{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:59:45Z","timestamp":1789761585007,"version":"4.0.1"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T00:00:00Z","timestamp":1729900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2023JJ41005"],"award-info":[{"award-number":["2023JJ41005"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["HNA202101028"],"award-info":[{"award-number":["HNA202101028"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2009800"],"award-info":[{"award-number":["2022YFC2009800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82172145"],"award-info":[{"award-number":["82172145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82202421"],"award-info":[{"award-number":["82202421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-76979-6","type":"journal-article","created":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T16:01:53Z","timestamp":1729958513000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["NSE and S100\u03b2 as serum alarmins in predicting neurological outcomes after cardiac arrest"],"prefix":"10.1038","volume":"14","author":[{"given":"Jiyun","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shucai","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,26]]},"reference":[{"issue":"10","key":"76979_CR1","doi-asserted-by":"publisher","first-page":"e146","DOI":"10.1161\/cir.0000000000000485","volume":"135","author":"EJ Benjamin","year":"2017","unstructured":"Benjamin, E. J. et al. Heart Disease and Stroke Statistics-2017 update: A report from the American Heart Association. Circulation. 135 (10), e146\u2013e603. https:\/\/doi.org\/10.1161\/cir.0000000000000485 (2017).","journal-title":"Circulation"},{"issue":"12","key":"76979_CR2","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1001\/jama.2019.1696","volume":"321","author":"LW Andersen","year":"2019","unstructured":"Andersen, L. W. et al. In-Hospital cardiac arrest: A review. Jama. 321 (12), 1200\u20131210. https:\/\/doi.org\/10.1001\/jama.2019.1696 (2019).","journal-title":"Jama"},{"key":"76979_CR3","doi-asserted-by":"publisher","unstructured":"Geocadin, R. G. et al. Standards for Studies of Neurological Prognostication in Comatose Survivors of Cardiac Arrest: A Scientific Statement From the American Heart Association. Circulation 140(9), e517\u2013e542. https:\/\/doi.org\/10.1161\/cir.0000000000000702 (2019).","DOI":"10.1161\/cir.0000000000000702"},{"issue":"8","key":"76979_CR4","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1056\/NEJMoa012689","volume":"346","author":"The Hypothermia after Cardiac Arrest Study Group","year":"2002","unstructured":"The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N. Engl. J. Med. 346(8), 549\u2013556. https:\/\/doi.org\/10.1056\/NEJMoa012689 (2002).","journal-title":"N. Engl. J. Med."},{"key":"76979_CR5","doi-asserted-by":"publisher","first-page":"109671","DOI":"10.1016\/j.resuscitation.2022.12.009","volume":"182","author":"CN Justice","year":"2023","unstructured":"Justice, C. N. et al. Extracorporeal cardiopulmonary resuscitation (eCPR) and cerebral perfusion: A narrative review. Resuscitation. 182, 109671. https:\/\/doi.org\/10.1016\/j.resuscitation.2022.12.009 (2023).","journal-title":"Resuscitation"},{"key":"76979_CR6","doi-asserted-by":"publisher","first-page":"109823","DOI":"10.1016\/j.resuscitation.2023.109823","volume":"188","author":"PJ Coppler","year":"2023","unstructured":"Coppler, P. J. et al. Duration of cardiopulmonary resuscitation and phenotype of post-cardiac arrest brain injury. Resuscitation. 188, 109823. https:\/\/doi.org\/10.1016\/j.resuscitation.2023.109823 (2023).","journal-title":"Resuscitation"},{"key":"76979_CR7","doi-asserted-by":"publisher","unstructured":"Safar, P. et al. Cerebral resuscitation potentials for cardiac arrest. Crit. Care Med. 30(4 Suppl). https:\/\/doi.org\/10.1097\/00003246-200204001-00004 (2002). S140-4.","DOI":"10.1097\/00003246-200204001-00004"},{"key":"76979_CR8","doi-asserted-by":"publisher","unstructured":"Graham, K. J. et al. Has the time come for a national cardiovascular emergency care system? Circulation 125(16), 2035\u20132044. https:\/\/doi.org\/10.1161\/circulationaha.111.084509 (2012).","DOI":"10.1161\/circulationaha.111.084509"},{"key":"76979_CR9","doi-asserted-by":"publisher","unstructured":"Ryczek, R. et al. Neuron-Specific Enolase and S100B: the earliest predictors of poor outcome in Cardiac arrest. J. Clin. Med. 11(9). https:\/\/doi.org\/10.3390\/jcm11092344 (2022).","DOI":"10.3390\/jcm11092344"},{"issue":"9","key":"76979_CR10","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1007\/s00134-021-06481-4","volume":"47","author":"M Moseby-Knappe","year":"2021","unstructured":"Moseby-Knappe, M. et al. Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest. Intensive Care Med. 47(9), 984\u2013994. https:\/\/doi.org\/10.1007\/s00134-021-06481-4 (2021).","journal-title":"Intensive Care Med."},{"issue":"1","key":"76979_CR11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s13054-022-03913-5","volume":"26","author":"J Humaloja","year":"2022","unstructured":"Humaloja, J., Ashton, N. J. & Skrifvars, M. B. Brain Injury biomarkers for predicting outcome after cardiac arrest. Crit. Care. 26 (1), 81. https:\/\/doi.org\/10.1186\/s13054-022-03913-5 (2022).","journal-title":"Crit. Care"},{"key":"76979_CR12","doi-asserted-by":"publisher","first-page":"111857","DOI":"10.1016\/j.intimp.2024.111857","volume":"131","author":"J Hu","year":"2024","unstructured":"Hu, J. et al. Meta-analysis of evaluating neuron specific enolase as a serum biomarker for sepsis-associated encephalopathy. Int. Immunopharmacol. 131, 111857. https:\/\/doi.org\/10.1016\/j.intimp.2024.111857 (2024).","journal-title":"Int. Immunopharmacol."},{"key":"76979_CR13","doi-asserted-by":"publisher","first-page":"1102126","DOI":"10.3389\/fimmu.2023.1102126","volume":"14","author":"J Hu","year":"2023","unstructured":"Hu, J. et al. Diagnostic and prognostic value of serum S100B in sepsis-associated encephalopathy: A systematic review and meta-analysis. Front. Immunol. 14, 1102126. https:\/\/doi.org\/10.3389\/fimmu.2023.1102126 (2023).","journal-title":"Front. Immunol."},{"key":"76979_CR14","doi-asserted-by":"publisher","unstructured":"Nolan, J. P., Soar, J., Cariou, A. & European Resuscitation Council and European Society of Intensive Care Medicine Guidelines for Post-resuscitation Care. : Sect.\u00a05 of the European Resuscitation Council Guidelines for Resuscitation 2015. Resuscitation 95, 202\u2013222. https:\/\/doi.org\/10.1016\/j.resuscitation.2015.07.018 (2015).","DOI":"10.1016\/j.resuscitation.2015.07.018"},{"key":"76979_CR15","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.resuscitation.2020.01.006","volume":"148","author":"CH Wang","year":"2020","unstructured":"Wang, C. H. et al. Neuroprognostic accuracy of blood biomarkers for post-cardiac arrest patients: A systematic review and meta-analysis. Resuscitation 148, 108\u2013117. https:\/\/doi.org\/10.1016\/j.resuscitation.2020.01.006 (2020).","journal-title":"Resuscitation"},{"issue":"4","key":"76979_CR16","doi-asserted-by":"publisher","first-page":"e13759","DOI":"10.1111\/ijcp.13759","volume":"75","author":"L Du","year":"2021","unstructured":"Du, L. et al. The first national survey on practices of neurological prognostication after cardiac arrest in China, still a lot to do. Int. J. Clin. Pract. 75(4), e13759. https:\/\/doi.org\/10.1111\/ijcp.13759 (2021).","journal-title":"Int. J. Clin. Pract."},{"issue":"4","key":"76979_CR17","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s00134-021-06368-4","volume":"47","author":"JP Nolan","year":"2021","unstructured":"Nolan, J. P. et al. European Resuscitation Council and European Society of Intensive Care Medicine guidelines 2021: Post-resuscitation care. Intensive Care Med. 47(4), 369\u2013421. https:\/\/doi.org\/10.1007\/s00134-021-06368-4 (2021).","journal-title":"Intensive Care Med."},{"key":"76979_CR18","doi-asserted-by":"publisher","first-page":"c332","DOI":"10.1136\/bmj.c332","volume":"340","author":"KF Schulz","year":"2010","unstructured":"Schulz, K. F., Altman, D. G. & Moher, D. CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trials. BMJ 340, c332. https:\/\/doi.org\/10.1136\/bmj.c332 (2010).","journal-title":"BMJ"},{"key":"76979_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.resuscitation.2021.12.022","volume":"172","author":"MMJ Nassal","year":"2022","unstructured":"Nassal, M. M. J. et al. External validation of Pittsburgh Cardiac arrest category illness severity score. Resuscitation. 172, 32\u201337. https:\/\/doi.org\/10.1016\/j.resuscitation.2021.12.022 (2022).","journal-title":"Resuscitation"},{"key":"76979_CR20","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.resuscitation.2019.03.018","volume":"138","author":"K Dyson","year":"2019","unstructured":"Dyson, K. et al. International variation in survival after out-of-hospital cardiac arrest: A validation study of the Utstein template. Resuscitation 138, 168\u2013181. https:\/\/doi.org\/10.1016\/j.resuscitation.2019.03.018 (2019).","journal-title":"Resuscitation"},{"issue":"8","key":"76979_CR21","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1001\/jama.2016.0701","volume":"315","author":"RC Tasker","year":"2016","unstructured":"Tasker, R. C. & Menon, D. K. Critical care and the brain. Jama 315(8), 749\u2013750. https:\/\/doi.org\/10.1001\/jama.2016.0701 (2016).","journal-title":"Jama"},{"issue":"1","key":"76979_CR22","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s13054-023-04454-1","volume":"27","author":"F Annoni","year":"2023","unstructured":"Annoni, F. et al. Hypertonic sodium lactate infusion reduces vasopressor requirements and biomarkers of brain and cardiac injury after experimental cardiac arrest. Crit. Care. 27(1), 161. https:\/\/doi.org\/10.1186\/s13054-023-04454-1 (2023).","journal-title":"Crit. Care"},{"key":"76979_CR23","doi-asserted-by":"publisher","unstructured":"Wang, X. et al. Hidden role of microglia during neurodegenerative disorders and neurocritical care: A mitochondrial perspective. Int. Immunopharmacol.. https:\/\/doi.org\/10.1016\/j.intimp.2024.113024 (2024). 142(Pt A):.","DOI":"10.1016\/j.intimp.2024.113024"},{"issue":"3","key":"76979_CR24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1097\/shk.0000000000002058","volume":"59","author":"Z Ye","year":"2023","unstructured":"Ye, Z. et al. Baicalein relieves brain injury via inhibiting ferroptosis and endoplasmic reticulum stress in a rat model of cardiac arrest. Shock 59(3), 434\u2013441. https:\/\/doi.org\/10.1097\/shk.0000000000002058 (2023).","journal-title":"Shock"},{"issue":"1","key":"76979_CR25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12964-023-01211-3","volume":"21","author":"ZL Yuan","year":"2023","unstructured":"Yuan, Z. L. et al. Inhibition of ERK downregulates autophagy via mitigating mitochondrial fragmentation to protect SH-SY5Y cells from OGD\/R injury. Cell. Commun. Signal. CCS 21(1), 204. https:\/\/doi.org\/10.1186\/s12964-023-01211-3 (2023).","journal-title":"Cell. Commun. Signal. CCS"},{"issue":"10307","key":"76979_CR26","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/s0140-6736(21)01257-5","volume":"398","author":"J Soar","year":"2021","unstructured":"Soar, J. et al. Cardiopulmonary resuscitation in special circumstances. Lancet (London England) 398 (10307), 1257\u20131268. https:\/\/doi.org\/10.1016\/s0140-6736(21)01257-5 (2021).","journal-title":"Lancet (London England)"},{"issue":"10","key":"76979_CR27","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1007\/s00134-020-06198-w","volume":"46","author":"C Sandroni","year":"2020","unstructured":"Sandroni, C. et al. Prediction of poor neurological outcome in comatose survivors of cardiac arrest: A systematic review. Intensive Care Med. 46 (10), 1803\u20131851. https:\/\/doi.org\/10.1007\/s00134-020-06198-w (2020).","journal-title":"Intensive Care Med."},{"issue":"12","key":"76979_CR28","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1016\/j.jacc.2017.07.780","volume":"70","author":"GA Ewy","year":"2017","unstructured":"Ewy, G. A. & Armstrong, P. W. A natural biomarker deserving attention: Gasping following primary cardiac arrest. J. Am. Coll. Cardiol. 70 (12), 1477\u20131478. https:\/\/doi.org\/10.1016\/j.jacc.2017.07.780 (2017).","journal-title":"J. Am. Coll. Cardiol."},{"key":"76979_CR29","doi-asserted-by":"publisher","first-page":"109668","DOI":"10.1016\/j.resuscitation.2022.12.006","volume":"184","author":"A Lagebrant","year":"2023","unstructured":"Lagebrant, A. et al. Brain injury markers in blood predict signs of hypoxic ischaemic encephalopathy on head computed tomography after cardiac arrest. Resuscitation 184, 109668. https:\/\/doi.org\/10.1016\/j.resuscitation.2022.12.006 (2023).","journal-title":"Resuscitation"},{"issue":"4","key":"76979_CR30","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1001\/jamaneurol.2021.5598","volume":"79","author":"RL Hoiland","year":"2022","unstructured":"Hoiland, R. L. et al. Neurologic prognostication after cardiac arrest using brain biomarkers: A systematic review and Meta-analysis. JAMA Neurol. 79 (4), 390\u2013398. https:\/\/doi.org\/10.1001\/jamaneurol.2021.5598 (2022).","journal-title":"JAMA Neurol."},{"issue":"9","key":"76979_CR31","doi-asserted-by":"publisher","first-page":"e2230518","DOI":"10.1001\/jamanetworkopen.2022.30518","volume":"5","author":"EL Fink","year":"2022","unstructured":"Fink, E. L. et al. Association of blood-based brain injury biomarker concentrations with outcomes after pediatric cardiac arrest. JAMA Netw. open. 5(9), e2230518. https:\/\/doi.org\/10.1001\/jamanetworkopen.2022.30518 (2022).","journal-title":"JAMA Netw. open."},{"issue":"4","key":"76979_CR32","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1001\/jamaneurol.2023.0050","volume":"80","author":"NJ Ashton","year":"2023","unstructured":"Ashton, N. J. et al. Alzheimer Disease blood biomarkers in patients with out-of-hospital cardiac arrest. JAMA Neurol. 80 (4), 388\u2013396. https:\/\/doi.org\/10.1001\/jamaneurol.2023.0050 (2023).","journal-title":"JAMA Neurol."},{"issue":"8","key":"76979_CR33","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1093\/ehjacc\/zuac066","volume":"11","author":"RP Beske","year":"2022","unstructured":"Beske, R. P. et al. MicroRNA-9-3p: A novel predictor of neurological outcome after cardiac arrest. Eur. Heart J. Acute Cardiovasc. care. 11(8), 609\u2013616. https:\/\/doi.org\/10.1093\/ehjacc\/zuac066 (2022).","journal-title":"Eur. Heart J. Acute Cardiovasc. care"},{"key":"76979_CR34","doi-asserted-by":"publisher","first-page":"1802879","DOI":"10.1155\/2019\/1802879","volume":"2019","author":"A Boileau","year":"2019","unstructured":"Boileau, A. et al. Circulating levels of mir-574-5p are Associated with neurological outcome after Cardiac arrest in women: A target temperature management (TTM) Trial Substudy. Dis. Markers. 2019, 1802879. https:\/\/doi.org\/10.1155\/2019\/1802879 (2019).","journal-title":"Dis. Markers"},{"key":"76979_CR35","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.resuscitation.2017.11.052","volume":"122","author":"CHV Duez","year":"2018","unstructured":"Duez, C. H. V. et al. Neuron-specific enolase and S-100b in prolonged targeted temperature management after cardiac arrest:A randomised study. Resuscitation 122, 79\u201386. https:\/\/doi.org\/10.1016\/j.resuscitation.2017.11.052 (2018).","journal-title":"Resuscitation"},{"issue":"16","key":"76979_CR36","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1056\/NEJMoa2208687","volume":"387","author":"J Kjaergaard","year":"2022","unstructured":"Kjaergaard, J. et al. Blood-pressure targets in comatose survivors of cardiac arrest. N. Engl. J. Med. 387 (16), 1456\u20131466. https:\/\/doi.org\/10.1056\/NEJMoa2208687 (2022).","journal-title":"N. Engl. J. Med."},{"issue":"16","key":"76979_CR37","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1056\/NEJMoa2208686","volume":"387","author":"H Schmidt","year":"2022","unstructured":"Schmidt, H. et al. Oxygen targets in comatose survivors of cardiac arrest. N. Engl. J. Med. 387 (16), 1467\u20131476. https:\/\/doi.org\/10.1056\/NEJMoa2208686 (2022).","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"76979_CR38","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1097\/ccm.0000000000005841","volume":"51","author":"A Vanat","year":"2023","unstructured":"Vanat, A. et al. Multimodal prediction of favorable outcome after cardiac arrest: A cohort study. Crit. Care Med. 51 (6), 706\u2013716. https:\/\/doi.org\/10.1097\/ccm.0000000000005841 (2023).","journal-title":"Crit. Care Med."},{"issue":"2","key":"76979_CR39","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1017\/s1049023x2000014x","volume":"35","author":"S Cakmak","year":"2020","unstructured":"Cakmak, S. et al. Serum copeptin levels predict the return of spontaneous circulation and the short-term prognosis of patients with out-of-hospital cardiac arrest: A randomized control study. Prehosp. Disaster Med. 35 (2), 120\u2013127. https:\/\/doi.org\/10.1017\/s1049023x2000014x (2020).","journal-title":"Prehosp. Disaster Med."},{"issue":"2","key":"76979_CR40","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s12024-020-00232-5","volume":"16","author":"C Xu","year":"2020","unstructured":"Xu, C. et al. Diagnostic role of postmortem CK-MB in cardiac death: A systematic review and meta-analysis. Forensic Sci. Med. Pathol. 16(2), 287\u2013294. https:\/\/doi.org\/10.1007\/s12024-020-00232-5 (2020).","journal-title":"Forensic Sci. Med. Pathol."},{"issue":"2","key":"76979_CR41","first-page":"127","volume":"5","author":"S P\u00e5hlman","year":"1984","unstructured":"P\u00e5hlman, S. et al. Purification and characterization of human neuron-specific enolase: Radioimmunoassay development. Tumour Biol. 5(2), 127\u2013139 (1984).","journal-title":"Tumour Biol."},{"issue":"3","key":"76979_CR42","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1177\/0394632016657091","volume":"29","author":"MJ Rogatzki","year":"2016","unstructured":"Rogatzki, M. J. et al. Biomarkers of brain injury following an American football game: A pilot study. Int. J. ImmunoPathol. Pharmacol. 29(3), 450\u2013457. https:\/\/doi.org\/10.1177\/0394632016657091 (2016).","journal-title":"Int. J. ImmunoPathol. Pharmacol."},{"issue":"3","key":"76979_CR43","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1097\/mcc.0000000000000406","volume":"23","author":"M Oddo","year":"2017","unstructured":"Oddo, M. & Friberg, H. Neuroprognostication after cardiac arrest in the light of targeted temperature management. Curr. Opin. Crit. Care. 23(3), 244\u2013250. https:\/\/doi.org\/10.1097\/mcc.0000000000000406 (2017).","journal-title":"Curr. Opin. Crit. Care"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76979-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76979-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76979-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T16:05:59Z","timestamp":1729958759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-76979-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,26]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["76979"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-76979-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,26]]},"assertion":[{"value":"26 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The experimental protocol was established, according to the ethical guidelines of the Helsinki Declaration and was approved by the Human Ethics Committee of Xiangya Hospital, Central South University (no.2019010006). Written informed consent was obtained from individual or guardian participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"25539"}}