{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T18:14:51Z","timestamp":1778091291037,"version":"3.51.4"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T00:00:00Z","timestamp":1729296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9,Canada"},{"DOI":"10.13039\/501100000406","name":"Motor Neurone Disease Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000406","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Research Chairs,Canada"},{"name":"Alzheimer Society,Canada"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research,Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-76245-9","type":"journal-article","created":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T09:02:22Z","timestamp":1729328542000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traits"],"prefix":"10.1038","volume":"14","author":[{"given":"Wiame","family":"Belbellaj","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frida","family":"Lona-Durazo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Bodano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Busseuil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Christyne","family":"Cyr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edoardo","family":"Fiorillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Mulas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvie","family":"Provost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maristella","family":"Steri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"Vanderwerff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiongming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross P.","family":"Byrne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cucca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Pierre","family":"Dub\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Ferrucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell L.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Zawistowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Gagliano Taliun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,19]]},"reference":[{"key":"76245_CR1","first-page":"1","volume":"19","author":"N Abbaspour","year":"2014","unstructured":"Abbaspour, N., Hurrell, R. & Kelishadi, R. Review on iron and its importance for human health. J. Res. Med. Sci. 19, 1 (2014).","journal-title":"J. Res. Med. Sci."},{"key":"76245_CR2","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.mam.2020.100864","volume":"75","author":"M Nairz","year":"2020","unstructured":"Nairz, M. & Weiss, G. Iron in infection and immunity. Mol. Asp. Med. 75, 864. https:\/\/doi.org\/10.1016\/j.mam.2020.100864 (2020).","journal-title":"Mol. Asp. Med."},{"key":"76245_CR3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/17474086.2016.1268047","volume":"10","author":"BT Paul","year":"2017","unstructured":"Paul, B. T., Manz, D. H., Torti, F. M. & Torti, S. V. Mitochondria and iron: Current questions. Expert Rev. Hematol. 10, 47. https:\/\/doi.org\/10.1080\/17474086.2016.1268047 (2017).","journal-title":"Expert Rev. Hematol."},{"key":"76245_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0753-3322(01)00068-3","volume":"55","author":"J Emerit","year":"2001","unstructured":"Emerit, J., Beaumont, C. & Trivin, F. Iron metabolism, free radicals, and oxidative injury. Biomed. Pharmacother. 55, 3. https:\/\/doi.org\/10.1016\/S0753-3322(01)00068-3 (2001).","journal-title":"Biomed. Pharmacother."},{"key":"76245_CR5","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3389\/fphar.2014.00117","volume":"5","author":"D Basuli","year":"2014","unstructured":"Basuli, D., Stevens, R. G., Torti, F. M. & Torti, S. V. Epidemiological associations between iron and cardiovascular disease and diabetes. Front. Pharmacol. 5, 117. https:\/\/doi.org\/10.3389\/fphar.2014.00117 (2014).","journal-title":"Front. Pharmacol."},{"key":"76245_CR6","doi-asserted-by":"publisher","first-page":"e0146129","DOI":"10.1371\/journal.pone.0146129","volume":"11","author":"MS Medeiros","year":"2016","unstructured":"Medeiros, M. S. et al. Iron and oxidative stress in Parkinson\u2019s disease: An observational study of injury biomarkers. PLoS ONE 11, e0146129 (2016).","journal-title":"PLoS ONE"},{"key":"76245_CR7","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1161\/JAHA.118.010887","volume":"8","author":"P Moliner","year":"2019","unstructured":"Moliner, P. et al. Association between norepinephrine levels and abnormal iron status in patients with chronic heart failure: Is iron deficiency more than a comorbidity? J. Am. Heart Assoc. 8, 887 (2019).","journal-title":"J. Am. Heart Assoc."},{"key":"76245_CR8","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3389\/fneur.2020.00380","volume":"11","author":"L Wang","year":"2020","unstructured":"Wang, L., Li, C., Chen, X., Li, S. & Shang, H. Abnormal serum iron-status indicator changes in amyotrophic lateral sclerosis (ALS) patients: A meta-analysis. Front. Neurol. 11, 380. https:\/\/doi.org\/10.3389\/fneur.2020.00380 (2020).","journal-title":"Front. Neurol."},{"key":"76245_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-022-22275-0","volume":"12","author":"S Guo","year":"2022","unstructured":"Guo, S., Mao, X., Li, X. & Ouyang, H. Association between iron status and incident coronary artery disease: a population based-cohort study. Sci. Rep. 12, 1 (2022).","journal-title":"Sci. Rep."},{"key":"76245_CR10","first-page":"1","volume":"4","author":"MH Eftekhari","year":"2013","unstructured":"Eftekhari, M. H., Mozaffari-Khosravi, H., Shidfar, F. & Zamani, A. Relation between body iron status and cardiovascular risk factors in patients with cardiovascular disease. Int. J. Prev. Med. 4, 1 (2013).","journal-title":"Int. J. Prev. Med."},{"key":"76245_CR11","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.atherosclerosis.2014.12.018","volume":"238","author":"S De Das","year":"2015","unstructured":"De Das, S., Krishna, S. & Jethwa, A. Iron status and its association with coronary heart disease: Systematic review and meta-analysis of prospective studies. Atherosclerosis 238, 296\u2013303 (2015).","journal-title":"Atherosclerosis"},{"key":"76245_CR12","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/S1047-2797(00)00068-5","volume":"10","author":"CT Sempos","year":"2000","unstructured":"Sempos, C. T. et al. Serum ferritin and death from all causes and cardiovascular disease: The NHANES II Mortality Study. National Health and Nutrition Examination Study. Ann. Epidemiol. 10, 441\u2013448 (2000).","journal-title":"Ann. Epidemiol."},{"key":"76245_CR13","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1093\/aje\/kwg121","volume":"158","author":"MW Knuiman","year":"2003","unstructured":"Knuiman, M. W., Divitini, M. L., Olynyk, J. K., Cullen, D. J. & Bartholomew, H. C. Serum ferritin and cardiovascular disease: A 17-year follow-up study in Busselton, Western Australia. Am. J. Epidemiol. 158, 144\u2013149 (2003).","journal-title":"Am. J. Epidemiol."},{"key":"76245_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000094777","volume":"61","author":"OT Njajou","year":"2006","unstructured":"Njajou, O. T. et al. Heritability of serum iron, ferritin and transferrin saturation in a genetically isolated population, the Erasmus Rucphen Family (ERF) study. Hum. Hered. 61, 1 (2006).","journal-title":"Hum. Hered."},{"key":"76245_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/01.STR.0000185719.66735.dd","volume":"36","author":"FA Sayed-Tabatabaei","year":"2005","unstructured":"Sayed-Tabatabaei, F. A. et al. Heritability of the function and structure of the arterial wall: Findings of the Erasmus Rucphen family (ERF) study. Stroke 36, 1 (2005).","journal-title":"Stroke"},{"key":"76245_CR16","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/s42003-022-03529-z","volume":"5","author":"MR Moksnes","year":"2022","unstructured":"Moksnes, M. R. et al. Genome-wide meta-analysis of iron status biomarkers and the effect of iron on all-cause mortality in HUNT. Commun. Biol. 5, 591 (2022).","journal-title":"Commun. Biol."},{"key":"76245_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s42003-020-01575-z","volume":"4","author":"S Bell","year":"2021","unstructured":"Bell, S. et al. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis. Commun. Biol. 4, 1 (2021).","journal-title":"Commun. Biol."},{"key":"76245_CR18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jjcc.2021.09.005","volume":"79","author":"H Tada","year":"2022","unstructured":"Tada, H., Fujino, N., Hayashi, K., Kawashiri, M. & Takamura, M. Human genetics and its impact on cardiovascular disease. J. Cardiol. 79, 5. https:\/\/doi.org\/10.1016\/j.jjcc.2021.09.005 (2022).","journal-title":"J. Cardiol."},{"key":"76245_CR19","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.nbd.2020.104953","volume":"142","author":"E Bellou","year":"2020","unstructured":"Bellou, E., Stevenson-Hoare, J. & Escott-Price, V. Polygenic risk and pleiotropy in neurodegenerative diseases. Neurobiol. Dis. 142, 953. https:\/\/doi.org\/10.1016\/j.nbd.2020.104953 (2020).","journal-title":"Neurobiol. Dis."},{"key":"76245_CR20","doi-asserted-by":"publisher","first-page":"e0281440","DOI":"10.1371\/journal.pone.0281440","volume":"18","author":"E Baker","year":"2023","unstructured":"Baker, E. et al. What does heritability of Alzheimer\u2019s disease represent? PLoS ONE 18, e0281440 (2023).","journal-title":"PLoS ONE"},{"key":"76245_CR21","doi-asserted-by":"publisher","first-page":"601","DOI":"10.3390\/nu12092601","volume":"12","author":"TG Kezele","year":"2020","unstructured":"Kezele, T. G. & \u0106urko-Cofek, B. Age-related changes and sex-related differences in brain iron metabolism. Nutrients 12, 601. https:\/\/doi.org\/10.3390\/nu12092601 (2020).","journal-title":"Nutrients"},{"key":"76245_CR22","doi-asserted-by":"publisher","first-page":"937","DOI":"10.3389\/fspor.2022.903937","volume":"4","author":"CE Badenhorst","year":"2022","unstructured":"Badenhorst, C. E., Forsyth, A. K. & Govus, A. D. A contemporary understanding of iron metabolism in active premenopausal females. Front. Sports Act. Living 4, 937. https:\/\/doi.org\/10.3389\/fspor.2022.903937 (2022).","journal-title":"Front. Sports Act. Living"},{"key":"76245_CR23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/japplphysiol.00290.2021","volume":"132","author":"BJ Ryan","year":"2022","unstructured":"Ryan, B. J., Charkoudian, N. & McClung, J. P. Consider iron status when making sex comparisons in human physiology. J. Appl. Physiol. 132, 1 (2022).","journal-title":"J. Appl. Physiol."},{"key":"76245_CR24","first-page":"84","volume-title":"Normal Human Aging: The Baltimore Study of Aging","author":"N Shock","year":"1984","unstructured":"Shock, N., Greulick, R. & Andres, R. Normal Human Aging: The Baltimore Study of Aging 84 (NIH Publication, 1984)."},{"key":"76245_CR25","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.1038\/ncomms5926","volume":"5","author":"B Benyamin","year":"2014","unstructured":"Benyamin, B. et al. Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nat. Commun. 5, 4926 (2014).","journal-title":"Nat. Commun."},{"key":"76245_CR26","doi-asserted-by":"publisher","first-page":"100257","DOI":"10.1016\/j.xgen.2023.100257","volume":"3","author":"M Zawistowski","year":"2023","unstructured":"Zawistowski, M. et al. The Michigan genomics initiative: A biobank linking genotypes and electronic clinical records in Michigan Medicine patients. Cell Genom. 3, 100257 (2023).","journal-title":"Cell Genom."},{"key":"76245_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pgen.0020132","volume":"2","author":"G Pilia","year":"2006","unstructured":"Pilia, G. et al. Heritability of cardiovascular and personality traits in 6,148 Sardinians. PLoS Genet. 2, 1 (2006).","journal-title":"PLoS Genet."},{"key":"76245_CR28","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1093\/ije\/dys095","volume":"42","author":"S Krokstad","year":"2013","unstructured":"Krokstad, S. et al. Cohort profile: The HUNT study, Norway. Int. J. Epidemiol. 42, 968\u2013977 (2013).","journal-title":"Int. J. Epidemiol."},{"key":"76245_CR29","doi-asserted-by":"publisher","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","volume":"26","author":"CJ Willer","year":"2010","unstructured":"Willer, C. J., Li, Y. & Abecasis, G. R. METAL: Fast and efficient meta-analysis of genomewide association scans. Bioinformatics 26, 2190\u20132191 (2010).","journal-title":"Bioinformatics"},{"key":"76245_CR30","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gkj144","volume":"34","author":"AS Hinrichs","year":"2006","unstructured":"Hinrichs, A. S. et al. The UCSC genome browser database: Update 2006. Nucleic Acids Res. 34, D590\u2013D598 (2006).","journal-title":"Nucleic Acids Res."},{"key":"76245_CR31","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1038\/s41467-017-01261-5","volume":"8","author":"K Watanabe","year":"2017","unstructured":"Watanabe, K., Taskesen, E., van Bochoven, A. & Posthuma, D. Functional mapping and annotation of genetic associations with FUMA. Nat. Commun. 8, 1826 (2017).","journal-title":"Nat. Commun."},{"key":"76245_CR32","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1038\/s41588-021-00921-z","volume":"53","author":"DP Wightman","year":"2021","unstructured":"Wightman, D. P. et al. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer\u2019s disease. Nat. Genet. 53, 1276\u20131282 (2021).","journal-title":"Nat. Genet."},{"key":"76245_CR33","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/ana.26090","volume":"90","author":"C Blauwendraat","year":"2021","unstructured":"Blauwendraat, C. et al. Investigation of autosomal genetic sex differences in Parkinson\u2019s disease. Ann. Neurol. 90, 35\u201342 (2021).","journal-title":"Ann. Neurol."},{"key":"76245_CR34","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1038\/s41588-021-00973-1","volume":"53","author":"W van Rheenen","year":"2021","unstructured":"van Rheenen, W. et al. Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology. Nat. Genet. 53, 1636\u20131648 (2021).","journal-title":"Nat. Genet."},{"key":"76245_CR35","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1038\/s41588-022-01233-6","volume":"54","author":"KG Aragam","year":"2022","unstructured":"Aragam, K. G. et al. Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants. Nat. Genet. 54, 1803\u20131815 (2022).","journal-title":"Nat. Genet."},{"key":"76245_CR36","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41467-019-13690-5","volume":"11","author":"S Shah","year":"2020","unstructured":"Shah, S. et al. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nat. Commun. 11, 163 (2020).","journal-title":"Nat. Commun."},{"key":"76245_CR37","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/s41586-022-05165-3","volume":"611","author":"A Mishra","year":"2022","unstructured":"Mishra, A. et al. Stroke genetics informs drug discovery and risk prediction across ancestries. Nature 611, 115\u2013123 (2022).","journal-title":"Nature"},{"key":"76245_CR38","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41586-021-04064-3","volume":"600","author":"SE Graham","year":"2021","unstructured":"Graham, S. E. et al. The power of genetic diversity in genome-wide association studies of lipids. Nature 600, 675\u2013679 (2021).","journal-title":"Nature"},{"key":"76245_CR39","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","volume":"47","author":"B Bulik-Sullivan","year":"2015","unstructured":"Bulik-Sullivan, B. et al. An atlas of genetic correlations across human diseases and traits. Nat. Genet. 47, 1236 (2015).","journal-title":"Nat. Genet."},{"key":"76245_CR40","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/s41588-022-01017-y","volume":"54","author":"J Werme","year":"2022","unstructured":"Werme, J., van der Sluis, S., Posthuma, D. & de Leeuw, C. A. An integrated framework for local genetic correlation analysis. Nat. Genet. 54, 274\u2013282 (2022).","journal-title":"Nat. Genet."},{"key":"76245_CR41","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","volume":"51","author":"BW Kunkle","year":"2019","unstructured":"Kunkle, B. W. et al. Genetic meta-analysis of diagnosed Alzheimer\u2019s disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing. Nat. Genet. 51, 414\u2013430 (2019).","journal-title":"Nat. Genet."},{"key":"76245_CR42","doi-asserted-by":"publisher","first-page":"D977","DOI":"10.1093\/nar\/gkac1010","volume":"51","author":"E Sollis","year":"2023","unstructured":"Sollis, E. et al. The NHGRI-EBI GWAS Catalog: Knowledgebase and deposition resource. Nucleic Acids Res. 51, D977\u2013D985 (2023).","journal-title":"Nucleic Acids Res."},{"key":"76245_CR43","doi-asserted-by":"publisher","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","volume":"35","author":"MA Kamat","year":"2019","unstructured":"Kamat, M. A. et al. PhenoScanner V2: An expanded tool for searching human genotype-phenotype associations. Bioinformatics 35, 4851\u20134853 (2019).","journal-title":"Bioinformatics"},{"key":"76245_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.34408","volume":"7","author":"G Hemani","year":"2018","unstructured":"Hemani, G. et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife 7, 1 (2018).","journal-title":"Elife"},{"key":"76245_CR45","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","volume":"32","author":"S Burgess","year":"2017","unstructured":"Burgess, S. & Thompson, S. G. Interpreting findings from Mendelian randomization using the MR-Egger method. Eur. J. Epidemiol. 32, 377\u2013389 (2017).","journal-title":"Eur. J. Epidemiol."},{"key":"76245_CR46","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","volume":"50","author":"M Verbanck","year":"2018","unstructured":"Verbanck, M., Chen, C.-Y., Neale, B. & Do, R. Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat. Genet. 50, 693\u2013698 (2018).","journal-title":"Nat. Genet."},{"key":"76245_CR47","doi-asserted-by":"publisher","DOI":"10.1101\/2024.05.25.24307829","author":"RP Byrne","year":"2024","unstructured":"Byrne, R. P. et al. Sex-specific risk loci and modified MEF2C expression in ALS. MedRxiv. https:\/\/doi.org\/10.1101\/2024.05.25.24307829 (2024).","journal-title":"MedRxiv."},{"key":"76245_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ajhg.2017.09.022","volume":"101","author":"H Shi","year":"2017","unstructured":"Shi, H., Mancuso, N., Spendlove, S. & Pasaniuc, B. Local genetic correlation gives insights into the shared genetic architecture of complex traits. Am. J. Hum. Genet. 101, 1 (2017).","journal-title":"Am. J. Hum. Genet."},{"key":"76245_CR49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41576-019-0137-z","volume":"20","author":"W van Rheenen","year":"2019","unstructured":"van Rheenen, W., Peyrot, W. J., Schork, A. J., Lee, S. H. & Wray, N. R. Genetic correlations of polygenic disease traits: From theory to practice. Nat. Rev. Genet. 20, 1. https:\/\/doi.org\/10.1038\/s41576-019-0137-z (2019).","journal-title":"Nat. Rev. Genet."},{"key":"76245_CR50","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1128\/IAI.00095-21","volume":"89","author":"AEF Sheppe","year":"2021","unstructured":"Sheppe, A. E. F. & Edelmann, M. J. Roles of eicosanoids in regulating inflammation and neutrophil migration as an innate host response to bacterial infections. Infect. Immunity 89, 21. https:\/\/doi.org\/10.1128\/IAI.00095-21 (2021).","journal-title":"Infect. Immunity"},{"key":"76245_CR51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.immuni.2022.10.016","volume":"55","author":"X Chen","year":"2022","unstructured":"Chen, X. & Holtzman, D. M. Emerging roles of innate and adaptive immunity in Alzheimer\u2019s disease. Immunity 55, 16. https:\/\/doi.org\/10.1016\/j.immuni.2022.10.016 (2022).","journal-title":"Immunity"},{"key":"76245_CR52","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1111\/imr.12896","volume":"297","author":"HE Ennerfelt","year":"2020","unstructured":"Ennerfelt, H. E. & Lukens, J. R. The role of innate immunity in Alzheimer\u2019s disease. Immunol. Rev. 297, 896. https:\/\/doi.org\/10.1111\/imr.12896 (2020).","journal-title":"Immunol. Rev."},{"key":"76245_CR53","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1146\/annurev.nutr.012809.104804","volume":"30","author":"M Wessling-Resnick","year":"2010","unstructured":"Wessling-Resnick, M. Iron homeostasis and the inflammatory response. Annu. Rev. Nutr. 30, 804. https:\/\/doi.org\/10.1146\/annurev.nutr.012809.104804 (2010).","journal-title":"Annu. Rev. Nutr."},{"key":"76245_CR54","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.scib.2021.02.010","volume":"66","author":"Q Mu","year":"2021","unstructured":"Mu, Q. et al. The role of iron homeostasis in remodeling immune function and regulating inflammatory disease. Sci. Bull. 66, 10. https:\/\/doi.org\/10.1016\/j.scib.2021.02.010 (2021).","journal-title":"Sci. Bull."},{"key":"76245_CR55","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/nrg1489","volume":"5","author":"R Horton","year":"2004","unstructured":"Horton, R. et al. Gene map of the extended human MHC. Nat. Rev. Genet. 5, 1489. https:\/\/doi.org\/10.1038\/nrg1489 (2004).","journal-title":"Nat. Rev. Genet."},{"key":"76245_CR56","doi-asserted-by":"publisher","first-page":"57","DOI":"10.12997\/jla.2021.10.1.57","volume":"10","author":"YK Cho","year":"2021","unstructured":"Cho, Y. K. & Hee Jung, C. Hdl-c and cardiovascular risk: You don\u2019t need to worry about extremely high HDL-C levels. J. Lipid Atheroscler. 10, 57. https:\/\/doi.org\/10.12997\/jla.2021.10.1.57 (2021).","journal-title":"J. Lipid Atheroscler."},{"key":"76245_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1476-5381.2012.02081.x","volume":"167","author":"KM Ali","year":"2012","unstructured":"Ali, K. M., Wonnerth, A., Huber, K. & Wojta, J. Cardiovascular disease risk reduction by raising HDL cholesterol\u2014Current therapies and future opportunities. Br. J. Pharmacol. 167, 1. https:\/\/doi.org\/10.1111\/j.1476-5381.2012.02081.x (2012).","journal-title":"Br. J. Pharmacol."},{"key":"76245_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.116.003456","volume":"6","author":"SK Das","year":"2017","unstructured":"Das, S. K. et al. Females are protected from iron-overload cardiomyopathy independent of iron metabolism: Key role of oxidative stress. J. Am. Heart Assoc. 6, 1 (2017).","journal-title":"J. Am. Heart Assoc."},{"key":"76245_CR59","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/JAHA.116.005459","volume":"6","author":"JS Shapiro","year":"2017","unstructured":"Shapiro, J. S., Chang, H. C. & Ardehali, H. Iron and sex cross paths in the heart. J. Am. Heart Assoc. 6, 1 (2017).","journal-title":"J. Am. Heart Assoc."},{"key":"76245_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.reprotox.2023.108381","volume":"118","author":"X Li","year":"2023","unstructured":"Li, X. et al. Iron deficiency and overload in men and woman of reproductive age, and pregnant women. Reprod. Toxicol. 118, 1 (2023).","journal-title":"Reprod. Toxicol."},{"key":"76245_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4254\/wjh.v2.i8.302","volume":"2","author":"DD Harrison-Findik","year":"2010","unstructured":"Harrison-Findik, D. D. Gender-related variations in iron metabolism and liver diseases. World J. Hepatol. 2, 1 (2010).","journal-title":"World J. Hepatol."},{"key":"76245_CR62","doi-asserted-by":"publisher","first-page":"1","DOI":"10.21037\/atm-20-5512","volume":"9","author":"GJ Anderson","year":"2021","unstructured":"Anderson, G. J. & Bardou-Jacquet, E. Revisiting hemochromatosis: Genetic vs phenotypic manifestations. Ann. Transl. Med. 9, 1 (2021).","journal-title":"Ann. Transl. Med."},{"key":"76245_CR63","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1055\/a-0885-1677","volume":"128","author":"M Hamad","year":"2020","unstructured":"Hamad, M., Bajbouj, K. & Taneera, J. The case for an estrogen-iron axis in health and disease. Exp. Clin. Endocrinol. Diabetes 128, 1677. https:\/\/doi.org\/10.1055\/a-0885-1677 (2020).","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"76245_CR64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11934-018-0808-x","volume":"19","author":"JS Gabrielsen","year":"2018","unstructured":"Gabrielsen, J. S., Lamb, D. J. & Lipshultz, L. I. Iron and a man\u2019s reproductive health: The good, the bad, and the ugly. Curr. Urol. Rep. 19, 1. https:\/\/doi.org\/10.1007\/s11934-018-0808-x (2018).","journal-title":"Curr. Urol. Rep."},{"key":"76245_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1210\/jc.2010-0864","volume":"95","author":"E Bachman","year":"2010","unstructured":"Bachman, E. et al. Testosterone suppresses hepcidin in men: A potential mechanism for testosterone-induced erythrocytosis. J. Clin. Endocrinol. Metab. 95, 1 (2010).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"76245_CR66","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.amjmed.2019.03.001","volume":"132","author":"MT Hayes","year":"2019","unstructured":"Hayes, M. T. Parkinson\u2019s disease and Parkinsonism. Am. J. Med. 132, 802\u2013807 (2019).","journal-title":"Am. J. Med."},{"key":"76245_CR67","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1146\/annurev.neuro.22.1.123","volume":"22","author":"CW Olanow","year":"1999","unstructured":"Olanow, C. W. & Tatton, W. G. Etiology and pathogenesis of Parkinson\u2019s disease. Annu. Rev. Neurosci. 22, 123\u2013144 (1999).","journal-title":"Annu. Rev. Neurosci."},{"key":"76245_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/nu12092601","volume":"12","author":"T Grubi\u0107 Kezele","year":"2020","unstructured":"Grubi\u0107 Kezele, T. & \u0106urko-Cofek, B. Age-related changes and sex-related differences in brain iron metabolism. Nutrients 12, 1 (2020).","journal-title":"Nutrients"},{"key":"76245_CR69","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3389\/fnagi.2019.00215","volume":"11","author":"L Shi","year":"2019","unstructured":"Shi, L. et al. The association of iron and the pathologies of Parkinson\u2019s diseases in MPTP\/MPP+-induced neuronal degeneration in non-human primates and in cell culture. Front. Aging Neurosci. 11, 215 (2019).","journal-title":"Front. Aging Neurosci."},{"key":"76245_CR70","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.clinsp.2022.100121","volume":"77","author":"LP de Souza Ferreira","year":"2022","unstructured":"de Souza Ferreira, L. P. et al. Sex differences in Parkinson\u2019s disease: An emerging health question. Clinics 77, 121. https:\/\/doi.org\/10.1016\/j.clinsp.2022.100121 (2022).","journal-title":"Clinics"},{"key":"76245_CR71","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3390\/brainsci12070917","volume":"12","author":"MC Russillo","year":"2022","unstructured":"Russillo, M. C. et al. Sex differences in Parkinson\u2019s disease: From bench to bedside. Brain Sci. 12, 917. https:\/\/doi.org\/10.3390\/brainsci12070917 (2022).","journal-title":"Brain Sci."},{"key":"76245_CR72","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3233\/JPD-191683","volume":"9","author":"S Cerri","year":"2019","unstructured":"Cerri, S., Mus, L. & Blandini, F. Parkinson\u2019s disease in women and men: What\u2019s the difference? J. Parkinsons Dis. 9, 501\u2013515 (2019).","journal-title":"J. Parkinsons Dis."},{"key":"76245_CR73","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.yfrne.2017.09.002","volume":"50","author":"JC Jurado-Coronel","year":"2018","unstructured":"Jurado-Coronel, J. C. et al. Sex differences in Parkinson\u2019s disease: Features on clinical symptoms, treatment outcome, sexual hormones and genetics. Front. Neuroendocrinol. 50, 18\u201330 (2018).","journal-title":"Front. Neuroendocrinol."},{"key":"76245_CR74","doi-asserted-by":"publisher","first-page":"157","DOI":"10.3389\/fnins.2020.00157","volume":"14","author":"Y-J Song","year":"2020","unstructured":"Song, Y.-J. et al. The effect of estrogen replacement therapy on Alzheimer\u2019s disease and Parkinson\u2019s disease in postmenopausal women: A meta-analysis. Front. Neurosci. 14, 157 (2020).","journal-title":"Front. Neurosci."},{"key":"76245_CR75","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.yjmcc.2021.06.005","volume":"159","author":"A Paterek","year":"2021","unstructured":"Paterek, A. et al. Systemic iron deficiency does not affect the cardiac iron content and progression of heart failure. J. Mol. Cell Cardiol. 159, 16\u201327 (2021).","journal-title":"J. Mol. Cell Cardiol."},{"key":"76245_CR76","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1002\/ejhf.1781","volume":"22","author":"VG Hirsch","year":"2020","unstructured":"Hirsch, V. G. et al. Cardiac iron concentration in relation to systemic iron status and disease severity in non-ischaemic heart failure with reduced ejection fraction. Eur. J. Heart Fail. 22, 2038\u20132046 (2020).","journal-title":"Eur. J. Heart Fail."},{"key":"76245_CR77","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.bbadis.2011.06.016","volume":"1822","author":"HM Schipper","year":"2012","unstructured":"Schipper, H. M. Neurodegeneration with brain iron accumulation\u2014Clinical syndromes and neuroimaging. Biochim. Biophys. Acta Mol. Basis Dis. 1822, 16. https:\/\/doi.org\/10.1016\/j.bbadis.2011.06.016 (2012).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"76245_CR78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-0381-6-18","volume":"6","author":"D Wolfe","year":"2013","unstructured":"Wolfe, D., Dudek, S., Ritchie, M. D. & Pendergrass, S. A. Visualizing genomic information across chromosomes with PhenoGram. BioData Min. 6, 1 (2013).","journal-title":"BioData Min."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76245-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76245-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76245-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T17:10:06Z","timestamp":1729617006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76245-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,19]]},"references-count":78,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["76245"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-76245-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,19]]},"assertion":[{"value":"31 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"MPD has minor equity interest in Dalcor Pharmaceuticals. MPD has a patent Methods for Treating or Preventing Cardiovascular Disorders and Lowering Risk of Cardiovascular Events issued to Dalcor Pharmaceuticals, no royalties received; a patent Genetic Markers for Predicting Responsiveness to Therapy with HDL-Raising or HDL Mimicking Agent issued to Dalcor Pharmaceuticals, no royalties received; and a patent Methods for using low dose colchicine after myocardial infarction, assigned to the Montreal Heart Institute. JCT holds research grants from Amarin, Ceapro, DalCor Pharmaceuticals, Esperion, Ionis, Merck, Novartis and Pfizer; fees from DalCor Pharmacuticals, HLS Pharmaceuticals, Pendopharm and Pfizer; and minor equity interest from DalCor Pharmaceuticals. The other authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24588"}}