{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:02:02Z","timestamp":1772805722410,"version":"3.50.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-76291-3","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T11:02:48Z","timestamp":1729594968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of mRNA expression profile in the treatment of diabetic foot ulcer healing by tibial cortex transverse distraction"],"prefix":"10.1038","volume":"14","author":[{"given":"Zhi-Qiang","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Fu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"issue":"3","key":"76291_CR1","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1177\/0141076816688346","volume":"110","author":"JZ Lim","year":"2017","unstructured":"Lim, J. Z., Ng, N. S. & Thomas, C. Prevention and treatment of diabetic foot ulcers. J. R. Soc. Med. 110(3), 104\u2013109 (2017).","journal-title":"J. R. Soc. Med."},{"key":"76291_CR2","doi-asserted-by":"publisher","first-page":"300060520954697","DOI":"10.1177\/0300060520954697","volume":"48","author":"ZQ Fan","year":"2020","unstructured":"Fan, Z. Q., Yu, Z. H., Zheng, J. Z., Yu, B. F. & Liu, D. W. Tibial cortex transverse distraction in treating diabetic foot ulcers: What are we concerned about. J. Int. Med. Res. 48, 300060520954697 (2020).","journal-title":"J. Int. Med. Res."},{"key":"76291_CR3","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13018-022-03042-3","volume":"17","author":"ZQ Fan","year":"2022","unstructured":"Fan, Z. Q. & Liu, D. W. Impairment characteristics of static balance and plantar load distribution of patients undergoing tibial cortex transverse distraction for diabetic foot ulcers. J. Orthop. Surg. Res. 17, 171 (2022).","journal-title":"J. Orthop. Surg. Res."},{"key":"76291_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"76291_CR5","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"76291_CR6","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013D592. https:\/\/doi.org\/10.1093\/nar\/gkac963 (2023).","journal-title":"Nucleic Acids Res."},{"key":"76291_CR7","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2021.113711","volume":"341","author":"YF Liu","year":"2021","unstructured":"Liu, Y. F. et al. CXCL5\/CXCR2 modulates inflammation-mediated neural repair after optic nerve injury. Exp. Neurol. 341, 113711 (2021).","journal-title":"Exp. Neurol."},{"key":"76291_CR8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.717483","volume":"12","author":"S Zhang","year":"2021","unstructured":"Zhang, S. et al. CXCL5 downregulation in villous tissue is correlated with recurrent spontaneous abortion. Front. Immunol. 12, 717483 (2021).","journal-title":"Front. Immunol."},{"key":"76291_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.944494","volume":"12","author":"J Deng","year":"2022","unstructured":"Deng, J., Jiang, R., Meng, E. & Wu, H. CXCL5: A coachman to drive cancer progression. Front. Oncol. 12, 944494 (2022).","journal-title":"Front. Oncol."},{"key":"76291_CR10","first-page":"673","volume":"18","author":"R Phillips","year":"2022","unstructured":"Phillips, R. CXCL5 effective in mouse model of SLE. Nat. Rev. Rheumatol. 18, 673 (2022).","journal-title":"Nat. Rev. Rheumatol."},{"key":"76291_CR11","doi-asserted-by":"publisher","first-page":"283","DOI":"10.5114\/pjp.2021.114174","volume":"72","author":"Z Wang","year":"2021","unstructured":"Wang, Z., Liang, X., Wang, X. & Yu, Q. Elevated expression of IGFL1 indicates unfavorable prognosis in lung adenocarcinoma through promotion of cell proliferation and inhibition of apoptosis. Pol. J. Pathol. 72, 283\u2013295. https:\/\/doi.org\/10.5114\/pjp.2021.114174 (2021).","journal-title":"Pol. J. Pathol."},{"key":"76291_CR12","doi-asserted-by":"publisher","first-page":"18969","DOI":"10.1074\/jbc.M111.224626","volume":"286","author":"AA Lobito","year":"2011","unstructured":"Lobito, A. A. et al. Murine insulin growth factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1. J. Biol. Chem. 286, 18969\u201318981. https:\/\/doi.org\/10.1074\/jbc.M111.224626 (2011).","journal-title":"J. Biol. Chem."},{"key":"76291_CR13","doi-asserted-by":"publisher","first-page":"258372","DOI":"10.1242\/jcs.258372","volume":"134","author":"L Yue","year":"2021","unstructured":"Yue, L. & Xu, H. TRP channels in health and disease at a glance. J Cell Sci. 134, 258372 (2021).","journal-title":"J Cell Sci."},{"key":"76291_CR14","doi-asserted-by":"publisher","first-page":"107412","DOI":"10.3390\/biom12040547","volume":"12","author":"MB Morelli","year":"2022","unstructured":"Morelli, M. B. & Amantini, C. Transient receptor potential (TRP) channels: Markers and therapeutic targets for cancer. Biomolecules 12, 107412 (2022).","journal-title":"Biomolecules"},{"key":"76291_CR15","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.3389\/fphys.2018.01731","volume":"9","author":"T Smani","year":"2018","unstructured":"Smani, T. et al. TRP channels in angiogenesis and other endothelial functions. Front. Physiol. 9, 1731 (2018).","journal-title":"Front. Physiol."},{"key":"76291_CR16","doi-asserted-by":"publisher","first-page":"826","DOI":"10.3390\/cells8080826","volume":"8","author":"LF Ng","year":"2019","unstructured":"Ng, L. F. et al. WNT signaling in disease. Cells 8, 826 (2019).","journal-title":"Cells"},{"key":"76291_CR17","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/164_2021_526","volume":"269","author":"G Davidson","year":"2021","unstructured":"Davidson, G. LRPs in WNT Signalling. Handb. Exp. Pharmacol. 269, 45\u201373 (2021).","journal-title":"Handb. Exp. Pharmacol."},{"key":"76291_CR18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/bs.ctdb.2018.11.010","volume":"133","author":"S Teufel","year":"2019","unstructured":"Teufel, S. & Hartmann, C. Wnt-signaling in skeletal development. Curr. Top. Dev. Biol. 133, 235\u2013279 (2019).","journal-title":"Curr. Top. Dev. Biol."},{"key":"76291_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.708470","volume":"8","author":"K Bundy","year":"2021","unstructured":"Bundy, K., Boone, J. & Simpson, C. L. Wnt signaling in vascular calcification. Front. Cardiovasc. Med. 8, 708470 (2021).","journal-title":"Front. Cardiovasc. Med."},{"key":"76291_CR20","doi-asserted-by":"publisher","first-page":"a011163","DOI":"10.1101\/cshperspect.a011163","volume":"4","author":"R Nusse","year":"2012","unstructured":"Nusse, R. Wnt signaling. Cold Spring Harb. Perspect. Biol. 4, a011163 (2012).","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"76291_CR21","doi-asserted-by":"publisher","first-page":"2168","DOI":"10.3390\/cells10082168","volume":"10","author":"CC Huang","year":"2021","unstructured":"Huang, C. C. et al. S1P increases VEGF production in osteoblasts and facilitates endothelial progenitor cell angiogenesis by inhibiting miR-16\u20135p expression via the c-Src\/FAK signaling pathway in rheumatoid arthritis. Cells 10, 2168 (2021).","journal-title":"Cells"},{"key":"76291_CR22","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.humpath.2017.05.002","volume":"65","author":"DA Kerr","year":"2017","unstructured":"Kerr, D. A., Busarla, S., Gimbel, D. C., Sohani, A. R. & Nazarian, R. M. mTOR, VEGF, PDGFR, and c-kit signaling pathway activation in Kaposi sarcoma. Hum. Pathol. 65, 157\u2013165 (2017).","journal-title":"Hum. Pathol."},{"key":"76291_CR23","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.sjbs.2021.10.024","volume":"29","author":"M Khedr","year":"2022","unstructured":"Khedr, M., Barakat, N., Mohey El-Deen, I. & Zahran, F. Impact of preconditioning stem cells with all-trans retinoic acid signaling pathway on cisplatin-induced nephrotoxicity by down-regulation of TGF\u03b21, IL-6, and caspase-3 and up-regulation of HIF1\u03b1 and VEGF. Saudi J. Biol. Sci. 29, 831\u2013839 (2022).","journal-title":"Saudi J. Biol. Sci."},{"key":"76291_CR24","doi-asserted-by":"publisher","first-page":"3522","DOI":"10.4081\/ejh.2022.3522","volume":"66","author":"M Zhang","year":"2022","unstructured":"Zhang, M. et al. VEGF promotes diabetic retinopathy by upregulating the PKC\/ET\/NF-\u03baB\/ICAM-1 signaling pathway. Eur. J. Histochem. 66, 3522 (2022).","journal-title":"Eur. J. Histochem."},{"key":"76291_CR25","doi-asserted-by":"publisher","first-page":"184","DOI":"10.3389\/fcimb.2020.00184","volume":"10","author":"JH Quan","year":"2020","unstructured":"Quan, J. H. et al. VEGF production is regulated by the AKT\/ERK1\/2 signaling pathway and controls the proliferation of Toxoplasma gondii in ARPE-19 cells. Front. Cell Infect. Microbiol. 10, 184 (2020).","journal-title":"Front. Cell Infect. Microbiol."},{"key":"76291_CR26","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.placenta.2020.10.005","volume":"103","author":"G Jing","year":"2021","unstructured":"Jing, G. et al. The role of \u03b2-HCG and VEGF-MEK\/ERK signaling pathway in villi angiogenesis in patients with missed abortion. Placenta 103, 16\u201323 (2021).","journal-title":"Placenta"},{"key":"76291_CR27","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1007\/s10637-020-00940-3","volume":"38","author":"BJ Kim","year":"2020","unstructured":"Kim, B. J. et al. Tivantinib inhibits the VEGF signaling pathway and induces apoptosis in gastric cancer cells with c-MET or VEGFA amplification. Invest. New Drugs 38, 1633\u20131640 (2020).","journal-title":"Invest. New Drugs"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76291-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76291-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76291-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T11:06:44Z","timestamp":1729595204000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76291-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["76291"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-76291-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"23 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was in accordance with the Declaration of Helsinki and was approved by the IRB of Jiangxi Provincial People\u2019s Hospital. All methods were performed in accordance with the relevant guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"24865"}}