflammation by regulating oxidative stress and gut microbiota in a colitis mouse model. Front. Cell. Infect. Microbiol. 11, 798052 (2021).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"74717_CR46","doi-asserted-by":"publisher","first-page":"846974","DOI":"10.3389\/fnut.2022.846974","volume":"9","author":"N Ma","year":"2022","unstructured":"Ma, N. et al. Micro-coevolution of genetics rather than diet with enterotype in pigs. Front. Nutr. 9, 846974 (2022).","journal-title":"Front. Nutr."},{"issue":"1","key":"74717_CR47","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1186\/s12884-022-04923-5","volume":"22","author":"M Wu","year":"2022","unstructured":"Wu, M. et al. Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study. BMC Pregnancy Childbirth 22(1), 592 (2022).","journal-title":"BMC Pregnancy Childbirth"},{"issue":"10263","key":"74717_CR48","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1016\/S0140-6736(20)30469-4","volume":"396","author":"AC Ford","year":"2020","unstructured":"Ford, A. C. et al. Functional dyspepsia. Lancet 396(10263), 1689\u20131702 (2020).","journal-title":"Lancet"},{"issue":"1","key":"74717_CR49","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/s40168-020-00843-8","volume":"8","author":"F Liu","year":"2020","unstructured":"Liu, F. et al. Mechanistic insights into the attenuation of intestinal inflammation and modulation of the gut microbiome by krill oil using in vitro and in vivo models. Microbiome 8(1), 83 (2020).","journal-title":"Microbiome"},{"issue":"1","key":"74717_CR50","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/ibd\/izaa107","volume":"27","author":"M Olaisen","year":"2021","unstructured":"Olaisen, M. et al. Bacterial mucosa-associated microbiome in inflamed and proximal noninflamed ileum of patients with Crohn\u2019s disease. Inflamm. Bowel Dis. 27(1), 12\u201324 (2021).","journal-title":"Inflamm. Bowel Dis."},{"issue":"1","key":"74717_CR51","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.1038\/s41598-021-85152-2","volume":"11","author":"J Sun","year":"2021","unstructured":"Sun, J. et al. Galectin-9 expression correlates with therapeutic effect in rheumatoid arthritis. Sci. Rep. 11(1), 5562 (2021).","journal-title":"Sci. Rep."},{"issue":"1","key":"74717_CR52","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1038\/s41467-018-03600-6","volume":"9","author":"MA Meyer","year":"2018","unstructured":"Meyer, M. A. et al. Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance. Nat. Commun. 9(1), 1250 (2018).","journal-title":"Nat. Commun."},{"key":"74717_CR53","doi-asserted-by":"crossref","unstructured":"Qiu, Y. et al.\u00a0Bioinformatics analysis of genes and mechanisms in postherpetic neuralgia. Pain Res. Manag. 2020, 1380504 (2020).","DOI":"10.1155\/2020\/1380504"},{"issue":"48","key":"74717_CR54","doi-asserted-by":"publisher","first-page":"7371","DOI":"10.3748\/wjg.v18.i48.7371","volume":"18","author":"X Huang","year":"2012","unstructured":"Huang, X. et al. Itopride therapy for functional dyspepsia: a meta-analysis. World J. Gastroenterol. 18(48), 7371\u20137377 (2012).","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"74717_CR55","doi-asserted-by":"publisher","first-page":"3114","DOI":"10.1111\/cas.15839","volume":"114","author":"K Zhang","year":"2023","unstructured":"Zhang, K. et al. Clostridium butyricum inhibits epithelial-mesenchymal transition of intestinal carcinogenesis through downregulating METTL3. Cancer Sci. 114(8), 3114\u20133127 (2023).","journal-title":"Cancer Sci."},{"key":"74717_CR56","doi-asserted-by":"crossref","unstructured":"Hecking, I. et al. Neuroprotective effects of VEGF in the enteric nervous system. Int. J. Mol. Sci. 23(12), 6756 (2022).","DOI":"10.3390\/ijms23126756"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74717-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74717-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74717-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T13:01:08Z","timestamp":1732885268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74717-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,11]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["74717"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-74717-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,11]]},"assertion":[{"value":"23 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23785"}}