{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:19:47Z","timestamp":1793330387341,"version":"4.5.0"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["951513"],"award-info":[{"award-number":["951513"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2020\/10246-0"],"award-info":[{"award-number":["#2020\/10246-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["511713970"],"award-info":[{"award-number":["511713970"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018774","name":"Bundesministerium f\u00fcr Klimaschutz, Umwelt, Energie, Mobilit\u00e4t, Innovation und Technologie","doi-asserted-by":"publisher","award":["microONE"],"award-info":[{"award-number":["microONE"]}],"id":[{"id":"10.13039\/100018774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010132","name":"\u00d6sterreichische Nationalstiftung f\u00fcr Forschung, Technologie und Entwicklung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006012","name":"Christian Doppler Forschungsgesellschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011699","name":"Siemens Healthineers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["P26011"],"award-info":[{"award-number":["P26011"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018818","name":"National Research, Development and Innovation Office","doi-asserted-by":"publisher","award":["OTKA-FK 138823"],"award-info":[{"award-number":["OTKA-FK 138823"]}],"id":[{"id":"10.13039\/501100018818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012550","name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","doi-asserted-by":"publisher","award":["\u00daNKP-22-5"],"award-info":[{"award-number":["\u00daNKP-22-5"]}],"id":[{"id":"10.13039\/501100012550","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Micro- and nanoplastics can interact with various biologically active compounds forming aggregates of which the effects have yet to be understood. To this end, it is vital to characterize these aggregates of key compounds and micro- and nanoplastics. In this study, we examined the adsorption of the antibiotic tetracycline on four different nanoplastics, made of polyethylene (PE), polypropylene (PP), polystyrene (PS), and nylon 6,6 (N66) through chemical computation. Two separate approaches were employed to generate relevant conformations of the tetracycline-plastic complexes. In the first approach, we folded the plastic particle from individual polymer chains in the presence of the drug through multiple separate simulated annealing setups. In the second, more biased, approach, the neat plastic was pre-folded through simulated annealing, and the drug was placed at its surface in multiple orientations. The former approach was clearly superior to the other, obtaining lower energy conformations even with the antibiotic buried inside the plastic particle. Quantum chemical calculations on the structures revealed that the adsorption energies show a trend of decreasing affinity to the drug in the order of N66&gt; PS&gt; PP&gt; PE. In vitro experiments on tetracycline-sensitive cell lines demonstrated that, in qualitative agreement with the calculations, the biological activity of tetracycline drops significantly in the presence of PS particles. Preliminary molecular dynamics simulations on two selected aggregates with each plastic served as first stability test of the aggregates under influence of temperature and in water. We found that all the selected cases persisted in water indicating that the aggregates may be stable also in more realistic environments. In summary, our data show that the interaction of micro- and nanoplastics with drugs can alter drug absorption, facilitate drug transport to new locations, and increase local antibiotic concentrations, potentially attenuating antibiotic effect and at the same time promoting antibiotic resistance.<\/jats:p>","DOI":"10.1038\/s41598-024-75785-4","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T12:03:05Z","timestamp":1730116985000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The adsorption of drugs on nanoplastics has severe biological impact"],"prefix":"10.1038","volume":"14","author":[{"given":"Leonard","family":"Dick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick R.","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Zaby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Manhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Kopatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Kogler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Grebien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vince","family":"Bakos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedek G.","family":"Pl\u00f3sz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola Zlatkov","family":"Kolev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Kenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Kirchner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oldamur","family":"Holl\u00f3czki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"75785_CR1","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1126\/science.178.4062.749","volume":"178","author":"EJ Carpenter","year":"1972","unstructured":"Carpenter, E. J., Anderson, S. J., Harvey, G. R., Miklas, H. P. & Peck, B. B. Polystyrene spherules in coastal waters. Science 178, 749\u2013750 (1972).","journal-title":"Science"},{"key":"75785_CR2","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1126\/science.1094559","volume":"304","author":"RC Thompson","year":"2004","unstructured":"Thompson, R. C. Lost at sea: Where is all the plastic?. Science 304, 838 (2004).","journal-title":"Science"},{"key":"75785_CR3","doi-asserted-by":"publisher","first-page":"2588","DOI":"10.1016\/j.marpolbul.2011.09.025","volume":"62","author":"M Cole","year":"2011","unstructured":"Cole, M., Lindeque, P., Halsband, C. & Galloway, T. S. Microplastics as contaminants in the marine environment: A review. Mar. Pollut. Bull. 62, 2588\u20132597 (2011).","journal-title":"Mar. Pollut. Bull."},{"key":"75785_CR4","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.marpolbul.2014.12.041","volume":"92","author":"S Gall","year":"2015","unstructured":"Gall, S. & Thompson, R. The impact of debris on marine life. Mar. Pollut. Bull. 92, 170\u2013179 (2015).","journal-title":"Mar. Pollut. Bull."},{"key":"75785_CR5","doi-asserted-by":"crossref","unstructured":"Gruber, E.\u00a0S. et al. To waste or not to waste: Questioning potential health risks of micro-and nanoplastics with a focus on their ingestion and potential carcinogenicity. Exposure Health. 1\u201319 (2022).","DOI":"10.1007\/s12403-022-00470-8"},{"key":"75785_CR6","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1039\/D0EM00446D","volume":"23","author":"C Wayman","year":"2021","unstructured":"Wayman, C. & Niemann, H. The fate of plastic in the ocean environment\u2014A minireview. Environ. Sci. Process. Impacts 23, 198\u2013212 (2021).","journal-title":"Environ. Sci. Process. Impacts"},{"key":"75785_CR7","volume-title":"Microplastics in Drinking Water","author":"P Marsden","year":"2019","unstructured":"Marsden, P. et al. Microplastics in Drinking Water (World Health Organization, 2019)."},{"key":"75785_CR8","doi-asserted-by":"publisher","first-page":"453","DOI":"10.7326\/M19-0618","volume":"171","author":"P Schwabl","year":"2019","unstructured":"Schwabl, P. et al. Detection of various microplastics in human stool: A prospective case series. Ann. Internal Med. 171, 453\u2013457 (2019).","journal-title":"Ann. Internal Med."},{"key":"75785_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107199","volume":"163","author":"HA Leslie","year":"2022","unstructured":"Leslie, H. A. et al. Discovery and quantification of plastic particle pollution in human blood. Environ. Int. 163, 107199 (2022).","journal-title":"Environ. Int."},{"key":"75785_CR10","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.3390\/nano13081404","volume":"13","author":"V Kopatz","year":"2023","unstructured":"Kopatz, V. et al. Micro-and nanoplastics breach the blood-brain barrier (bbb): Biomolecular corona\u2019s role revealed. Nanomaterials 13, 1404 (2023).","journal-title":"Nanomaterials"},{"key":"75785_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.134261","volume":"298","author":"S Shan","year":"2022","unstructured":"Shan, S., Zhang, Y., Zhao, H., Zeng, T. & Zhao, X. Polystyrene nanoplastics penetrate across the blood-brain barrier and induce activation of microglia in the brain of mice. Chemosphere 298, 134261 (2022).","journal-title":"Chemosphere"},{"key":"75785_CR12","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2021.132631","volume":"288","author":"X Meng","year":"2022","unstructured":"Meng, X. et al. Effects of nano-and microplastics on kidney: Physicochemical properties, bioaccumulation, oxidative stress and immunoreaction. Chemosphere 288, 132631 (2022).","journal-title":"Chemosphere"},{"key":"75785_CR13","doi-asserted-by":"crossref","unstructured":"Horvatits, T. et al. Microplastics detected in cirrhotic liver tissue. EBioMedicine. 82 (2022).","DOI":"10.1016\/j.ebiom.2022.104147"},{"key":"75785_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.165922","volume":"901","author":"L Montano","year":"2023","unstructured":"Montano, L. et al. Raman microspectroscopy evidence of microplastics in human semen. Sci. Total Environ. 901, 165922 (2023).","journal-title":"Sci. Total Environ."},{"key":"75785_CR15","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.trac.2018.11.023","volume":"110","author":"R Triebskorn","year":"2019","unstructured":"Triebskorn, R. et al. Relevance of nano-and microplastics for freshwater ecosystems: A critical review. TrAC Trends Analyt. Chem. 110, 375\u2013392 (2019).","journal-title":"TrAC Trends Analyt. Chem."},{"key":"75785_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.eti.2019.100352","volume":"14","author":"N Laskar","year":"2019","unstructured":"Laskar, N. & Kumar, U. Plastics and microplastics: A threat to environment. Environ. Technol. Innovat. 14, 100352 (2019).","journal-title":"Environ. Technol. Innovat."},{"key":"75785_CR17","doi-asserted-by":"crossref","unstructured":"Thompson, R.\u00a0C. Microplastics in the marine environment: Sources, consequences and solutions. Mar. Anthropogenic Litter. 185\u2013200 (2015).","DOI":"10.1007\/978-3-319-16510-3_7"},{"key":"75785_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.126059","volume":"249","author":"Q Yu","year":"2020","unstructured":"Yu, Q. et al. Distribution, abundance and risks of microplastics in the environment. Chemosphere 249, 126059 (2020).","journal-title":"Chemosphere"},{"key":"75785_CR19","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/s42003-019-0629-6","volume":"2","author":"NR Brun","year":"2019","unstructured":"Brun, N. R. et al. Polystyrene nanoplastics disrupt glucose metabolism and cortisol levels with a possible link to behavioural changes in larval zebrafish. Commun. Biol. 2, 382 (2019).","journal-title":"Commun. Biol."},{"key":"75785_CR20","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1021\/acs.bioconjchem.9b00015","volume":"30","author":"S Kihara","year":"2019","unstructured":"Kihara, S. et al. Soft and hard interactions between polystyrene nanoplastics and human serum albumin protein corona. Bioconjugate Chem. 30, 1067\u20131076 (2019).","journal-title":"Bioconjugate Chem."},{"key":"75785_CR21","doi-asserted-by":"publisher","first-page":"8860","DOI":"10.1038\/s41598-019-45139-6","volume":"9","author":"PM Gopinath","year":"2019","unstructured":"Gopinath, P. M. et al. Assessment on interactive prospectives of nanoplastics with plasma proteins and the toxicological impacts of virgin, coronated and environmentally released-nanoplastics. Sci. Rep. 9, 8860 (2019).","journal-title":"Sci. Rep."},{"key":"75785_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2020.111403","volume":"158","author":"S Wang","year":"2020","unstructured":"Wang, S., Liu, M., Wang, J., Huang, J. & Wang, J. Polystyrene nanoplastics cause growth inhibition, morphological damage and physiological disturbance in the marine microalga platymonas helgolandica. Mar. Poll. Bull. 158, 111403 (2020).","journal-title":"Mar. Poll. Bull."},{"key":"75785_CR23","doi-asserted-by":"crossref","unstructured":"Machado, M.\u00a0C., Vimbela, G.\u00a0V., Silva-Oliveira, T.\u00a0T., Bose, A. & Tripathi, A. The response of synechococcus sp. pcc 7002 to micro-\/nano polyethylene particles-investigation of a key anthropogenic stressor. PloS One. 15, e0232745 (2020).","DOI":"10.1371\/journal.pone.0232745"},{"key":"75785_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12989-020-00358-y","volume":"17","author":"M Pr\u00fcst","year":"2020","unstructured":"Pr\u00fcst, M., Meijer, J. & Westerink, R. H. The plastic brain: Neurotoxicity of micro-and nanoplastics. Part. Fibre Toxicol. 17, 1\u201316 (2020).","journal-title":"Part. Fibre Toxicol."},{"key":"75785_CR25","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1080\/17435390.2017.1391344","volume":"11","author":"NR Brun","year":"2017","unstructured":"Brun, N. R., Beenakker, M. M., Hunting, E. R., Ebert, D. & Vijver, M. G. Brood pouch-mediated polystyrene nanoparticle uptake during daphnia magna embryogenesis. Nanotoxicology 11, 1059\u20131069 (2017).","journal-title":"Nanotoxicology"},{"key":"75785_CR26","doi-asserted-by":"crossref","unstructured":"Oliveira, Y.\u00a0M., Vernin, N.\u00a0S., Zhang, Y., Maginn, E. & Tavares, F.\u00a0W. Interaction between endocrine disruptors and polyethylene nanoplastic by molecular dynamics simulations. J. Phys. Chem. B. (2024).","DOI":"10.1021\/acs.jpcb.3c07966"},{"key":"75785_CR27","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.3390\/ijerph18052392","volume":"18","author":"S D\u2019Angelo","year":"2021","unstructured":"D\u2019Angelo, S. & Meccariello, R. Microplastics: A threat for male fertility. Int. J. Environ. Res. Pub. Health 18, 2392 (2021).","journal-title":"Int. J. Environ. Res. Pub. Health"},{"key":"75785_CR28","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","volume":"76","author":"K Fent","year":"2006","unstructured":"Fent, K., Weston, A. A. & Caminada, D. Ecotoxicology of human pharmaceutical. Aquat. Toxicol. 76, 122\u2013159 (2006).","journal-title":"Aquat. Toxicol."},{"key":"75785_CR29","doi-asserted-by":"crossref","unstructured":"Baysal, A. & Saygin, H. Co-occurence of antibiotics and micro (nano) plastics: A systematic review between 2016-2021. J. Environ. Sci. Health Part A. 1\u201321 (2022).","DOI":"10.1080\/10934529.2022.2082222"},{"key":"75785_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.142370","volume":"750","author":"M Yilimulati","year":"2021","unstructured":"Yilimulati, M., Wang, L., Ma, X., Yang, C. & Habibul, N. Adsorption of ciprofloxacin to functionalized nano-sized polystyrene plastic: Kinetics, thermochemistry and toxicity. Sci. Total Environ. 750, 142370 (2021).","journal-title":"Sci. Total Environ."},{"key":"75785_CR31","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1021\/acs.est.9b00493","volume":"53","author":"P Liu","year":"2019","unstructured":"Liu, P. et al. New insights into the aging behavior of microplastics accelerated by advanced oxidation processes. Environ. Sci. Technol. 53, 3579\u20133588 (2019).","journal-title":"Environ. Sci. Technol."},{"key":"75785_CR32","doi-asserted-by":"publisher","first-page":"3178","DOI":"10.1039\/D0EN00651C","volume":"7","author":"J Nath","year":"2020","unstructured":"Nath, J., Dror, I. & Berkowitz, B. Effect of nanoplastics on the transport of platinum-based pharmaceuticals in water-saturated natural soil and their effect on a soil microbial community. Environ. Sci. Nano 7, 3178\u20133188 (2020).","journal-title":"Environ. Sci. Nano"},{"key":"75785_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.127976","volume":"263","author":"A Puckowski","year":"2021","unstructured":"Puckowski, A., Cwiek, W., Mioduszewska, K., Stepnowski, P. & Bia\u0142k-Bieli\u0144ska, A. Sorption of pharmaceuticals on the surface of microplastics. Chemosphere 263, 127976 (2021).","journal-title":"Chemosphere"},{"key":"75785_CR34","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1038\/nrmicro3439","volume":"13","author":"TU Berendonk","year":"2015","unstructured":"Berendonk, T. U. et al. Tackling antibiotic resistance: The environmental framework. Nat. Rev. Microbiol. 13, 310\u2013317 (2015).","journal-title":"Nat. Rev. Microbiol."},{"key":"75785_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-020-01176-w","volume":"3","author":"IC Stanton","year":"2020","unstructured":"Stanton, I. C., Murray, A. K., Zhang, L., Snape, J. & Gaze, W. H. Evolution of antibiotic resistance at low antibiotic concentrations including selection below the minimal selective concentration. Commun. Biol. 3, 1\u201311 (2020).","journal-title":"Commun. Biol."},{"key":"75785_CR36","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2021.117533","volume":"203","author":"FC Elder","year":"2021","unstructured":"Elder, F. C. et al. Spatiotemporal profiling of antibiotics and resistance genes in a river catchment: Human population as the main driver of antibiotic and antibiotic resistance gene presence in the environment. Water Res. 203, 117533 (2021).","journal-title":"Water Res."},{"key":"75785_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.watres.2021.117233","volume":"200","author":"AK Murray","year":"2021","unstructured":"Murray, A. K., Stanton, I., Gaze, W. H. & Snape, J. Dawning of a new era: Environmental risk assessment of antibiotics and their potential to select for antimicrobial resistance. Water Res. 200, 117233 (2021).","journal-title":"Water Res."},{"key":"75785_CR38","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1038\/s41522-021-00251-2","volume":"7","author":"A Penesyan","year":"2021","unstructured":"Penesyan, A., Paulsen, I. T., Kjelleberg, S. & Gillings, M. R. Three faces of biofilms: A microbial lifestyle, a nascent multicellular organism, and an incubator for diversity. NPJ Biofilms Microbiomes. 7, 80 (2021).","journal-title":"NPJ Biofilms Microbiomes."},{"key":"75785_CR39","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.watres.2017.06.027","volume":"123","author":"E Torresi","year":"2017","unstructured":"Torresi, E. et al. Diffusion and sorption of organic micropollutants in biofilms with varying thicknesses. Water Res. 123, 388\u2013400 (2017).","journal-title":"Water Res."},{"key":"75785_CR40","doi-asserted-by":"publisher","first-page":"9279","DOI":"10.1021\/acs.est.6b02007","volume":"50","author":"E Torresi","year":"2016","unstructured":"Torresi, E. et al. Biofilm thickness influences biodiversity in nitrifying mbbrs implications on micropollutant removal. Environ. Sci. Technol. 50, 9279\u20139288 (2016).","journal-title":"Environ. Sci. Technol."},{"key":"75785_CR41","volume":"6","author":"P Sooriyakumar","year":"2022","unstructured":"Sooriyakumar, P. et al. Biofilm formation and its implications on the properties and fate of microplastics in aquatic environments: A review. J. Hazard. Mat. Adv. 6, 100077 (2022).","journal-title":"J. Hazard. Mat. Adv."},{"key":"75785_CR42","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.envpol.2018.02.058","volume":"237","author":"M Arias-Andres","year":"2018","unstructured":"Arias-Andres, M., Kl\u00fcmper, U., Rojas-Jimenez, K. & Grossart, H.-P. Microplastic pollution increases gene exchange in aquatic ecosystems. Environ. Pollut. 237, 253\u2013261 (2018).","journal-title":"Environ. Pollut."},{"key":"75785_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.116278","volume":"270","author":"Y Su","year":"2021","unstructured":"Su, Y. et al. Microplastics act as vectors for antibiotic resistance genes in landfill leachate: The enhanced roles of the long-term aging process. Environ. Pollut. 270, 116278 (2021).","journal-title":"Environ. Pollut."},{"key":"75785_CR44","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.envpol.2018.02.050","volume":"237","author":"J Li","year":"2018","unstructured":"Li, J., Zhang, K. & Zhang, H. Adsorption of antibiotics on microplastics. Environ. Pollut. 237, 460\u2013467 (2018).","journal-title":"Environ. Pollut."},{"key":"75785_CR45","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.envpol.2018.04.113","volume":"240","author":"B Xu","year":"2018","unstructured":"Xu, B., Liu, F., Brookes, P. C. & Xu, J. Microplastics play a minor role in tetracycline sorption in the presence of dissolved organic matter. Environ. Pollut. 240, 87\u201394 (2018).","journal-title":"Environ. Pollut."},{"key":"75785_CR46","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.137729","volume":"721","author":"F Yu","year":"2020","unstructured":"Yu, F. et al. Interfacial interaction between diverse microplastics and tetracycline by adsorption in an aqueous solution. Sci. Tot. Environ. 721, 137729 (2020).","journal-title":"Sci. Tot. Environ."},{"key":"75785_CR47","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1016\/j.envpol.2018.09.122","volume":"243","author":"H Zhang","year":"2018","unstructured":"Zhang, H. et al. Enhanced adsorption of oxytetracycline to weathered microplastic polystyrene: Kinetics, isotherms and influencing factors. Environ. Pollut. 243, 1550\u20131557 (2018).","journal-title":"Environ. Pollut."},{"key":"75785_CR48","doi-asserted-by":"publisher","first-page":"17989","DOI":"10.1038\/s41598-023-44288-z","volume":"13","author":"M Zahmatkesh Anbarani","year":"2023","unstructured":"Zahmatkesh Anbarani, M., Najafpoor, A., Barikbin, B. & Bonyadi, Z. Adsorption of tetracycline on polyvinyl chloride microplastics in aqueous environments. Sci. Rep. 13, 17989 (2023).","journal-title":"Sci. Rep."},{"key":"75785_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.161022","volume":"863","author":"L Wang","year":"2023","unstructured":"Wang, L., Yang, H., Guo, M., Wang, Z. & Zheng, X. Adsorption of antibiotics on different microplastics (mps): Behavior and mechanism. Sci. Tot. Environ. 863, 161022 (2023).","journal-title":"Sci. Tot. Environ."},{"key":"75785_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157109","volume":"845","author":"H Wang","year":"2022","unstructured":"Wang, H. et al. Adsorption of tetracycline and cd (ii) on polystyrene and polyethylene terephthalate microplastics with ultraviolet and hydrogen peroxide aging treatment. Sci. Tot. Environ. 845, 157109 (2022).","journal-title":"Sci. Tot. Environ."},{"key":"75785_CR51","doi-asserted-by":"publisher","DOI":"10.1002\/qua.26372","volume":"121","author":"O Holl\u00f3czki","year":"2021","unstructured":"Holl\u00f3czki, O. Evidence for protein misfolding in the presence of nanoplastics. Int. J. Quant. Chem. 121, e26372 (2021).","journal-title":"Int. J. Quant. Chem."},{"key":"75785_CR52","doi-asserted-by":"crossref","unstructured":"Holloczki, O. & Gehrke, S. Nanoplastics can change the secondary structure of proteins. Sci. Rep. 9 (2019).","DOI":"10.1038\/s41598-019-52495-w"},{"key":"75785_CR53","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1093\/protein\/7.2.235","volume":"7","author":"C Laughton","year":"1994","unstructured":"Laughton, C. A study of simulated annealing protocols for use with molecular dynamics in protein structure prediction. Protein Eng. Design Select. 7, 235\u2013241 (1994).","journal-title":"Protein Eng. Design Select."},{"key":"75785_CR54","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/0009-2614(87)87091-4","volume":"133","author":"L Wille","year":"1987","unstructured":"Wille, L. Minimum-energy configurations of atomic clusters: New results obtained by simulated annealing. Chem. Phys. Lett. 133, 405\u2013410 (1987).","journal-title":"Chem. Phys. Lett."},{"key":"75785_CR55","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1016\/S0040-4039(00)80498-0","volume":"29","author":"SR Wilson","year":"1988","unstructured":"Wilson, S. R., Cui, W., Moskowitz, J. W. & Schmidt, K. E. Conformational analysis of flexible molecules: Location of the global minimum energy conformation by the simulated annealing method. Tetrahedron Lett. 29, 4373\u20134376 (1988).","journal-title":"Tetrahedron Lett."},{"key":"75785_CR56","first-page":"225","volume":"29","author":"SR Wilson","year":"1990","unstructured":"Wilson, S. R. & Cui, W. Applications of simulated annealing to peptides. Biopolym. Original Res. Biomol. 29, 225\u2013235 (1990).","journal-title":"Biopolym. Original Res. Biomol."},{"key":"75785_CR57","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.4155\/fmc-2017-0061","volume":"9","author":"MM Hatmal","year":"2017","unstructured":"Hatmal, M. M. & Taha, M. O. Simulated annealing molecular dynamics and ligand-receptor contacts analysis for pharmacophore modeling. Future Med. Chem. 9, 1141\u20131159 (2017).","journal-title":"Future Med. Chem."},{"key":"75785_CR58","doi-asserted-by":"publisher","first-page":"15568","DOI":"10.1038\/srep15568","volume":"5","author":"G-F Hao","year":"2015","unstructured":"Hao, G.-F., Xu, W.-F., Yang, S.-G. & Yang, G.-F. Multiple simulated annealing-molecular dynamics (msa-md) for conformational space search of peptide and miniprotein. Sci. Rep. 5, 15568 (2015).","journal-title":"Sci. Rep."},{"key":"75785_CR59","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.1021\/ja00214a001","volume":"110","author":"WL Jorgensen","year":"1988","unstructured":"Jorgensen, W. L. & Tirado-Rives, J. The opls [optimized potentials for liquid simulations] potential functions for proteins, energy minimizations for crystals of cyclic peptides and crambin. J. Am. Chem. Society 110, 1657\u20131666 (1988).","journal-title":"J. Am. Chem. Society"},{"key":"75785_CR60","doi-asserted-by":"publisher","first-page":"11225","DOI":"10.1021\/ja9621760","volume":"118","author":"WL Jorgensen","year":"1996","unstructured":"Jorgensen, W. L., Maxwell, D. S. & Tirado-Rives, J. Development and testing of the opls all-atom force field on conformational energetics and properties of organic liquids. J. Am. Chem. Society 118, 11225\u201311236 (1996).","journal-title":"J. Am. Chem. Society"},{"key":"75785_CR61","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1021\/acs.jctc.7b00118","volume":"13","author":"S Grimme","year":"2017","unstructured":"Grimme, S., Bannwarth, C. & Shushkov, P. A robust and accurate tight-binding quantum chemical method for structures, vibrational frequencies, and noncovalent interactions of large molecular systems parametrized for all spd-block elements (z = 1\u201386). J. Chem. Theory Comput. 13, 1989\u20132009 (2017).","journal-title":"J. Chem. Theory Comput."},{"key":"75785_CR62","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1021\/acs.jctc.8b01176","volume":"15","author":"C Bannwarth","year":"2019","unstructured":"Bannwarth, C., Ehlert, S. & Grimme, S. Gfn2-xtb-an accurate and broadly parametrized self-consistent tight-binding quantum chemical method with multipole electrostatics and density-dependent dispersion contributions. J. Chem. Theory Comput. 15, 1652\u20131671 (2019).","journal-title":"J. Chem. Theory Comput."},{"key":"75785_CR63","first-page":"1","volume":"4","author":"S Plimpton","year":"1995","unstructured":"Plimpton, S. Fast parallel algorithms for short-range molecular dynamics. J. Comput. Chem. 4, 1\u201319 (1995).","journal-title":"J. Comput. Chem."},{"key":"75785_CR64","doi-asserted-by":"publisher","first-page":"6269","DOI":"10.1021\/j100308a038","volume":"91","author":"HJC Berendsen","year":"1987","unstructured":"Berendsen, H. J. C., Grigera, J. R. & Straatsma, T. P. The missing term in effective pair potentials. J. Phys. Chem. 91, 6269\u20136271 (1987).","journal-title":"J. Phys. Chem."},{"key":"75785_CR65","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","volume":"23","author":"J-P Ryckaert","year":"1977","unstructured":"Ryckaert, J.-P., Ciccotti, G. & Berendsen, H. J. Numerical integration of the cartesian equations of motion of a system with constraints: Molecular dynamics of n-alkanes. J. Comput. Phys. 23, 327\u2013341 (1977).","journal-title":"J. Comput. Phys."},{"key":"75785_CR66","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1021\/ci200217w","volume":"51","author":"M Brehm","year":"2011","unstructured":"Brehm, M. & Kirchner, B. Travis\u2014A free analyzer and visualizer for monte carlo and molecular dynamics trajectories. J. Chem. Inf. Model. 51, 2007\u20132023 (2011).","journal-title":"J. Chem. Inf. Model."},{"key":"75785_CR67","doi-asserted-by":"publisher","first-page":"3271","DOI":"10.1002\/cphc.201500471","volume":"16","author":"M Brehm","year":"2015","unstructured":"Brehm, M., Weber, H., Thomas, M., Holl\u00f3czki, O. & Kirchner, B. Domain analysis in nanostructured liquids: A post-molecular dynamics study at the example of ionic liquids. ChemPhysChem 16, 3271\u20133277 (2015).","journal-title":"ChemPhysChem"},{"key":"75785_CR68","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1039\/C9EN00365G","volume":"6","author":"AG Rodr\u00edguez-Hern\u00e1ndez","year":"2019","unstructured":"Rodr\u00edguez-Hern\u00e1ndez, A. G., Mu\u00f1oz-Tabares, J. A., Aguilar-Guzm\u00e1n, J. C. & Vazquez-Duhalt, R. A novel and simple method for polyethylene terephthalate (pet) nanoparticle production. Environ. Sci. Nano. 6, 2031\u20132036 (2019).","journal-title":"Environ. Sci. Nano."},{"key":"75785_CR69","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1038\/s41375-019-0382-3","volume":"33","author":"L Schmidt","year":"2019","unstructured":"Schmidt, L. et al. Cebpa-mutated leukemia is sensitive to genetic and pharmacological targeting of the mll1 complex. Leukemia 33, 1608\u20131619 (2019).","journal-title":"Leukemia"},{"key":"75785_CR70","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.1038\/s41467-018-04329-y","volume":"9","author":"A Skucha","year":"2018","unstructured":"Skucha, A. et al. Mll-fusion-driven leukemia requires setd2 to safeguard genomic integrity. Nat. Commun. 9, 1983 (2018).","journal-title":"Nat. Commun."},{"key":"75785_CR71","doi-asserted-by":"publisher","first-page":"1628","DOI":"10.1101\/gad.17269211","volume":"25","author":"J Zuber","year":"2011","unstructured":"Zuber, J. et al. An integrated approach to dissecting oncogene addition implicates a myb-coordinated self-renewal program as essential for leukemia maintenance. Genes Develop. 25, 1628\u20131640 (2011).","journal-title":"Genes Develop."},{"key":"75785_CR72","doi-asserted-by":"publisher","first-page":"5761","DOI":"10.1021\/ja910675v","volume":"132","author":"D Walczyk","year":"2010","unstructured":"Walczyk, D., Bombelli, F. B., Monopoli, M. P., Lynch, I. & Dawson, K. A. What the cell \u201csees\u2019\u2019 in bionanoscience. J. Am. Chem. Soc. 132, 5761\u20135768 (2010).","journal-title":"J. Am. Chem. Soc."},{"key":"75785_CR73","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/nnano.2009.248","volume":"4","author":"I Lynch","year":"2009","unstructured":"Lynch, I., Salvati, A. & Dawson, K. A. What does the cell see?. Nat. Nanotechnol. 4, 546\u2013547 (2009).","journal-title":"Nat. Nanotechnol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75785-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75785-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75785-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T13:03:09Z","timestamp":1730120589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-75785-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":73,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["75785"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-75785-4","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4612937\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"20 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25853"}}