{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:08:53Z","timestamp":1793149733347,"version":"4.5.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Henan Province Young and Middle aged Talent Plan Project","award":["YXKC2022046"],"award-info":[{"award-number":["YXKC2022046"]}]},{"name":"Henan Province Science and Technology Research and Development Plan","award":["LHGJ20220188"],"award-info":[{"award-number":["LHGJ20220188"]}]},{"name":"Henan Province Science and Technology Research and Development Plan","award":["SBGJ202102069"],"award-info":[{"award-number":["SBGJ202102069"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-75252-0","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T03:02:02Z","timestamp":1728529322000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Association between the neutrophil-to-lymphocyte ratio and cancer in adults from NHANES 2005\u20132018: a cross-sectional study"],"prefix":"10.1038","volume":"14","author":[{"given":"Gang-Ping","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Fang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Jiang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Jie","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Dong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Wen","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"75252_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2017. CA Cancer J. Clin. 67, 7\u201330 (2017).","journal-title":"CA Cancer J. Clin."},{"key":"75252_CR2","unstructured":"Global Burden of Disease Cancer Collaboration et al. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol. 3, 524\u2013548 (2017)."},{"key":"75252_CR3","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1111\/j.1468-0009.2005.00398.x","volume":"83","author":"AR Omran","year":"2005","unstructured":"Omran, A. R. The epidemiologic transition: A theory of the epidemiology of population change. Milbank Q. 83, 731\u2013757 (2005).","journal-title":"Milbank Q."},{"key":"75252_CR4","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860\u2013867 (2002).","journal-title":"Nature"},{"key":"75252_CR5","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: The next generation. Cell 144, 646\u2013674 (2011).","journal-title":"Cell"},{"key":"75252_CR6","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","volume":"140","author":"SI Grivennikov","year":"2010","unstructured":"Grivennikov, S. I., Greten, F. R. & Karin, M. Immunity, inflammation, and cancer. Cell 140, 883\u2013899 (2010).","journal-title":"Cell"},{"key":"75252_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-030-35723-8_1","volume":"1224","author":"L Wu","year":"2020","unstructured":"Wu, L., Saxena, S. & Singh, R. K. Neutrophils in the tumor microenvironment. Adv. Exp. Med. Biol. 1224, 1\u201320 (2020).","journal-title":"Adv. Exp. Med. Biol."},{"key":"75252_CR8","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12885-023-11775-5","volume":"24","author":"F Tabatabaei","year":"2024","unstructured":"Tabatabaei, F. et al. Neutrophil to lymphocyte ratio as an assessment tool to differentiate between uterine sarcoma and myoma: A systematic review and meta-analysis. BMC Cancer 24, 12 (2024).","journal-title":"BMC Cancer"},{"key":"75252_CR9","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12894-024-01569-7","volume":"24","author":"S Babadi","year":"2024","unstructured":"Babadi, S. et al. Relationship between NLR and penile squamous cell carcinoma: A systematic review and meta-analysis. BMC Urol. 24, 194 (2024).","journal-title":"BMC Urol."},{"key":"75252_CR10","first-page":"1","volume":"1","author":"G Zipf","year":"2013","unstructured":"Zipf, G. et al. National health and nutrition examination survey: Plan and operations, 1999\u20132010. Vital. Health Stat. 1, 1\u201337 (2013).","journal-title":"Vital. Health Stat."},{"key":"75252_CR11","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.640785","author":"Q Yang","year":"2021","unstructured":"Yang, Q. et al. Association between preadmission metformin use and outcomes in intensive care unit patients with sepsis and type 2 diabetes: A cohort study. Front. Med. https:\/\/doi.org\/10.3389\/fmed.2021.640785 (2021).","journal-title":"Front. Med."},{"key":"75252_CR12","first-page":"474","volume":"122","author":"R Zahorec","year":"2021","unstructured":"Zahorec, R. Neutrophil-to-lymphocyte ratio, past, present and future perspectives. Bratisl Lek Listy 122, 474\u2013488 (2021).","journal-title":"Bratisl Lek Listy"},{"key":"75252_CR13","doi-asserted-by":"publisher","first-page":"22362","DOI":"10.1038\/s41598-023-49403-8","volume":"13","author":"Q-C Wang","year":"2023","unstructured":"Wang, Q.-C. & Wang, Z.-Y. Comparative analysis of neutrophil-to-lymphocyte ratio and remnant cholesterol in predicting cardiovascular events and mortality in general adult population. Sci. Rep. 13, 22362 (2023).","journal-title":"Sci. Rep."},{"key":"75252_CR14","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.critrevonc.2013.03.010","volume":"88","author":"GJK Guthrie","year":"2013","unstructured":"Guthrie, G. J. K. et al. The systemic inflammation-based neutrophil-lymphocyte ratio: Experience in patients with cancer. Crit. Rev. Oncol. Hematol. 88, 218\u2013230 (2013).","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"75252_CR15","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/s12916-020-01817-1","volume":"18","author":"MA Cupp","year":"2020","unstructured":"Cupp, M. A. et al. Neutrophil to lymphocyte ratio and cancer prognosis: An umbrella review of systematic reviews and meta-analyses of observational studies. BMC Med. 18, 360 (2020).","journal-title":"BMC Med."},{"key":"75252_CR16","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.ajem.2019.10.023","volume":"38","author":"Z Huang","year":"2020","unstructured":"Huang, Z., Fu, Z., Huang, W. & Huang, K. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: A meta-analysis. Am. J. Emerg. Med. 38, 641\u2013647 (2020).","journal-title":"Am. J. Emerg. Med."},{"key":"75252_CR17","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.eprac.2021.11.083","volume":"28","author":"P Hashemi Moghanjoughi","year":"2022","unstructured":"Hashemi Moghanjoughi, P., Neshat, S., Rezaei, A. & Heshmat-Ghahdarijani, K. Is the neutrophil-to-lymphocyte ratio an exceptional indicator for metabolic syndrome disease and outcomes?. Endocr. Pract. 28, 342\u2013348 (2022).","journal-title":"Endocr. Pract."},{"key":"75252_CR18","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.jad.2022.04.092","volume":"309","author":"Y Wei","year":"2022","unstructured":"Wei, Y., Feng, J., Ma, J., Chen, D. & Chen, J. Neutrophil\/lymphocyte, platelet\/lymphocyte and monocyte\/lymphocyte ratios in patients with affective disorders. J. Affect. Disord. 309, 221\u2013228 (2022).","journal-title":"J. Affect. Disord."},{"key":"75252_CR19","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.1002\/cam4.5185","volume":"12","author":"CE Thomas","year":"2023","unstructured":"Thomas, C. E. et al. Neutrophil-lymphocyte ratio in relation to risk of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease. Cancer Med. 12, 3589\u20133600 (2023).","journal-title":"Cancer Med."},{"key":"75252_CR20","doi-asserted-by":"publisher","first-page":"107327482210768","DOI":"10.1177\/10732748221076805","volume":"29","author":"C Hu","year":"2022","unstructured":"Hu, C. et al. Relationship between neutrophil-to-lymphocyte ratio and brain metastasis in non-small cell lung cancer patients. Cancer Control 29, 107327482210768 (2022).","journal-title":"Cancer Control"},{"key":"75252_CR21","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.ygyno.2017.02.026","volume":"145","author":"J-L Ethier","year":"2017","unstructured":"Ethier, J.-L. et al. Is the neutrophil-to-lymphocyte ratio prognostic of survival outcomes in gynecologic cancers? A systematic review and meta-analysis. Gynecol. Oncol. 145, 584\u2013594 (2017).","journal-title":"Gynecol. Oncol."},{"key":"75252_CR22","doi-asserted-by":"publisher","first-page":"106959","DOI":"10.1016\/j.ijsu.2022.106959","volume":"107","author":"N Lin","year":"2022","unstructured":"Lin, N. et al. Prognostic value of neutrophil-to-lymphocyte ratio in colorectal cancer liver metastasis: A meta-analysis of results from multivariate analysis. Int. J. Surg. 107, 106959 (2022).","journal-title":"Int. J. Surg."},{"key":"75252_CR23","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2019.2.97","author":"A \u015eahin","year":"2019","unstructured":"\u015eahin, A. et al. Increased neutrophil\/lymphocyte ratio in testicular cancer. Archivio Italiano di Urologia e Andrologia https:\/\/doi.org\/10.4081\/aiua.2019.2.97 (2019).","journal-title":"Archivio Italiano di Urologia e Andrologia"},{"key":"75252_CR24","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1186\/s12885-020-07429-5","volume":"20","author":"J Mazaki","year":"2020","unstructured":"Mazaki, J. et al. Neutrophil-to-lymphocyte ratio is a prognostic factor for colon cancer: A propensity score analysis. BMC Cancer 20, 922 (2020).","journal-title":"BMC Cancer"},{"key":"75252_CR25","doi-asserted-by":"publisher","first-page":"2827","DOI":"10.1097\/JS9.0000000000000535","volume":"109","author":"K Wang","year":"2023","unstructured":"Wang, K., Chen, Y., Nie, Z. & Wang, J. Neutrophil-to-lymphocyte ratio to estimate colorectal cancer liver metastasis: A commentary. Int. J. Surg. 109, 2827\u20132828 (2023).","journal-title":"Int. J. Surg."},{"key":"75252_CR26","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s00404-022-06726-7","volume":"307","author":"A von Au","year":"2023","unstructured":"von Au, A. et al. Predictive value of neutrophil-to-lymphocyte-ratio in neoadjuvant-treated patients with breast cancer. Arch. Gynecol. Obstet. 307, 1105\u20131113 (2023).","journal-title":"Arch. Gynecol. Obstet."},{"key":"75252_CR27","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.jss.2023.11.075","volume":"296","author":"H Ijichi","year":"2024","unstructured":"Ijichi, H. et al. Preoperative neutrophil-to-lymphocyte ratio in postmenopausal breast cancer patients. J. Surg. Res. 296, 98\u2013105 (2024).","journal-title":"J. Surg. Res."},{"key":"75252_CR28","doi-asserted-by":"publisher","first-page":"2403","DOI":"10.1002\/ijc.28536","volume":"134","author":"M-X Li","year":"2014","unstructured":"Li, M.-X. et al. Prognostic role of neutrophil-to-lymphocyte ratio in colorectal cancer: A systematic review and meta-analysis. Int. J. Cancer 134, 2403\u20132413 (2014).","journal-title":"Int. J. Cancer"},{"key":"75252_CR29","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.cca.2018.01.024","volume":"479","author":"Y Zhou","year":"2018","unstructured":"Zhou, Y. et al. Prognostic role of the neutrophil-to-lymphocyte ratio in pancreatic cancer: A meta-analysis containing 8252 patients. Clin. Chim. Acta Int. J. Clin. Chem. 479, 181\u2013189 (2018).","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"75252_CR30","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1007\/s00404-018-4678-8","volume":"297","author":"Z Zhao","year":"2018","unstructured":"Zhao, Z. et al. Prognostic roles of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in ovarian cancer: A meta-analysis of retrospective studies. Arch. Gynecol. Obstet. 297, 849\u2013857 (2018).","journal-title":"Arch. Gynecol. Obstet."},{"key":"75252_CR31","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3816\/CCC.2006.n.048","volume":"6","author":"M Michael","year":"2006","unstructured":"Michael, M. et al. Prognostic factors predictive of response and survival to a modified FOLFOX regimen: Importance of an increased neutrophil count. Clin. Colorectal Cancer 6, 297\u2013304 (2006).","journal-title":"Clin. Colorectal Cancer"},{"key":"75252_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-022-06726-w","author":"Y Inoue","year":"2022","unstructured":"Inoue, Y. Clinical significance of the neutrophil-to-lymphocyte ratio in oligometastatic breast cancer. Breast Cancer Res. Treat. https:\/\/doi.org\/10.1007\/s10549-022-06726-w (2022).","journal-title":"Breast Cancer Res. Treat."},{"key":"75252_CR33","unstructured":"Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/33213430\/."},{"key":"75252_CR34","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s00595-016-1433-2","volume":"47","author":"Y Iseki","year":"2017","unstructured":"Iseki, Y. et al. The impact of the preoperative peripheral lymphocyte count and lymphocyte percentage in patients with colorectal cancer. Surg. Today 47, 743\u2013754 (2017).","journal-title":"Surg. Today"},{"key":"75252_CR35","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nri2888","volume":"11","author":"D Finlay","year":"2011","unstructured":"Finlay, D. & Cantrell, D. A. Metabolism, migration and memory in cytotoxic T cells. Nat. Rev. Immunol. 11, 109\u2013117 (2011).","journal-title":"Nat. Rev. Immunol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75252-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75252-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75252-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T07:01:46Z","timestamp":1728802906000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75252-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,10]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["75252"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-75252-0","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,10]]},"assertion":[{"value":"7 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23678"}}