{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T01:12:06Z","timestamp":1775265126079,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T00:00:00Z","timestamp":1729814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-76159-6","type":"journal-article","created":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T02:02:15Z","timestamp":1729821735000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["U-shaped nonlinear relationship between dietary copper intake and peripheral neuropathy"],"prefix":"10.1038","volume":"14","author":[{"given":"Zhe","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyue","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,25]]},"reference":[{"key":"76159_CR1","doi-asserted-by":"publisher","first-page":"e89","DOI":"10.1017\/jns.2022.83","volume":"11","author":"LM Klevay","year":"2022","unstructured":"Klevay, L. M. The contemporaneous epidemic of chronic, copper deficiency. J. Nutr. Sci.\u00a011, e89 (2022).","journal-title":"J. Nutr. Sci."},{"key":"76159_CR2","first-page":"732","volume":"102","author":"G Castelli","year":"2020","unstructured":"Castelli, G., Desai, K. M. & Cantone, R. E. Peripheral neuropathy: evaluation and Differential diagnosis. Am. Fam Physician. 102, 732\u2013739 (2020).","journal-title":"Am. Fam Physician"},{"key":"76159_CR3","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1079\/BJN2002558","volume":"87","author":"M Bonham","year":"2002","unstructured":"Bonham, M., O\u2019Connor, J. M., Hannigan, B. M. & Strain, J. J. The immune system as a physiological indicator of marginal copper status? Br. J. Nutr.\u00a087, 393\u2013403 (2002).","journal-title":"Br. J. Nutr."},{"key":"76159_CR4","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.mam.2005.07.015","volume":"26","author":"JY Uriu-Adams","year":"2005","unstructured":"Uriu-Adams, J. Y. & Keen, C. L. Copper, oxidative stress, and human health. Mol. Aspects Med.\u00a026, 268\u2013298 (2005).","journal-title":"Mol. Aspects Med."},{"key":"76159_CR5","doi-asserted-by":"publisher","first-page":"13850","DOI":"10.3390\/ijms232213850","volume":"23","author":"Y An","year":"2022","unstructured":"An, Y. et al. The role of copper homeostasis in Brain Disease. Int. J. Mol. Sci.\u00a023, 13850 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"76159_CR6","first-page":"195","volume":"10","author":"M Bisaglia","year":"2020","unstructured":"Bisaglia, M. & Bubacco, L. Copper ions and Parkinson\u2019s Disease. Why Is Homeost. So Relevant? Biomolecules. 10, 195 (2020).","journal-title":"Why Is Homeost. So Relevant? Biomolecules"},{"key":"76159_CR7","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1093\/aje\/kwac040","volume":"191","author":"J Wei","year":"2022","unstructured":"Wei, J. et al. The associations of Dietary Copper with cognitive outcomes. Am. J. Epidemiol.\u00a0191, 1202\u20131211 (2022).","journal-title":"Am. J. Epidemiol."},{"key":"76159_CR8","doi-asserted-by":"publisher","first-page":"942000","DOI":"10.3389\/fcvm.2022.942000","volume":"9","author":"H Wen","year":"2022","unstructured":"Wen, H. et al. Dietary copper intake and risk of myocardial infarction in US adults: a propensity score-matched analysis. Front. Cardiovasc. Med.\u00a09, 942000 (2022).","journal-title":"Front. Cardiovasc. Med."},{"key":"76159_CR9","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3390\/nu14030409","volume":"14","author":"L Yang","year":"2022","unstructured":"Yang, L., Chen, X., Cheng, H. & Zhang, L. Dietary copper intake and risk of stroke in adults: a case-control study based on National Health and Nutrition Examination Survey 2013\u20132018. Nutrients. 14, 409 (2022).","journal-title":"Nutrients"},{"key":"76159_CR10","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jad.2017.12.004","volume":"228","author":"Z Li","year":"2018","unstructured":"Li, Z., Wang, W., Xin, X., Song, X. & Zhang, D. Association of total zinc, iron, copper and selenium intakes with depression in the US adults. J. Affect. Disord. 228, 68\u201374 (2018).","journal-title":"J. Affect. Disord"},{"key":"76159_CR11","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/cid\/ciz001","volume":"69","author":"EU Patel","year":"2019","unstructured":"Patel, E. U., Thio, C. L., Boon, D., Thomas, D. L. & Tobian, A. A. R. Prevalence of Hepatitis B and Hepatitis D Virus Infections in the United States, 2011\u20132016. Clin. Infect. Dis.\u00a069, 709\u2013712 (2019).","journal-title":"Clin. Infect. Dis."},{"key":"76159_CR12","doi-asserted-by":"publisher","first-page":"167","DOI":"10.7326\/M20-1340","volume":"174","author":"CW Hicks","year":"2021","unstructured":"Hicks, C. W., Wang, D., Matsushita, K., Windham, B. G. & Selvin, E. Peripheral neuropathy and all-cause and Cardiovascular Mortality in US adults. Ann. Intern. Med.\u00a0174, 167\u2013174 (2021).","journal-title":"Ann. Intern. Med."},{"key":"76159_CR13","doi-asserted-by":"publisher","first-page":"9259","DOI":"10.3390\/ijms21239259","volume":"21","author":"G Gromadzka","year":"2020","unstructured":"Gromadzka, G., Tarnacka, B., Flaga, A. & Adamczyk, A. Copper dyshomeostasis in neurodegenerative diseases\u2014therapeutic implications. Int. J. Mol. Sci.\u00a021, 9259 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"76159_CR14","doi-asserted-by":"publisher","first-page":"P1464","DOI":"10.1212\/WNL.90.15_supplement.P1.464","volume":"90","author":"J Haynes","year":"2018","unstructured":"Haynes, J., Luo, J., Bumanlag, F. & Clinical Laboratory and Electrodiagnostic features of Peripheral Neuropathy in Copper Deficiency and Copper Toxicity (P1.464). Neurology. 90, P1464 (2018).","journal-title":"Neurology"},{"key":"76159_CR15","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1136\/jnnp-2017-316304","volume":"88","author":"SW Taylor","year":"2017","unstructured":"Taylor, S. W. et al. Clinical, physiological and pathological characterisation of the sensory predominant peripheral neuropathy in copper deficiency. J. Neurol. Neurosurg. Psychiatry. 88, 839\u2013845 (2017).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"76159_CR16","doi-asserted-by":"publisher","first-page":"340e5","DOI":"10.1016\/j.ajem.2015.06.024","volume":"34","author":"L Coyle","year":"2016","unstructured":"Coyle, L. et al. The perfect storm: copper deficiency presenting as progressive peripheral neuropathy. Am. J. Emerg. Med.\u00a034, 340e5\u2013340e6 (2016).","journal-title":"Am. J. Emerg. Med."},{"key":"76159_CR17","doi-asserted-by":"publisher","first-page":"2063","DOI":"10.2169\/internalmedicine.47.1323","volume":"47","author":"O Imataki","year":"2008","unstructured":"Imataki, O. et al. Pancytopenia complicated with peripheral neuropathy due to copper deficiency: clinical diagnostic review. Intern. Med.\u00a047, 2063\u20132065 (2008).","journal-title":"Intern. Med."},{"key":"76159_CR18","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3390\/biom11040564","volume":"11","author":"D Letchumanan","year":"2021","unstructured":"Letchumanan, D., Sok, S. P. M., Ibrahim, S., Nagoor, N. H. & Arshad, N. M. Plant-based biosynthesis of copper\/copper oxide nanoparticles: an update on their applications in biomedicine, mechanisms, and toxicity. Biomolecules.\u00a011, 564 (2021).","journal-title":"Biomolecules"},{"key":"76159_CR19","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1001\/archneur.61.5.762","volume":"61","author":"N Kumar","year":"2004","unstructured":"Kumar, N., Crum, B., Petersen, R. C., Vernino, S. A. & Ahlskog, J. E. Copper deficiency myelopathy. Arch. Neurol.\u00a061, 762\u2013766 (2004).","journal-title":"Arch. Neurol."},{"key":"76159_CR20","doi-asserted-by":"publisher","first-page":"e01007","DOI":"10.1128\/mBio.01007-15","volume":"6","author":"A Durand","year":"2015","unstructured":"Durand, A. et al. c-Type cytochrome assembly is a key target of copper toxicity within the bacterial periplasm. mBio. 6, e01007\u2013e01015 (2015).","journal-title":"mBio"},{"key":"76159_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3389\/fmolb.2017.00009","volume":"4","author":"LM Bittner","year":"2017","unstructured":"Bittner, L. M., Kraus, A., Sch\u00e4kermann, S. & Narberhaus, F. The copper Efflux Regulator CueR is subject to ATP-Dependent proteolysis in Escherichia coli. Front. Mol. Biosci.\u00a04, 9 (2017).","journal-title":"Front. Mol. Biosci."},{"key":"76159_CR22","doi-asserted-by":"crossref","unstructured":"Bitter, R. M. et al. Structure of the Wilson disease copper transporter ATP7B. Sci. Adv.\u00a08, eabl5508 (2022).","DOI":"10.1126\/sciadv.abl5508"},{"key":"76159_CR23","doi-asserted-by":"publisher","first-page":"1800058","DOI":"10.1002\/gch2.201800058","volume":"3","author":"J Li","year":"2018","unstructured":"Li, J. et al. Vanadium Dioxide Nanocoating induces Tumor Cell Death through Mitochondrial Electron Transport Chain Interruption. Glob Chall.\u00a03, 1800058 (2018).","journal-title":"Glob Chall."},{"key":"76159_CR24","doi-asserted-by":"publisher","first-page":"8161","DOI":"10.1073\/pnas.1806296115","volume":"115","author":"S Soma","year":"2018","unstructured":"Soma, S. et al. Elesclomol restores mitochondrial function in genetic models of copper deficiency. Proc. Natl. Acad. Sci. U S A. 115, 8161\u20138166 (2018).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"76159_CR25","doi-asserted-by":"publisher","first-page":"6459585","DOI":"10.1155\/2022\/6459585","volume":"2022","author":"X Liu","year":"2022","unstructured":"Liu, X. et al. Mitochondrial-endoplasmic reticulum communication-mediated oxidative stress and autophagy. Biomed Res Int.\u00a02022, 6459585 (2022).","journal-title":"Biomed Res Int"},{"key":"76159_CR26","doi-asserted-by":"publisher","first-page":"393","DOI":"10.13075\/mp.5893.00137","volume":"66","author":"M Czerska","year":"2015","unstructured":"Czerska, M., Miko\u0142ajewska, K., Zieli\u0144ski, M., Gromadzi\u0144ska, J. & W\u0105sowicz, W. Today\u2019s oxidative stress markers. Med. Pr. 66, 393\u2013405 (2015).","journal-title":"Med. Pr"},{"key":"76159_CR27","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1051\/medsci\/2006223266","volume":"22","author":"R Barouki","year":"2006","unstructured":"Barouki, R. Ageing free radicals and cellular stress. Med. Sci. (Paris). 22, 266\u2013272 (2006).","journal-title":"Med. Sci. (Paris)"},{"key":"76159_CR28","doi-asserted-by":"publisher","first-page":"4427","DOI":"10.1021\/ja108890c","volume":"133","author":"KL Haas","year":"2011","unstructured":"Haas, K. L., Putterman, A. B., White, D. R., Thiele, D. J. & Franz, K. J. Model peptides provide New insights into the role of histidine residues as potential ligands in Human Cellular Copper Acquisition via Ctr1. J. Am. Chem. Soc.\u00a0133, 4427\u20134437 (2011).","journal-title":"J. Am. Chem. Soc."},{"key":"76159_CR29","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1007\/s00277-018-3407-5","volume":"97","author":"ZW Myint","year":"2018","unstructured":"Myint, Z. W., Oo, T. H., Thein, K. Z., Tun, A. M. & Saeed, H. Copper deficiency anemia: review article. Ann. Hematol.\u00a097, 1527\u20131534 (2018).","journal-title":"Ann. Hematol."},{"key":"76159_CR30","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1016\/j.jnutbio.2015.03.012","volume":"26","author":"F Piacenza","year":"2015","unstructured":"Piacenza, F. et al. Effect of six-month caloric restriction on Cu bound to Ceruloplasmin in adult overweight subjects. J. Nutr. Biochem.\u00a026, 876\u2013882 (2015).","journal-title":"J. Nutr. Biochem."},{"key":"76159_CR31","doi-asserted-by":"publisher","first-page":"14430","DOI":"10.1038\/s41598-024-65495-2","volume":"14","author":"W Perveen","year":"2024","unstructured":"Perveen, W. et al. Prevalence of peripheral neuropathy, amputation, and quality of life in patients with diabetes mellitus. Sci. Rep.\u00a014, 14430 (2024).","journal-title":"Sci. Rep."},{"key":"76159_CR32","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1002\/oby.21050","volume":"23","author":"SN Bleich","year":"2015","unstructured":"Bleich, S. N. & Wolfson, J. A. Trends in SSBs and snack consumption among children by age, body weight and race\/ethnicity. Obes. (Silver Spring). 23, 1039\u20131046 (2015).","journal-title":"Obes. (Silver Spring)"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76159-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76159-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76159-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,25]],"date-time":"2024-10-25T02:03:48Z","timestamp":1729821828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76159-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,25]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["76159"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-76159-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,25]]},"assertion":[{"value":"11 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25263"}}