{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T18:54:18Z","timestamp":1740164058253,"version":"3.37.3"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP22K06815","JP22K11498"],"award-info":[{"award-number":["JP22K06815","JP22K11498"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP21wm0525026"],"award-info":[{"award-number":["JP21wm0525026"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-76762-7","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T08:43:52Z","timestamp":1730105032000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Suppression of Pcdh8\/paraxial protocadherin is required for efficient neighbor exchange in morphogenetic cell movement during zebrafish notochord formation"],"prefix":"10.1038","volume":"14","author":[{"given":"Masatake","family":"Kai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"76762_CR1","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/nrm.2015.14","volume":"17","author":"R Mayor","year":"2016","unstructured":"Mayor, R. & Etienne-Manneville, S. The front and rear of collective cell migration. Nat. Rev. Mol. Cell. Biol.17, 97\u2013109. https:\/\/doi.org\/10.1038\/nrm.2015.14 (2016).","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"76762_CR2","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ceb.2005.08.006","volume":"17","author":"R Keller","year":"2005","unstructured":"Keller, R. Cell migration during gastrulation. Curr. Opin. Cell. Biol.17, 533\u2013541. https:\/\/doi.org\/10.1016\/j.ceb.2005.08.006 (2005).","journal-title":"Curr. Opin. Cell. Biol."},{"key":"76762_CR3","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0070-2153(09)89007-8","volume":"89","author":"C Yin","year":"2009","unstructured":"Yin, C., Ciruna, B. & Solnica-Krezel, L. Convergence and extension movements during vertebrate gastrulation. Curr. Top. Dev. Biol.89, 163\u2013192. https:\/\/doi.org\/10.1016\/S0070-2153(09)89007-8 (2009).","journal-title":"Curr. Top. Dev. Biol."},{"key":"76762_CR4","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1242\/dev.015701","volume":"135","author":"M Hammerschmidt","year":"2008","unstructured":"Hammerschmidt, M. & Wedlich, D. Regulated adhesion as a driving force of gastrulation movements. Development. 135, 3625\u20133641. https:\/\/doi.org\/10.1242\/dev.015701 (2008).","journal-title":"Development"},{"issue":"09","key":"76762_CR5","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/S1937-6448","volume":"278","author":"R Winklbauer","year":"2009","unstructured":"Winklbauer, R. Cell adhesion in amphibian gastrulation. Int. Rev. Cell. Mol. Biol.278 (09), 215\u2013275. https:\/\/doi.org\/10.1016\/S1937-6448 (2009).","journal-title":"Int. Rev. Cell. Mol. Biol."},{"key":"76762_CR6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/s41586-018-0479-2","volume":"561","author":"A Mongera","year":"2018","unstructured":"Mongera, A. et al. A fluid-to-solid jamming transition underlies vertebrate body axis elongation. Nature. 561, 401\u2013405. https:\/\/doi.org\/10.1038\/s41586-018-0479-2 (2018).","journal-title":"Nature"},{"key":"76762_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/1471-213X-7-130","volume":"7","author":"MJ Harrington","year":"2007","unstructured":"Harrington, M. J., Hong, E., Fasanmi, O. & Brewster, R. Cadherin-mediated adhesion regulates posterior body formation. BMC Dev. Biol.7, 130. https:\/\/doi.org\/10.1186\/1471-213X-7-130 (2007).","journal-title":"BMC Dev. Biol."},{"key":"76762_CR8","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.ceb.2007.09.006","volume":"19","author":"H Morishita","year":"2007","unstructured":"Morishita, H. & Yagi, T. Protocadherin family: Diversity, structure, and function. Curr. Opin. Cell. Biol.19, 584\u2013592. https:\/\/doi.org\/10.1016\/j.ceb.2007.09.006 (2007).","journal-title":"Curr. Opin. Cell. Biol."},{"key":"76762_CR9","doi-asserted-by":"publisher","first-page":"4681","DOI":"10.1242\/dev.125.23.4681","volume":"125","author":"SH Kim","year":"1998","unstructured":"Kim, S. H., Yamamoto, A., Bouwmeester, T., Agius, E. & Robertis, E. M. The role of paraxial protocadherin in selective adhesion and cell movements of the mesoderm during Xenopus gastrulation. Development. 125, 4681\u20134690. https:\/\/doi.org\/10.1242\/dev.125.23.4681 (1998).","journal-title":"Development"},{"key":"76762_CR10","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1242\/dev.125.17.3389","volume":"125","author":"A Yamamoto","year":"1998","unstructured":"Yamamoto, A. et al. Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm. Development. 125, 3389\u20133397. https:\/\/doi.org\/10.1242\/dev.125.17.3389 (1998).","journal-title":"Development"},{"key":"76762_CR11","doi-asserted-by":"publisher","first-page":"e0115111","DOI":"10.1371\/journal.pone.0115111","volume":"10","author":"M Kai","year":"2015","unstructured":"Kai, M., Ueno, N. & Kinoshita, N. Phosphorylation-dependent ubiquitination of paraxial protocadherin (PAPC) controls gastrulation cell movements. PLoS One. 10, e0115111. https:\/\/doi.org\/10.1371\/journal.pone.0115111 (2015).","journal-title":"PLoS One"},{"key":"76762_CR12","doi-asserted-by":"publisher","first-page":"R213","DOI":"10.1016\/j.cub.2005.03.016","volume":"15","author":"L Solnica-Krezel","year":"2005","unstructured":"Solnica-Krezel, L. Conserved patterns of cell movements during vertebrate gastrulation. Curr. Biol.15, R213\u2013228. https:\/\/doi.org\/10.1016\/j.cub.2005.03.016 (2005).","journal-title":"Curr. Biol."},{"key":"76762_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/bs.ctdb.2019.08.001","volume":"136","author":"MLK Williams","year":"2020","unstructured":"Williams, M. L. K. & Solnica-Krezel, L. Cellular and molecular mechanisms of convergence and extension in zebrafish. Curr. Top. Dev. Biol.136, 377\u2013407. https:\/\/doi.org\/10.1016\/bs.ctdb.2019.08.001 (2020).","journal-title":"Curr. Top. Dev. Biol."},{"key":"76762_CR14","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.1038\/sj.emboj.7600329","volume":"23","author":"A Medina","year":"2004","unstructured":"Medina, A., Swain, R. K., Kuerner, K. M. & Steinbeisser, H. Xenopus paraxial protocadherin has signaling functions and is involved in tissue separation. EMBO J.23, 3249\u20133258. https:\/\/doi.org\/10.1038\/sj.emboj.7600329 (2004).","journal-title":"EMBO J."},{"key":"76762_CR15","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1083\/jcb.200602062","volume":"174","author":"X Chen","year":"2006","unstructured":"Chen, X. & Gumbiner, B. M. Paraxial protocadherin mediates cell sorting and tissue morphogenesis by regulating C-cadherin adhesion activity. J. Cell. Biol.174, 301\u2013313. https:\/\/doi.org\/10.1083\/jcb.200602062 (2006).","journal-title":"J. Cell. Biol."},{"key":"76762_CR16","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1038\/sj.emboj.7600332","volume":"23","author":"F Unterseher","year":"2004","unstructured":"Unterseher, F. et al. Paraxial protocadherin coordinates cell polarity during convergent extension via rho A and JNK. EMBO J.23, 3259\u20133269. https:\/\/doi.org\/10.1038\/sj.emboj.7600332 (2004).","journal-title":"EMBO J."},{"key":"76762_CR17","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/embor.2011.240","volume":"13","author":"A Kietzmann","year":"2012","unstructured":"Kietzmann, A., Wang, Y., Weber, D. & Steinbeisser, H. Xenopus paraxial protocadherin inhibits Wnt\/\u03b2-catenin signalling via casein kinase 2\u03b2. EMBO Rep.13, 129\u2013134. https:\/\/doi.org\/10.1038\/embor.2011.240 (2012).","journal-title":"EMBO Rep."},{"key":"76762_CR18","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1101\/gad.452908","volume":"22","author":"Y Wang","year":"2008","unstructured":"Wang, Y. et al. Xenopus paraxial protocadherin regulates morphogenesis by antagonizing Sprouty. Genes Dev.22, 878\u2013883. https:\/\/doi.org\/10.1101\/gad.452908 (2008).","journal-title":"Genes Dev."},{"key":"76762_CR19","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.diff.2016.10.002","volume":"93","author":"R Kumar","year":"2017","unstructured":"Kumar, R., Ciprianidis, A., Thei\u00df, S., Steinbei\u00dfer, H. & Kaufmann, L. T. Nemo-like kinase 1 (Nlk1) and paraxial protocadherin (PAPC) cooperatively control Xenopus gastrulation through regulation of Wnt\/planar cell polarity (PCP) signaling. Differentiation. 93, 27\u201338. https:\/\/doi.org\/10.1016\/j.diff.2016.10.002 (2017).","journal-title":"Differentiation"},{"key":"76762_CR20","doi-asserted-by":"publisher","unstructured":"Barua, D., Nagel, M. & Winklbauer, R. Cell-cell contact landscapes in Xenopus gastrula tissues. Proc. Natl. Acad. Sci. U S A. 118https:\/\/doi.org\/10.1073\/pnas.2107953118 (2021).","DOI":"10.1073\/pnas.2107953118"},{"key":"76762_CR21","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.cub.2007.02.013","volume":"17","author":"S von der Hardt","year":"2007","unstructured":"von der Hardt, S. et al. The Bmp gradient of the zebrafish gastrula guides migrating lateral cells by regulating cell-cell adhesion. Curr. Biol.17, 475\u2013487. https:\/\/doi.org\/10.1016\/j.cub.2007.02.013 (2007).","journal-title":"Curr. Biol."},{"key":"76762_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.4161\/cam.5.2.14374","volume":"5","author":"SY Kim","year":"2011","unstructured":"Kim, S. Y., Yasuda, S., Tanaka, H., Yamagata, K. & Kim, H. Non-clustered protocadherin. Cell. Adh Migr.5, 97\u2013105. https:\/\/doi.org\/10.4161\/cam.5.2.14374 (2011).","journal-title":"Cell. Adh Migr."},{"key":"76762_CR23","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.semcdb.2017.07.043","volume":"69","author":"KM Mah","year":"2017","unstructured":"Mah, K. M. & Weiner, J. A. Regulation of wnt signaling by protocadherins. Semin Cell. Dev. Biol.69, 158\u2013171. https:\/\/doi.org\/10.1016\/j.semcdb.2017.07.043 (2017).","journal-title":"Semin Cell. Dev. Biol."},{"key":"76762_CR24","doi-asserted-by":"publisher","unstructured":"Yu, J. S. et al. PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer. Oncogene 27, 4657\u20134665. (2008). https:\/\/doi.org\/10.1038\/onc.2008.101","DOI":"10.1038\/onc.2008.101"},{"key":"76762_CR25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1038\/nprot.2007.514","volume":"3","author":"C Thisse","year":"2008","unstructured":"Thisse, C. & Thisse, B. High-resolution in situ hybridization to whole-mount zebrafish embryos. Nat. Protoc.3, 59\u201369. https:\/\/doi.org\/10.1038\/nprot.2007.514 (2008).","journal-title":"Nat. Protoc."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76762-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76762-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76762-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T09:02:53Z","timestamp":1730106173000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76762-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["76762"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-76762-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"11 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25697"}}