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Here, we compared two mouse lines differing in resistance to infection with the enteric nematode\n                    <jats:italic>Heligmosomoides polygyrus bakeri<\/jats:italic>\n                    despite the similar instruction of GATA-3+ T effector cells. Resistant BALB\/c mice rapidly recruited high numbers of Th2 cells to the gut within the 1-week time frame required for larval development in the intestinal submucosa. C57BL\/6 mice failed in the optimal control of early nematode fitness, with mucosal Th2 response peaking after 2 weeks when the larvae had left the tissue and relocated to the gut lumen as adult worms. The faster homing of Th2 cells to the gut of BALB\/c mice is related to the extensive expression of the chemokine receptor CCR9 in GATA-3+ cells and higher frequencies of aldehyde dehydrogenase expressing dendritic cells present in mesenteric lymph nodes. Furthermore, nematode-infected older BALB\/c mice displayed impaired resistance due to delayed mucosal homing of effector cells, which synergized with more numerous Th2\/1 hybrid cells acting as IFN-\u03b3-dependent confounders of type 2 responses. Hence, the distinct kinetics of effector cell recruitment to the infected gut and the quality of GATA-3+ T cell responses contribute to the genotype- and age-dependent resistance to intestinal nematode infections.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-76204-4","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T15:07:51Z","timestamp":1738768071000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Differential resistance to nematode infection is associated with the genotype- and age-dependent pace of intestinal T cell homing"],"prefix":"10.1038","volume":"15","author":[{"given":"Joshua","family":"Adjah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavya","family":"Kapse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rausch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"76204_CR1","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.3389\/fimmu.2020.01286","volume":"11","author":"SAP Colombo","year":"2020","unstructured":"Colombo, S. 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