{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:37:59Z","timestamp":1787063879381,"version":"build-2736575974"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H02535"],"award-info":[{"award-number":["20H02535"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H02535"],"award-info":[{"award-number":["20H02535"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23811701"],"award-info":[{"award-number":["23811701"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23811701"],"award-info":[{"award-number":["23811701"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["23811701"],"award-info":[{"award-number":["23811701"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018456","name":"Kanagawa Institute of Industrial Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-74962-9","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T18:01:34Z","timestamp":1728842494000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of oxytocin receptor agonists on hair growth promotion"],"prefix":"10.1038","volume":"14","author":[{"given":"Tatsuto","family":"Kageyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jieun","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junji","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"74962_CR1","doi-asserted-by":"publisher","first-page":"1938","DOI":"10.1080\/09546634.2021.1959506","volume":"33","author":"AK Gupta","year":"2022","unstructured":"Gupta, A. K., Venkataraman, M., Talukder, M. & Bamimore, M. A. Finasteride for hair loss: A review. J. Dermatol. Treat 33, 1938\u20131946. https:\/\/doi.org\/10.1080\/09546634.2021.1959506 (2022).","journal-title":"J. Dermatol. Treat"},{"key":"74962_CR2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2174\/1574884712666170310111125","volume":"12","author":"T Arif","year":"2017","unstructured":"Arif, T., Dorjay, K., Adil, M. & Sami, M. Dutasteride in androgenetic alopecia: An update. Curr. Clin. Pharmacol. 12, 31\u201335. https:\/\/doi.org\/10.2174\/1574884712666170310111125 (2017).","journal-title":"Curr. Clin. Pharmacol."},{"key":"74962_CR3","doi-asserted-by":"publisher","first-page":"e2320351","DOI":"10.1001\/jamanetworkopen.2023.20351","volume":"6","author":"M Liu","year":"2023","unstructured":"Liu, M. et al. Janus kinase inhibitors for alopecia areata: A systematic review and meta-analysis. JAMA Netw. Open 6, e2320351. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.20351 (2023).","journal-title":"JAMA Netw. Open"},{"key":"74962_CR4","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1001\/jamadermatol.2023.2581","volume":"159","author":"JM Ko","year":"2023","unstructured":"Ko, J. M. et al. Clinical outcomes for uptitration of baricitinib therapy in patients with severe alopecia areata: A pooled analysis of the BRAVE-AA1 and BRAVE-AA2 trials. JAMA Dermatol. 159, 970\u2013976. https:\/\/doi.org\/10.1001\/jamadermatol.2023.2581 (2023).","journal-title":"JAMA Dermatol."},{"key":"74962_CR5","doi-asserted-by":"publisher","first-page":"923","DOI":"10.3390\/medicina58070923","volume":"58","author":"T Florea","year":"2022","unstructured":"Florea, T. et al. Oxytocin: Narrative expert review of current perspectives on the relationship with other neurotransmitters and the impact on the main psychiatric disorders. Medicina (Kaunas) 58, 923. https:\/\/doi.org\/10.3390\/medicina58070923 (2022).","journal-title":"Medicina (Kaunas)"},{"key":"74962_CR6","doi-asserted-by":"publisher","first-page":"742236","DOI":"10.3389\/fendo.2021.742236","volume":"12","author":"MH Walter","year":"2021","unstructured":"Walter, M. H., Abele, H. & Plappert, C. F. The role of oxytocin and the effect of stress during childbirth: Neurobiological basics and implications for mother and child. Front Endocrinol (Lausanne). 12, 742236. https:\/\/doi.org\/10.3389\/fendo.2021.742236 (2021).","journal-title":"Front Endocrinol (Lausanne)."},{"key":"74962_CR7","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3390\/ijms23010150","volume":"23","author":"Y Takayanagi","year":"2021","unstructured":"Takayanagi, Y. & Onaka, T. Roles of oxytocin in stress responses, allostasis and resilience. Int. J. Mol. Sci. 23, 150. https:\/\/doi.org\/10.3390\/ijms23010150 (2021).","journal-title":"Int. J. Mol. Sci."},{"key":"74962_CR8","doi-asserted-by":"publisher","first-page":"15587","DOI":"10.1038\/s41598-023-40521-x","volume":"13","author":"T Kageyama","year":"2023","unstructured":"Kageyama, T., Seo, J., Yan, L. & Fukuda, J. Effects of oxytocin on the hair growth ability of dermal papilla cells. Sci. Rep. 13, 15587. https:\/\/doi.org\/10.1038\/s41598-023-40521-x (2023).","journal-title":"Sci. Rep."},{"key":"74962_CR9","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12413","author":"G Leng","year":"2016","unstructured":"Leng, G. & Sabatier, N. Measuring oxytocin and vasopressin: Bioassays, immunoassays and random numbers. J. Neuroendocrinol. https:\/\/doi.org\/10.1111\/jne.12413 (2016).","journal-title":"J. Neuroendocrinol."},{"key":"74962_CR10","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/s0014-5793(96)01135-0","volume":"397","author":"B Chini","year":"1996","unstructured":"Chini, B. et al. Two aromatic residues regulate the response of the human oxytocin receptor to the partial agonist arginine vasopressin. FEBS Lett. 397, 201\u2013206. https:\/\/doi.org\/10.1016\/s0014-5793(96)01135-0 (1996).","journal-title":"FEBS Lett."},{"key":"74962_CR11","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1016\/j.celrep.2017.10.063","volume":"21","author":"Y Nersesyan","year":"2017","unstructured":"Nersesyan, Y. et al. Oxytocin modulates nociception as an agonist of pain-sensing TRPV1. Cell Rep. 21, 1681\u20131691. https:\/\/doi.org\/10.1016\/j.celrep.2017.10.063 (2017).","journal-title":"Cell Rep."},{"key":"74962_CR12","doi-asserted-by":"publisher","first-page":"51","DOI":"10.5049\/EBP.2008.6.1.51","volume":"6","author":"YK Oh","year":"2008","unstructured":"Oh, Y. K. Vasopressin and vasopressin receptor antagonists. Electrolyte Blood Press 6, 51\u201355. https:\/\/doi.org\/10.5049\/EBP.2008.6.1.51 (2008).","journal-title":"Electrolyte Blood Press"},{"key":"74962_CR13","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1111\/j.1365-2826.2012.02311.x","volume":"24","author":"C Hicks","year":"2012","unstructured":"Hicks, C. et al. The nonpeptide oxytocin receptor agonist WAY 267,464: receptor-binding profile, prosocial effects and distribution of c-Fos expression in adolescent rats. J. Neuroendocrinol. 24, 1012\u20131029. https:\/\/doi.org\/10.1111\/j.1365-2826.2012.02311.x (2012).","journal-title":"J. Neuroendocrinol."},{"key":"74962_CR14","doi-asserted-by":"publisher","first-page":"8670","DOI":"10.1021\/acs.jmedchem.8b00697","volume":"61","author":"MC Frantz","year":"2018","unstructured":"Frantz, M. C. et al. LIT-001, the first nonpeptide oxytocin receptor agonist that improves social interaction in a mouse model of autism. J. Med. Chem. 61, 8670\u20138692. https:\/\/doi.org\/10.1021\/acs.jmedchem.8b00697 (2018).","journal-title":"J. Med. Chem."},{"key":"74962_CR15","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1038\/s41598-020-59929-w","volume":"10","author":"L Hilfiger","year":"2020","unstructured":"Hilfiger, L. et al. A nonpeptide oxytocin receptor agonist for a durable relief of inflammatory pain. Sci. Rep. 10, 3017. https:\/\/doi.org\/10.1038\/s41598-020-59929-w (2020).","journal-title":"Sci. Rep."},{"key":"74962_CR16","doi-asserted-by":"publisher","first-page":"4847","DOI":"10.1038\/s41598-023-31842-y","volume":"13","author":"T Kageyama","year":"2023","unstructured":"Kageyama, T., Miyata, H., Seo, J., Nanmo, A. & Fukuda, J. In vitro hair follicle growth model for drug testing. Sci. Rep. 13, 4847. https:\/\/doi.org\/10.1038\/s41598-023-31842-y (2023).","journal-title":"Sci. Rep."},{"key":"74962_CR17","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1152\/physrev.00031.2017","volume":"98","author":"B Jurek","year":"2018","unstructured":"Jurek, B. & Neumann, I. D. The oxytocin receptor: From intracellular signaling to behavior. Physiol. Rev. 98, 1805\u20131908. https:\/\/doi.org\/10.1152\/physrev.00031.2017 (2018).","journal-title":"Physiol. Rev."},{"key":"74962_CR18","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1038\/s41386-022-01490-3","volume":"48","author":"S Potretzke","year":"2023","unstructured":"Potretzke, S. et al. Male-selective effects of oxytocin agonism on alcohol intake: Behavioral assessment in socially housed prairie voles and involvement of RAGE. Neuropsychopharmacology 48, 920\u2013928. https:\/\/doi.org\/10.1038\/s41386-022-01490-3 (2023).","journal-title":"Neuropsychopharmacology"},{"key":"74962_CR19","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.euroneuro.2023.09.005","volume":"78","author":"D Piotrowska","year":"2024","unstructured":"Piotrowska, D., Potasiewicz, A., Popik, P. & Nikiforuk, A. Pro-social and pro-cognitive effects of LIT-001, a novel oxytocin receptor agonist in a neurodevelopmental model of schizophrenia. Eur. Neuropsychopharmacol. 78, 30\u201342. https:\/\/doi.org\/10.1016\/j.euroneuro.2023.09.005 (2024).","journal-title":"Eur. Neuropsychopharmacol."},{"key":"74962_CR20","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1111\/exd.12155","volume":"22","author":"V Deing","year":"2013","unstructured":"Deing, V. et al. Oxytocin modulates proliferation and stress responses of human skin cells: Implications for atopic dermatitis. Exp. Dermatol. 22, 399\u2013405. https:\/\/doi.org\/10.1111\/exd.12155 (2013).","journal-title":"Exp. Dermatol."},{"key":"74962_CR21","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1034\/j.1600-0625.2000.009003165.x","volume":"9","author":"JD Bos","year":"2000","unstructured":"Bos, J. D. & Meinardi, M. M. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp. Dermatol. 9, 165\u2013169. https:\/\/doi.org\/10.1034\/j.1600-0625.2000.009003165.x (2000).","journal-title":"Exp. Dermatol."},{"key":"74962_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103381","volume":"72","author":"L Tian","year":"2022","unstructured":"Tian, L. et al. Co-delivery of bioactive peptides by nanoliposomes for promotion of hair growth. J. Drug. Delivery Sci. Tech. 72, 103381. https:\/\/doi.org\/10.1016\/j.jddst.2022.103381 (2022).","journal-title":"J. Drug. Delivery Sci. Tech."},{"key":"74962_CR23","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1517\/17425247.2013.776038","volume":"10","author":"A Patzelt","year":"2013","unstructured":"Patzelt, A. et al. Drug delivery to hair follicles. Expert. Opin. Drug. Deliv. 10, 787\u2013797. https:\/\/doi.org\/10.1517\/17425247.2013.776038 (2013).","journal-title":"Expert. Opin. Drug. Deliv."},{"key":"74962_CR24","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/522410a","volume":"522","author":"H Shen","year":"2015","unstructured":"Shen, H. Neuroscience: The hard science of oxytocin. Nature 522, 410\u2013412. https:\/\/doi.org\/10.1038\/522410a (2015).","journal-title":"Nature"},{"key":"74962_CR25","doi-asserted-by":"publisher","first-page":"792","DOI":"10.3390\/ani9100792","volume":"9","author":"S Marshall-Pescini","year":"2019","unstructured":"Marshall-Pescini, S. et al. The role of oxytocin in the dog-owner relationship. Animals (Basel) 9, 792. https:\/\/doi.org\/10.3390\/ani9100792 (2019).","journal-title":"Animals (Basel)"},{"key":"74962_CR26","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1038\/s41419-022-05075-2","volume":"13","author":"Y Zhu","year":"2022","unstructured":"Zhu, Y., Zhu, L., Wang, X. & Jin, H. RNA-based therapeutics: an overview and prospectus. Cell Death Dis. 13, 644. https:\/\/doi.org\/10.1038\/s41419-022-05075-2 (2022).","journal-title":"Cell Death Dis."},{"key":"74962_CR27","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/s12276-022-00757-5","volume":"54","author":"YK Kim","year":"2022","unstructured":"Kim, Y. K. RNA therapy: Rich history, various applications and unlimited future prospects. Exp. Mol. Med. 54, 455\u2013465. https:\/\/doi.org\/10.1038\/s12276-022-00757-5 (2022).","journal-title":"Exp. Mol. Med."},{"key":"74962_CR28","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1021\/acs.molpharmaceut.2c00510","volume":"20","author":"IJ Moon","year":"2023","unstructured":"Moon, I. J. et al. Efficacy of asymmetric siRNA targeting androgen receptors for the treatment of androgenetic alopecia. Mol. Pharm. 20, 128\u2013135. https:\/\/doi.org\/10.1021\/acs.molpharmaceut.2c00510 (2023).","journal-title":"Mol. Pharm."},{"key":"74962_CR29","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1038\/s41598-022-05544-w","volume":"12","author":"SI Yun","year":"2022","unstructured":"Yun, S. I. et al. Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia. Sci. Rep. 12, 1607. https:\/\/doi.org\/10.1038\/s41598-022-05544-w (2022).","journal-title":"Sci. Rep."},{"key":"74962_CR30","doi-asserted-by":"publisher","first-page":"eadd4603","DOI":"10.1126\/sciadv.add4603","volume":"8","author":"T Kageyama","year":"2022","unstructured":"Kageyama, T. et al. Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction. Sci. Adv. 8, eadd4603. https:\/\/doi.org\/10.1126\/sciadv.add4603 (2022).","journal-title":"Sci. Adv."},{"key":"74962_CR31","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/j.jbiosc.2022.09.004","volume":"134","author":"T Kageyama","year":"2022","unstructured":"Kageyama, T., Anakama, R., Togashi, H. & Fukuda, J. Impacts of manipulating cell sorting on in vitro hair follicle regeneration. J. Biosci. Bioeng. 134, 534\u2013540. https:\/\/doi.org\/10.1016\/j.jbiosc.2022.09.004 (2022).","journal-title":"J. Biosci. Bioeng."},{"key":"74962_CR32","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1046\/j.0022-202x.2001.01670.x","volume":"118","author":"SE Millar","year":"2002","unstructured":"Millar, S. E. Molecular mechanisms regulating hair follicle development. J. Invest. Dermatol. 118, 216\u2013225. https:\/\/doi.org\/10.1046\/j.0022-202x.2001.01670.x (2002).","journal-title":"J. Invest. Dermatol."},{"key":"74962_CR33","doi-asserted-by":"publisher","first-page":"130","DOI":"10.2174\/187221312800166859","volume":"6","author":"A Rossi","year":"2012","unstructured":"Rossi, A. et al. Minoxidil use in dermatology, side effects and recent patents. Recent Pat Inflamm. Allergy Drug. Discov. 6, 130\u2013136. https:\/\/doi.org\/10.2174\/187221312800166859 (2012).","journal-title":"Recent Pat Inflamm. Allergy Drug. Discov."},{"key":"74962_CR34","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.jdermsci.2011.01.013","volume":"62","author":"MH Kwack","year":"2011","unstructured":"Kwack, M. H., Kang, B. M., Kim, M. K., Kim, J. C. & Sung, Y. K. Minoxidil activates beta-catenin pathway in human dermal papilla cells: a possible explanation for its anagen prolongation effect. J. Dermatol. Sci. 62, 154\u2013159. https:\/\/doi.org\/10.1016\/j.jdermsci.2011.01.013 (2011).","journal-title":"J. Dermatol. Sci."},{"key":"74962_CR35","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.jdermsci.2004.01.002","volume":"34","author":"JH Han","year":"2004","unstructured":"Han, J. H. et al. Effect of minoxidil on proliferation and apoptosis in dermal papilla cells of human hair follicle. J. Dermatol. Sci. 34, 91\u201398. https:\/\/doi.org\/10.1016\/j.jdermsci.2004.01.002 (2004).","journal-title":"J. Dermatol. Sci."},{"key":"74962_CR36","doi-asserted-by":"publisher","first-page":"8047","DOI":"10.3892\/mmr.2018.8917","volume":"17","author":"CY Lee","year":"2018","unstructured":"Lee, C. Y. et al. Hair growth is promoted by BeauTop via expression of EGF and FGF-7. Mol. Med. Rep. 17, 8047\u20138052. https:\/\/doi.org\/10.3892\/mmr.2018.8917 (2018).","journal-title":"Mol. Med. Rep."},{"key":"74962_CR37","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res 51, D587\u2013D592. https:\/\/doi.org\/10.1093\/nar\/gkac963 (2023).","journal-title":"Nucleic Acids Res"},{"key":"74962_CR38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"74962_CR39","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74962-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74962-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74962-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T22:03:51Z","timestamp":1729116231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-74962-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,13]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["74962"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-74962-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,13]]},"assertion":[{"value":"24 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23935"}}