{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:55:25Z","timestamp":1791946525489,"version":"4.3.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C4001596"],"award-info":[{"award-number":["2021R1A2C4001596"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1I1A1A01070668"],"award-info":[{"award-number":["2020R1I1A1A01070668"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-75637-1","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T19:02:08Z","timestamp":1728932528000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Proteomic analysis of CD29+\u2009M\u00fcller cells reveals metabolic reprogramming in rabbit myopia model"],"prefix":"10.1038","volume":"14","author":[{"given":"Chae\u2011Eun","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Ki","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Min","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Woo","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"75637_CR1","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","volume":"123","author":"BA Holden","year":"2016","unstructured":"Holden, B. A. et al. Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050. Ophthalmology. 123, 1036\u20131042. https:\/\/doi.org\/10.1016\/j.ophtha.2016.01.006 (2016).","journal-title":"Ophthalmology"},{"key":"75637_CR2","doi-asserted-by":"publisher","first-page":"406","DOI":"10.4103\/0301-4738.100535","volume":"60","author":"KD Frick","year":"2012","unstructured":"Frick, K. D. What the comprehensive economics of blindness and visual impairment can help us understand. Indian J. Ophthalmol. 60, 406\u2013410. https:\/\/doi.org\/10.4103\/0301-4738.100535 (2012).","journal-title":"Indian J. Ophthalmol."},{"key":"75637_CR3","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/eye.2013.256","volume":"28","author":"B Holden","year":"2014","unstructured":"Holden, B. et al. Myopia, an underrated global challenge to vision: Where the current data takes us on myopia control. Eye (London England). 28, 142\u2013146. https:\/\/doi.org\/10.1038\/eye.2013.256 (2014).","journal-title":"Eye (London England)"},{"key":"75637_CR4","doi-asserted-by":"publisher","unstructured":"M\u00e9rida, S. et al. Glutathione and a pool of metabolites partly related to oxidative stress are associated with low and high myopia in an altered bioenergetic environment. Antioxid. (Basel Switzerland). 13. https:\/\/doi.org\/10.3390\/antiox13050539 (2024).","DOI":"10.3390\/antiox13050539"},{"key":"75637_CR5","doi-asserted-by":"publisher","first-page":"109670","DOI":"10.1016\/j.exer.2023.109670","volume":"237","author":"Q Yu","year":"2023","unstructured":"Yu, Q. et al. Association between inflammatory cytokines and oxidative stress levels in aqueous humor with axial length in human myopia. Exp. Eye Res. 237, 109670. https:\/\/doi.org\/10.1016\/j.exer.2023.109670 (2023).","journal-title":"Exp. Eye Res."},{"key":"75637_CR6","doi-asserted-by":"publisher","unstructured":"Wu, W. et al. Hypoxia-induced scleral HIF-2\u03b1 upregulation contributes to rises in MMP-2 expression and myopia development in mice. Invest. Ophthalmol. Vis. Sci. 63https:\/\/doi.org\/10.1167\/iovs.63.8.2 (2022). 2.","DOI":"10.1167\/iovs.63.8.2"},{"key":"75637_CR7","doi-asserted-by":"publisher","unstructured":"Moon, C. E. et al. Retinal proteome analysis reveals a region-specific change in the rabbit myopia model. Int. J. Mol. Sci. 24https:\/\/doi.org\/10.3390\/ijms24021286 (2023).","DOI":"10.3390\/ijms24021286"},{"key":"75637_CR8","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/glia.23727","volume":"68","author":"A Reichenbach","year":"2020","unstructured":"Reichenbach, A. & Bringmann, A. Glia of the human retina. Glia. 68, 768\u2013796. https:\/\/doi.org\/10.1002\/glia.23727 (2020).","journal-title":"Glia"},{"key":"75637_CR9","doi-asserted-by":"publisher","unstructured":"Wang, D., Gao, F., Hu, F. & Wu, J. Nobiletin alleviates astrocyte activation and oxidative stress induced by hypoxia in vitro. Molecules (Basel Switzerland). 27. https:\/\/doi.org\/10.3390\/molecules27061962 (2022).","DOI":"10.3390\/molecules27061962"},{"key":"75637_CR10","doi-asserted-by":"publisher","first-page":"197","DOI":"10.21037\/atm-22-2204","volume":"11","author":"X Ding","year":"2023","unstructured":"Ding, X. et al. Inhibition of NF-\u03baB ameliorates aberrant retinal glia activation and inflammatory responses in streptozotocin-induced diabetic rats. Ann. Transl. Med. 11, 197. https:\/\/doi.org\/10.21037\/atm-22-2204 (2023).","journal-title":"Annals Translational Med."},{"key":"75637_CR11","doi-asserted-by":"publisher","unstructured":"Lee, S. H., Park, Y. S., Paik, S. S. & Kim, I. B. Differential Response of M\u00fcller Cells and Microglia in a mouse retinal detachment model and its implications in detached and non-detached regions. Cells. 10https:\/\/doi.org\/10.3390\/cells10081972 (2021).","DOI":"10.3390\/cells10081972"},{"key":"75637_CR12","doi-asserted-by":"publisher","first-page":"116538","DOI":"10.1016\/j.biopha.2024.116538","volume":"174","author":"LH Wu","year":"2024","unstructured":"Wu, L. H. et al. A novel HDAC8 inhibitor H7E exerts retinoprotective effects against glaucomatous injury via ameliorating aberrant M\u00fcller glia activation and oxidative stress. Biomed. Pharmacother. 174, 116538. https:\/\/doi.org\/10.1016\/j.biopha.2024.116538 (2024).","journal-title":"Biomed. Pharmacother."},{"key":"75637_CR13","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/s0074-7696(03)30005-1","volume":"230","author":"GP Lewis","year":"2003","unstructured":"Lewis, G. P. & Fisher, S. K. Up-regulation of glial fibrillary acidic protein in response to retinal injury: Its potential role in glial remodeling and a comparison to vimentin expression. Int. Rev. Cytol. 230, 263\u2013290. https:\/\/doi.org\/10.1016\/s0074-7696(03)30005-1 (2003).","journal-title":"Int. Rev. Cytol."},{"key":"75637_CR14","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1002\/glia.20516","volume":"55","author":"DM Inman","year":"2007","unstructured":"Inman, D. M. & Horner, P. J. Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia. 55, 942\u2013953. https:\/\/doi.org\/10.1002\/glia.20516 (2007).","journal-title":"Glia"},{"key":"75637_CR15","first-page":"2738","volume":"17","author":"M Hollborn","year":"2011","unstructured":"Hollborn, M. et al. The human M\u00fcller cell line MIO-M1 expresses opsins. Mol. Vis. 17, 2738\u20132750 (2011).","journal-title":"Mol. Vis."},{"key":"75637_CR16","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/s1350-9462(02)00063-0","volume":"22","author":"NA McBrien","year":"2003","unstructured":"McBrien, N. A. & Gentle, A. Role of the sclera in the development and pathological complications of myopia. Prog. Retin. Eye Res. 22, 307\u2013338. https:\/\/doi.org\/10.1016\/s1350-9462(02)00063-0 (2003).","journal-title":"Prog. Retin. Eye Res."},{"key":"75637_CR17","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.exer.2013.05.004","volume":"114","author":"TT Norton","year":"2013","unstructured":"Norton, T. T. & Siegwart, J. T. Jr. Light levels, refractive development, and myopia\u2013A speculative review. Exp. Eye Res. 114, 48\u201357. https:\/\/doi.org\/10.1016\/j.exer.2013.05.004 (2013).","journal-title":"Exp. Eye Res."},{"key":"75637_CR18","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","volume":"25","author":"A Bringmann","year":"2006","unstructured":"Bringmann, A. et al. M\u00fcller cells in the healthy and diseased retina. Prog. Retin. Eye Res. 25, 397\u2013424. https:\/\/doi.org\/10.1016\/j.preteyeres.2006.05.003 (2006).","journal-title":"Prog. Retin. Eye Res."},{"key":"75637_CR19","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1186\/s12886-022-02643-0","volume":"22","author":"X Zhang","year":"2022","unstructured":"Zhang, X. et al. Functions of retinal astrocytes and M\u00fcller cells in mammalian myopia. BMC Ophthalmol. 22, 451. https:\/\/doi.org\/10.1186\/s12886-022-02643-0 (2022).","journal-title":"BMC Ophthalmol."},{"key":"75637_CR20","doi-asserted-by":"publisher","unstructured":"Lin, C. et al. Myopia alters the structural organization of the retinal vasculature, GFAP-positive glia, and ganglion cell layer thickness. Int. J. Mol. Sci. 23. https:\/\/doi.org\/10.3390\/ijms23116202 (2022).","DOI":"10.3390\/ijms23116202"},{"key":"75637_CR21","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1002\/jnr.23583","volume":"93","author":"JB Hurley","year":"2015","unstructured":"Hurley, J. B., Lindsay, K. J. & Du, J. Glucose, lactate, and shuttling of metabolites in vertebrate retinas. J. Neurosci. Res. 93, 1079\u20131092. https:\/\/doi.org\/10.1002\/jnr.23583 (2015).","journal-title":"J. Neurosci. Res."},{"key":"75637_CR22","doi-asserted-by":"publisher","first-page":"3424","DOI":"10.1172\/jci83194","volume":"125","author":"JB Hurley","year":"2015","unstructured":"Hurley, J. B. & Chao, J. R. It\u2019s never too late to save a photoreceptor. J. Clin. Invest. 125, 3424\u20133426. https:\/\/doi.org\/10.1172\/jci83194 (2015).","journal-title":"J. Clin. Invest."},{"key":"75637_CR23","first-page":"3183","volume":"41","author":"BS Winkler","year":"2000","unstructured":"Winkler, B. S., Arnold, M. J., Brassell, M. A. & Puro, D. G. Energy metabolism in human retinal M\u00fcller cells. Invest. Ophthalmol. Vis. Sci. 41, 3183\u20133190 (2000).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"75637_CR24","doi-asserted-by":"publisher","first-page":"5401","DOI":"10.1096\/fj.201902961R","volume":"34","author":"JYS Han","year":"2020","unstructured":"Han, J. Y. S. et al. Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion. FASEB J.. 34, 5401\u20135419. https:\/\/doi.org\/10.1096\/fj.201902961R (2020).","journal-title":"FASEB J."},{"key":"75637_CR25","doi-asserted-by":"publisher","first-page":"15947","DOI":"10.1074\/jbc.RA118.004180","volume":"293","author":"M \u017ddralevi\u0107","year":"2018","unstructured":"\u017ddralevi\u0107, M. et al. Double genetic disruption of lactate dehydrogenases a and B is required to ablate the Warburg effect restricting tumor growth to oxidative metabolism. J. Biol. Chem. 293, 15947\u201315961. https:\/\/doi.org\/10.1074\/jbc.RA118.004180 (2018).","journal-title":"J. Biol. Chem."},{"key":"75637_CR26","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1006\/exer.1999.0745","volume":"69","author":"RJ Buono","year":"1999","unstructured":"Buono, R. J. & Lang, R. K. Hypoxic repression of lactate dehydrogenase-B in retina. Exp. Eye Res. 69, 685\u2013693. https:\/\/doi.org\/10.1006\/exer.1999.0745 (1999).","journal-title":"Exp. Eye Res."},{"key":"75637_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-019-0233-3","volume":"51","author":"EJ Yeo","year":"2019","unstructured":"Yeo, E. J. Hypoxia and aging. Exp. Mol. Med. 51, 1\u201315. https:\/\/doi.org\/10.1038\/s12276-019-0233-3 (2019).","journal-title":"Exp. Mol. Med."},{"key":"75637_CR28","doi-asserted-by":"publisher","first-page":"103684","DOI":"10.1016\/j.jprot.2020.103684","volume":"221","author":"FJ Yu","year":"2020","unstructured":"Yu, F. J. et al. Alteration of retinal metabolism and oxidative stress may implicate myopic eye growth: Evidence from discovery and targeted proteomics in an animal model. J. Proteom. 221, 103684. https:\/\/doi.org\/10.1016\/j.jprot.2020.103684 (2020).","journal-title":"J. Proteom."},{"key":"75637_CR29","doi-asserted-by":"publisher","first-page":"15022","DOI":"10.1038\/s41598-019-50866-x","volume":"9","author":"J G\u00f3mez-Escudero","year":"2019","unstructured":"G\u00f3mez-Escudero, J. et al. PKM2 regulates endothelial cell junction dynamics and angiogenesis via ATP production. Sci. Rep. 9, 15022. https:\/\/doi.org\/10.1038\/s41598-019-50866-x (2019).","journal-title":"Sci. Rep."},{"key":"75637_CR30","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1080\/02713683.2022.2029904","volume":"47","author":"Q Hui","year":"2022","unstructured":"Hui, Q., Zheng, F., Qin, L. & Pei, C. Annexin A1 promotes reparative angiogenesis and ameliorates neuronal injury in ischemic retinopathy. Curr. Eye Res. 47, 791\u2013801. https:\/\/doi.org\/10.1080\/02713683.2022.2029904 (2022).","journal-title":"Curr. Eye Res."},{"key":"75637_CR31","doi-asserted-by":"publisher","first-page":"2637","DOI":"10.1007\/s00018-008-8086-2","volume":"65","author":"MT Swulius","year":"2008","unstructured":"Swulius, M. T. & Waxham, M. N. Ca(2+)\/calmodulin-dependent protein kinases. Cell. Mol. Life Sci. 65, 2637\u20132657. https:\/\/doi.org\/10.1007\/s00018-008-8086-2 (2008).","journal-title":"Cell. Mol. Life Sci."},{"key":"75637_CR32","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1007\/s00204-021-03032-0","volume":"95","author":"N Verma","year":"2021","unstructured":"Verma, N., Pink, M. & Schmitz-Spanke, S. A new perspective on calmodulin-regulated calcium and ROS homeostasis upon carbon black nanoparticle exposure. Arch. Toxicol. 95, 2007\u20132018. https:\/\/doi.org\/10.1007\/s00204-021-03032-0 (2021).","journal-title":"Arch. Toxicol."},{"key":"75637_CR33","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1681\/asn.2007101085","volume":"19","author":"H Nishi","year":"2008","unstructured":"Nishi, H. et al. Hemoglobin is expressed by mesangial cells and reduces oxidant stress. J. Am. Soc. Nephrol. JASN. 19, 1500\u20131508. https:\/\/doi.org\/10.1681\/asn.2007101085 (2008).","journal-title":"J. Am. Soc. Nephrol. JASN"},{"key":"75637_CR34","doi-asserted-by":"publisher","first-page":"e24363","DOI":"10.1371\/journal.pone.0024363","volume":"6","author":"W Liu","year":"2011","unstructured":"Liu, W., Baker, S. S., Baker, R. D., Nowak, N. J. & Zhu, L. Upregulation of hemoglobin expression by oxidative stress in hepatocytes and its implication in nonalcoholic steatohepatitis. PloS One. 6, e24363. https:\/\/doi.org\/10.1371\/journal.pone.0024363 (2011).","journal-title":"PloS One"},{"key":"75637_CR35","doi-asserted-by":"publisher","unstructured":"Orrico, F. et al. Oxidative stress in healthy and pathological red blood cells. Biomolecules. 13https:\/\/doi.org\/10.3390\/biom13081262 (2023).","DOI":"10.3390\/biom13081262"},{"key":"75637_CR36","doi-asserted-by":"publisher","first-page":"12189","DOI":"10.1021\/bi970258a","volume":"36","author":"YI Miller","year":"1997","unstructured":"Miller, Y. I., Altamentova, S. M. & Shaklai, N. Oxidation of low-density lipoprotein by hemoglobin stems from a heme-initiated globin radical: Antioxidant role of haptoglobin. Biochemistry. 36, 12189\u201312198. https:\/\/doi.org\/10.1021\/bi970258a (1997).","journal-title":"Biochemistry"},{"key":"75637_CR37","doi-asserted-by":"publisher","first-page":"e100745","DOI":"10.1371\/journal.pone.0100745","volume":"9","author":"E Bertaggia","year":"2014","unstructured":"Bertaggia, E. et al. Haptoglobin is required to prevent oxidative stress and muscle atrophy. PloS One. 9, e100745. https:\/\/doi.org\/10.1371\/journal.pone.0100745 (2014).","journal-title":"PloS One"},{"key":"75637_CR38","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/glia.20207","volume":"50","author":"M Pekny","year":"2005","unstructured":"Pekny, M. & Nilsson, M. Astrocyte activation and reactive gliosis. Glia. 50, 427\u2013434. https:\/\/doi.org\/10.1002\/glia.20207 (2005).","journal-title":"Glia"},{"key":"75637_CR39","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/glia.24283","volume":"71","author":"L Kaplan","year":"2023","unstructured":"Kaplan, L. et al. Retinal regions shape human and murine M\u00fcller cell proteome profile and functionality. Glia. 71, 391\u2013414. https:\/\/doi.org\/10.1002\/glia.24283 (2023).","journal-title":"Glia"},{"key":"75637_CR40","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1038\/nprot.2008.211","volume":"4","author":"W Huang da","year":"2009","unstructured":"Huang da, W., Sherman, B. T. & Lempicki, R. A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protoc. 4, 44\u201357. https:\/\/doi.org\/10.1038\/nprot.2008.211 (2009).","journal-title":"Nat. Protoc."},{"key":"75637_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000328979","volume":"227","author":"A Bringmann","year":"2012","unstructured":"Bringmann, A. & Wiedemann, P. M\u00fcller glial cells in retinal disease. Ophthalmologica. 227, 1\u201319. https:\/\/doi.org\/10.1159\/000328979 (2012).","journal-title":"Ophthalmologica"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75637-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75637-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75637-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T19:03:08Z","timestamp":1728932588000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75637-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,14]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["75637"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-75637-1","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,14]]},"assertion":[{"value":"17 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24072"}}