{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T21:53:09Z","timestamp":1768686789003,"version":"3.49.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-77062-w","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T15:04:09Z","timestamp":1730127849000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Development of a gradient method for sulfamethoxazole, trimethoprim, isoniazid, and pyridoxine hydrochloride in rabbit plasma through QbD-driven investigation"],"prefix":"10.1038","volume":"14","author":[{"given":"Premsagar","family":"K M","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhagyalakshmi","family":"C","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyong","family":"Sola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akramul","family":"Ansary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tridib","family":"Kumar Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Yunus","family":"Pasha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koushik Nandan","family":"Dutta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramesh","family":"B","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Majumder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"77062_CR1","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1053\/j.semdp.2017.05.001","volume":"34","author":"C del Rio","year":"2017","unstructured":"del Rio, C. The global HIV epidemic: What the pathologist needs to know. Semin. Diagn. Pathol. 34, 314\u2013317 (2017).","journal-title":"Semin. Diagn. Pathol."},{"key":"77062_CR2","doi-asserted-by":"crossref","unstructured":"Ratnam, M. V. R. et al. CD4 cell counts and oral manifestations in HIV infected and AIDS patients. J. Oral Maxillofac. Pathol. 22 (2018).","DOI":"10.4103\/jomfp.JOMFP_191_17"},{"key":"77062_CR3","doi-asserted-by":"publisher","unstructured":"Birmeka, M. Distribution pattern and prevalence of opportunistic infections and their possible reciprocal effects among HIV patients, Burayu Health Centers. https:\/\/doi.org\/10.3855\/jidc.15105","DOI":"10.3855\/jidc.15105"},{"key":"77062_CR4","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/ofid\/ofac487","volume":"9","author":"HI Henderson","year":"2022","unstructured":"Henderson, H. I. et al. Predicting risk of multidrug-resistant enterobacterales infections among people with HIV. Open Forum Infect. Dis. 9, 487 (2022).","journal-title":"Open Forum Infect. Dis."},{"key":"77062_CR5","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1007\/s10238-021-00751-7","volume":"22","author":"A Abdoli","year":"2022","unstructured":"Abdoli, A., Falahi, S. & Kenarkoohi, A. COVID-19-associated opportunistic infections: A snapshot on the current reports. Clin. Exp. Med. 22, 327\u2013346 (2022).","journal-title":"Clin. Exp. Med."},{"key":"77062_CR6","doi-asserted-by":"crossref","unstructured":"Ali, M. et al. HIV and AIDS-defining opportunistic illnesses in the state of Qatar: A cohort population-based retrospective study covering 17 years (2000\u20132016). Ann. Med. Surg. 78 (2022).","DOI":"10.1016\/j.amsu.2022.103842"},{"key":"77062_CR7","doi-asserted-by":"crossref","unstructured":"Madhavan, A., Sachu, A., Samuel, A. & Vasudevapanicker, J. Cryptococcal antigen prevalence in HIV patients from a tertiary care centre in South India. 14, 740\u2013745 (2022).","DOI":"10.18502\/ijm.v14i5.10970"},{"key":"77062_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136280","volume":"10","author":"P Indira","year":"2015","unstructured":"Indira, P., Kumar, P. M., Shalini, S. & Vaman, K. Opportunistic infections among people living with HIV (PLHIV) with diabetes mellitus (DM) attending a tertiary care hospital in coastal city of South India. PLoS One 10, e0136280 (2015).","journal-title":"PLoS One"},{"key":"77062_CR9","doi-asserted-by":"crossref","unstructured":"Duff, P. Prevention of opportunistic infections in women with HIV infection. Clin. Obstet. Gynecol. 62 (2019).","DOI":"10.1097\/GRF.0000000000000483"},{"key":"77062_CR10","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1016\/S1473-3099(15)00242-X","volume":"15","author":"AD Harries","year":"2015","unstructured":"Harries, A. D., Lawn, S. D., Suthar, A. B. & Granich, R. Benefits of combined preventive therapy with co-trimoxazole and isoniazid in adults living with HIV: Time to consider a fixed-dose, single tablet coformulation. Lancet. Infect. Dis. 15, 1492\u20131496 (2015).","journal-title":"Lancet. Infect. Dis."},{"key":"77062_CR11","unstructured":"World Health Organization. WHO-PQ recommended summary of product haracteristics. 3\u20133 (2021)."},{"key":"77062_CR12","doi-asserted-by":"publisher","first-page":"S343","DOI":"10.1093\/cid\/ciab789","volume":"73","author":"E Letang","year":"2021","unstructured":"Letang, E. et al. Minimally invasive tissue sampling: a tool to guide efforts to reduce AIDS-related mortality in resource-limited settings. Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am. 73, S343\u2013S350 (2021).","journal-title":"Clin. Infect. Dis. Off. Publ. Infect. Dis. Soc. Am."},{"key":"77062_CR13","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12879-016-1462-x","volume":"16","author":"LE Coelho","year":"2016","unstructured":"Coelho, L. E. et al. Predictors of opportunistic illnesses incidence in post combination antiretroviral therapy era in an urban cohort from Rio de Janeiro. Brazil. BMC Infect. Dis. 16, 134 (2016).","journal-title":"Brazil. BMC Infect. Dis."},{"key":"77062_CR14","doi-asserted-by":"publisher","first-page":"97C","DOI":"10.1016\/j.jchromb.2014.10.018","volume":"973","author":"Y Cui","year":"2014","unstructured":"Cui, Y. et al. Development of an ultra fast liquid chromatography-tandem mass spectrometry method for simultaneous determination of cefazedone and etimicin in beagle dog plasma: Application to the pharmacokinetic study of the combination of cefazedone and etimicin inje. J. Chromatogr. Anal. Technol. Biomed. Life Sci. 973, 97C\u2013103 (2014).","journal-title":"J. Chromatogr. Anal. Technol. Biomed. Life Sci."},{"key":"77062_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408347.2023.2253321","volume":"8","author":"L Chiarentin","year":"2023","unstructured":"Chiarentin, L. et al. Drilling into \u2018quality by design\u2019 approach for analytical methods. Crit. Rev. Anal. Chem. 8, 1\u201342. https:\/\/doi.org\/10.1080\/10408347.2023.2253321 (2023).","journal-title":"Crit. Rev. Anal. Chem."},{"key":"77062_CR16","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.jchromb.2019.05.001","volume":"1120","author":"G Sharma","year":"2019","unstructured":"Sharma, G., Thakur, K., Raza, K. & Katare, O. P. Stability kinetics of fusidic acid: Development and validation of stability indicating analytical method by employing analytical quality by design approach in medicinal product(s). J. Chromatogr. B Anal. Technol. Biomed. Life Sci. 1120, 113\u2013124 (2019).","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"77062_CR17","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jpba.2016.11.010","volume":"134","author":"A Tumpa","year":"2017","unstructured":"Tumpa, A., Staji\u0107, A., Jan\u010di\u0107-Stojanovi\u0107, B. & Medenica, M. Quality by design in the development of hydrophilic interaction liquid chromatography method with gradient elution for the analysis of olanzapine. J. Pharm. Biomed. Anal. 134, 18\u201326 (2017).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"77062_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2023.115645","volume":"235","author":"M Ra\u0161evi\u0107","year":"2023","unstructured":"Ra\u0161evi\u0107, M., Malenovi\u0107, A., Proti\u0107, A. & Ze\u010devi\u0107, M. Analytical method development supported by DoE-DS approach for enantioseparation of (S, S)- and (R, R)-moxifloxacin. J. Pharm. Biomed. Anal. 235, 115645 (2023).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"77062_CR19","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2024.110292","volume":"200","author":"SM Aboelghar","year":"2024","unstructured":"Aboelghar, S. M., Hegazy, M. A. & Wagdy, H. A. Ecofriendly bioanalytical validated RP-HPLC method for simultaneous determination of COVID-19 co-prescribed drugs employing quality by design and green chemistry. Microchem. J. 200, 110292 (2024).","journal-title":"Microchem. J."},{"key":"77062_CR20","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1093\/jaoacint\/qsab078","volume":"104","author":"PB Prajapati","year":"2021","unstructured":"Prajapati, P. B., Bagul, N. & Kalyankar, G. Implementation of DoE and risk-based enhanced analytical quality by design approach to stability-indicating RP-HPLC method for stability study of bosutinib. J. AOAC Int. 104, 1742\u20131753 (2021).","journal-title":"J. AOAC Int."},{"key":"77062_CR21","doi-asserted-by":"publisher","first-page":"19138","DOI":"10.1038\/s41598-022-22998-0","volume":"12","author":"SK Muchakayala","year":"2022","unstructured":"Muchakayala, S. K. et al. AQbD based green UPLC method to determine mycophenolate mofetil impurities and Identification of degradation products by QToF LCMS. Sci. Rep. 12, 19138 (2022).","journal-title":"Sci. Rep."},{"key":"77062_CR22","doi-asserted-by":"publisher","first-page":"3602","DOI":"10.1002\/jssc.201700416","volume":"40","author":"M Taheri","year":"2017","unstructured":"Taheri, M., Bagheri, M., Moazeni-Pourasil, R. S. & Ghassempour, A. Response surface methodology based on central composite design accompanied by multivariate curve resolution to model gradient hydrophilic interaction liquid chromatography: Prediction of separation for five major opium alkaloids. J. Sep. Sci. 40, 3602\u20133611 (2017).","journal-title":"J. Sep. Sci."},{"key":"77062_CR23","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s42250-023-00819-9","volume":"7","author":"P Prajapati","year":"2024","unstructured":"Prajapati, P., Salunkhe, M., Pulusu, V. S. & Shah, S. Integrated approach of white analytical chemistry and analytical quality by design to multipurpose RP-HPLC method for synchronous estimation of multiple fixed-dose combinations of paracetamol. Chem. Africa 7, 1353\u20131371 (2024).","journal-title":"Chem. Africa"},{"key":"77062_CR24","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1007\/s42250-023-00835-9","volume":"7","author":"P Prajapati","year":"2024","unstructured":"Prajapati, P., Rana, B., Pulusu, V. S. & Mishra, A. Multipurpose RP-HPLC method for simultaneous estimation of fixed-dose combinations of anti-diabetic drugs: Integrating green, economical, and robust approaches with design of experiments and white analytical chemistry. Chem. Afr. 7, 1385\u20131400 (2024).","journal-title":"Chem. Afr."},{"key":"77062_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s43094-023-00546-5","volume":"9","author":"P Prajapati","year":"2023","unstructured":"Prajapati, P., Rana, B., Pulusu, V. S. & Shah, S. Method operable design region for robust RP-HPLC analysis of pioglitazone hydrochloride and teneligliptin hydrobromide hydrate: Incorporating hybrid principles of white analytical chemistry and design of experiments. Futur. J. Pharm. Sci. 9, 93 (2023).","journal-title":"Futur. J. Pharm. Sci."},{"key":"77062_CR26","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/sscp.202100063","volume":"5","author":"N Konduru","year":"2022","unstructured":"Konduru, N., Gundla, R., Dongala, T., Katari, N. K. & Mallavarapu, R. Development and validation of liquid chromatography method for determination of Ibrutinib in finished dosage forms using quality by design approach. Sep. Sci. PLUS 5, 254\u2013266 (2022).","journal-title":"Sep. Sci. PLUS"},{"key":"77062_CR27","unstructured":"FDA, F. & D. A. Bioanalytical Method Validation Guidance. Food Drug Adm. 1043, 25 (2018)."},{"key":"77062_CR28","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jchromb.2018.10.014","volume":"1102\u20131103","author":"AV Dalvi","year":"2018","unstructured":"Dalvi, A. V., Uppuluri, C. T., Bommireddy, E. P. & Ravi, P. R. Design of experiments-based RP\u2013HPLC bioanalytical method development for estimation of Rufinamide in rat plasma and brain and its application in pharmacokinetic study. J. Chromatogr. B 1102\u20131103, 74\u201382 (2018).","journal-title":"J. Chromatogr. B"},{"key":"77062_CR29","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.aca.2015.12.041","volume":"908","author":"G Yang","year":"2016","unstructured":"Yang, G., Tazoe, H. & Yamada, M. Rapid determination of 135Cs and precise 135Cs\/137Cs atomic ratio in environmental samples by single-column chromatography coupled to triple-quadrupole inductively coupled plasma-mass spectrometry. Anal. Chim. Acta 908, 177\u2013184 (2016).","journal-title":"Anal. Chim. Acta"},{"key":"77062_CR30","doi-asserted-by":"crossref","unstructured":"Hailat, M., Al-Ani, I., Hamad, M., Zakareia, Z. & Abu Dayyih, W. Development and validation of a method for quantification of favipiravir as COVID-19 management in spiked human plasma. Molecules 26 (2021).","DOI":"10.3390\/molecules26133789"},{"key":"77062_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.microc.2020.105711","volume":"160","author":"EM Abdel-Moety","year":"2021","unstructured":"Abdel-Moety, E. M., Rezk, M. R., Wadie, M. & Tantawy, M. A. A combined approach of green chemistry and quality-by-design for sustainable and robust analysis of two newly introduced pharmaceutical formulations treating benign prostate hyperplasia. Microchem. J. 160, 105711 (2021).","journal-title":"Microchem. J."},{"key":"77062_CR32","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.jchromb.2016.01.013","volume":"1012\u20131013","author":"M Meng","year":"2016","unstructured":"Meng, M. et al. Simultaneous quantitation of polymyxin B1, polymyxin B2 and polymyxin B1\u20131 in human plasma and treated human urine using solid phase extraction and liquid chromatography\u2013tandem mass spectrometry. J. Chromatogr. B 1012\u20131013, 23\u201336 (2016).","journal-title":"J. Chromatogr. B"},{"key":"77062_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.07.013","volume":"175","author":"DH Surve","year":"2019","unstructured":"Surve, D. H. & Jindal, A. B. Development and validation of reverse-phase high-performance liquid chromatographic (RP-HPLC) method for quantification of Efavirenz in Efavirenz-Enfuvirtide co-loaded polymer-lipid hybrid nanoparticles. J. Pharm. Biomed. Anal. 175, 112765 (2019).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"77062_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2020.120867","volume":"215","author":"E Alladio","year":"2020","unstructured":"Alladio, E. et al. Effective validation of chromatographic analytical methods: The illustrative case of androgenic steroids. Talanta 215, 120867 (2020).","journal-title":"Talanta"},{"key":"77062_CR35","doi-asserted-by":"publisher","first-page":"8959","DOI":"10.1021\/ac5018265","volume":"86","author":"H Gu","year":"2014","unstructured":"Gu, H., Liu, G., Wang, J., Aubry, A. F. & Arnold, M. E. Selecting the correct weighting factors for linear and quadratic calibration curves with least-squares regression algorithm in bioanalytical LC-MS\/MS assays and impacts of using incorrect weighting factors on curve stability, data quality, and assay perfo. Anal. Chem. 86, 8959\u20138966 (2014).","journal-title":"Anal. Chem."},{"key":"77062_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5641","volume":"37","author":"A Pant","year":"2023","unstructured":"Pant, A. et al. Quality by design-steered development and validation of analytical and bioanalytical methods for raloxifene: Application of Monte Carlo simulations and variance inflation factor. Biomed. Chromatogr. 37, e5641 (2023).","journal-title":"Biomed. Chromatogr."},{"key":"77062_CR37","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1093\/chromsci\/bmy094","volume":"57","author":"NS Abdelwahab","year":"2019","unstructured":"Abdelwahab, N. S., Ali, N. W., Zaki, M. M., Sharkawi, S. M. Z. & Abdelkawy, M. M. Simultaneous determination of thalidomide and dexamethasone in rat plasma by validated HPLC and HPTLC with pharmacokinetic study. J. Chromatogr. Sci. 57, 130\u2013138 (2019).","journal-title":"J. Chromatogr. Sci."},{"key":"77062_CR38","unstructured":"Method, B., An, V., Goch, W. & Giebu\u0142towicz, J. Replicates number for drug stability testing during bioanalytical method validation\u2014An experimental and retrospective approach (2022)."},{"key":"77062_CR39","doi-asserted-by":"crossref","unstructured":"Patel, K. Y., Dedania, Z. R., Dedania, R. R. & Patel, U. QbD approach to HPLC method development and validation of ceftriaxone sodium 4 (2021).","DOI":"10.1186\/s43094-021-00286-4"},{"key":"77062_CR40","doi-asserted-by":"publisher","first-page":"21618","DOI":"10.1021\/acsomega.3c00956","volume":"8","author":"A Shamim","year":"2023","unstructured":"Shamim, A. et al. QbD-engineered development and validation of a RP-HPLC method for simultaneous estimation of rutin and ciprofloxacin HCl in bilosomal nanoformulation. ACS Omega 8, 21618\u201321627 (2023).","journal-title":"ACS Omega"},{"key":"77062_CR41","doi-asserted-by":"publisher","unstructured":"Kumari, M. & Gupta, S. K. Response surface methodological ( RSM ) approach for optimizing the removal of trihalomethanes (THMs) and its precursor\u2019s by surfactant modified magnetic nanoadsorbents (sMNP)\u2014An endeavor to diminish probable cancer risk 1\u201311. https:\/\/doi.org\/10.1038\/s41598-019-54902-8 (2019).","DOI":"10.1038\/s41598-019-54902-8"},{"key":"77062_CR42","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.chroma.2017.12.044","volume":"1534","author":"RS Hanafi","year":"2018","unstructured":"Hanafi, R. S. & L\u00e4mmerhofer, M. Response surface methodology for the determination of the design space of enantiomeric separations on cinchona-based zwitterionic chiral stationary phases by high performance liquid chromatography. J. Chromatogr. A 1534, 55\u201363 (2018).","journal-title":"J. Chromatogr. A"},{"key":"77062_CR43","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmac090","author":"PKR Surapuraju","year":"2022","unstructured":"Surapuraju, P. K. R. & Juturu, R. R. Development, robustness by design expert and validation of a method for enantiomeric impurity content determination in pretomanid drug substance and pharmaceutical dosage form. J. Chromatogr. Sci. https:\/\/doi.org\/10.1093\/chromsci\/bmac090 (2022).","journal-title":"J. Chromatogr. Sci."},{"key":"77062_CR44","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1002\/chir.23315","volume":"33","author":"RM Hassan","year":"2021","unstructured":"Hassan, R. M., Saleh, O. A., El-Azzouny, A. A., Aboul-Enein, H. Y. & Fouad, M. A. Experimental design optimization of simultaneous enantiomeric separation of atenolol and chlorthalidone binary mixture by high-performance liquid chromatography using polysaccharide-based stationary phases. Chirality 33, 397\u2013408 (2021).","journal-title":"Chirality"},{"key":"77062_CR45","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.chroma.2018.11.072","volume":"1585","author":"B da Silva","year":"2019","unstructured":"da Silva, B., Valdomiro Gonzaga, L., Fett, R. & Oliveira Costa, A. C. Simplex-centroid design and Derringer\u2019s desirability function approach for simultaneous separation of phenolic compounds from Mimosa scabrella Bentham honeydew honeys by HPLC\/DAD. J. Chromatogr. A 1585, 182\u2013191 (2019).","journal-title":"J. Chromatogr. A"},{"key":"77062_CR46","unstructured":"Variables, R. SS symmetry on the application of a design of experiments along with an ANFIS and a desirability function to model response variables (2021)."},{"key":"77062_CR47","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1093\/jaoacint\/qsad108","volume":"107","author":"P Prajapati","year":"2024","unstructured":"Prajapati, P., Rana, B., Pulusu, V. S. & Shah, S. Simultaneous chromatographic estimation of vildagliptin and dapagliflozin using hybrid principles of white analytical chemistry and analytical quality by design. J. AOAC Int. 107, 212\u2013222 (2024).","journal-title":"J. AOAC Int."},{"key":"77062_CR48","doi-asserted-by":"publisher","first-page":"108944","DOI":"10.1016\/j.microc.2023.108944","volume":"193","author":"Salwa","year":"2023","unstructured":"Salwa, & Kumar, L. Quality-by-design driven analytical method (AQbD) development and validation of HPLC\u2013UV technique to quantify rivastigmine hydrogen tartrate in lipidic nanocarriers: Forced degradation, and assessment of drug content and in vitro release studies. Microchem. J. 193, 108944 (2023).","journal-title":"Microchem. J."},{"key":"77062_CR49","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jpha.2022.03.001","volume":"12","author":"RG Ingle","year":"2022","unstructured":"Ingle, R. G., Zeng, S., Jiang, H. & Fang, W.-J. Current developments of bioanalytical sample preparation techniques in pharmaceuticals. J. Pharm. Anal. 12, 517\u2013529 (2022).","journal-title":"J. Pharm. Anal."},{"key":"77062_CR50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2022.114642","volume":"212","author":"E Eckern\u00e4s","year":"2022","unstructured":"Eckern\u00e4s, E. et al. Development and application of a highly sensitive LC-MS\/MS method for simultaneous quantification of N,N-dimethyltryptamine and two of its metabolites in human plasma. J. Pharm. Biomed. Anal. 212, 114642 (2022).","journal-title":"J. Pharm. Biomed. Anal."},{"key":"77062_CR51","doi-asserted-by":"crossref","unstructured":"Chapter 2 Fundamental strategies for bioanalytical sample preparation. in High Throughput Bioanalytical Sample Preparation (ed. Wells, D. A. B. T.-P. in P. and B. A.) vol. 5 41\u201374 (Elsevier, 2003).","DOI":"10.1016\/S1464-3456(03)80004-2"},{"key":"77062_CR52","doi-asserted-by":"crossref","unstructured":"Baldelli, S., Marrubini, G., Cattaneo, D., Clementi, E. & Cerea, M. Application of Quality by Design Approach to Bioanalysis: Development of a Method for Elvitegravir Quantification in Human Plasma. Therapeutic Drug Monitoring vol. 39 (2017).","DOI":"10.1097\/FTD.0000000000000428"},{"key":"77062_CR53","doi-asserted-by":"publisher","first-page":"13896","DOI":"10.1039\/D2RA00966H","volume":"12","author":"MY Fares","year":"2022","unstructured":"Fares, M. Y., Hegazy, M. A., El-Sayed, G. M., Abdelrahman, M. M. & Abdelwahab, N. S. Quality by design approach for green HPLC method development for simultaneous analysis of two thalassemia drugs in biological fluid with pharmacokinetic study. RSC Adv. 12, 13896\u201313916 (2022).","journal-title":"RSC Adv."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77062-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77062-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77062-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T15:16:23Z","timestamp":1730128583000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77062-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":53,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["77062"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-77062-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,28]]},"assertion":[{"value":"7 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25806"}}