{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T17:44:54Z","timestamp":1791481494402,"version":"4.3.4"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Sichuan Provincial Department of Science and Technology","doi-asserted-by":"crossref","award":["2022YFS0331"],"award-info":[{"award-number":["2022YFS0331"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-76825-9","type":"journal-article","created":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T09:03:17Z","timestamp":1730365397000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Resveratrol improved mitochondrial biogenesis by activating SIRT1\/PGC-1\u03b1 signal pathway in SAP"],"prefix":"10.1038","volume":"14","author":[{"given":"Shu-kun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"issue":"4","key":"76825_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1001\/jama.2020.20317","volume":"325","author":"MA Mederos","year":"2021","unstructured":"Mederos, M. A., Reber, H. A. & Girgis, M. D. Acute pancreatitis: a review. JAMA. 325 (4), 382\u2013390 (2021).","journal-title":"JAMA"},{"issue":"9988","key":"76825_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0140-6736(14)60649-8","volume":"386","author":"PG Lankisch","year":"2015","unstructured":"Lankisch, P. G., Apte, M. & Banks, P. A. Acute pancreatitis. Lancet. 386 (9988), 85\u201396 (2015).","journal-title":"Lancet"},{"issue":"4","key":"76825_CR3","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1159\/000506830","volume":"102","author":"N Gliem","year":"2021","unstructured":"Gliem, N., Ammer-Herrmenau, C., Ellenrieder, V. & Neesse, A. Management of severe acute pancreatitis: an update. Digestion. 102 (4), 503\u2013507 (2021).","journal-title":"Digestion"},{"issue":"38","key":"76825_CR4","doi-asserted-by":"publisher","first-page":"13879","DOI":"10.3748\/wjg.v20.i38.13879","volume":"20","author":"E Zerem","year":"2014","unstructured":"Zerem, E. Treatment of severe acute pancreatitis and its complications. World J. Gastroenterol. 20 (38), 13879\u201313892 (2014).","journal-title":"World J. Gastroenterol."},{"key":"76825_CR5","doi-asserted-by":"publisher","first-page":"l6227","DOI":"10.1136\/bmj.l6227","volume":"367","author":"OJ Hines","year":"2019","unstructured":"Hines, O. J. & Pandol, S. J. Management of severe acute pancreatitis. BMJ. 367, l6227. https:\/\/doi.org\/10.1136\/bmj.l6227 (2019).","journal-title":"BMJ"},{"issue":"17","key":"76825_CR6","doi-asserted-by":"publisher","first-page":"3533","DOI":"10.1111\/bph.15499","volume":"178","author":"L Gao","year":"2021","unstructured":"Gao, L. et al. Acinar cell NLRP3 inflammasome and gasdermin D (GSDMD) activation mediates pyroptosis and systemic inflammation in acute pancreatitis. Br. J. Pharmacol. 178 (17), 3533\u20133552 (2021).","journal-title":"Br. J. Pharmacol."},{"issue":"Pt A","key":"76825_CR7","doi-asserted-by":"publisher","first-page":"110950","DOI":"10.1016\/j.intimp.2023.110950","volume":"125","author":"Y Lu","year":"2023","unstructured":"Lu, Y. et al. HDL inhibits pancreatic acinar cell NLRP3 inflammasome activation and protect against acinar cell pyroptosis in acute pancreatitis. Int. Immunopharmacol. 125 (Pt A), 110950 (2023).","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"76825_CR8","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1038\/s42255-023-00783-1","volume":"5","author":"AS Monzel","year":"2023","unstructured":"Monzel, A. S., Enr\u00edquez, J. A. & Picard, M. Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction. Nat. Metab. 5 (4), 546\u2013562 (2023).","journal-title":"Nat. Metab."},{"key":"76825_CR9","doi-asserted-by":"publisher","first-page":"1125866","DOI":"10.3389\/fphar.2023.1125866","volume":"14","author":"Y Zhang","year":"2023","unstructured":"Zhang, Y. et al. ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock. Front. Pharmacol. 14, 1125866 (2023).","journal-title":"Front. Pharmacol."},{"issue":"1","key":"76825_CR10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1002\/path.5166","volume":"247","author":"S P\u00e9rez","year":"2019","unstructured":"P\u00e9rez, S. et al. Obesity causes PGC-1\u03b1 deficiency in the pancreas leading to marked IL-6 upregulation via NF-\u03baB in acute pancreatitis. J. Pathol. 247 (1), 48\u201359 (2019).","journal-title":"J. Pathol."},{"issue":"1","key":"76825_CR11","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/bjs.10978","volume":"106","author":"A Budai","year":"2019","unstructured":"Budai, A. et al. Mitochondrial function after associating liver partition and portal vein ligation for staged hepatectomy in an experimental model. Br. J. Surg. 106 (1), 120\u2013131 (2019).","journal-title":"Br. J. Surg."},{"issue":"35","key":"76825_CR12","doi-asserted-by":"publisher","first-page":"9377","DOI":"10.1021\/acs.jafc.0c03310","volume":"68","author":"YZ Dong","year":"2020","unstructured":"Dong, Y. Z., Li, L., Espe, M., Lu, K. L. & Rahimnejad, S. Hydroxytyrosol attenuates hepatic Fat Accumulation via activating mitochondrial Biogenesis and Autophagy through the AMPK pathway. J. Agric. Food Chem. 68 (35), 9377\u20139386 (2020).","journal-title":"J. Agric. Food Chem."},{"key":"76825_CR13","doi-asserted-by":"crossref","unstructured":"Chen, J.-W., et al. mito-TEMPO attenuates oxidative stress and mitochondrial dysfunction in noise-Induced hearing loss via maintaining TFAM-mtDNA Interaction and mitochondrial Biogenesis. Front. Cell. Neurosci. 8, 16803718 (2022).","DOI":"10.3389\/fncel.2022.803718"},{"key":"76825_CR14","doi-asserted-by":"crossref","unstructured":"Malaguarnera Influence of Resveratrol on the Immune response. Nutrients. 11 (5), 946 (2019).","DOI":"10.3390\/nu11050946"},{"issue":"1","key":"76825_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12868-023-00797-1","volume":"24","author":"M Yang","year":"2023","unstructured":"Yang, M. et al. Protective effect of resveratrol on mitochondrial biogenesis during hyperoxia-induced brain injury in neonatal pups. BMC Neurosci. 24 (1), 27 (2023).","journal-title":"BMC Neurosci."},{"issue":"2","key":"76825_CR16","first-page":"428","volume":"166","author":"J Ghosh","year":"2018","unstructured":"Ghosh, J. et al. Cigarette smoke toxins-Induced mitochondrial dysfunction and pancreatitis involves aryl hydrocarbon receptor mediated Cyp1 gene expression: Protective effects of Resveratrol. Toxicol. Sci. 166 (2), 428\u2013440 (2018).","journal-title":"Toxicol. Sci."},{"issue":"1","key":"76825_CR17","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1007\/s10620-022-07497-6","volume":"68","author":"Q Song","year":"2023","unstructured":"Song, Q. et al. Gabexate mesylate-poloxamer 407 conjugate alleviates sodium taurocholate-induced severe acute pancreatitis in an optimized rat model. Dig. Dis. Sci. 68 (1), 138\u2013146 (2023).","journal-title":"Dig. Dis. Sci."},{"issue":"4","key":"76825_CR18","first-page":"325","volume":"46","author":"DL Liu","year":"2020","unstructured":"Liu, D. L., Song, G. D., Ma, Z. L. & Song, Z. S. Efficacy of resveratrol in treating rat models with severe acute pancreatitis. Jiangsu Med. J. 46 (4), 325\u2013328 (2020).","journal-title":"Jiangsu Med. J."},{"key":"76825_CR19","doi-asserted-by":"publisher","first-page":"8891544","DOI":"10.1155\/2021\/8891544","volume":"2021","author":"Y Rong","year":"2021","unstructured":"Rong, Y. et al. Resveratrol suppresses severe Acute Pancreatitis-Induced Microcirculation disturbance through Targeting SIRT1-FOXO1 Axis. Oxid. Med. Cell. Longev. 2021, 8891544 (2021).","journal-title":"Oxid. Med. Cell. Longev."},{"key":"76825_CR20","doi-asserted-by":"publisher","first-page":"e40160","DOI":"10.1371\/journal.pone.0040160","volume":"7","author":"J Wang","year":"2012","unstructured":"Wang, J. et al. Amelioration of experimental acute pancreatitis with Dachengqi Decoction via regulation of necrosis-apoptosis switch in the pancreatic acinar cell. PLoS One. 7, e40160 (2012).","journal-title":"PLoS One"},{"key":"76825_CR21","doi-asserted-by":"publisher","unstructured":"Changsheng, Y. Endoplasmic reticulum stress promotes caspase-1-dependent acinar cell pyroptosis through the PERK pathway to aggravate acute pancreatitis. Int. Immunopharmacol. 120, 110293. https:\/\/doi.org\/10.1016\/j.intimp.2023.110293 (2023).","DOI":"10.1016\/j.intimp.2023.110293"},{"issue":"12","key":"76825_CR22","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1111\/jcmm.12928","volume":"20","author":"L Ji","year":"2016","unstructured":"Ji, L. et al. Hydrogen sulphide exacerbates acute pancreatitis by over-activating autophagy via AMPK\/mTOR pathway. J. Cell. Mol. Med. 20 (12), 2349\u20132461 (2016).","journal-title":"J. Cell. Mol. Med."},{"key":"76825_CR23","first-page":"636","volume":"43","author":"L Ji","year":"2019","unstructured":"Ji, L. et al. Hypoxia-inducible factor-1\u03b1 knockdown plus glutamine supplementation attenuates the predominance of necrosis over apoptosis by relieving cellular energy stress in acute pancreatitis. Oxid. Med. Cell. Longev. 43, 636\u2013672 (2019).","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"76825_CR24","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.abb.2009.12.019","volume":"495","author":"H Sebai","year":"2010","unstructured":"Sebai, H. et al. Protective effect of resveratrol against LPS-induced extracellular lipoperoxidation in AR42J cells partly via a Myd88-dependent signaling pathway. Arch. Biochem. Biophys. 495 (1), 56\u201361 (2010).","journal-title":"Arch. Biochem. Biophys."},{"key":"76825_CR25","doi-asserted-by":"crossref","unstructured":"Li, Y. Deoxyarbutin attenuates severe acute pancreatitis via the HtrA2\/PGC-1\u03b1 pathway. Free Radic. Res. ;56(9\u201310), 651\u2013665 (2022).","DOI":"10.1080\/10715762.2022.2163244"},{"issue":"7717","key":"76825_CR26","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","volume":"560","author":"Z Zhong","year":"2018","unstructured":"Zhong, Z. et al. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 560 (7717), 198\u2013203 (2018).","journal-title":"Nature"},{"issue":"9","key":"76825_CR27","doi-asserted-by":"publisher","first-page":"e148852","DOI":"10.1172\/JCI148852","volume":"132","author":"Y Huang","year":"2022","unstructured":"Huang, Y. et al. Brown adipose TRX2 deficiency activates mtDNA-NLRP3 to impair thermogenesis and protect against diet-induced insulin resistance. J. Clin. Investig. 132 (9), e148852 (2022).","journal-title":"J. Clin. Investig."},{"issue":"4","key":"76825_CR28","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1159\/000513884","volume":"7","author":"M Jiang","year":"2021","unstructured":"Jiang, M. et al. SIRT1 alleviates aldosterone-induced podocyte injury by suppressing mitochondrial dysfunction and NLRP3 inflammasome activation. Kidney Dis. (Basel). 7 (4), 293\u2013305 (2021).","journal-title":"Kidney Dis. (Basel)"},{"key":"76825_CR29","doi-asserted-by":"publisher","first-page":"3129","DOI":"10.2147\/JIR.S306456","volume":"14","author":"W Wan","year":"2021","unstructured":"Wan, W. et al. Grape seed proanthocyanidin extract moderated retinal pigment epithelium cellular senescence through NAMPT\/SIRT1\/NLRP3 pathway. J. Inflamm. Res. 14, 3129\u20133143 (2021).","journal-title":"J. Inflamm. Res."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76825-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76825-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76825-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T09:10:47Z","timestamp":1730365847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76825-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["76825"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-76825-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"8 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"We are willing to pay the page charges if accepted for publication and the study are reported in accordance with ARRIVE guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement"}}],"article-number":"26216"}}