{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T22:58:28Z","timestamp":1778885908438,"version":"3.51.4"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-77375-w","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T08:29:40Z","timestamp":1730190580000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Tracing the path of Quorum sensing molecules in cystic fibrosis mucus in a biomimetic in vitro permeability platform"],"prefix":"10.1038","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1600-5338","authenticated-orcid":false,"given":"Olga Valentina","family":"Garbero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-9390","authenticated-orcid":false,"given":"Lorenzo","family":"Sardelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8620-3391","authenticated-orcid":false,"given":"Cosmin Stefan","family":"Butnarasu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5682-6115","authenticated-orcid":false,"given":"Enrica","family":"Frasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9772-6814","authenticated-orcid":false,"given":"Claudio","family":"Medana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0726-3025","authenticated-orcid":false,"given":"Federica","family":"Dal Bello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7262-6166","authenticated-orcid":false,"given":"Sonja","family":"Visentin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"77375_CR1","doi-asserted-by":"crossref","unstructured":"Li, Z. et al. Infection and lung disease progression in children with cystic fibrosis. 293, 581\u2013588 (2017).","DOI":"10.1001\/jama.293.5.581"},{"key":"77375_CR2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1183\/09031936.00163208","volume":"34","author":"MP Murray","year":"2008","unstructured":"Murray, M. P., Pentland, J. L., Turnbull, K., MacQuarrie, S. & Hill, A. T. Sputum colour: a useful clinical tool in non-cystic fibrosis bronchiectasis. Eur. Respir. J. 34, 361\u2013364 (2008).","journal-title":"Eur. Respir. J."},{"key":"77375_CR3","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1086\/318075","volume":"183","author":"JL Burns","year":"2001","unstructured":"Burns, J. L. et al. Longitudinal assessment of Pseudomonas aeruginosa in young children with cystic fibrosis. J. Infect. Dis. 183, 444\u2013452 (2001).","journal-title":"J. Infect. Dis."},{"key":"77375_CR4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/MOP.0b013e3280123a5d","volume":"19","author":"TS Murray","year":"2007","unstructured":"Murray, T. S., Egan, M. & Kazmierczak, B. I. Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients. Curr. Opin. Pediatr. 19, 83\u201388 (2007).","journal-title":"Curr. Opin. Pediatr."},{"key":"77375_CR5","doi-asserted-by":"crossref","unstructured":"Ramsey, A. K. A. et al. Page 1 of 38 1\u201338 (2014).","DOI":"10.1016\/S0147-0272(14)00007-5"},{"key":"77375_CR6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1128\/MMBR.05007-11","volume":"76","author":"P Nadal Jimenez","year":"2012","unstructured":"Nadal Jimenez, P. et al. The multiple signaling systems regulating virulence in Pseudomonas aeruginosa. Microbiol. Mol. Biol. Rev. 76, 46\u201365 (2012).","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"77375_CR7","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/j.1365-2958.2006.05306.x","volume":"61","author":"LEP Dietrich","year":"2006","unstructured":"Dietrich, L. E. P., Price-Whelan, A., Petersen, A., Whiteley, M. & Newman, D. K. The phenazine pyocyanin is a terminal signalling factor in the quorum sensing network of Pseudomonas aeruginosa. Mol. Microbiol. 61, 1308\u20131321 (2006).","journal-title":"Mol. Microbiol."},{"key":"77375_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.01748-15","volume":"7","author":"MM Kendall","year":"2016","unstructured":"Kendall, M. M. & Sperandio, V. What a dinner party! Mechanisms and functions of interkingdom signaling in host-pathogen associations. MBio 7, 1\u201314 (2016).","journal-title":"MBio"},{"key":"77375_CR9","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1128\/jb.176.2.269-275.1994","volume":"176","author":"WC Fuqua","year":"1994","unstructured":"Fuqua, W. C., Winans, S. C. & Greenberg, E. P. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. J. Bacteriol. 176, 269\u2013275 (1994).","journal-title":"J. Bacteriol."},{"key":"77375_CR10","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s13238-014-0100-x","volume":"6","author":"J Lee","year":"2015","unstructured":"Lee, J. & Zhang, L. The hierarchy quorum sensing network in Pseudomonas aeruginosa. Protein Cell 6, 26\u201341 (2015).","journal-title":"Protein Cell"},{"key":"77375_CR11","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.tim.2008.12.003","volume":"17","author":"DJ Hasseb","year":"2009","unstructured":"Hasseb, D. J. et al. Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways. Trends Microbiol. 17, 130\u2013138 (2009).","journal-title":"Trends Microbiol."},{"key":"77375_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12890-023-02611-4","volume":"23","author":"H Ryan","year":"2023","unstructured":"Ryan, H. et al. A systematic review of the clinical impact of small colony variants in patients with cystic fibrosis. BMC Pulm. Med. 23, 1\u201310 (2023).","journal-title":"BMC Pulm. Med."},{"key":"77375_CR13","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1086\/599360","volume":"200","author":"C Hoboth","year":"2009","unstructured":"Hoboth, C. et al. Dynamics of adaptive microevolution of hypermutable Pseudomonas aeruginosa during chronic pulmonary infection in patients with cystic fibrosis. J. Infect. Dis. 200, 118\u2013130 (2009).","journal-title":"J. Infect. Dis."},{"key":"77375_CR14","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41579-020-00477-5","volume":"19","author":"E Rossi","year":"2021","unstructured":"Rossi, E. et al. Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis. Nat. Rev. Microbiol. 19, 331\u2013342 (2021).","journal-title":"Nat. Rev. Microbiol."},{"key":"77375_CR15","doi-asserted-by":"publisher","unstructured":"Limoli, D. H., Jones, C. J. & Wozniak, D. J. Bacterial extracellular polysaccharides in biofilm formation and function. Microb. Biofilms 223\u2013247. https:\/\/doi.org\/10.1128\/9781555817466.ch11 (2015).","DOI":"10.1128\/9781555817466.ch11"},{"key":"77375_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/jb.00568-21","volume":"204","author":"HM Jacobs","year":"2022","unstructured":"Jacobs, H. M. et al. Mucoid Pseudomonas aeruginosa can produce calcium-gelled biofilms independent of the matrix components Psl and CdrA. J. Bacteriol. 204, 1\u201315 (2022).","journal-title":"J. Bacteriol."},{"key":"77375_CR17","first-page":"594","volume":"3","author":"S Malhotra","year":"2019","unstructured":"Malhotra, S. et al. Cystic fibrosis and Pseudomonas aeruginosa: the host\u2013microbe interface sankalp. Br. Med. J. 3, 594 (2019).","journal-title":"Br. Med. J."},{"key":"77375_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcimb.2017.00039","volume":"7","author":"MF Moradali","year":"2017","unstructured":"Moradali, M. F., Ghods, S. & Rehm, B. H. A. Pseudomonas aeruginosa lifestyle: a paradigm for adaptation, survival, and persistence. Front. Cell. Infect. Microbiol. 7, 1\u201329 (2017).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"77375_CR19","doi-asserted-by":"publisher","first-page":"4744","DOI":"10.1128\/IAI.67.9.4744-4750.1999","volume":"67","author":"RB Parad","year":"1999","unstructured":"Parad, R. B., Gerard, C. J., Zurakowski, D., Nichols, D. P. & Pier, G. B. Pulmonary outcome in cystic fibrosis is influenced primarily by mucoid Pseudomonas aeruginosa infection and immune status and only modestly by genotype. Infect. Immun. 67, 4744\u20134750 (1999).","journal-title":"Infect. Immun."},{"key":"77375_CR20","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1146\/annurev-micro-092412-155635","volume":"67","author":"M Schuster","year":"2013","unstructured":"Schuster, M. et al. Acyl-homoserine lactone quorum sensing: from evolution to application. Annu. Rev. Microbiol. 67, 43\u201363 (2013).","journal-title":"Annu. Rev. Microbiol."},{"key":"77375_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2022.996871","volume":"13","author":"G Bernab\u00e8","year":"2022","unstructured":"Bernab\u00e8, G. et al. A novel phenolic derivative inhibits AHL-dependent quorum sensing signaling in Pseudomonas aeruginosa. Front. Pharmacol. 13, 1\u201320 (2022).","journal-title":"Front. Pharmacol."},{"key":"77375_CR22","doi-asserted-by":"publisher","first-page":"e01274","DOI":"10.1128\/mBio.01274-18","volume":"9","author":"F Ding","year":"2018","unstructured":"Ding, F. et al. The Pseudomonas aeruginosa orphan quorum sensing signal receptor QscR regulates global quorum sensing gene expression by activating a single linked operon. MBio 9, e01274\u2013e01218 (2018).","journal-title":"MBio"},{"key":"77375_CR23","doi-asserted-by":"crossref","unstructured":"Sperandio, V., Torres, A. G., Jarvis, B., Nataro, J. P. & Kaper, J. B. Bacteria-host communication: The language of hormones. Proc. Natl. Acad. Sci. U.S.A. 100, 8951\u20138956 (2003).","DOI":"10.1073\/pnas.1537100100"},{"key":"77375_CR24","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1038\/s41586-023-06287-y","volume":"621","author":"J Major","year":"2023","unstructured":"Major, J. et al. Endothelial AHR activity prevents lung barrier disruption in viral infection. Nature 621, 813\u2013820 (2023).","journal-title":"Nature"},{"key":"77375_CR25","doi-asserted-by":"crossref","unstructured":"Puccetti, M. et al. Towards targeting the aryl hydrocarbon receptor in cystic fibrosis. Mediat. Inflamm. 1\u20137 (2018).","DOI":"10.1155\/2018\/1601486"},{"key":"77375_CR26","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.3390\/cells10071601","volume":"10","author":"M Puccetti","year":"2021","unstructured":"Puccetti, M. et al. Targeted drug delivery technologies potentiate the overall therapeutic efficacy of an indole derivative in a mouse cystic fibrosis setting. Cells 10, 1622 (2021).","journal-title":"Cells"},{"key":"77375_CR27","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1165\/rcmb.2022-0196OC","volume":"68","author":"M Pariano","year":"2023","unstructured":"Pariano, M. et al. Aryl hydrocarbon receptor agonism antagonizes the hypoxia-driven inflammation in cystic fibrosis. Am. J. Respir. Cell. Mol. Biol. 68, 288\u2013301 (2023).","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"77375_CR28","doi-asserted-by":"crossref","unstructured":"Moura-Alves, P. et al. Host monitoring of quorum sensing during Pseudomonas aeruginosa infection. Science 366 (2019).","DOI":"10.1126\/science.aaw1629"},{"key":"77375_CR29","doi-asserted-by":"publisher","first-page":"4408","DOI":"10.1128\/JB.01444-07","volume":"190","author":"A Jahoor","year":"2008","unstructured":"Jahoor, A. et al. Peroxisome proliferator-activated receptors mediate host cell proinflammatory responses to Pseudomonas aeruginosa autoinducer. J. Bacteriol. 190, 4408\u20134415 (2008).","journal-title":"J. Bacteriol."},{"key":"77375_CR30","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.3389\/fmicb.2015.01226","volume":"6","author":"YC Liu","year":"2015","unstructured":"Liu, Y. C., Chan, K. G. & Chang, C. Y. Modulation of host biology by Pseudomonas aeruginosa quorum sensing signal molecules: messengers or traitors. Front. Microbiol. 6, 1226 (2015).","journal-title":"Front. Microbiol."},{"key":"77375_CR31","doi-asserted-by":"publisher","first-page":"e1002953","DOI":"10.1371\/journal.ppat.1002953","volume":"8","author":"T Karlsson","year":"2012","unstructured":"Karlsson, T., Turkina, M. V., Yakymenko, O., Magnusson, K. E. & Vikstr\u00f6m, E. The Pseudomonas aeruginosa N-acylhomoserine lactone quorum sensing molecules target IQGAP1 and modulate epithelial cell migration. PLoS Pathog. 8, e1002953 (2012).","journal-title":"PLoS Pathog"},{"key":"77375_CR32","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1021\/jm970530e","volume":"41","author":"M Kansy","year":"1998","unstructured":"Kansy, M., Senner, F. & Gubernator, K. Screening: parallel artificial membrane permeation assay in the description of. J. Med. Chem. 41, 1007\u20131010 (1998).","journal-title":"J. Med. Chem."},{"key":"77375_CR33","doi-asserted-by":"publisher","first-page":"4940","DOI":"10.1039\/C9TB00957D","volume":"7","author":"DP Pacheco","year":"2019","unstructured":"Pacheco, D. P. et al. Disassembling the complexity of mucus barriers to develop a fast screening tool for early drug discovery. J. Mater. Chem. B 7, 4940\u20134952 (2019).","journal-title":"J. Mater. Chem. B"},{"key":"77375_CR34","doi-asserted-by":"publisher","first-page":"520","DOI":"10.1021\/acs.molpharmaceut.1c00644","volume":"19","author":"C Butnarasu","year":"2022","unstructured":"Butnarasu, C., Caron, G., Pacheco, D. P., Petrini, P. & Visentin, S. Cystic fibrosis mucus model to design more efficient drug therapies. Mol. Pharm. 19, 520\u2013531 (2022).","journal-title":"Mol. Pharm."},{"key":"77375_CR35","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/nchembio764","volume":"2","author":"A Price-Whelan","year":"2006","unstructured":"Price-Whelan, A., Dietrich, L. E. P. & Newman, D. K. Rethinking \u2018secondary\u2019 metabolism: physiological roles for phenazine antibiotics. Nat. Chem. Biol. 2, 71\u201378 (2006).","journal-title":"Nat. Chem. Biol."},{"key":"77375_CR36","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3390\/pharmaceutics15020380","volume":"15","author":"C Butnarasu","year":"2023","unstructured":"Butnarasu, C., Garbero, O. V., Petrini, P., Visai, L. & Visentin, S. Permeability assessment of a high-throughput mucosal platform. Pharmaceutics 15, 380 (2023).","journal-title":"Pharmaceutics"},{"key":"77375_CR37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"X Li","year":"2017","unstructured":"Li, X., Mu, P., Wen, J. & Deng, Y. Carrier-mediated and energy-dependent uptake and efflux of deoxynivalenol in mammalian cells. Sci. Rep. 7, 1\u201310 (2017).","journal-title":"Sci. Rep."},{"key":"77375_CR38","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1111\/jphp.12551","volume":"68","author":"M Ates","year":"2016","unstructured":"Ates, M., Kaynak, M. S. & Sahin, S. Effect of permeability enhancers on paracellular permeability of acyclovir. J. Pharm. Pharmacol. 68, 781\u2013790 (2016).","journal-title":"J. Pharm. Pharmacol."},{"key":"77375_CR39","doi-asserted-by":"crossref","unstructured":"Garti, N. Delivery and Controlled Release of Bioactives in Foods and Nutraceuticals (Woodhead Printing, 2008).","DOI":"10.1533\/9781845694210"},{"key":"77375_CR40","first-page":"1","volume":"3","author":"RM Davis","year":"2015","unstructured":"Davis, R. M., Muller, R. Y. & Haynes, K. A. Can the natural diversity of quorum-sensing advance synthetic biology? Front. Bioeng. Biotechnol. 3, 1\u201310 (2015).","journal-title":"Front. Bioeng. Biotechnol."},{"key":"77375_CR41","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1128\/JB.181.4.1203-1210.1999","volume":"181","author":"JP Pearson","year":"1999","unstructured":"Pearson, J. P., Van Delden, C. & Iglewski, B. H. Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals. J. Bacteriol. 181, 1203\u20131210 (1999).","journal-title":"J. Bacteriol."},{"key":"77375_CR42","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/nature03925","volume":"437","author":"LM Mashburn","year":"2005","unstructured":"Mashburn, L. M. & Whiteley, M. Membrane vesicles traffic signals and facilitate group activities in a prokaryote. Nature 437, 422\u2013425 (2005).","journal-title":"Nature"},{"key":"77375_CR43","doi-asserted-by":"crossref","unstructured":"Florez, C., Raab, J. E., Cooke, A. C. & Schertzer, J. W. Membrane distribution of the pseudomonas quinolone signal modulates outer membrane vesicle production in Pseudomonas aeruginosa. MBio 1\u201313 (2017).","DOI":"10.1128\/mBio.01034-17"},{"key":"77375_CR44","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/nature13684","volume":"512","author":"P Moura-Alves","year":"2014","unstructured":"Moura-Alves, P. et al. AhR sensing of bacterial pigments regulates antibacterial defence. Nature 512, 387\u2013392 (2014).","journal-title":"Nature"},{"key":"77375_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-28009-5","volume":"8","author":"ES Gloag","year":"2018","unstructured":"Gloag, E. S., German, G. K., Stoodley, P. & Wozniak, D. J. Viscoelastic properties of Pseudomonas aeruginosa variant biofilms. Sci. Rep. 8, 1\u201311 (2018).","journal-title":"Sci. Rep."},{"key":"77375_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/mBio.01536-14","volume":"5","author":"SC Chew","year":"2014","unstructured":"Chew, S. C. et al. Dynamic remodeling of microbial biofilms by functionally distinct exopolysaccharides. MBio 5, 1\u201311 (2014).","journal-title":"MBio"},{"key":"77375_CR47","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.1002\/bit.27816","volume":"118","author":"L Sardelli","year":"2021","unstructured":"Sardelli, L. et al. Technological tools and strategies for culturing human gut microbiota in engineered in vitro models. Biotechnol. Bioeng. 118, 2886\u20132905 (2021).","journal-title":"Biotechnol. Bioeng."},{"key":"77375_CR48","doi-asserted-by":"publisher","first-page":"15887","DOI":"10.1039\/C9RA02368B","volume":"9","author":"L Sardelli","year":"2019","unstructured":"Sardelli, L. et al. Towards bioinspired: in vitro models of intestinal mucus. RSC Adv. 9, 15887\u201315899 (2019).","journal-title":"RSC Adv."},{"key":"77375_CR49","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1021\/acs.biomac.8b01467","volume":"20","author":"J Witten","year":"2019","unstructured":"Witten, J., Samad, T. & Ribbeck, K. Molecular characterization of mucus binding. Biomacromolecules 20, 1505\u20131513 (2019).","journal-title":"Biomacromolecules"},{"key":"77375_CR50","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ijpharm.2013.05.040","volume":"453","author":"HH Sigurdsson","year":"2013","unstructured":"Sigurdsson, H. H., Kirch, J. & Lehr, C. M. Mucus as a barrier to lipophilic drugs. Int. J. Pharm. 453, 56\u201364 (2013).","journal-title":"Int. J. Pharm."},{"key":"77375_CR51","doi-asserted-by":"publisher","first-page":"e96166","DOI":"10.1371\/journal.pone.0096166","volume":"9","author":"B Ryall","year":"2014","unstructured":"Ryall, B. et al. The mucoid switch in Pseudomonas aeruginosa represses quorum sensing systems and leads to complex changes to stationary phase virulence factor regulation. PLoS ONE 9, e96166 (2014).","journal-title":"PLoS ONE"},{"key":"77375_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1183\/13993003.01297-2018","volume":"52","author":"DB Hill","year":"2018","unstructured":"Hill, D. B. et al. Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH. Eur. Respir. J. 52, 1\u201318 (2018).","journal-title":"Eur. Respir. J."},{"key":"77375_CR53","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1016\/j.ejcb.2018.06.001","volume":"97","author":"MM Massip-Copiz","year":"2018","unstructured":"Massip-Copiz, M. M. & Santa-Coloma, T. A. Extracellular pH and lung infections in cystic fibrosis. Eur. J. Cell. Biol. 97, 402\u2013410 (2018).","journal-title":"Eur. J. Cell. Biol."},{"key":"77375_CR54","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1136\/thorax.57.11.926","volume":"57","author":"S Tate","year":"2002","unstructured":"Tate, S., MacGregor, G., Davis, M., Innes, J. A. & Greening, A. P. Airways in cystic fibrosis are acidified: detection by exhaled breath condensate. Thorax 57, 926\u2013929 (2002).","journal-title":"Thorax"},{"key":"77375_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/spectrum.02731-23","volume":"11","author":"LD Morales","year":"2023","unstructured":"Morales, L. D., Av-Gay, Y. & Murphy, M. E. P. Acidic pH modulates Burkholderia cenocepacia antimicrobial susceptibility in the cystic fibrosis nutritional environment. Microbiol. Spectr. 11, 1\u201313 (2023).","journal-title":"Microbiol. Spectr."},{"key":"77375_CR56","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1007\/s11947-023-03207-w","volume":"17","author":"M Mao","year":"2024","unstructured":"Mao, M. et al. Study on the interactions between oral mucin and cyanidin 3-O-glucoside: the effect of oxidized quinone. Food Bioprocess. Technol. 17, 1335\u20131345 (2024).","journal-title":"Food Bioprocess. Technol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77375-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77375-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77375-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T11:58:47Z","timestamp":1732967927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77375-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,29]]},"references-count":56,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["77375"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-77375-w","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,29]]},"assertion":[{"value":"9 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"25907"}}