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These organisms do not typically cause disease; however, they can act as a reservoir for antimicrobial resistance genes that can be acquired by pathogenic\n                    <jats:italic>Neisseria species<\/jats:italic>\n                    . This study characterised the carriage and antimicrobial susceptibility profiles of\n                    <jats:italic>N<\/jats:italic>\n                    c from the oropharynx of 50 participants. Carriage prevalence of\n                    <jats:italic>N<\/jats:italic>\n                    c species was 86% with 66% of participants colonised with more than one isolate. Isolates were identified by MALDI-ToF and the most common species was\n                    <jats:italic>N. subflava<\/jats:italic>\n                    (61.4%). Minimum inhibitory concentrations (MICs) to penicillin, ceftriaxone, ciprofloxacin, azithromycin, tetracycline, and gentamicin were determined by agar dilution and E-test was used for cefixime. Using\n                    <jats:italic>Ng<\/jats:italic>\n                    CLSI\/EUCAST guidelines,\n                    <jats:italic>Nc<\/jats:italic>\n                    resistance rates were above the WHO threshold of 5% resistance in circulating strains for changing the first line treatment empirical antimicrobial: 5% (CLSI) and 13 (EUCAST) for ceftriaxone and 29.3% for azithromycin. Whole genome sequencing of 30\n                    <jats:italic>N<\/jats:italic>\n                    c isolates was performed, which identified AMR genes to macrolides and tetracycline. Core gene MLST clustered\n                    <jats:italic>Nc<\/jats:italic>\n                    into three main groups. Gonococcal DNA uptake sequences were identified in two\n                    <jats:italic>Nc<\/jats:italic>\n                    clusters. This suggests that\n                    <jats:italic>N<\/jats:italic>\n                    c have the potential AMR gene pool and transfer sequences that can result in resistance transfer to pathogenic\n                    <jats:italic>Neisseria<\/jats:italic>\n                    within the nasopharyngeal niche.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-75130-9","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T05:03:46Z","timestamp":1729659826000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Carriage and antimicrobial susceptibility of commensal Neisseria species from the human oropharynx"],"prefix":"10.1038","volume":"14","author":[{"given":"Victoria F.","family":"Miari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Bonnin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imogen K. 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