{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:09:30Z","timestamp":1791216570531,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T00:00:00Z","timestamp":1729555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100005756","name":"Shahrekord University of Medical Sciences","doi-asserted-by":"publisher","award":["3579"],"award-info":[{"award-number":["3579"]}],"id":[{"id":"10.13039\/501100005756","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Research Institute of Balearic Islands","award":["CIBEROBN CB12\/03\/30038"],"award-info":[{"award-number":["CIBEROBN CB12\/03\/30038"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-77099-x","type":"journal-article","created":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T21:01:56Z","timestamp":1729630916000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sinapinic acid as a potential therapeutic agent for epilepsy through targeting NMDA receptors and nitrite level"],"prefix":"10.1038","volume":"14","author":[{"given":"Mohsen","family":"Ghasemi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Amini-Khoei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Bijad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Rafieian-Kopaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Sureda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Lorigooini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,10,22]]},"reference":[{"key":"77099_CR1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.seizure.2022.06.010","volume":"107","author":"J Christensen","year":"2023","unstructured":"Christensen, J. et al. Estimates of epilepsy prevalence, psychiatric co-morbidity and cost. Seizure. 107, 162\u2013171 (2023).","journal-title":"Seizure"},{"key":"77099_CR2","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1111\/dmcn.15633","volume":"65","author":"N Paneth","year":"2023","unstructured":"Paneth, N. The contribution of epidemiology to the understanding of neurodevelopmental disabilities. Dev. Med. Child. Neurol. 65, 1551\u20131556 (2023).","journal-title":"Dev. Med. Child. Neurol."},{"key":"77099_CR3","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1212\/WNL.60.3.395","volume":"60","author":"DJ Strauss","year":"2003","unstructured":"Strauss, D. J., Day, S. M., Shavelle, R. M. & Wu, Y. W. Remote symptomatic epilepsy: does seizure severity increase mortality? Neurology. 60, 395\u2013399 (2003).","journal-title":"Neurology"},{"key":"77099_CR4","unstructured":"Bourgeois, B. F., Dodson, E., Nordli, D. R. Jr, Pellock, J. M. & Sankar, R. Pediatric Epilepsy: Diagnosis and Therapy (Demos Medical Publishing, 2007)."},{"key":"77099_CR5","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.yebeh.2011.07.024","volume":"22","author":"M Ghasemi","year":"2011","unstructured":"Ghasemi, M. & Schachter, S. C. The NMDA receptor complex as a therapeutic target in epilepsy: a review. Epilepsy Behav. 22, 617\u2013640 (2011).","journal-title":"Epilepsy Behav."},{"key":"77099_CR6","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s12028-013-9939-6","volume":"20","author":"F Zeiler","year":"2014","unstructured":"Zeiler, F., Teitelbaum, J., Gillman, L. & West M. NMDA antagonists for refractory seizures. Neurocrit. Care. 20, 502\u2013513 (2014).","journal-title":"Neurocrit. Care"},{"key":"77099_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-015-0157-8","volume":"22","author":"YH Ho","year":"2015","unstructured":"Ho, Y. H. et al. Peripheral inflammation increases seizure susceptibility via the induction of neuroinflammation and oxidative stress in the hippocampus. J. Biomed. Sci. 22, 1\u201314 (2015).","journal-title":"J. Biomed. Sci."},{"key":"77099_CR8","doi-asserted-by":"crossref","unstructured":"Nasiri-Boroujeni, S. et al. NMDA receptor mediates the anticonvulsant effect of hydroalcoholic extract of Artemisia persica in PTZ-induced seizure in mice. Evidence-Based Complementary and Alternative Medicine (2021). (2021).","DOI":"10.1155\/2021\/6422451"},{"key":"77099_CR9","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3389\/fphar.2014.00284","volume":"5","author":"C Rosa-Falero","year":"2015","unstructured":"Rosa-Falero, C. et al. Citrus aurantium increases seizure latency to PTZ induced seizures in zebrafish thru NMDA and mGluR\u2019s I and II. Front. Pharmacol. 5, 284 (2015).","journal-title":"Front. Pharmacol."},{"key":"77099_CR10","doi-asserted-by":"publisher","first-page":"808","DOI":"10.2174\/187152711798072347","volume":"10","author":"M Banach","year":"2011","unstructured":"Banach, M., Piskorska, B., Czuczwar, J., Borowicz, K. & S. & Nitric oxide, epileptic seizures, and action of antiepileptic drugs. CNS Neurol. Disorders-Drug Targets (Formerly Curr. Drug Targets-CNS Neurol. Disorders). 10, 808\u2013819 (2011).","journal-title":"CNS Neurol. Disorders-Drug Targets (Formerly Curr. Drug Targets-CNS Neurol. Disorders)"},{"key":"77099_CR11","doi-asserted-by":"crossref","unstructured":"Eghbali, F., Dehkordi, H. T., Amini-Khoei, H., Lorigooini, Z. & Rahimi-Madiseh, M. The potential role of nitric oxide in the anticonvulsant effects of betulin in pentylenetetrazole (PTZ)-induced seizures in mice. IBRO Neurosci. Rep. (2024).","DOI":"10.1016\/j.ibneur.2024.04.003"},{"key":"77099_CR12","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1002\/biof.1516","volume":"45","author":"Z Keshavarzi","year":"2019","unstructured":"Keshavarzi, Z. et al. Medicinal plants in traumatic brain injury: neuroprotective mechanisms revisited. Biofactors. 45, 517\u2013535 (2019).","journal-title":"Biofactors"},{"key":"77099_CR13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.4103\/2322-1232.222612","volume":"6","author":"R Mohebbati","year":"2017","unstructured":"Mohebbati, R., Khazdair, M. R. & Hedayati, M. Neuroprotective effects of medicinal plants and their constituents on different induced neurotoxicity methods: a review. J. Rep. Pharm. Sci. 6, 34\u201350 (2017).","journal-title":"J. Rep. Pharm. Sci."},{"key":"77099_CR14","first-page":"39","volume":"41","author":"H Hameed","year":"2016","unstructured":"Hameed, H., Aydin, S. & Ba\u015faran, N. Sinapic acid: is it safe for humans? FABAD J. Pharm. Sci. 41, 39 (2016).","journal-title":"FABAD J. Pharm. Sci."},{"key":"77099_CR15","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.neuropharm.2010.03.012","volume":"59","author":"DH Kim","year":"2010","unstructured":"Kim, D. H. et al. Sinapic acid attenuates kainic acid-induced hippocampal neuronal damage in mice. Neuropharmacology. 59, 20\u201330 (2010).","journal-title":"Neuropharmacology"},{"key":"77099_CR16","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/1541-4337.12041","volume":"13","author":"N Ni\u0107iforovi\u0107","year":"2014","unstructured":"Ni\u0107iforovi\u0107, N. & Abramovi\u010d, H. Sinapic acid and its derivatives: natural sources and bioactivity. Compr. Rev. Food Sci. Food Saf. 13, 34\u201351 (2014).","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"77099_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12993-020-00169-3","volume":"16","author":"T Mahmoudi","year":"2020","unstructured":"Mahmoudi, T. et al. Effect of Curcuma zedoaria hydro-alcoholic extract on learning, memory deficits and oxidative damage of brain tissue following seizures induced by pentylenetetrazole in rat. Behav. Brain Funct. 16, 1\u201312 (2020).","journal-title":"Behav. Brain Funct."},{"key":"77099_CR18","doi-asserted-by":"crossref","unstructured":"Rahimi-Madiseh, M., Lorigooini, Z., Boroujeni, S. N., Taji, M. & Amini-Khoei, H. The role of the NMDA receptor in the anticonvulsant effect of ellagic acid in pentylenetetrazole-induced seizures in male Mice. Behav. Neurol. (2022). (2022).","DOI":"10.1155\/2022\/9015842"},{"key":"77099_CR19","doi-asserted-by":"crossref","unstructured":"Ghasemi-Dehnoo, M. et al. Anethole ameliorates acetic acid-induced colitis in mice: Anti-inflammatory and antioxidant effects. Evidence-Based Complementary and Alternative Medicine (2022). (2022).","DOI":"10.1155\/2022\/9057451"},{"key":"77099_CR20","doi-asserted-by":"crossref","unstructured":"Granger, D. L., Taintor, R. R., Boockvar, K. S. & HibbsJr J. B. in Methods in enzymology Vol. 268 142\u2013151Elsevier, (1996).","DOI":"10.1016\/S0076-6879(96)68016-1"},{"key":"77099_CR21","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1111\/j.1528-1157.1992.tb06221.x","volume":"33","author":"K Gale","year":"1992","unstructured":"Gale, K. GABA and epilepsy: basic concepts from preclinical research. Epilepsia. 33, S3\u201312 (1992).","journal-title":"Epilepsia"},{"key":"77099_CR22","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.3390\/antiox12051049","volume":"12","author":"K \u0141ukawski","year":"2023","unstructured":"\u0141ukawski, K. & Czuczwar, S. J. Oxidative stress and neurodegeneration in animal models of seizures and epilepsy. Antioxidants. 12, 1049 (2023).","journal-title":"Antioxidants"},{"key":"77099_CR23","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.pbb.2012.08.015","volume":"103","author":"HE Lee","year":"2012","unstructured":"Lee, H. E. et al. Neuroprotective effect of sinapic acid in a mouse model of amyloid \u03b21\u201342 protein-induced Alzheimer\u2019s disease. Pharmacol. Biochem. Behav. 103, 260\u2013266 (2012).","journal-title":"Pharmacol. Biochem. Behav."},{"key":"77099_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11011-014-9604-6","volume":"30","author":"K Zare","year":"2015","unstructured":"Zare, K., Eidi, A., Roghani, M. & Rohani, A. H. The neuroprotective potential of sinapic acid in the 6-hydroxydopamine-induced hemi-parkinsonian rat. Metab. Brain Dis. 30, 205\u2013213 (2015).","journal-title":"Metab. Brain Dis."},{"key":"77099_CR25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1254\/jphs.11026FP","volume":"116","author":"V Sharma","year":"2011","unstructured":"Sharma, V., Gilhotra, R., Dhingra, D. & Gilhotra, N. Possible underlying influence of p38MAPK and NF-\u03baB in the diminished anti-anxiety effect of diazepam in stressed mice. J. Pharmacol. Sci. 116, 257\u2013263 (2011).","journal-title":"J. Pharmacol. Sci."},{"key":"77099_CR26","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s002109900197","volume":"361","author":"A K\u0142odzi\u0144ska","year":"2000","unstructured":"K\u0142odzi\u0144ska, A. et al. Roles of group II metabotropic glutamate receptors in modulation of seizure activity. Naunyn. Schmiedebergs Arch. Pharmacol. 361, 283\u2013288 (2000).","journal-title":"Naunyn. Schmiedebergs Arch. Pharmacol."},{"key":"77099_CR27","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1111\/j.1528-1157.1999.tb01584.x","volume":"40","author":"N Mikuni","year":"1999","unstructured":"Mikuni, N. et al. NMDA-receptors 1 and 2A\/B coassembly increased in human epileptic focal cortical dysplasia. Epilepsia. 40, 1683\u20131687 (1999).","journal-title":"Epilepsia"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77099-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77099-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77099-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T21:02:30Z","timestamp":1729630950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77099-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,22]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["77099"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-77099-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,22]]},"assertion":[{"value":"16 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors have agreed to publish this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"24941"}}