{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T17:18:59Z","timestamp":1790356739779,"version":"4.1.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T00:00:00Z","timestamp":1728000000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Research and Development Fund of Kangda College of Nanjing Medical University","award":["KD2021KYJJZD026"],"award-info":[{"award-number":["KD2021KYJJZD026"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-74883-7","type":"journal-article","created":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T04:11:41Z","timestamp":1728015101000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Evidence of the association between asthma and lung cancer risk from mendelian randomization analysis"],"prefix":"10.1038","volume":"14","author":[{"given":"Lingling","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan\u2019an","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,4]]},"reference":[{"issue":"3","key":"74883_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung, H. et al. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.71 (3), 209\u2013249 (2021).","journal-title":"CA Cancer J. Clin."},{"issue":"6","key":"74883_CR2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.3322\/caac.21492","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray, F. et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin.68 (6), 394\u2013424 (2018).","journal-title":"CA Cancer J. Clin."},{"issue":"9","key":"74883_CR3","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/s41571-023-00798-3","volume":"20","author":"A Leiter","year":"2023","unstructured":"Leiter, A., Veluswamy, R. R. & Wisnivesky, J. P. The global burden of lung cancer: current status and future trends. Nat. Rev. Clin. Oncol.20 (9), 624\u2013639 (2023).","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"3","key":"74883_CR4","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1093\/carcin\/bgr307","volume":"33","author":"A Rosenberger","year":"2012","unstructured":"Rosenberger, A. et al. Asthma and lung cancer risk: a systematic investigation by the International Lung Cancer Consortium. Carcinogenesis. 33 (3), 587\u2013597 (2012).","journal-title":"Carcinogenesis"},{"issue":"6","key":"74883_CR5","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1136\/oemed-2018-105447","volume":"76","author":"MK Honaryar","year":"2019","unstructured":"Honaryar, M. K. et al. Welding fumes and lung cancer: a meta-analysis of case-control and cohort studies. Occup. Environ. Med.76 (6), 422\u2013431 (2019).","journal-title":"Occup. Environ. Med."},{"issue":"1","key":"74883_CR6","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jtho.2021.07.031","volume":"17","author":"A Kerpel-Fronius","year":"2022","unstructured":"Kerpel-Fronius, A. et al. Screening for Lung Cancer in individuals who never smoked: an International Association for the Study of Lung Cancer Early Detection and Screening Committee Report. J. Thorac. Oncol.17 (1), 56\u201366 (2022).","journal-title":"J. Thorac. Oncol."},{"issue":"1","key":"74883_CR7","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1001\/jama.2015.17703","volume":"315","author":"LA Mucci","year":"2016","unstructured":"Mucci, L. A. et al. Familial risk and heritability of Cancer among Twins in Nordic Countries. Jama. 315 (1), 68\u201376 (2016).","journal-title":"Jama"},{"issue":"5","key":"74883_CR8","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1398-9995.2004.00526.x","volume":"59","author":"M Masoli","year":"2004","unstructured":"Masoli, M., Fabian, D., Holt, S. & Beasley, R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 59 (5), 469\u2013478 (2004).","journal-title":"Allergy"},{"issue":"10","key":"74883_CR9","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1164\/rccm.201606-1129OC","volume":"195","author":"EA Jacobsen","year":"2017","unstructured":"Jacobsen, E. A. et al. Lung pathologies in a chronic inflammation mouse model are Independent of Eosinophil Degranulation. Am. J. Respir Crit. Care Med.195 (10), 1321\u20131332 (2017).","journal-title":"Am. J. Respir Crit. Care Med."},{"issue":"9","key":"74883_CR10","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1111\/j.1398-9995.2008.01772.x","volume":"63","author":"CL Van Hove","year":"2008","unstructured":"Van Hove, C. L., Maes, T., Joos, G. F. & Tournoy, K. G. Chronic inflammation in asthma: a contest of persistence vs resolution. Allergy. 63 (9), 1095\u20131109 (2008).","journal-title":"Allergy"},{"key":"74883_CR11","doi-asserted-by":"crossref","unstructured":"Kankaanranta, H., Kauppi, P., Tuomisto, L. E. & Ilmarinen, P. Emerging Comorbidities in Adult Asthma: Risks, Clinical Associations, and Mechanisms. Mediators Inflamm 2016:3690628. (2016).","DOI":"10.1155\/2016\/3690628"},{"issue":"3","key":"74883_CR12","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1164\/rccm.201810-1980LE","volume":"200","author":"DK Yon","year":"2019","unstructured":"Yon, D. K. et al. Indoor exposure and sensitization to Formaldehyde among Inner-City children with increased risk for Asthma and Rhinitis. Am. J. Respir Crit. Care Med.200 (3), 388\u2013393 (2019).","journal-title":"Am. J. Respir Crit. Care Med."},{"issue":"1","key":"74883_CR13","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.jaci.2020.04.041","volume":"147","author":"A Woo","year":"2021","unstructured":"Woo, A. et al. Incidence of cancer after asthma development: 2 independent population-based cohort studies. J. Allergy Clin. Immunol.147 (1), 135\u2013143 (2021).","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"74883_CR14","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/S1081-1206(10)60632-1","volume":"99","author":"RM Merrill","year":"2007","unstructured":"Merrill, R. M., Isakson, R. T. & Beck, R. E. The association between allergies and cancer: what is currently known? Ann. Allergy Asthma Immunol.99 (2), 102\u2013116 (2007). quiz 117\u2009\u2013\u2009109, 150.","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"1","key":"74883_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10937400701436460","volume":"11","author":"N Azad","year":"2008","unstructured":"Azad, N., Rojanasakul, Y. & Vallyathan, V. Inflammation and lung cancer: roles of reactive oxygen\/nitrogen species. J. Toxicol. Environ. Health B Crit. Rev.11 (1), 1\u201315 (2008).","journal-title":"J. Toxicol. Environ. Health B Crit. Rev."},{"key":"74883_CR16","doi-asserted-by":"publisher","first-page":"115015","DOI":"10.1016\/j.biopha.2023.115015","volume":"164","author":"M Nigam","year":"2023","unstructured":"Nigam, M. et al. Evaluation of the association of chronic inflammation and cancer: insights and implications. Biomed. Pharmacother. 164, 115015 (2023).","journal-title":"Biomed. Pharmacother"},{"issue":"11","key":"74883_CR17","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1038\/nrc3611","volume":"13","author":"E Elinav","year":"2013","unstructured":"Elinav, E. et al. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms. Nat. Rev. Cancer. 13 (11), 759\u2013771 (2013).","journal-title":"Nat. Rev. Cancer"},{"issue":"6917","key":"74883_CR18","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature. 420 (6917), 860\u2013867 (2002).","journal-title":"Nature"},{"issue":"1","key":"74883_CR19","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/s41392-021-00658-5","volume":"6","author":"H Zhao","year":"2021","unstructured":"Zhao, H. et al. Inflammation and tumor progression: signaling pathways and targeted intervention. Signal. Transduct. Target. Ther.6 (1), 263 (2021).","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"74883_CR20","doi-asserted-by":"publisher","first-page":"4539","DOI":"10.1038\/s41598-021-84012-3","volume":"11","author":"L Jiang","year":"2021","unstructured":"Jiang, L. et al. Asthma and asthma symptom control in relation to incidence of lung cancer in the HUNT study. Sci. Rep.11 (1), 4539 (2021).","journal-title":"Sci. Rep."},{"issue":"1","key":"74883_CR21","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1183\/09031936.02.00245802","volume":"19","author":"P Boffetta","year":"2002","unstructured":"Boffetta, P., Ye, W., Boman, G. & Nyr\u00e9n Lung cancer risk in a population-based cohort of patients hospitalized for asthma in Sweden. Eur. Respir J.19 (1), 127\u2013133 (2002).","journal-title":"Eur. Respir J."},{"issue":"8","key":"74883_CR22","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1158\/1055-9965.EPI-18-1330","volume":"28","author":"ED Kantor","year":"2019","unstructured":"Kantor, E. D., Hsu, M., Du, M. & Signorello, L. B. Allergies and asthma in relation to Cancer Risk. Cancer Epidemiol. Biomarkers Prev.28 (8), 1395\u20131403 (2019).","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"issue":"4","key":"74883_CR23","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1023\/A:1023982402137","volume":"14","author":"AA Santillan","year":"2003","unstructured":"Santillan, A. A., Camargo, C. A. Jr. & Colditz, G. A. A meta-analysis of asthma and risk of lung cancer (United States). Cancer Causes Control. 14 (4), 327\u2013334 (2003).","journal-title":"Cancer Causes Control"},{"issue":"10","key":"74883_CR24","doi-asserted-by":"publisher","first-page":"11871","DOI":"10.1002\/cam4.5875","volume":"12","author":"Y Guo","year":"2023","unstructured":"Guo, Y. et al. Cancer incidence after asthma diagnosis: evidence from a large clinical research network in the United States. Cancer Med.12 (10), 11871\u201311877 (2023).","journal-title":"Cancer Med."},{"issue":"5","key":"74883_CR25","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/sj.bjc.6604890","volume":"100","author":"J Ji","year":"2009","unstructured":"Ji, J. et al. Cancer risk in hospitalised asthma patients. Br. J. Cancer. 100 (5), 829\u2013833 (2009).","journal-title":"Br. J. Cancer"},{"issue":"8","key":"74883_CR26","doi-asserted-by":"publisher","first-page":"20147","DOI":"10.1007\/s11356-022-23631-3","volume":"30","author":"HH Rahman","year":"2023","unstructured":"Rahman, H. H., Niemann, D. & Munson-McGee, S. H. Association between Asthma, chronic bronchitis, emphysema, chronic obstructive pulmonary disease, and lung cancer in the US population. Environ. Sci. Pollut Res. Int.30 (8), 20147\u201320158 (2023).","journal-title":"Environ. Sci. Pollut Res. Int."},{"issue":"2","key":"74883_CR27","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.anai.2019.04.029","volume":"123","author":"N Anooshiravani","year":"2019","unstructured":"Anooshiravani, N., Nagarajan, S., Vastardi, M. A. & Joks, R. Inverse association of asthma and hay fever with cancer in the 2015 National Health interview Survey database. Ann. Allergy Asthma Immunol.123 (2), 219\u2013220 (2019).","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"6","key":"74883_CR28","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1093\/carcin\/bgi309","volume":"27","author":"A Seow","year":"2006","unstructured":"Seow, A. et al. Joint effect of asthma\/atopy and an IL-6 gene polymorphism on lung cancer risk among lifetime non-smoking Chinese women. Carcinogenesis. 27 (6), 1240\u20131244 (2006).","journal-title":"Carcinogenesis"},{"key":"74883_CR29","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"CAKA Emdin","year":"2017","unstructured":"Emdin, C. A. K. A. & Kathiresan, S. Mendelian randomization. Jama. 318, 1925\u20131926 (2017).","journal-title":"Jama"},{"issue":"1","key":"74883_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/ije\/dyg070","volume":"32","author":"GD Smith","year":"2003","unstructured":"Smith, G. D. & Ebrahim, S. Mendelian randomization\u2019: can genetic epidemiology contribute to understanding environmental determinants of disease? Int. J. Epidemiol.32 (1), 1\u201322 (2003).","journal-title":"Int. J. Epidemiol."},{"issue":"8","key":"74883_CR31","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/sim.3034","volume":"27","author":"DA Lawlor","year":"2008","unstructured":"Lawlor, D. A., Harbord, R. M., Sterne, J. A., Timpson, N. & Davey Smith, G. Mendelian randomization: using genes as instruments for making causal inferences in epidemiology. Stat. Med.27 (8), 1133\u20131163 (2008).","journal-title":"Stat. Med."},{"issue":"3","key":"74883_CR32","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s10654-021-00726-8","volume":"36","author":"S Burgess","year":"2021","unstructured":"Burgess, S., Swanson, S. A. & Labrecque, J. A. Are mendelian randomization investigations immune from bias due to reverse causation? Eur. J. Epidemiol.36 (3), 253\u2013257 (2021).","journal-title":"Eur. J. Epidemiol."},{"key":"74883_CR33","unstructured":"Mitchell, R. E. B. et al. MRC IEU UK Biobank GWAS pipeline version 2. data. bris University of Bristol (2019)."},{"issue":"3","key":"74883_CR34","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/ije\/dyr036","volume":"40","author":"S Burgess","year":"2011","unstructured":"Burgess, S. & Thompson, S. G. Avoiding bias from weak instruments in mendelian randomization studies. Int. J. Epidemiol.40 (3), 755\u2013764 (2011).","journal-title":"Int. J. Epidemiol."},{"issue":"R2","key":"74883_CR35","doi-asserted-by":"publisher","first-page":"R195","DOI":"10.1093\/hmg\/ddy163","volume":"27","author":"G Hemani","year":"2018","unstructured":"Hemani, G., Bowden, J. & Davey Smith, G. Evaluating the potential role of pleiotropy in mendelian randomization studies. Hum. Mol. Genet.27 (R2), R195\u2013r208 (2018).","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"74883_CR36","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1002\/gepi.21965","volume":"40","author":"J Bowden","year":"2016","unstructured":"Bowden, J., Davey Smith, G., Haycock, P. C. & Burgess, S. Consistent estimation in mendelian randomization with some Invalid instruments using a weighted median estimator. Genet. Epidemiol.40 (4), 304\u2013314 (2016).","journal-title":"Genet. Epidemiol."},{"issue":"2","key":"74883_CR37","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","volume":"44","author":"J Bowden","year":"2015","unstructured":"Bowden, J., Davey Smith, G. & Burgess, S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int. J. Epidemiol.44 (2), 512\u2013525 (2015).","journal-title":"Int. J. Epidemiol."},{"key":"74883_CR38","doi-asserted-by":"publisher","first-page":"1125233","DOI":"10.3389\/fcell.2023.1125233","volume":"11","author":"S Wang","year":"2023","unstructured":"Wang, S. et al. Systemic inflammatory regulators and risk of acute-on-chronic liver failure: a bidirectional mendelian-randomization study. Front. Cell. Dev. Biol.11, 1125233 (2023).","journal-title":"Front. Cell. Dev. Biol."},{"issue":"23","key":"74883_CR39","doi-asserted-by":"publisher","first-page":"9160","DOI":"10.1002\/cam4.3493","volume":"9","author":"X Chen","year":"2020","unstructured":"Chen, X. et al. Depression and prostate cancer risk: a mendelian randomization study. Cancer Med.9 (23), 9160\u20139167 (2020).","journal-title":"Cancer Med."},{"issue":"3","key":"74883_CR40","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1093\/ije\/dyy258","volume":"48","author":"J Bowden","year":"2019","unstructured":"Bowden, J. et al. Improving the accuracy of two-sample summary-data mendelian randomization: moving beyond the NOME assumption. Int. J. Epidemiol.48 (3), 728\u2013742 (2019).","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"74883_CR41","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck, M., Chen, C. Y., Neale, B. & Do, R. Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat. Genet.50 (5), 693\u2013698 (2018).","journal-title":"Nat. Genet."},{"issue":"R1","key":"74883_CR42","doi-asserted-by":"publisher","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","volume":"23","author":"G Davey Smith","year":"2014","unstructured":"Davey Smith, G. & Hemani, G. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum. Mol. Genet.23 (R1), R89\u201398 (2014).","journal-title":"Hum. Mol. Genet."},{"issue":"11","key":"74883_CR43","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.1111\/jdv.18437","volume":"36","author":"Q Luo","year":"2022","unstructured":"Luo, Q. et al. Psoriasis may increase the risk of lung cancer: a two-sample mendelian randomization study. J. Eur. Acad. Dermatol. Venereol.36 (11), 2113\u20132119 (2022).","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"74883_CR44","doi-asserted-by":"publisher","first-page":"3285","DOI":"10.1038\/s41598-021-81836-x","volume":"11","author":"T Gebresilase","year":"2021","unstructured":"Gebresilase, T. et al. Replication of HLA class II locus association with susceptibility to podoconiosis in three Ethiopian ethnic groups. Sci. Rep.11 (1), 3285 (2021).","journal-title":"Sci. Rep."},{"issue":"2","key":"74883_CR45","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/cam4.192","volume":"3","author":"D Chen","year":"2014","unstructured":"Chen, D. & Gyllensten, U. A cis-eQTL of HLA-DRB1 and a frameshift mutation of MICA contribute to the pattern of association of HLA alleles with cervical cancer. Cancer Med.3 (2), 445\u2013452 (2014).","journal-title":"Cancer Med."},{"issue":"5","key":"74883_CR46","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1080\/08820139.2020.1737539","volume":"49","author":"A Aureli","year":"2020","unstructured":"Aureli, A. et al. Breast Cancer is Associated with increased HLA-DRB1*11:01 and HLA-DRB1*10:01 allele frequency in a Population of patients from Central Italy. Immunol. Invest.49 (5), 489\u2013497 (2020).","journal-title":"Immunol. Invest."},{"issue":"1","key":"74883_CR47","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0304-3835(99)00437-1","volume":"152","author":"C Yoshimura","year":"2000","unstructured":"Yoshimura, C. et al. Analysis of serum ErbB-2 protein and HLA-DRB1 in Japanese patients with lung cancer. Cancer Lett.152 (1), 87\u201395 (2000).","journal-title":"Cancer Lett."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74883-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74883-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74883-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T05:04:28Z","timestamp":1728018268000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74883-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,4]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["74883"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-74883-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,4]]},"assertion":[{"value":"13 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declared no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"We utilized summary data derived from published studies that were approved by the respective institutional review boards. No further ethical approval was required for secondary analysis of the summary data.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}],"article-number":"23047"}}