{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T06:06:59Z","timestamp":1793772419638,"version":"4.6.1"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100018788","name":"Veterinary Clinical Sciences Department, College of Veterinary Medicine, University of Minnesota","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018788","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Hormel Foundation, a \"Paint the Town Pink\" award"},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["RSG-21-034-01-TBG"],"award-info":[{"award-number":["RSG-21-034-01-TBG"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over half of all people diagnosed with cancer receive radiation therapy. Moderate to severe radiation dermatitis occurs in most human radiation patients, causing pain, aesthetic distress, and a negative impact on tumor control. No effective prevention or treatment for radiation dermatitis exists. The lack of well-characterized, clinically relevant animal models of human radiation dermatitis contributes to the absence of strategies to mitigate radiation dermatitis. Here, we establish and characterize a hairless SKH-1 mouse model of human radiation dermatitis by correlating temporal stages of clinical and pathological skin injury. We demonstrate that a single ionizing radiation treatment of 30\u00a0Gy using 6\u00a0MeV electrons induces severe clinical grade 3 peak toxicity at 12 days, defined by marked erythema, desquamation and partial ulceration, with resolution occurring by 25 days. Histopathology reveals that radiation-induced skin injury features temporally unique inflammatory changes. Upregulation of epidermal and dermal TGF-\u00df1 and COX-2 protein expression occurs at peak dermatitis, with sustained epidermal TGF-\u00df1 expression beyond resolution. Specific histopathological variables that remain substantially high at peak toxicity and early clinical resolution, including epidermal thickening, hyperkeratosis and dermal fibroplasia\/fibrosis, serve as specific measurable parameters for in vivo interventional preclinical studies that seek to mitigate radiation-induced skin injury.<\/jats:p>","DOI":"10.1038\/s41598-024-76021-9","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T02:02:20Z","timestamp":1729562540000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Radiation dermatitis in the hairless mouse model mimics human radiation dermatitis"],"prefix":"10.1038","volume":"14","author":[{"given":"Jessica","family":"Lawrence","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis","family":"Seelig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Demos-Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sk. Kayum","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rendong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alonso","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke H.","family":"Hoeppner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"76021_CR1","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1002\/1097-0142(19830615)51:12+<2401::AID-CNCR2820511302>3.0.CO;2-7","volume":"51","author":"VT DeVita","year":"1983","unstructured":"DeVita, V. T. Jr. Progress in cancer management. Keynote address. Cancer. 51, 2401\u20132409 (1983).","journal-title":"Cancer"},{"key":"76021_CR2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3322\/caac.21349","volume":"66","author":"KD Miller","year":"2016","unstructured":"Miller, K. D. et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J. Clin. 66, 271\u2013289. https:\/\/doi.org\/10.3322\/caac.21349 (2016).","journal-title":"CA Cancer J. Clin."},{"key":"76021_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21551","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2019. CA Cancer J. Clin. 69, 7\u201334. https:\/\/doi.org\/10.3322\/caac.21551 (2019).","journal-title":"CA Cancer J. Clin."},{"key":"76021_CR4","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1200\/JCO.2005.04.9148","volume":"24","author":"EA Elliott","year":"2006","unstructured":"Elliott, E. A. et al. Phase III trial of an emulsion containing trolamine for the prevention of radiation dermatitis in patients with advanced squamous cell carcinoma of the head and neck: results of Radiation Therapy Oncology Group Trial 99\u2009\u2013\u200913. J. Clin. Oncol. 24, 2092\u20132097. https:\/\/doi.org\/10.1200\/JCO.2005.04.9148 (2006).","journal-title":"J. Clin. Oncol."},{"key":"76021_CR5","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.jpainsymman.2005.04.012","volume":"30","author":"JT Hickok","year":"2005","unstructured":"Hickok, J. T., Morrow, G. R., Roscoe, J. A., Mustian, K. & Okunieff, P. Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer. J. Pain Symptom Manag. 30, 433\u2013442. https:\/\/doi.org\/10.1016\/j.jpainsymman.2005.04.012 (2005).","journal-title":"J. Pain Symptom Manag."},{"key":"76021_CR6","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jaad.2005.08.054","volume":"54","author":"SR Hymes","year":"2006","unstructured":"Hymes, S. R., Strom, E. A. & Fife, C. Radiation dermatitis: clinical presentation, pathophysiology, and treatment 2006. J. Am. Acad. Dermatol. 54, 28\u201346. https:\/\/doi.org\/10.1016\/j.jaad.2005.08.054 (2006).","journal-title":"J. Am. Acad. Dermatol."},{"key":"76021_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.047","author":"A Rosenthal","year":"2019","unstructured":"Rosenthal, A., Israilevich, R. & Moy, R. Management of acute radiation dermatitis: a review of the literature and proposal for treatment algorithm. J. Am. Acad. Dermatol. https:\/\/doi.org\/10.1016\/j.jaad.2019.02.047 (2019).","journal-title":"J. Am. Acad. Dermatol."},{"key":"76021_CR8","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/jid.2011.411","volume":"132","author":"JL Ryan","year":"2012","unstructured":"Ryan, J. L. Ionizing radiation: the good, the bad, and the ugly. J. Investig. Dermatol. 132, 985\u2013993. https:\/\/doi.org\/10.1038\/jid.2011.411 (2012).","journal-title":"J. Investig Dermatol."},{"key":"76021_CR9","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s40257-016-0186-4","volume":"17","author":"M Singh","year":"2016","unstructured":"Singh, M., Alavi, A., Wong, R. & Akita, S. Radiodermatitis: a review of our current understanding. Am. J. Clin. Dermatol. 17, 277\u2013292. https:\/\/doi.org\/10.1007\/s40257-016-0186-4 (2016).","journal-title":"Am. J. Clin. Dermatol."},{"key":"76021_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0167-8140(01)00429-7","volume":"61","author":"W Dorr","year":"2001","unstructured":"Dorr, W. & Hendry, J. H. Consequential late effects in normal tissues. Radiother Oncol. 61, 223\u2013231 (2001).","journal-title":"Radiother Oncol."},{"key":"76021_CR11","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1016\/j.soncn.2011.02.009","volume":"27","author":"M McQuestion","year":"2011","unstructured":"McQuestion, M. Evidence-based skin care management in radiation therapy: clinical update. Semin Oncol. Nurs. 27, e1\u201317. https:\/\/doi.org\/10.1016\/j.soncn.2011.02.009 (2011).","journal-title":"Semin Oncol. Nurs."},{"key":"76021_CR12","doi-asserted-by":"publisher","first-page":"94","DOI":"10.3747\/co.v17i4.493","volume":"17","author":"N Salvo","year":"2010","unstructured":"Salvo, N. et al. Prophylaxis and management of acute radiation-induced skin reactions: a systematic review of the literature. Curr. Oncol. 17, 94\u2013112 (2010).","journal-title":"Curr. Oncol."},{"key":"76021_CR13","doi-asserted-by":"publisher","first-page":"3154","DOI":"10.1002\/cncr.31533","volume":"124","author":"AS Ho","year":"2018","unstructured":"Ho, A. S. et al. Quantitative survival impact of composite treatment delays in head and neck cancer. Cancer. 124, 3154\u20133162. https:\/\/doi.org\/10.1002\/cncr.31533 (2018).","journal-title":"Cancer"},{"key":"76021_CR14","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3109\/02841868809090333","volume":"27","author":"HR Withers","year":"1988","unstructured":"Withers, H. R., Taylor, J. M. & Maciejewski, B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol. 27, 131\u2013146 (1988).","journal-title":"Acta Oncol."},{"key":"76021_CR15","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2018.2716","author":"EM Graboyes","year":"2018","unstructured":"Graboyes, E. M. et al. Association of treatment delays with survival for patients with head and neck cancer: a systematic review. JAMA Otolaryngol. Head Neck Surg. https:\/\/doi.org\/10.1001\/jamaoto.2018.2716 (2018).","journal-title":"JAMA Otolaryngol. Head Neck Surg."},{"key":"76021_CR16","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1093\/annonc\/mdm400","volume":"19","author":"J Bernier","year":"2008","unstructured":"Bernier, J. et al. Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. Ann. Oncol. Off J. Eur. Soc. Med. Oncol\/ESMO. 19, 142\u2013149. https:\/\/doi.org\/10.1093\/annonc\/mdm400 (2008).","journal-title":"Ann. Oncol. Off J. Eur. Soc. Med. Oncol\/ESMO"},{"key":"76021_CR17","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.radonc.2008.09.007","volume":"90","author":"C Giro","year":"2009","unstructured":"Giro, C. et al. High rate of severe radiation dermatitis during radiation therapy with concurrent cetuximab in head and neck cancer: results of a survey in EORTC institutes. Radiother Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 90, 166\u2013171. https:\/\/doi.org\/10.1016\/j.radonc.2008.09.007 (2009).","journal-title":"Radiother Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"76021_CR18","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.radonc.2008.09.018","volume":"90","author":"DI Pryor","year":"2009","unstructured":"Pryor, D. I. et al. Enhanced toxicity with concurrent cetuximab and radiotherapy in head and neck cancer. Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 90, 172\u2013176. https:\/\/doi.org\/10.1016\/j.radonc.2008.09.018 (2009).","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"76021_CR19","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.radonc.2010.11.009","volume":"98","author":"L Walsh","year":"2011","unstructured":"Walsh, L. et al. Toxicity of cetuximab versus cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell cancer (LAHNSCC). Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 98, 38\u201341. https:\/\/doi.org\/10.1016\/j.radonc.2010.11.009 (2011).","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"76021_CR20","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4606-2","author":"P Bonomo","year":"2018","unstructured":"Bonomo, P. et al. Management of severe bio-radiation dermatitis induced by radiotherapy and cetuximab in patients with head and neck cancer: emphasizing the role of calcium alginate dressings. Support. Care Cancer Off J. Multinatl Assoc. Support. Care Cancer. https:\/\/doi.org\/10.1007\/s00520-018-4606-2 (2018).","journal-title":"Support. Care Cancer Off J. Multinatl Assoc. Support. Care Cancer"},{"key":"76021_CR21","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13014-019-1215-2","volume":"14","author":"M Kawamura","year":"2019","unstructured":"Kawamura, M. et al. A scoring system predicting acute radiation dermatitis in patients with head and neck cancer treated with intensity-modulated radiotherapy. Radiat. Oncol. 14, 14. https:\/\/doi.org\/10.1186\/s13014-019-1215-2 (2019).","journal-title":"Radiat. Oncol."},{"key":"76021_CR22","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S0167-8140(01)00327-9","volume":"59","author":"A Bostrom","year":"2001","unstructured":"Bostrom, A., Lindman, H., Swartling, C., Berne, B. & Bergh, J. Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: results from a double-blind, randomized study. Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 59, 257\u2013265 (2001).","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"76021_CR23","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/S0360-3016(00)00782-3","volume":"48","author":"J Fisher","year":"2000","unstructured":"Fisher, J. et al. Randomized phase III study comparing best supportive care to Biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97\u2009\u2013\u200913. Int. J. Radiat. Oncol. Biol. Phys. 48, 1307\u20131310 (2000).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"76021_CR24","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1097\/00002820-200212000-00007","volume":"25","author":"S Heggie","year":"2002","unstructured":"Heggie, S. et al. A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue. Cancer Nurs. 25, 442\u2013451 (2002).","journal-title":"Cancer Nurs."},{"key":"76021_CR25","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1007\/s00520-011-1250-5","volume":"20","author":"S Hemati","year":"2012","unstructured":"Hemati, S. et al. Topical silver sulfadiazine for the prevention of acute dermatitis during irradiation for breast cancer. Support. Care Cancer Off J. Multinatl Assoc. Support. Care Cancer. 20, 1613\u20131618. https:\/\/doi.org\/10.1007\/s00520-011-1250-5 (2012).","journal-title":"Support. Care Cancer Off J. Multinatl Assoc. Support. Care Cancer"},{"key":"76021_CR26","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0167-8140(96)01882-8","volume":"42","author":"V Liguori","year":"1997","unstructured":"Liguori, V., Guillemin, C., Pesce, G. F., Mirimanoff, R. O. & Bernier, J. Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy. Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 42, 155\u2013161 (1997).","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"76021_CR27","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.ctcp.2005.02.001","volume":"11","author":"W Maddocks-Jennings","year":"2005","unstructured":"Maddocks-Jennings, W., Wilkinson, J. M. & Shillington, D. Novel approaches to radiotherapy-induced skin reactions: a literature review. Complement. Ther. Clin. Pract. 11, 224\u2013231. https:\/\/doi.org\/10.1016\/j.ctcp.2005.02.001 (2005).","journal-title":"Complement. Ther. Clin. Pract."},{"key":"76021_CR28","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1016\/j.ijrobp.2010.01.031","volume":"79","author":"RC Miller","year":"2011","unstructured":"Miller, R. C. et al. Mometasone furoate effect on acute skin toxicity in breast cancer patients receiving radiotherapy: a phase III double-blind, randomized trial from the North Central Cancer Treatment Group N06C4. Int. J. Radiat. Oncol. Biol. Phys. 79, 1460\u20131466. https:\/\/doi.org\/10.1016\/j.ijrobp.2010.01.031 (2011).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"76021_CR29","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/S0167-8140(00)00322-4","volume":"58","author":"I Roy","year":"2001","unstructured":"Roy, I., Fortin, A. & Larochelle, M. The impact of skin washing with water and soap during breast irradiation: a randomized study. Radiother. Oncol. 58, 333\u2013339 (2001).","journal-title":"Radiother. Oncol."},{"key":"76021_CR30","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.radonc.2004.07.032","volume":"73","author":"M Wells","year":"2004","unstructured":"Wells, M. et al. Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial. Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol. 73, 153\u2013162. https:\/\/doi.org\/10.1016\/j.radonc.2004.07.032 (2004).","journal-title":"Radiother. Oncol. J. Eur. Soc. Ther. Radiol. Oncol."},{"key":"76021_CR31","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0360-3016(96)00320-3","volume":"36","author":"MS Williams","year":"1996","unstructured":"Williams, M. S. et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int. J. Radiat. Oncol. Biol. Phys. 36, 345\u2013349 (1996).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"76021_CR32","doi-asserted-by":"publisher","first-page":"401","DOI":"10.2147\/CMAR.S52256","volume":"5","author":"RJ Bensadoun","year":"2013","unstructured":"Bensadoun, R. J. et al. Daily baseline skin care in the prevention, treatment, and supportive care of skin toxicity in oncology patients: recommendations from a multinational expert panel. Cancer Manag. Res. 5, 401\u2013408. https:\/\/doi.org\/10.2147\/CMAR.S52256 (2013).","journal-title":"Cancer Manag. Res."},{"key":"76021_CR33","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s00411-014-0540-y","volume":"53","author":"JJ Hu","year":"2014","unstructured":"Hu, J. J. et al. Complementary and alternative medicine in reducing radiation-induced skin toxicity. Radiat. Environ. Biophys. 53, 621\u2013626. https:\/\/doi.org\/10.1007\/s00411-014-0540-y (2014).","journal-title":"Radiat. Environ. Biophys."},{"key":"76021_CR34","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1159\/000487404","volume":"31","author":"E Meimeti","year":"2018","unstructured":"Meimeti, E. et al. Topical treatment of skin Injury Inflicted in mice by X-Ray irradiation. Skin. Pharmacol. Physiol. 31, 175\u2013183. https:\/\/doi.org\/10.1159\/000487404 (2018).","journal-title":"Skin. Pharmacol. Physiol."},{"key":"76021_CR35","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1093\/jrr\/rrw039","volume":"57","author":"Y Nakagami","year":"2016","unstructured":"Nakagami, Y. & Masuda, K. A novel Nrf2 activator from microbial transformation inhibits radiation-induced dermatitis in mice. J. Radiat. Res. 57, 567\u2013571. https:\/\/doi.org\/10.1093\/jrr\/rrw039 (2016).","journal-title":"J. Radiat. Res."},{"key":"76021_CR36","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1667\/RR2861.1","volume":"178","author":"S Ning","year":"2012","unstructured":"Ning, S. et al. Mitigation of radiation-induced dermatitis by activation of aldehyde dehydrogenase 2 using topical alda-1 in mice. Radiat. Res. 178, 69\u201374 (2012).","journal-title":"Radiat. Res."},{"key":"76021_CR37","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s10103-020-03123-x","volume":"36","author":"JH Park","year":"2021","unstructured":"Park, J. H. et al. Effect of photobiomodulation therapy on radiodermatitis in a mouse model: an experimental animal study. Lasers Med. Sci. 36, 843\u2013853. https:\/\/doi.org\/10.1007\/s10103-020-03123-x (2021).","journal-title":"Lasers Med. Sci."},{"key":"76021_CR38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jdermsci.2008.08.012","volume":"53","author":"F Benavides","year":"2009","unstructured":"Benavides, F., Oberyszyn, T. M., VanBuskirk, A. M., Reeve, V. E. & Kusewitt, D. F. The hairless mouse in skin research. J. Dermatol. Sci. 53, 10\u201318. https:\/\/doi.org\/10.1016\/j.jdermsci.2008.08.012 (2009).","journal-title":"J. Dermatol. Sci."},{"key":"76021_CR39","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1006\/bbrc.2000.4201","volume":"280","author":"M Athar","year":"2001","unstructured":"Athar, M. et al. Ultraviolet B(UVB)-induced cox-2 expression in murine skin: an immunohistochemical study. Biochem. Biophys. Res. Commun. 280, 1042\u20131047. https:\/\/doi.org\/10.1006\/bbrc.2000.4201 (2001).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"76021_CR40","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/carcin\/bgs358","volume":"34","author":"S Byun","year":"2013","unstructured":"Byun, S. et al. Src kinase is a direct target of apigenin against UVB-induced skin inflammation. Carcinogenesis. 34, 397\u2013405. https:\/\/doi.org\/10.1093\/carcin\/bgs358 (2013).","journal-title":"Carcinogenesis"},{"key":"76021_CR41","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/php.12337","volume":"91","author":"HC Pal","year":"2015","unstructured":"Pal, H. C., Athar, M., Elmets, C. A. & Afaq, F. Fisetin inhibits UVB-induced cutaneous inflammation and activation of PI3K\/AKT\/NFkappaB signaling pathways in SKH-1 hairless mice. Photochem. Photobiol. 91, 225\u2013234. https:\/\/doi.org\/10.1111\/php.12337 (2015).","journal-title":"Photochem. Photobiol."},{"key":"76021_CR42","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/1523-1747.ep12519287","volume":"81","author":"T Ruzicka","year":"1983","unstructured":"Ruzicka, T., Walter, J. F. & Printz, M. P. Changes in arachidonic acid metabolism in UV-irradiated hairless mouse skin. J. Investig. Dermatol. 81, 300\u2013303. https:\/\/doi.org\/10.1111\/1523-1747.ep12519287 (1983).","journal-title":"J. Investig. Dermatol."},{"key":"76021_CR43","doi-asserted-by":"publisher","first-page":"84924","DOI":"10.18632\/oncotarget.12913","volume":"7","author":"A Singh","year":"2016","unstructured":"Singh, A., Willems, E., Singh, A., Ong, I. M. & Verma, A. K. Ultraviolet radiation-induced differential microRNA expression in the skin of hairless SKH1 mice, a widely used mouse model for dermatology research. Oncotarget. 7, 84924\u201384937. https:\/\/doi.org\/10.18632\/oncotarget.12913 (2016).","journal-title":"Oncotarget"},{"key":"76021_CR44","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1111\/exd.14864","volume":"32","author":"AY Voigt","year":"2023","unstructured":"Voigt, A. Y. et al. Microbiome modulates immunotherapy response in cutaneous squamous cell carcinoma. Exp. Dermatol. 32, 1624\u20131632. https:\/\/doi.org\/10.1111\/exd.14864 (2023).","journal-title":"Exp. Dermatol."},{"key":"76021_CR45","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.mayocp.2021.08.018","volume":"97","author":"SP Hartono","year":"2022","unstructured":"Hartono, S. P. et al. Vascular endothelial growth factor as an immediate-early activator of ultraviolet-Induced skin Injury. Mayo Clin. Proc. 97, 154\u2013164. https:\/\/doi.org\/10.1016\/j.mayocp.2021.08.018 (2022).","journal-title":"Mayo Clin. Proc."},{"key":"76021_CR46","doi-asserted-by":"publisher","first-page":"19216","DOI":"10.1038\/srep19216","volume":"6","author":"WH Jang","year":"2016","unstructured":"Jang, W. H. et al. In vivo characterization of early-stage radiation skin injury in a mouse model by two-photon microscopy. Sci. Rep. 6, 19216. https:\/\/doi.org\/10.1038\/srep19216 (2016).","journal-title":"Sci. Rep."},{"key":"76021_CR47","doi-asserted-by":"publisher","unstructured":"Jang, H. et al. Impaired skin barrier due to sebaceous gland atrophy in the latent stage of radiation-induced skin injury: application of non-invasive diagnostic methods. Int. J. Mol. Sci. 19. https:\/\/doi.org\/10.3390\/ijms19010185 (2018).","DOI":"10.3390\/ijms19010185"},{"key":"76021_CR48","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1517\/17460441.2013.761202","volume":"8","author":"P Avci","year":"2013","unstructured":"Avci, P. et al. Animal models of skin disease for drug discovery. Expert Opin. Drug Discov. 8, 331\u2013355. https:\/\/doi.org\/10.1517\/17460441.2013.761202 (2013).","journal-title":"Expert Opin. Drug Discov."},{"key":"76021_CR49","doi-asserted-by":"publisher","first-page":"155932581770501","DOI":"10.1177\/1559325817705019","volume":"15","author":"CBV de Andrade","year":"2017","unstructured":"de Andrade, C. B. V. et al. Radiotherapy-induced skin reactions induce fibrosis mediated by TGF-beta1 cytokine. Dose Response. 15, 1559325817705019. https:\/\/doi.org\/10.1177\/1559325817705019 (2017).","journal-title":"Dose Response"},{"key":"76021_CR50","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1186\/s12967-023-04554-0","volume":"21","author":"Z Yu","year":"2023","unstructured":"Yu, Z. et al. Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances. J. Transl. Med. 21, 708. https:\/\/doi.org\/10.1186\/s12967-023-04554-0 (2023).","journal-title":"J. Transl. Med."},{"key":"76021_CR51","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/s0041-008x(03)00301-6","volume":"192","author":"JL Lee","year":"2003","unstructured":"Lee, J. L., Mukhtar, H., Bickers, D. R., Kopelovich, L. & Athar, M. Cyclooxygenases in the skin: pharmacological and toxicological implications. Toxicol. Appl. Pharmacol. 192, 294\u2013306. https:\/\/doi.org\/10.1016\/s0041-008x(03)00301-6 (2003).","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"76021_CR52","unstructured":"Institute, N. C. (ed) (ed DCTD Division of Cancer Treatment & Diagnosis) (2017)."},{"key":"76021_CR53","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12885-019-6472-9","volume":"20","author":"H Fowler","year":"2020","unstructured":"Fowler, H. et al. Comorbidity prevalence among cancer patients: a population-based cohort study of four cancers. BMC Cancer.  20, 2. https:\/\/doi.org\/10.1186\/s12885-019-6472-9 (2020).","journal-title":"BMC Cancer"},{"key":"76021_CR54","doi-asserted-by":"publisher","first-page":"690390","DOI":"10.3389\/fonc.2021.690390","volume":"11","author":"MS Simon","year":"2021","unstructured":"Simon, M. S. et al. A review of research on disparities in the care of black and white patients with cancer in detroit. Front. Oncol. 11, 690390. https:\/\/doi.org\/10.3389\/fonc.2021.690390 (2021).","journal-title":"Front. Oncol."},{"key":"76021_CR55","doi-asserted-by":"publisher","first-page":"107327482110119","DOI":"10.1177\/10732748211011956","volume":"28","author":"N Afshar","year":"2021","unstructured":"Afshar, N., English, D. R. & Milne, R. L. Factors explaining socio-economic inequalities in cancer survival: a systematic review. Cancer Control. 28, 10732748211011956. https:\/\/doi.org\/10.1177\/10732748211011956 (2021).","journal-title":"Cancer Control"},{"key":"76021_CR56","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2147\/VHRM.S343319","volume":"18","author":"L Hojman","year":"2022","unstructured":"Hojman, L. & Karsulovic, C. Cardiovascular disease-associated skin conditions. Vasc. Health Risk Manag.  18, 43\u201353. https:\/\/doi.org\/10.2147\/VHRM.S343319 (2022).","journal-title":"Vasc. Health Risk Manag."},{"key":"76021_CR57","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1590\/abd1806-4841.20175514","volume":"92","author":"AL Mendes","year":"2017","unstructured":"Mendes, A. L., Miot, H. A. & Haddad, V. J. Diabetes mellitus and the skin. Bras. Dermatol. 92, 8\u201320. https:\/\/doi.org\/10.1590\/abd1806-4841.20175514 (2017).","journal-title":"Bras. Dermatol."},{"key":"76021_CR58","first-page":"18","volume":"47","author":"RA Bryant","year":"2001","unstructured":"Bryant, R. A. & Rolstad, B. S. Examining threats to skin integrity. Ostomy Wound Manag. 47, 18\u201327 (2001).","journal-title":"Ostomy Wound Manag."},{"key":"76021_CR59","doi-asserted-by":"publisher","first-page":"100131","DOI":"10.1016\/j.xjidi.2022.100131","volume":"2","author":"LA Beck","year":"2022","unstructured":"Beck, L. A. et al. Type 2 inflammation contributes to skin barrier dysfunction in atopic dermatitis. JID Innov. 2, 100131. https:\/\/doi.org\/10.1016\/j.xjidi.2022.100131 (2022).","journal-title":"JID Innov."},{"key":"76021_CR60","doi-asserted-by":"publisher","first-page":"e0281662","DOI":"10.1371\/journal.pone.0281662","volume":"18","author":"L Bromberger","year":"2023","unstructured":"Bromberger, L. et al. Radiation-induced alterations in multi-layered, in-vitro skin models detected by optical coherence tomography and histological methods. PloS One. 18, e0281662. https:\/\/doi.org\/10.1371\/journal.pone.0281662 (2023).","journal-title":"PloS One"},{"key":"76021_CR61","first-page":"5627","volume":"62","author":"KB Ewan","year":"2002","unstructured":"Ewan, K. B. et al. Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. Cancer Res. 62, 5627\u20135631 (2002).","journal-title":"Cancer Res."},{"key":"76021_CR62","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1016\/s0002-9440(10)63582-1","volume":"163","author":"KC Flanders","year":"2003","unstructured":"Flanders, K. C. et al. Interference with transforming growth factor-beta\/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am. J. Pathol. 163, 2247\u20132257. https:\/\/doi.org\/10.1016\/s0002-9440(10)63582-1 (2003).","journal-title":"Am. J. Pathol."},{"key":"76021_CR63","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.0959-9673.2004.00377.x","volume":"85","author":"KC Flanders","year":"2004","unstructured":"Flanders, K. C. Smad3 as a mediator of the fibrotic response. Int. J. Exp. Pathol. 85, 47\u201364. https:\/\/doi.org\/10.1111\/j.0959-9673.2004.00377.x (2004).","journal-title":"Int. J. Exp. Pathol."},{"key":"76021_CR64","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1080\/09553009514551231","volume":"68","author":"K Randall","year":"1995","unstructured":"Randall, K. & Coggle, J. E. Expression of transforming growth factor-beta 1 in mouse skin during the acute phase of radiation damage. Int. J. Radiat. Biol. 68, 301\u2013309. https:\/\/doi.org\/10.1080\/09553009514551231 (1995).","journal-title":"Int. J. Radiat. Biol."},{"key":"76021_CR65","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1080\/095530096145085","volume":"70","author":"K Randall","year":"1996","unstructured":"Randall, K. & Coggle, J. E. Long-term expression of transforming growth factor TGF beta 1 in mouse skin after localized beta-irradiation. Int. J. Radiat. Biol. 70, 351\u2013360. https:\/\/doi.org\/10.1080\/095530096145085 (1996).","journal-title":"Int. J. Radiat. Biol."},{"key":"76021_CR66","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1186\/s13014-015-0508-3","volume":"10","author":"S Koerdt","year":"2015","unstructured":"Koerdt, S. et al. An expression analysis of markers of radiation-induced skin fibrosis and angiogenesis in wound healing disorders of the head and neck. Radiat. Oncol. 10, 202. https:\/\/doi.org\/10.1186\/s13014-015-0508-3 (2015).","journal-title":"Radiat. Oncol."},{"key":"76021_CR67","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/S0002-9440(10)64926-7","volume":"160","author":"KC Flanders","year":"2002","unstructured":"Flanders, K. C. et al. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am. J. Pathol. 160, 1057\u20131068. https:\/\/doi.org\/10.1016\/S0002-9440(10)64926-7 (2002).","journal-title":"Am. J. Pathol."},{"key":"76021_CR68","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10549-017-4382-6","volume":"166","author":"Y Chihara","year":"2017","unstructured":"Chihara, Y. et al. A small-molecule inhibitor of SMAD3 attenuates resistance to anti-HER2 drugs in HER2-positive breast cancer cells. Breast Cancer Res. Treat. 166, 55\u201368. https:\/\/doi.org\/10.1007\/s10549-017-4382-6 (2017).","journal-title":"Breast Cancer Res. Treat."},{"key":"76021_CR69","doi-asserted-by":"publisher","first-page":"302","DOI":"10.2174\/1389450119666180803121737","volume":"20","author":"N Toloczko-Iwaniuk","year":"2019","unstructured":"Toloczko-Iwaniuk, N., Dziemianczyk-Pakiela, D., Nowaszewska, B. K., Celinska-Janowicz, K. & Miltyk, W. Celecoxib in cancer therapy and prevention\u2014review. Curr. Drug Targets. 20, 302\u2013315. https:\/\/doi.org\/10.2174\/1389450119666180803121737 (2019).","journal-title":"Curr. Drug Targets"},{"key":"76021_CR70","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1562\/0031-8655(2002)076<0073:ceimah>2.0.co;2","volume":"76","author":"KP An","year":"2002","unstructured":"An, K. P. et al. Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem. Photobiol.  76, 73\u201380. https:\/\/doi.org\/10.1562\/0031-8655(2002)076%3C0073:ceimah%3E2.0.co;2 (2002).","journal-title":"Photochem. Photobiol"},{"key":"76021_CR71","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1097\/01.COC.0000074149.95710.40","volume":"26","author":"L Liang","year":"2003","unstructured":"Liang, L. et al. Celecoxib reduces skin damage after radiation: selective reduction of chemokine and receptor mRNA expression in irradiated skin but not in irradiated mammary tumor. Am. J. Clin. Oncol. 26, 114\u2013121. https:\/\/doi.org\/10.1097\/01.COC.0000074149.95710.40 (2003).","journal-title":"Am. J. Clin. Oncol."},{"key":"76021_CR72","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2174\/1871523017666180411162114","volume":"17","author":"A Ghasemi","year":"2018","unstructured":"Ghasemi, A., Danesh, B., Yazdani-Charati, J. & Hosseinimehr, S. J. Randomized double-blind placebo-controlled trial of celecoxib for the prevention of skin toxicity in patients receiving radiation therapy for breast cancer. Antiinflamm. Antiallergy Agents Med. Chem. 17, 57\u201367. https:\/\/doi.org\/10.2174\/1871523017666180411162114 (2018).","journal-title":"Antiinflamm. Antiallergy Agents Med. Chem."},{"key":"76021_CR73","doi-asserted-by":"publisher","first-page":"3987","DOI":"10.1200\/JCO.2008.16.9896","volume":"26","author":"AP Brown","year":"2008","unstructured":"Brown, A. P., Wendler, D. S., Camphausen, K. A., Miller, F. G. & Citrin, D. Performing nondiagnostic research biopsies in irradiated tissue: a review of scientific, clinical, and ethical considerations. J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol. 26, 3987\u20133994. https:\/\/doi.org\/10.1200\/JCO.2008.16.9896 (2008).","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"76021_CR74","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel, R. L., Miller, K. D. & Jemal, A. Cancer statistics, 2017. CA Cancer J. Clin. 67, 7\u201330. https:\/\/doi.org\/10.3322\/caac.21387 (2017).","journal-title":"CA Cancer J. Clin."},{"key":"76021_CR75","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21654","volume":"71","author":"RL Siegel","year":"2021","unstructured":"Siegel, R. L., Miller, K. D., Fuchs, H. E. & Jemal, A. Cancer statistics, 2021. CA Cancer J. Clin. 71, 7\u201333. https:\/\/doi.org\/10.3322\/caac.21654 (2021).","journal-title":"CA Cancer J. Clin."},{"key":"76021_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2019.03.017","author":"MA Fuzissaki","year":"2019","unstructured":"Fuzissaki, M. A., Paiva, C. E., de Oliveira, M. A., Canto, P. P. L. & Maia, Y. C. The impact of radiodermatitis on breast cancer patients\u2019 quality of life during treatment: a prospective cohort study. J. Pain Symptom Manag. https:\/\/doi.org\/10.1016\/j.jpainsymman.2019.03.017 (2019).","journal-title":"J. Pain Symptom Manag."},{"key":"76021_CR77","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/j.ijrobp.2014.06.042","volume":"90","author":"JL Wright","year":"2014","unstructured":"Wright, J. L. et al. Racial variations in radiation-induced skin toxicity severity: data from a prospective cohort receiving postmastectomy radiation. Int. J. Radiat. Oncol. Biol. Phys. 90, 335\u2013343. https:\/\/doi.org\/10.1016\/j.ijrobp.2014.06.042 (2014).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"76021_CR78","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.jaad.2017.05.009","volume":"77","author":"MBC Maymone","year":"2017","unstructured":"Maymone, M. B. C. et al. The impact of skin hyperpigmentation and hyperchromia on quality of life: a cross-sectional study. J. Am. Acad. Dermatol. 77, 775\u2013778. https:\/\/doi.org\/10.1016\/j.jaad.2017.05.009 (2017).","journal-title":"J. Am. Acad. Dermatol."},{"key":"76021_CR79","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1007\/s11136-017-1526-4","volume":"26","author":"J Lee","year":"2017","unstructured":"Lee, J. et al. Patient-reported symptoms of radiation dermatitis during breast cancer radiotherapy: a pilot study. Qual. Life Res. 26, 1713\u20131719. https:\/\/doi.org\/10.1007\/s11136-017-1526-4 (2017).","journal-title":"Qual. Life Res."},{"key":"76021_CR80","doi-asserted-by":"publisher","first-page":"W335","DOI":"10.2214\/AJR.13.12029","volume":"202","author":"S Balter","year":"2014","unstructured":"Balter, S. & Miller, D. L. Patient skin reactions from interventional fluoroscopy procedures. AJR Am. J. Roentgenol. 202, W335\u2013342. https:\/\/doi.org\/10.2214\/AJR.13.12029 (2014).","journal-title":"AJR Am. J. Roentgenol."},{"key":"76021_CR81","unstructured":"Blades, R., Chan, R., Yates, P. & McPhail, S. in Oncology Nursing Society (ONS) Annual Congress."},{"key":"76021_CR82","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.21873\/anticanres.11960","volume":"37","author":"F Haruna","year":"2017","unstructured":"Haruna, F., Lipsett, A. & Marignol, L. Topical management of acute radiation dermatitis in breast cancer patients: a systematic review and meta-analysis. Anticancer Res. 37, 5343\u20135353. https:\/\/doi.org\/10.21873\/anticanres.11960 (2017).","journal-title":"Anticancer Res."},{"key":"76021_CR83","doi-asserted-by":"publisher","first-page":"2857","DOI":"10.1007\/s00520-017-3701-0","volume":"25","author":"P Lucey","year":"2017","unstructured":"Lucey, P. et al. Practice patterns for the prophylaxis and treatment of acute radiation dermatitis in the United States. Support Care Cancer. 25, 2857\u20132862. https:\/\/doi.org\/10.1007\/s00520-017-3701-0 (2017).","journal-title":"Support Care Cancer"},{"key":"76021_CR84","doi-asserted-by":"publisher","unstructured":"Iddins, C. J., DiCarlo, A. L., Ervin, M. D., Herrera-Reyes, E. & Goans, R. E. Cutaneous and local radiation injuries. J. Radiol. Prot. 42. https:\/\/doi.org\/10.1088\/1361-6498\/ac241a (2022).","DOI":"10.1088\/1361-6498\/ac241a"},{"key":"76021_CR85","doi-asserted-by":"publisher","first-page":"383","DOI":"10.7556\/jaoa.2014.075","volume":"114","author":"DM Christensen","year":"2014","unstructured":"Christensen, D. M., Parillo, S. J., Glassman, E. S. & Sugarman, S. L. Management of ionizing radiation injuries and illnesses, part 2: nontherapeutic radiologic\/nuclear incidents. J. Am. Osteopath. Assoc. 114, 383\u2013389. https:\/\/doi.org\/10.7556\/jaoa.2014.075 (2014).","journal-title":"J. Am. Osteopath. Assoc."},{"key":"76021_CR86","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1148\/radiol.2542082312","volume":"254","author":"S Balter","year":"2010","unstructured":"Balter, S., Hopewell, J. W., Miller, D. L., Wagner, L. K. & Zelefsky, M. J. Fluoroscopically guided interventional procedures: a review of radiation effects on patients\u2019 skin and hair. Radiology. 254, 326\u2013341. https:\/\/doi.org\/10.1148\/radiol.2542082312 (2010).","journal-title":"Radiology"},{"key":"76021_CR87","doi-asserted-by":"publisher","first-page":"e13526","DOI":"10.1002\/acm2.13526","volume":"23","author":"RF Fisher","year":"2022","unstructured":"Fisher, R. F. et al. AAPM medical physics practice guideline 12.A: Fluoroscopy dose management. J. Appl. Clin. Med. Phys. 23, e13526. https:\/\/doi.org\/10.1002\/acm2.13526 (2022).","journal-title":"J. Appl. Clin. Med. Phys."},{"key":"76021_CR88","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00109-021-02146-3","volume":"100","author":"KC Wei","year":"2022","unstructured":"Wei, K. C. et al. An innovative targeted therapy for fluoroscopy-induced chronic radiation dermatitis. J. Mol. Med. (Berl). 100, 135\u2013146. https:\/\/doi.org\/10.1007\/s00109-021-02146-3 (2022).","journal-title":"J. Mol. Med. (Berl)"},{"key":"76021_CR89","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1667\/0033-7587(2001)155[0409:toolri]2.0.co;2","volume":"155","author":"P Gottlober","year":"2001","unstructured":"Gottlober, P. et al. The outcome of local radiation injuries: 14 years of follow-up after the Chernobyl accident. Radiat. Res. 155, 409\u2013416. https:\/\/doi.org\/10.1667\/0033-7587(2001)155[0409:toolri]2.0.co;2 (2001).","journal-title":"Radiat. Res."},{"key":"76021_CR90","doi-asserted-by":"publisher","unstructured":"Kiang, J. G. & Ledney, G. D. Skin injuries reduce survival and modulate corticosterone, C-reactive protein, complement component 3, IgM, and prostaglandin E 2 after whole-body reactor-produced mixed field (n\u2009+\u2009gamma-photons) irradiation. Oxid Med Cell Longev 821541 (2013). https:\/\/doi.org\/10.1155\/2013\/821541","DOI":"10.1155\/2013\/821541"},{"key":"76021_CR91","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s13555-016-0120-y","volume":"6","author":"FN Bray","year":"2016","unstructured":"Bray, F. N., Simmons, B. J., Wolfson, A. H. & Nouri, K. Acute and chronic cutaneous reactions to ionizing radiation therapy. Dermatol. Ther. (Heidelb). 6, 185\u2013206. https:\/\/doi.org\/10.1007\/s13555-016-0120-y (2016).","journal-title":"Dermatol. Ther. (Heidelb)"},{"key":"76021_CR92","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0167-8140(02)00060-9","volume":"63","author":"JW Denham","year":"2002","unstructured":"Denham, J. W. & Hauer-Jensen, M. The radiotherapeutic injury\u2013a complex \u2018wound\u2019. Radiother Oncol. 63, 129\u2013145 (2002).","journal-title":"Radiother Oncol."},{"key":"76021_CR93","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","volume":"139","author":"EJ Benjamin","year":"2019","unstructured":"Benjamin, E. J. et al. Heart disease and stroke statistics-2019 update: a report from the American Heart Association. Circulation. 139, e56\u2013e528. https:\/\/doi.org\/10.1161\/CIR.0000000000000659 (2019).","journal-title":"Circulation"},{"key":"76021_CR94","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1562\/0031-8655(2003)078<0037:AOUHMV>2.0.CO;2","volume":"78","author":"TH Kim","year":"2003","unstructured":"Kim, T. H., Ananthaswamy, H. N., Kripke, M. L. & Ullrich, S. E. Advantages of using hairless mice versus haired mice to test sunscreen efficacy against photoimmune suppressions. Photochem. Photobiol. 78, 37\u201342 (2003).","journal-title":"Photochem. Photobiol"},{"key":"76021_CR95","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ejmp.2014.08.005","volume":"31","author":"HR Baghani","year":"2015","unstructured":"Baghani, H. R. et al. Dosimetric evaluation of gafchromic EBT2 film for breast intraoperative electron radiotherapy verification. Phys. Med. 31, 37\u201342. https:\/\/doi.org\/10.1016\/j.ejmp.2014.08.005 (2015).","journal-title":"Phys. Med."},{"key":"76021_CR96","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s12895-015-0029-7","volume":"15","author":"SA Reisman","year":"2015","unstructured":"Reisman, S. A. et al. Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers. BMC Dermatol. 15, 10. https:\/\/doi.org\/10.1186\/s12895-015-0029-7 (2015).","journal-title":"BMC Dermatol."},{"key":"76021_CR97","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1093\/bioinformatics\/btm453","volume":"23","author":"MD Robinson","year":"2007","unstructured":"Robinson, M. D. & Smyth, G. K. Moderated statistical tests for assessing differences in tag abundance. Bioinformatics. 23, 2881\u20132887. https:\/\/doi.org\/10.1093\/bioinformatics\/btm453 (2007).","journal-title":"Bioinformatics"},{"key":"76021_CR98","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie, M. E. et al. Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 43, e47. https:\/\/doi.org\/10.1093\/nar\/gkv007 (2015).","journal-title":"Nucleic Acids Res."},{"key":"76021_CR99","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/s41416-020-0923-6","volume":"123","author":"SK Alam","year":"2020","unstructured":"Alam, S. K. et al. ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation. Br. J. Cancer. 123, 819\u2013832. https:\/\/doi.org\/10.1038\/s41416-020-0923-6 (2020).","journal-title":"Br. J. Cancer"},{"key":"76021_CR100","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/s0360-3016(00)00435-1","volume":"47","author":"M Martin","year":"2000","unstructured":"Martin, M., Lefaix, J. & Delanian, S. TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int. J. Radiat. Oncol. Biol. Phys. 47, 277\u2013290. https:\/\/doi.org\/10.1016\/s0360-3016(00)00435-1 (2000).","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"76021_CR101","doi-asserted-by":"publisher","first-page":"173","DOI":"10.2174\/1874467211666180219102520","volume":"11","author":"M Cheki","year":"2018","unstructured":"Cheki, M. et al. COX-2 in radiotherapy: a potential target for Radioprotection and Radiosensitization. Curr. Mol. Pharmacol. 11, 173\u2013183. https:\/\/doi.org\/10.2174\/1874467211666180219102520 (2018).","journal-title":"Curr. Mol. Pharmacol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76021-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76021-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76021-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T06:12:53Z","timestamp":1729836773000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76021-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":101,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["76021"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-76021-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.05.21.595074","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"20 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24819"}}