{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T11:40:45Z","timestamp":1741866045194,"version":"3.38.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100009367","name":"Mansoura University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Girls and women with Turner syndrome (TS) suffer from increased risk of cardiovascular diseases. We hypothesized that left ventricular (LV) myocardial strain and aortic elasticity will be impaired in girls with TS. Cardiac MRI of 45 girls with TS and 14 healthy control girls was performed. Tissue tracking was used to assess LV Global Longitudinal (GLS), circumferential (GCS), radial short and long axes (GRS SAX and GRS LAX) in patients compared to controls. Maximal and minimal aortic areas were measured in ascending aorta, proximal descending, and aorta at diaphragm. Regional strain and distensibility were calculated using previously validated formulas. Comparisons were made between patients with and without bicuspid aortic valve (BAV). Inter-observer agreement was assessed for myocardial strain and aortic strain and distensibility. Results of the study showed GLS was significantly impaired in TS patients \u2212\u200915.6\u2009\u00b1\u20091.8% compared to the control group \u2212\u200917.2\u2009\u00b1\u20091%, p value\u2009=\u20090.013. No significant differences were observed in other strain parameters. Aortic diameter was similar in patients and control groups. Ascending aorta strain and distensibility were significantly lower in TS patients (33\u2009\u00b1\u200919% and 9.1\u2009\u00b1\u20095.5\u00a0mm Hg<jats:sup>\u2212\u20091<\/jats:sup>) compared to control group (55\u2009\u00b1\u200917% and 13.9\u2009\u00b1\u20094.9 10<jats:sup>\u2212\u20093<\/jats:sup> mm Hg<jats:sup>\u2212\u20091<\/jats:sup>), p values 0.004 and 0.013. No significant differences were found in aortic strain and distensibility in the other 2 regions. No significant differences were observed between TS patients with and without BAV in myocardial strain and aortic strain and distensibility. Substantial to perfect inter-observer agreement was found for myocardial strain and aortic strain and distensibility. Cardiac MRI measurements of LV deformation and aortic function carry potential value as markers for early detection of myocardial and aortic disease in TS patients. Validation of the clinical impact and prognostic role require further longitudinal studies.<\/jats:p>","DOI":"10.1038\/s41598-024-75312-5","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:45:41Z","timestamp":1741743941000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impaired myocardial deformation and aortic distensibility by cardiac MRI in girls with Turner syndrome"],"prefix":"10.1038","volume":"15","author":[{"given":"Nihal M.","family":"Batouty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah A.","family":"Shokeir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donia M.","family":"Sobh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma","family":"Gadelhak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wafaa","family":"Laimon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanees Abdelbadie","family":"Salem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Abdelghafar","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed M.","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"75312_CR1","doi-asserted-by":"publisher","first-page":"408","DOI":"10.4274\/jcrpe.galenos.2021.2021.0030","volume":"13","author":"NA Salem","year":"2021","unstructured":"Salem, N. A. et al. Epicardial and perihepatic fat as cardiometabolic risk predictors in girls with turner syndrome: A cardiac magnetic resonance study. J. Clin. Res. Pediatr. Endocrinol. 13, 408\u2013417 (2021).","journal-title":"J. Clin. Res. Pediatr. Endocrinol."},{"key":"75312_CR2","doi-asserted-by":"crossref","unstructured":"Oberhoffer, F.S., Abdul-Khaliq, H., Jung, A.M., Rohrer, T.R. & Abd El Rahman, M. Left ventricular remodelling among Turner syndrome patients: Insights from non-invasive 3D echocardiography-derived pressure-volume loop analysis. Clin. Res. Cardiol. 109, 892\u2013903 (2020).","DOI":"10.1007\/s00392-019-01579-8"},{"key":"75312_CR3","doi-asserted-by":"crossref","unstructured":"Silberbach, M., et al. American Heart Association Council on cardiovascular disease in the young; Council on genomic and precision medicine; and council on peripheral vascular disease. Cardiovascular Health in Turner Syndrome: A Scientific Statement From the American Heart Association. Circ. Genom. Precis. Med. 11, e000048 (2018).","DOI":"10.1161\/HCG.0000000000000048"},{"key":"75312_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12968-017-0331-0","volume":"19","author":"DG Devos","year":"2017","unstructured":"Devos, D. G. et al. Proximal aortic stiffening in Turner patients may be present before dilation can be detected: A segmental functional MRI study. J. Cardiovasc. Magn. Reson. 19, 27 (2017).","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"75312_CR5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12968-018-0497-0","volume":"20","author":"J Wen","year":"2018","unstructured":"Wen, J. et al. Impaired aortic distensibility and elevated central blood pressure in Turner syndrome: A cardiovascular magnetic resonance study. J. Cardiovasc. Magn. Reson. 20, 80 (2018).","journal-title":"J. Cardiovasc. Magn. Reson."},{"key":"75312_CR6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.21037\/qims.2019.09.19","volume":"10","author":"FS Oberhoffer","year":"2020","unstructured":"Oberhoffer, F. S. et al. Assessment of left ventricular myocardial work in Turner syndrome patients: Insights from the novel non-invasive pressure-strain loop analysis method. Quant. Imaging Med. Surg. 10, 15\u201325 (2020).","journal-title":"Quant. Imaging Med. Surg."},{"key":"75312_CR7","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1136\/hrt.2005.081471","volume":"92","author":"NH Andersen","year":"2006","unstructured":"Andersen, N. H. et al. Subclinical left ventricular dysfunction in normotensive women with Turner\u2019s syndrome. Heart 92, 1516\u20131517 (2006).","journal-title":"Heart"},{"key":"75312_CR8","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1002\/jmri.27700","volume":"54","author":"DM Sobh","year":"2021","unstructured":"Sobh, D. M. et al. Left ventricular strain analysis by tissue tracking-cardiac magnetic resonance for early detection of cardiac dysfunction in children with end-stage renal disease. J. Magn. Reason. Imaging 54, 1476\u20131485 (2021).","journal-title":"J. Magn. Reason. Imaging"},{"key":"75312_CR9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/RTI.0000000000000716","volume":"39","author":"AM Tawfik","year":"2024","unstructured":"Tawfik, A. M. et al. Right ventricular strain analysis by tissue tracking cardiac magnetic resonance imaging in pediatric patients with end-stage renal disease. J. Thorac. Imaging 39, 49\u201356 (2024).","journal-title":"J. Thorac. Imaging"},{"key":"75312_CR10","doi-asserted-by":"publisher","first-page":"11079","DOI":"10.1038\/s41598-022-15017-9","volume":"12","author":"DM Sobh","year":"2022","unstructured":"Sobh, D. M. et al. Impaired aortic strain and distensibility by cardiac MRI in children with chronic kidney disease. Sci. Rep. 12, 11079 (2022).","journal-title":"Sci. Rep."},{"key":"75312_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072068","volume":"8","author":"M Bonthuis","year":"2013","unstructured":"Bonthuis, M. et al. Application of body mass index according to height-age in short and tall children. PLoS ONE 8, e72068 (2013).","journal-title":"PLoS ONE"},{"key":"75312_CR12","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1002\/ajmg.a.37208","volume":"167","author":"E Quezada","year":"2015","unstructured":"Quezada, E., Lapidus, J., Shaughnessy, R., Chen, Z. & Silberbach, M. Aortic dimensions in Turner syndrome. Am. J. Med. Genet. A 167, 2527\u20132532 (2015).","journal-title":"Am. J. Med. Genet. A"},{"key":"75312_CR13","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1002\/ajmg.a.62259","volume":"185","author":"ID Noordman","year":"2021","unstructured":"Noordman, I. D. et al. Cardiac abnormalities in girls with Turner syndrome: ECG abnormalities, myocardial strain imaging, and karyotype-phenotype associations. Am. J. Med. Genet. A 185, 2399\u20132408 (2021).","journal-title":"Am. J. Med. Genet. A"},{"key":"75312_CR14","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1515\/jpem-2018-0207","volume":"31","author":"AF AbdelMassih","year":"2018","unstructured":"AbdelMassih, A. F., Attia, M., Ismail, M. M. & Samir, M. Insulin resistance linked to subtle myocardial dysfunction in normotensive Turner syndrome young patients without structural heart diseases. J. Pediatr. Endocrinol. Metab. 31, 1355\u20131361 (2018).","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"75312_CR15","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1111\/echo.12500","volume":"31","author":"F Oz","year":"2014","unstructured":"Oz, F. et al. Doppler-derived strain imaging detects left ventricular systolic dysfunction in children with Turner syndrome. Echocardiography 31, 1017\u20131022 (2014).","journal-title":"Echocardiography"},{"key":"75312_CR16","doi-asserted-by":"publisher","first-page":"357","DOI":"10.32604\/CHD.2021.014462","volume":"16","author":"AT Hoven","year":"2021","unstructured":"Hoven, A. T. et al. Systolic and diastolic strain measurements show left ventricular dysfunction in women with turner syndrome. Congenital Heart Dis. 16, 357\u2013368 (2021).","journal-title":"Congenital Heart Dis."},{"key":"75312_CR17","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4330\/wjc.v10.i11.210","volume":"10","author":"D Muser","year":"2018","unstructured":"Muser, D., Castro, S. A., Santangeli, P. & Nucifora, G. Clinical applications of feature-tracking cardiac magnetic resonance imaging. World J. Cardiol. 10, 210\u2013221 (2018).","journal-title":"World J. Cardiol."},{"key":"75312_CR18","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/ejcts\/ezy168","volume":"54","author":"M Sch\u00e4fer","year":"2018","unstructured":"Sch\u00e4fer, M. et al. Aortic stiffness in adolescent Turner and Marfan syndrome patients. Eur. J. Cardiothorac. Surg. 54, 926\u2013932 (2018).","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"75312_CR19","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.jjcc.2016.03.006","volume":"69","author":"K De Groote","year":"2017","unstructured":"De Groote, K. et al. Increased aortic stiffness in prepubertal girls with Turner syndrome. J. Cardiol. 69, 201\u2013207 (2017).","journal-title":"J. Cardiol."},{"key":"75312_CR20","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1007\/s00380-018-1187-4","volume":"33","author":"C Pees","year":"2018","unstructured":"Pees, C. et al. Aortic elasticity deterioration proves intrinsic abnormality of the ascending aorta in pediatric Turner syndrome unrelated to the aortic valve morphology. Heart Vessels 33, 1350\u20131357 (2018).","journal-title":"Heart Vessels"},{"key":"75312_CR21","doi-asserted-by":"publisher","first-page":"2553","DOI":"10.1210\/jc.2007-2313","volume":"93","author":"J Van den Berg","year":"2008","unstructured":"Van den Berg, J. et al. Cardiac status after childhood growth hormone treatment of Turner syndrome. J. Clin. Endocrinol. Metab. 93, 2553\u20132558 (2008).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"75312_CR22","doi-asserted-by":"crossref","unstructured":"Obara-Moszynska, M., et al. The usefulness of magnetic resonance imaging of the cardiovascular system in the diagnostic work-up of patients with turner syndrome. Front. Endocrinol. 16, 609 (2018).","DOI":"10.3389\/fendo.2018.00609"},{"key":"75312_CR23","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1111\/j.1540-8175.2009.00902.x","volume":"26","author":"AB Sozen","year":"2009","unstructured":"Sozen, A. B. et al. Left ventricular thickness is increased in nonhypertensive Turner\u2019s syndrome. Echocardiography 26, 943\u2013949 (2009).","journal-title":"Echocardiography"},{"key":"75312_CR24","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1111\/j.1540-8175.2012.01754.x","volume":"29","author":"KH Mortensen","year":"2012","unstructured":"Mortensen, K. H., Gravholt, C. H., Hjerrild, B. E., Stochholm, K. & Andersen, N. H. Left ventricular hypertrophy in Turner syndrome: A prospective echocardiographic study. Echocardiography 29, 1022\u20131030 (2012).","journal-title":"Echocardiography"},{"key":"75312_CR25","first-page":"S1","volume":"20S","author":"G Scalia","year":"2011","unstructured":"Scalia, G., Hamilton-Craig, C., Slaughter, R. & Cain, P. Left ventricular mass-volume index: A new parameter for the assessment of \u201cdisproportionate\u201d left ventricular hypertrophy by echocardiography. Heart Lung Circ 20S, S1\u2013S155 (2011).","journal-title":"Heart Lung Circ"},{"key":"75312_CR26","doi-asserted-by":"crossref","unstructured":"Lee, S., James, N. C. & Srivastava, S. U. S. Simplifying the diagnosis of left ventricular hypertrophy: Is left ventricular mass to volume ratio constant in children throughout growth?. J. Cardiovasc. Magn. Reason. 18, 122 (2016).","DOI":"10.1186\/1532-429X-18-S1-P122"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75312-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75312-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75312-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T10:35:43Z","timestamp":1741862143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75312-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["75312"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-75312-5","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2025,3,12]]},"assertion":[{"value":"6 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"8457"}}