{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:15:27Z","timestamp":1788347727611,"version":"build-2803163510"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T00:00:00Z","timestamp":1730505600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-77911-8","type":"journal-article","created":{"date-parts":[[2024,11,2]],"date-time":"2024-11-02T09:02:16Z","timestamp":1730538136000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Temporal variation in p38-mediated regulation of DUX4 in facioscapulohumeral muscular dystrophy"],"prefix":"10.1038","volume":"14","author":[{"given":"Rajanikanth","family":"Vangipurapu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis M.","family":"Sverdrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,2]]},"reference":[{"key":"77911_CR1","doi-asserted-by":"publisher","first-page":"104137","DOI":"10.1016\/j.isci.2022.104137","volume":"25","author":"S Vuoristo","year":"2022","unstructured":"Vuoristo, S. et al. <ArticleTitle Language=\u201cEn\u201d>DUX4 is a multifunctional factor priming human embryonic genome activation. iScience  25, 104137. https:\/\/doi.org\/10.1016\/j.isci.2022.104137 (2022).","journal-title":"iScience"},{"key":"77911_CR2","doi-asserted-by":"publisher","unstructured":"Mocciaro, E., Runfola, V., Ghezzi, P., Pannese, M. & Gabellini, D. DUX4 role in normal physiology and in FSHD muscular dystrophy. Cells 10 https:\/\/doi.org\/10.3390\/cells10123322 (2021).","DOI":"10.3390\/cells10123322"},{"key":"77911_CR3","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.molmed.2011.01.001","volume":"17","author":"SM van der Maarel","year":"2011","unstructured":"van der Maarel, S. M., Tawil, R. & Tapscott, S. J. Facioscapulohumeral muscular dystrophy and DUX4: breaking the silence. Trends Mol. Med. 17, 252\u2013258. https:\/\/doi.org\/10.1016\/j.molmed.2011.01.001 (2011).","journal-title":"Trends Mol. Med."},{"key":"77911_CR4","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1038\/ejhg.2014.191","volume":"23","author":"M Larsen","year":"2015","unstructured":"Larsen, M. et al. Diagnostic approach for FSHD revisited: SMCHD1 mutations cause FSHD2 and act as modifiers of disease severity in FSHD1. Eur. J. Hum. Genet.  23, 808\u2013816. https:\/\/doi.org\/10.1038\/ejhg.2014.191 (2015).","journal-title":"Eur. J. Hum. Genet."},{"key":"77911_CR5","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.ajhg.2016.03.013","volume":"98","author":"ML van den Boogaard","year":"2016","unstructured":"van den Boogaard, M. L. et al. Mutations in DNMT3B modify epigenetic repression of the D4Z4 repeat and the penetrance of facioscapulohumeral dystrophy. Am. J. Hum. Genet. 98, 1020\u20131029. https:\/\/doi.org\/10.1016\/j.ajhg.2016.03.013 (2016).","journal-title":"Am. J. Hum. Genet."},{"key":"77911_CR6","doi-asserted-by":"publisher","first-page":"e2441","DOI":"10.1212\/WNL.0000000000009617","volume":"94","author":"K Hamanaka","year":"2020","unstructured":"Hamanaka, K. et al. Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy. Neurology  94, e2441\u2013e2447. https:\/\/doi.org\/10.1212\/WNL.0000000000009617 (2020).","journal-title":"Neurology"},{"key":"77911_CR7","doi-asserted-by":"publisher","first-page":"1942","DOI":"10.1128\/MCB.00149-14","volume":"34","author":"CL Himeda","year":"2014","unstructured":"Himeda, C. L. et al. Myogenic enhancers regulate expression of the facioscapulohumeral muscular dystrophy-associated DUX4 gene. Mol. Cell. Biol.  34, 1942\u20131955. https:\/\/doi.org\/10.1128\/MCB.00149-14 (2014).","journal-title":"Mol. Cell. Biol."},{"key":"77911_CR8","doi-asserted-by":"publisher","unstructured":"DeSimone, A. M., Cohen, J., Lek, M. & Lek, A. Cellular and animal models for facioscapulohumeral muscular dystrophy. Dis. Model. Mech.  13 https:\/\/doi.org\/10.1242\/dmm.046904 (2020).","DOI":"10.1242\/dmm.046904"},{"key":"77911_CR9","doi-asserted-by":"publisher","unstructured":"Ansseau, E. et al. Antisense oligonucleotides used to target the DUX4 mRNA as therapeutic approaches in faciosScapuloHumeral muscular dystrophy (FSHD). Genes (Basel)  8. https:\/\/doi.org\/10.3390\/genes8030093 (2017).","DOI":"10.3390\/genes8030093"},{"key":"77911_CR10","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1093\/hmg\/ddab136","volume":"30","author":"N Lu-Nguyen","year":"2021","unstructured":"Lu-Nguyen, N., Malerba, A., Herath, S., Dickson, G. & Popplewell, L. Systemic antisense therapeutics inhibiting DUX4 expression ameliorates FSHD-like pathology in an FSHD mouse model. Hum. Mol. Genet. 30, 1398\u20131412. https:\/\/doi.org\/10.1093\/hmg\/ddab136 (2021).","journal-title":"Hum. Mol. Genet."},{"key":"77911_CR11","doi-asserted-by":"publisher","first-page":"16509","DOI":"10.1073\/pnas.1909649117","volume":"117","author":"KRQ Lim","year":"2020","unstructured":"Lim, K. R. Q. et al. Inhibition of DUX4 expression with antisense LNA gapmers as a therapy for facioscapulohumeral muscular dystrophy. Proc. Natl. Acad. Sci. U.S.A.  117, 16509\u201316515. https:\/\/doi.org\/10.1073\/pnas.1909649117 (2020).","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"77911_CR12","doi-asserted-by":"publisher","first-page":"e26820","DOI":"10.1371\/journal.pone.0026820","volume":"6","author":"C Vanderplanck","year":"2011","unstructured":"Vanderplanck, C. et al. The FSHD atrophic myotube phenotype is caused by DUX4 expression. PloS ONE  6, e26820. https:\/\/doi.org\/10.1371\/journal.pone.0026820 (2011).","journal-title":"PloS one"},{"key":"77911_CR13","doi-asserted-by":"publisher","first-page":"4817","DOI":"10.1093\/hmg\/ddv206","volume":"24","author":"JW Lim","year":"2015","unstructured":"Lim, J. W. et al. DICER\/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD. Hum. Mol. Genet.  24, 4817\u20134828. https:\/\/doi.org\/10.1093\/hmg\/ddv206 (2015).","journal-title":"Hum. Mol. Genet."},{"key":"77911_CR14","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1212\/WNL.98.18_supplement.1776","volume":"98","author":"B Malecova","year":"2022","unstructured":"Malecova, B. et al. DUX4 siRNA optimization for the development of an antibody-Oligonucleotide conjugate (AOC) for the treatment of FSHD (P17-13.009). Neurology  98, 1776 (2022).","journal-title":"Neurology"},{"key":"77911_CR15","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1124\/jpet.119.259663","volume":"370","author":"J Oliva","year":"2019","unstructured":"Oliva, J. et al. Clinically advanced p38 inhibitors suppress DUX4 expression in cellular and animal models of facioscapulohumeral muscular dystrophy. J. Pharmacol. Exp. Ther. 370, 219\u2013230. https:\/\/doi.org\/10.1124\/jpet.119.259663 (2019).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"77911_CR16","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1124\/jpet.119.264689","volume":"374","author":"LA Rojas","year":"2020","unstructured":"Rojas, L. A. et al. p38alpha regulates expression of DUX4 in a model of facioscapulohumeral muscular dystrophy. J. Pharmacol. Exp. Ther. 374, 489\u2013498. https:\/\/doi.org\/10.1124\/jpet.119.264689 (2020).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"77911_CR17","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S1474-4422(24)00073-5","volume":"23","author":"R Tawil","year":"2024","unstructured":"Tawil, R. et al. Safety and efficacy of losmapimod in facioscapulohumeral muscular dystrophy (ReDUX4): a randomised, double-blind, placebo-controlled phase 2b trial. Lancet Neurol.  23, 477\u2013486. https:\/\/doi.org\/10.1016\/S1474-4422(24)00073-5 (2024).","journal-title":"Lancet Neurol."},{"key":"77911_CR18","doi-asserted-by":"publisher","first-page":"e1008754","DOI":"10.1371\/journal.pgen.1008754","volume":"16","author":"S Jiang","year":"2020","unstructured":"Jiang, S. et al. Single-nucleus RNA-seq identifies divergent populations of FSHD2 myotube nuclei. PLoS Genet.  16, e1008754. https:\/\/doi.org\/10.1371\/journal.pgen.1008754 (2020).","journal-title":"PLoS Genet."},{"key":"77911_CR19","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1002\/humu.24171","volume":"42","author":"J Chau","year":"2021","unstructured":"Chau, J. et al. Relationship of DUX4 and target gene expression in FSHD myocytes. Hum. Mutat.  42, 421\u2013433. https:\/\/doi.org\/10.1002\/humu.24171 (2021).","journal-title":"Hum. Mutat."},{"key":"77911_CR20","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/2044-5040-4-12","volume":"4","author":"R Tawil","year":"2014","unstructured":"Tawil, R., van der Maarel, S. M. & Tapscott, S. J. Facioscapulohumeral dystrophy: the path to consensus on pathophysiology. Skelet. Muscle   4, 12. https:\/\/doi.org\/10.1186\/2044-5040-4-12 (2014).","journal-title":"Skelet. Muscle"},{"key":"77911_CR21","unstructured":"Wang, L. H. L. T., Han, R., Jiang, J. & Shoskes, J. J. in American Academy of Neurology 2023 Annual Meeting."},{"key":"77911_CR22","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1016\/j.celrep.2019.10.025","volume":"29","author":"R Resnick","year":"2019","unstructured":"Resnick, R. et al. DUX4-Induced histone variants H3.X and H3.Y Mark DUX4 target genes for expression. Cell. Rep. 29, 1812\u20131820. https:\/\/doi.org\/10.1016\/j.celrep.2019.10.025 (2019). e1815.","journal-title":"Cell. Rep."},{"key":"77911_CR23","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s13395-022-00310-y","volume":"13","author":"C Claus","year":"2023","unstructured":"Claus, C. et al. The double homeodomain protein DUX4c is associated with regenerating muscle fibers and RNA-binding proteins. Skelet. Muscle   13, 5. https:\/\/doi.org\/10.1186\/s13395-022-00310-y (2023).","journal-title":"Skelet. Muscle"},{"key":"77911_CR24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s13104-022-06054-8","volume":"15","author":"ML Beermann","year":"2022","unstructured":"Beermann, M. L., Homma, S. & Miller, J. B. Proximity ligation assay to detect DUX4 protein in FSHD1 muscle: a pilot study. BMC Res. Notes   15, 163. https:\/\/doi.org\/10.1186\/s13104-022-06054-8 (2022).","journal-title":"BMC Res. Notes"},{"key":"77911_CR25","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.1016\/j.ajpath.2012.07.007","volume":"181","author":"YD Krom","year":"2012","unstructured":"Krom, Y. D. et al. Generation of isogenic D4Z4 contracted and noncontracted immortal muscle cell clones from a mosaic patient: a cellular model for FSHD. Am. J. Pathol. 181, 1387\u20131401. https:\/\/doi.org\/10.1016\/j.ajpath.2012.07.007 (2012).","journal-title":"Am. J. Pathol."},{"key":"77911_CR26","doi-asserted-by":"publisher","first-page":"4419","DOI":"10.1093\/hmg\/dds284","volume":"21","author":"TI Jones","year":"2012","unstructured":"Jones, T. I. et al. Facioscapulohumeral muscular dystrophy family studies of DUX4 expression: evidence for disease modifiers and a quantitative model of pathogenesis. Hum. Mol. Genet.  21, 4419\u20134430. https:\/\/doi.org\/10.1093\/hmg\/dds284 (2012).","journal-title":"Hum. Mol. Genet."},{"key":"77911_CR27","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s13072-018-0215-z","volume":"11","author":"P Haynes","year":"2018","unstructured":"Haynes, P., Bomsztyk, K. & Miller, D. G. Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele. Epigenetics Chromatin   11, 47. https:\/\/doi.org\/10.1186\/s13072-018-0215-z (2018).","journal-title":"Epigenetics Chromatin"},{"key":"77911_CR28","doi-asserted-by":"publisher","first-page":"16957","DOI":"10.1038\/s41598-018-35150-8","volume":"8","author":"D Bosnakovski","year":"2018","unstructured":"Bosnakovski, D. et al. Low level DUX4 expression disrupts myogenesis through deregulation of myogenic gene expression. Sci. Rep. 8, 16957. https:\/\/doi.org\/10.1038\/s41598-018-35150-8 (2018).","journal-title":"Sci. Rep."},{"key":"77911_CR29","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1038\/emboj.2008.201","volume":"27","author":"D Bosnakovski","year":"2008","unstructured":"Bosnakovski, D. et al. An isogenetic myoblast expression screen identifies DUX4-mediated FSHD-associated molecular pathologies. EMBO J. 27, 2766\u20132779. https:\/\/doi.org\/10.1038\/emboj.2008.201 (2008).","journal-title":"EMBO J."},{"key":"77911_CR30","doi-asserted-by":"publisher","unstructured":"Young, J. M. et al. DUX4 binding to retroelements creates promoters that are active in FSHD muscle and testis. PLoS Genetics 9, e1003947 (2013). https:\/\/doi.org\/10.1371\/journal.pgen.1003947","DOI":"10.1371\/journal.pgen.1003947"},{"key":"77911_CR31","doi-asserted-by":"publisher","first-page":"4661","DOI":"10.1093\/hmg\/ddt314","volume":"22","author":"GJ Block","year":"2013","unstructured":"Block, G. J. et al. Wnt\/beta-catenin signaling suppresses DUX4 expression and prevents apoptosis of FSHD muscle cells. Hum. Mol. Genet. 22, 4661\u20134672. https:\/\/doi.org\/10.1093\/hmg\/ddt314 (2013).","journal-title":"Hum. Mol. Genet."},{"key":"77911_CR32","doi-asserted-by":"publisher","first-page":"5901","DOI":"10.1093\/hmg\/ddv315","volume":"24","author":"AM Rickard","year":"2015","unstructured":"Rickard, A. M., Petek, L. M. & Miller, D. G. Endogenous DUX4 expression in FSHD myotubes is sufficient to cause cell death and disrupts RNA splicing and cell migration pathways. Hum. Mol. Genet. 24, 5901\u20135914. https:\/\/doi.org\/10.1093\/hmg\/ddv315 (2015).","journal-title":"Hum. Mol. Genet."},{"key":"77911_CR33","doi-asserted-by":"publisher","first-page":"e1001181","DOI":"10.1371\/journal.pgen.1001181","volume":"6","author":"L Snider","year":"2010","unstructured":"Snider, L. et al. Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene. PLoS Genet. 6, e1001181. https:\/\/doi.org\/10.1371\/journal.pgen.1001181 (2010).","journal-title":"PLoS Genet."},{"key":"77911_CR34","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1582-4934.2012.01647.x","volume":"17","author":"A Tassin","year":"2013","unstructured":"Tassin, A. et al. DUX4 expression in FSHD muscle cells: how could such a rare protein cause a myopathy? J. Cell. Mol. Med. 17, 76\u201389. https:\/\/doi.org\/10.1111\/j.1582-4934.2012.01647.x (2013).","journal-title":"J. Cell. Mol. Med."},{"key":"77911_CR35","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1080\/15592294.2015.1113798","volume":"10","author":"J Balog","year":"2015","unstructured":"Balog, J. et al. Increased DUX4 expression during muscle differentiation correlates with decreased SMCHD1 protein levels at D4Z4. Epigenetics: official J. DNA Methylation Soc. 10, 1133\u20131142. https:\/\/doi.org\/10.1080\/15592294.2015.1113798 (2015).","journal-title":"Epigenetics: official J. DNA Methylation Soc."},{"key":"77911_CR36","doi-asserted-by":"publisher","first-page":"e13695","DOI":"10.15252\/emmm.202013695","volume":"13","author":"CRS Banerji","year":"2021","unstructured":"Banerji, C. R. S. & Zammit, P. S. Pathomechanisms and biomarkers in facioscapulohumeral muscular dystrophy: roles of DUX4 and PAX7. EMBO Mol. Med. 13, e13695. https:\/\/doi.org\/10.15252\/emmm.202013695 (2021).","journal-title":"EMBO Mol. Med."},{"key":"77911_CR37","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/S1097-2765(02)00481-1","volume":"9","author":"DA Bergstrom","year":"2002","unstructured":"Bergstrom, D. A. et al. Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression. Mol. Cell   9, 587\u2013600 (2002).","journal-title":"Mol. Cell"},{"key":"77911_CR38","doi-asserted-by":"publisher","first-page":"2348","DOI":"10.1101\/gad.1234304","volume":"18","author":"BH Penn","year":"2004","unstructured":"Penn, B. H., Bergstrom, D. A., Dilworth, F. J., Bengal, E. & Tapscott, S. J. A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation. Genes Dev. 18, 2348\u20132353. https:\/\/doi.org\/10.1101\/gad.1234304 (2004).","journal-title":"Genes Dev."},{"key":"77911_CR39","doi-asserted-by":"publisher","first-page":"3951","DOI":"10.1128\/MCB.20.11.3951-3964.2000","volume":"20","author":"Z Wu","year":"2000","unstructured":"Wu, Z. et al. p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol. Cell. Biol. 20, 3951\u20133964 (2000).","journal-title":"Mol. Cell. Biol."},{"key":"77911_CR40","doi-asserted-by":"publisher","first-page":"5193","DOI":"10.1074\/jbc.274.8.5193","volume":"274","author":"A Zetser","year":"1999","unstructured":"Zetser, A., Gredinger, E. & Bengal, E. p38 mitogen-activated protein kinase pathway promotes skeletal muscle differentiation. Participation of the Mef2c transcription factor. J. Biol. Chem. 274, 5193\u20135200 (1999).","journal-title":"J. Biol. Chem."},{"key":"77911_CR41","doi-asserted-by":"publisher","unstructured":"Brennan, C. M. et al. DUX4 expression activates JNK and p38 MAP kinases in myoblasts. Dis. Model. Mech. 15 https:\/\/doi.org\/10.1242\/dmm.049516 (2022).","DOI":"10.1242\/dmm.049516"},{"key":"77911_CR42","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1093\/hmg\/ddaa164","volume":"29","author":"CRS Banerji","year":"2020","unstructured":"Banerji, C. R. S., Henderson, D., Tawil, R. N. & Zammit, P. S. Skeletal muscle regeneration in facioscapulohumeral muscular dystrophy is correlated with pathological severity. Hum. Mol. Genet. 29, 2746\u20132760. https:\/\/doi.org\/10.1093\/hmg\/ddaa164 (2020).","journal-title":"Hum. Mol. Genet."},{"key":"77911_CR43","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13395-015-0046-6","volume":"5","author":"S Schiaffino","year":"2015","unstructured":"Schiaffino, S., Rossi, A. C., Smerdu, V., Leinwand, L. A. & Reggiani, C. Developmental myosins: expression patterns and functional significance. Skelet. Muscle   5, 22. https:\/\/doi.org\/10.1186\/s13395-015-0046-6 (2015).","journal-title":"Skelet. Muscle"},{"key":"77911_CR44","unstructured":"Fulcrum Therapeutics, I. (2021)."},{"key":"77911_CR45","doi-asserted-by":"publisher","unstructured":"Campbell, A. E. et al. NuRD and CAF-1-mediated silencing of the D4Z4 array is modulated by DUX4-induced MBD3L proteins. Elife   7 https:\/\/doi.org\/10.7554\/eLife.31023 (2018).","DOI":"10.7554\/eLife.31023"},{"key":"77911_CR46","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3727\/000000005783982837","volume":"14","author":"SD Silva-Barbosa","year":"2005","unstructured":"Silva-Barbosa, S. D., Butler-Browne, G. S., Di Santo, J. P. & Mouly, V. Comparative analysis of genetically engineered immunodeficient mouse strains as recipients for human myoblast transplantation. Cell. Transpl.  14, 457\u2013467 (2005).","journal-title":"Cell. Transpl."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77911-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77911-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77911-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:06:38Z","timestamp":1730811998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77911-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,2]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["77911"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-77911-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,2]]},"assertion":[{"value":"22 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The animal study protocol was approved by the Saint Louis University Institutional Animal Care and Use Committee (IACUC) for the appropriate care and use of laboratory animals. Saint Louis University is a USDA registered research facility (43-R-011), is regularly inspected and files all required documentation, including an annual report. In addition, under the provisions of the Public Health Service Policy on the Humane Care and Use of Laboratory Animals, the University files required assurance documents to the Office of Laboratory Animal Welfare (OLAW). (OLAW Assurance Number D16-00141). The Animal Care and Use Program at Saint Louis University is also FULLY ACCREDITED by the Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALACi). All procedures were performed in accordance with the Guide for the Care and Use of Laboratory Animals (NIH, Bethesda, Maryland, USA).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}}],"article-number":"26437"}}