{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T01:26:32Z","timestamp":1785288392099,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-76801-3","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T18:12:46Z","timestamp":1739470366000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Characterization of RNF144B and PPP2R2A identified by a novel approach using TCGA data in ovarian cancer"],"prefix":"10.1038","volume":"15","author":[{"given":"P.","family":"Manasa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Krishnapriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Sidhanth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Vasudevan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Murhekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. S.","family":"Ganesan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"76801_CR1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660","author":"H Sung","year":"2020","unstructured":"Sung, H. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 71 (3):209-249 (2021).","journal-title":"CA Cancer J Clin."},{"issue":"11","key":"76801_CR2","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/nrc4019","volume":"15","author":"DD Bowtell","year":"2015","unstructured":"Bowtell, D. D. et al. Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer. Nat. Rev. Cancer 15(11), 668\u2013679 (2015).","journal-title":"Nat. Rev. Cancer"},{"issue":"9972","key":"76801_CR3","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/S0140-6736(14)62038-9","volume":"385","author":"C Allemani","year":"2015","unstructured":"Allemani, C. et al. Global surveillance of cancer survival 1995\u20132009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2). Lancet 385(9972), 977\u20131010 (2015).","journal-title":"Lancet"},{"issue":"7353","key":"76801_CR4","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/nature10166","volume":"474","author":"Cancer Genome Atlas Research N","year":"2011","unstructured":"Cancer Genome Atlas Research N. Integrated genomic analyses of ovarian carcinoma. Nature 474(7353), 609\u2013615s (2011).","journal-title":"Nature"},{"issue":"11","key":"76801_CR5","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1016\/j.bbamcr.2014.08.001","volume":"1843","author":"O Krijgsman","year":"2014","unstructured":"Krijgsman, O., Carvalho, B., Meijer, G. A., Steenbergen, R. D. & Ylstra, B. Focal chromosomal copy number aberrations in cancer-Needles in a genome haystack. Biochem. Biophys. Acta. 1843(11), 2698\u20132704 (2014).","journal-title":"Biochem. Biophys. Acta."},{"issue":"7696","key":"76801_CR6","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/nature25480","volume":"555","author":"SN Grobner","year":"2018","unstructured":"Grobner, S. N. et al. The landscape of genomic alterations across childhood cancers. Nature 555(7696), 321\u2013327 (2018).","journal-title":"Nature"},{"issue":"3\u20134","key":"76801_CR7","doi-asserted-by":"publisher","first-page":"122","DOI":"10.18632\/genesandcancer.206","volume":"11","author":"P Manasa","year":"2020","unstructured":"Manasa, P., Sidhanth, C., Krishnapriya, S., Vasudevan, S. & Ganesan, T. S. Oncogenes in high grade serous adenocarcinoma of the ovary. Genes Cancer 11(3\u20134), 122\u2013136 (2020).","journal-title":"Genes Cancer"},{"issue":"10","key":"76801_CR8","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1002\/1878-0261.12112","volume":"11","author":"W Zhou","year":"2017","unstructured":"Zhou, W. et al. Identification of driver copy number alterations in diverse cancer types and application in drug repositioning. Mol. Oncol. 11(10), 1459\u20131474 (2017).","journal-title":"Mol. Oncol."},{"issue":"6","key":"76801_CR9","doi-asserted-by":"publisher","first-page":"e2114162","DOI":"10.1001\/jamanetworkopen.2021.14162","volume":"4","author":"RP Graf","year":"2021","unstructured":"Graf, R. P., Eskander, R., Brueggeman, L. & Stupack, D. G. Association of copy number variation signature and survival in patients with serous ovarian cancer. JAMA Netw. Open 4(6), e2114162 (2021).","journal-title":"JAMA Netw. Open"},{"key":"76801_CR10","doi-asserted-by":"publisher","first-page":"854190","DOI":"10.3389\/fgene.2022.854190","volume":"13","author":"M Sudhakar","year":"2022","unstructured":"Sudhakar, M., Rengaswamy, R. & Raman, K. Multi-omic data improve prediction of personalized tumor suppressors and oncogenes. Front. Genet. 13, 854190 (2022).","journal-title":"Front. Genet."},{"issue":"5","key":"76801_CR11","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","volume":"2","author":"E Cerami","year":"2012","unstructured":"Cerami, E. et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2(5), 401\u2013404 (2012).","journal-title":"Cancer Discov."},{"issue":"6127","key":"76801_CR12","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1126\/science.1235122","volume":"339","author":"B Vogelstein","year":"2013","unstructured":"Vogelstein, B. et al. Cancer genome landscapes. Science 339(6127), 1546\u20131558 (2013).","journal-title":"Science"},{"issue":"5853","key":"76801_CR13","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1126\/science.1145720","volume":"318","author":"LD Wood","year":"2007","unstructured":"Wood, L. D. et al. The genomic landscapes of human breast and colorectal cancers. Science 318(5853), 1108\u20131113 (2007).","journal-title":"Science"},{"issue":"1","key":"76801_CR14","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/s42003-022-03796-w","volume":"5","author":"G Perron","year":"2022","unstructured":"Perron, G. et al. Pan-cancer analysis of mRNA stability for decoding tumour post-transcriptional programs. Commun. Biol. 5(1), 851 (2022).","journal-title":"Commun. Biol."},{"issue":"Suppl 5","key":"76801_CR15","first-page":"918","volume":"22","author":"PW Wang","year":"2022","unstructured":"Wang, P. W., Su, Y. H., Chou, P. H., Huang, M. Y. & Chen, T. W. Survival-related genes are diversified across cancers but generally enriched in cancer hallmark pathways. BMC Genomics 22(Suppl 5), 918 (2022).","journal-title":"BMC Genomics"},{"issue":"2","key":"76801_CR16","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1006\/excr.1995.1184","volume":"218","author":"SW Tsao","year":"1995","unstructured":"Tsao, S. W. et al. Characterization of human ovarian surface epithelial cells immortalized by human papilloma viral oncogenes (HPV-E6E7 ORFs). Exp. Cell Res. 218(2), 499\u2013507 (1995).","journal-title":"Exp. Cell Res."},{"issue":"9","key":"76801_CR17","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1038\/nprot.2012.097","volume":"7","author":"AM Karst","year":"2012","unstructured":"Karst, A. M. & Drapkin, R. Primary culture and immortalization of human fallopian tube secretory epithelial cells. Nat. Protoc. 7(9), 1755\u20131764 (2012).","journal-title":"Nat. Protoc."},{"issue":"40","key":"76801_CR18","doi-asserted-by":"publisher","first-page":"4758","DOI":"10.1038\/onc.2012.497","volume":"32","author":"F Conforti","year":"2013","unstructured":"Conforti, F. et al. PIR2\/Rnf144B regulates epithelial homeostasis by mediating degradation of p21WAF1 and p63. Oncogene 32(40), 4758\u20134765 (2013).","journal-title":"Oncogene"},{"issue":"24","key":"76801_CR19","doi-asserted-by":"publisher","first-page":"6414","DOI":"10.1158\/0008-5472.CAN-12-1667","volume":"72","author":"P Kalev","year":"2012","unstructured":"Kalev, P. et al. Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition. Cancer Res. 72(24), 6414\u20136424 (2012).","journal-title":"Cancer Res."},{"issue":"1","key":"76801_CR20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1042\/BCJ20210173","volume":"479","author":"C Sidhanth","year":"2022","unstructured":"Sidhanth, C. et al. LASP-1 interacts with ErbB2 in ovarian cancer cells. Biochem. J. 479(1), 23\u201338 (2022).","journal-title":"Biochem. J."},{"issue":"4","key":"76801_CR21","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s13402-020-00504-w","volume":"43","author":"S Sneha","year":"2020","unstructured":"Sneha, S. et al. The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary. Cell. Oncol. 43(4), 601\u2013616 (2020).","journal-title":"Cell. Oncol."},{"issue":"1","key":"76801_CR22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s10147-016-1033-6","volume":"22","author":"S Krishna Priya","year":"2017","unstructured":"Krishna Priya, S. et al. Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance. Int. J. Clin. Oncol. 22(1), 107\u2013117 (2017).","journal-title":"Int. J. Clin. Oncol."},{"issue":"3","key":"76801_CR23","first-page":"397","volume":"28","author":"RP Nagare","year":"2020","unstructured":"Nagare, R. P. et al. Expression of cancer stem cell markers CD24, EPHA1 and CD9 and their correlation with clinical outcome in epithelial ovarian tumours. Cancer Biomark. Sect. A Dis. Markers 28(3), 397\u2013408 (2020).","journal-title":"Cancer Biomark. Sect. A Dis. Markers"},{"issue":"4","key":"76801_CR24","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/gb-2011-12-4-r41","volume":"12","author":"CH Mermel","year":"2011","unstructured":"Mermel, C. H. et al. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 12(4), 41 (2011).","journal-title":"Genome Biol."},{"issue":"5","key":"76801_CR25","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1007\/s10565-021-09609-w","volume":"38","author":"Y Li","year":"2022","unstructured":"Li, Y. et al. RNF144A suppresses ovarian cancer stem cell properties and tumor progression through regulation of LIN28B degradation via the ubiquitin-proteasome pathway. Cell Biol. Toxicol. 38(5), 809\u2013824 (2022).","journal-title":"Cell Biol. Toxicol."},{"issue":"8","key":"76801_CR26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1007\/s12032-024-02395-5","volume":"41","author":"F Wang","year":"2024","unstructured":"Wang, F. et al. PARK2 suppresses the proliferation of high-grade serous ovarian carcinoma via inducing the proteasomal degradation of ZNF703. Med Oncol 41(8), 207 (2024).","journal-title":"Med Oncol"},{"issue":"269","key":"76801_CR27","doi-asserted-by":"publisher","first-page":"pl1","DOI":"10.1126\/scisignal.2004088","volume":"6","author":"J Gao","year":"2013","unstructured":"Gao, J. et al. Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci. Signal. 6(269), pl1 (2013).","journal-title":"Sci. Signal."},{"issue":"1","key":"76801_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1476-5586(04)80047-2","volume":"6","author":"DR Rhodes","year":"2004","unstructured":"Rhodes, D. R. et al. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 6(1), 1\u20136 (2004).","journal-title":"Neoplasia"},{"key":"76801_CR29","doi-asserted-by":"publisher","first-page":"100850","DOI":"10.1016\/j.gore.2021.100850","volume":"37","author":"B Margolis","year":"2021","unstructured":"Margolis, B. et al. CCNE1 amplification among metastatic sites in patients with gynecologic high-grade serous carcinoma. Gynecol. Oncol. Rep. 37, 100850 (2021).","journal-title":"Gynecol. Oncol. Rep."},{"issue":"3","key":"76801_CR30","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.ygyno.2014.09.014","volume":"135","author":"E Despierre","year":"2014","unstructured":"Despierre, E. et al. Somatic copy number alterations predict response to platinum therapy in epithelial ovarian cancer. Gynecol. Oncol. 135(3), 415\u2013422 (2014).","journal-title":"Gynecol. Oncol."},{"issue":"5","key":"76801_CR31","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/s41419-018-0521-1","volume":"9","author":"Q Zhou","year":"2018","unstructured":"Zhou, Q. et al. Pir2\/Rnf144b is a potential endometrial cancer biomarker that promotes cell proliferation. Cell death Dis. 9(5), 504 (2018).","journal-title":"Cell death Dis."},{"issue":"3","key":"76801_CR32","first-page":"1007","volume":"24","author":"CB Wang","year":"2020","unstructured":"Wang, C. B., Wang, Y., Wang, J. J. & Guo, X. L. LINC00662 triggers malignant progression of chordoma by the activation of RNF144B via targeting miR-16-5p. Eur. Rev. Med. Pharmacol. Sci. 24(3), 1007\u20131022 (2020).","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"issue":"1","key":"76801_CR33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/s41392-020-0107-0","volume":"5","author":"L Deng","year":"2020","unstructured":"Deng, L., Meng, T., Chen, L., Wei, W. & Wang, P. The role of ubiquitination in tumorigenesis and targeted drug discovery. Sig. Transduct. Target. Ther. 5(1), 11 (2020).","journal-title":"Sig. Transduct. Target. Ther."},{"issue":"4","key":"76801_CR34","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1007\/s10555-017-9703-z","volume":"36","author":"D Wang","year":"2017","unstructured":"Wang, D., Ma, L., Wang, B., Liu, J. & Wei, W. E3 ubiquitin ligases in cancer and implications for therapies. Cancer Metastasis Rev. 36(4), 683\u2013702 (2017).","journal-title":"Cancer Metastasis Rev."},{"issue":"3","key":"76801_CR35","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/bjc.1995.367","volume":"72","author":"AN Shelling","year":"1995","unstructured":"Shelling, A. N., Cooke, I. E. & Ganesan, T. S. The genetic analysis of ovarian cancer. Br. J. Cancer 72(3), 521\u2013527 (1995).","journal-title":"Br. J. Cancer"},{"issue":"1","key":"76801_CR36","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0165-4608(01)00419-8","volume":"129","author":"I Pribill","year":"2001","unstructured":"Pribill, I. et al. High frequency of allelic imbalance at regions of chromosome arm 8p in ovarian carcinoma. Cancer Genet. Cytogenet. 129(1), 23\u201329 (2001).","journal-title":"Cancer Genet. Cytogenet."},{"issue":"2","key":"76801_CR37","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/sj.bjc.6600674","volume":"88","author":"J Lai","year":"2003","unstructured":"Lai, J., Flanagan, J., Phillips, W. A., Chenevix-Trench, G. & Arnold, J. Analysis of the candidate 8p21 tumour suppressor, BNIP3L, in breast and ovarian cancer. Br. J. Cancer 88(2), 270\u2013276 (2003).","journal-title":"Br. J. Cancer"},{"issue":"7","key":"76801_CR38","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.cancergen.2011.05.002","volume":"204","author":"Y Cheng","year":"2011","unstructured":"Cheng, Y. et al. Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study. Cancer Genet. 204(7), 375\u2013381 (2011).","journal-title":"Cancer Genet."},{"issue":"3","key":"76801_CR39","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1111\/jcmm.12760","volume":"20","author":"LP Zeng","year":"2016","unstructured":"Zeng, L. P., Hu, Z. M., Li, K. & Xia, K. miR-222 attenuates cisplatin-induced cell death by targeting the PPP2R2A\/Akt\/mTOR Axis in bladder cancer cells. J. Cell. Mol. Med. 20(3), 559\u2013567 (2016).","journal-title":"J. Cell. Mol. Med."},{"issue":"9","key":"76801_CR40","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1089\/thy.2017.0665","volume":"28","author":"Y Huang","year":"2018","unstructured":"Huang, Y. et al. MicroRNA-222 promotes invasion and metastasis of papillary thyroid cancer through targeting protein phosphatase 2 regulatory subunit B alpha expression. Thyroid\u202f: Off. J. Am. Thyroid Assoc. 28(9), 1162\u20131173 (2018).","journal-title":"Thyroid : Off. J. Am. Thyroid Assoc."},{"issue":"12","key":"76801_CR41","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.1016\/j.celrep.2017.02.081","volume":"18","author":"G Di Conza","year":"2017","unstructured":"Di Conza, G., Trusso Cafarello, S., Zheng, X., Zhang, Q. & Mazzone, M. PHD2 targeting overcomes breast cancer cell death upon glucose starvation in a PP2A\/B55alpha-mediated manner. Cell Rep. 18(12), 2836\u20132844 (2017).","journal-title":"Cell Rep."},{"issue":"12","key":"76801_CR42","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/s41389-019-0180-9","volume":"8","author":"Z Zhao","year":"2019","unstructured":"Zhao, Z. et al. PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55alpha\/PP2A reconstitution that triggers centrosome destabilization. Oncogenesis 8(12), 72 (2019).","journal-title":"Oncogenesis"},{"issue":"4","key":"76801_CR43","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1158\/1535-7163.MCT-13-0150","volume":"13","author":"I Cristobal","year":"2014","unstructured":"Cristobal, I. et al. PP2A inhibition is a common event in colorectal cancer and its restoration using FTY720 shows promising therapeutic potential. Mol. Cancer Ther. 13(4), 938\u2013947 (2014).","journal-title":"Mol. Cancer Ther."},{"issue":"3","key":"76801_CR44","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3109\/10409238.2016.1143913","volume":"51","author":"N Wlodarchak","year":"2016","unstructured":"Wlodarchak, N. & Xing, Y. PP2A as a master regulator of the cell cycle. Crit. Rev. Biochem. Mol. Boil. 51(3), 162\u2013184 (2016).","journal-title":"Crit. Rev. Biochem. Mol. Boil."},{"issue":"16","key":"76801_CR45","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1158\/0008-5472.CAN-20-0057","volume":"80","author":"Z Qiu","year":"2020","unstructured":"Qiu, Z. et al. A genome-wide pooled shRNA screen identifies PPP2R2A as a predictive biomarker for the response to ATR and CHK1 inhibitors. Cancer Res. 80(16), 3305\u20133318 (2020).","journal-title":"Cancer Res."},{"issue":"5","key":"76801_CR46","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1158\/1535-7163.MCT-21-0880","volume":"22","author":"RA Avelar","year":"2023","unstructured":"Avelar, R. A. et al. Small-molecule-mediated stabilization of PP2A modulates the homologous recombination pathway and potentiates DNA damage-induced cell death. Mol. Cancer Ther. 22(5), 599\u2013615 (2023).","journal-title":"Mol. Cancer Ther."},{"issue":"6","key":"76801_CR47","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1158\/1535-7163.MCT-15-0039","volume":"14","author":"SJ Davis","year":"2015","unstructured":"Davis, S. J. et al. Enhanced GAB2 expression is associated with improved survival in high-grade serous ovarian cancer and sensitivity to PI3K inhibition. Mol. cancer Ther. 14(6), 1495\u20131503 (2015).","journal-title":"Mol. cancer Ther."},{"key":"76801_CR48","doi-asserted-by":"publisher","first-page":"102277","DOI":"10.1016\/j.tice.2023.102277","volume":"86","author":"H Zhuang","year":"2024","unstructured":"Zhuang, H., Zhang, Z., Wang, W. & Qu, H. RNF144B-mediated p21 degradation regulated by HDAC3 contribute to enhancing ovarian cancer growth and metastasis. Tissue Cell 86, 102277 (2024).","journal-title":"Tissue Cell"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76801-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76801-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76801-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T18:12:49Z","timestamp":1739470369000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76801-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["76801"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-76801-3","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"assertion":[{"value":"16 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5414"}}