{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T18:36:51Z","timestamp":1762108611808,"version":"build-2065373602"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-77983-6","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T14:01:20Z","timestamp":1731420080000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Murine vaginal secretory responses to a male volatile chemical messenger"],"prefix":"10.1038","volume":"14","author":[{"given":"Natalia","family":"Murataeva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam","family":"Mattox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Yust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Straiker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"77983_CR1","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.yfrne.2013.07.007","volume":"34","author":"A Petrulis","year":"2013","unstructured":"Petrulis, A. Chemosignals and hormones in the neural control of mammalian sexual behavior. Front. Neuroendocrinol. 34, 255\u2013267. https:\/\/doi.org\/10.1016\/j.yfrne.2013.07.007 (2013).","journal-title":"Front. Neuroendocrinol."},{"key":"77983_CR2","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1146\/annurev.ne.10.030187.001545","volume":"10","author":"M Halpern","year":"1987","unstructured":"Halpern, M. The organization and function of the vomeronasal system. Annu. Rev. Neurosci. 10, 325\u2013362. https:\/\/doi.org\/10.1146\/annurev.ne.10.030187.001545 (1987).","journal-title":"Annu. Rev. Neurosci."},{"key":"77983_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1159\/000112981","volume":"49","author":"KM Dorries","year":"1997","unstructured":"Dorries, K. M., Adkins-Regan, E. & Halpern, B. P. Sensitivity and behavioral responses to the pheromone androstenone are not mediated by the vomeronasal organ in domestic pigs. Brain Behav. Evol. 49, 53\u201362. https:\/\/doi.org\/10.1159\/000112981 (1997).","journal-title":"Brain Behav. Evol."},{"key":"77983_CR4","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/nature04033","volume":"437","author":"H Kimoto","year":"2005","unstructured":"Kimoto, H., Haga, S., Sato, K. & Touhara, K. Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons. Nature. 437, 898\u2013901. https:\/\/doi.org\/10.1038\/nature04033 (2005).","journal-title":"Nature"},{"key":"77983_CR5","doi-asserted-by":"publisher","first-page":"104685","DOI":"10.1016\/j.jprot.2022.104685","volume":"266","author":"AJ Barabas","year":"2022","unstructured":"Barabas, A. J., Aryal, U. K. & Gaskill, B. N. Protein profiles from used nesting material, saliva, and urine correspond with social behavior in group housed male mice, Mus musculus. J. Proteom. 266, 104685. https:\/\/doi.org\/10.1016\/j.jprot.2022.104685 (2022).","journal-title":"J. Proteom."},{"key":"77983_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1677\/joe.0.0130399","volume":"13","author":"WK Whitten","year":"1956","unstructured":"Whitten, W. K. Modification of the oestrous cycle of the mouse by external stimuli associated with the male. J. Endocrinol. 13, 5 (1956).","journal-title":"J. Endocrinol."},{"key":"77983_CR7","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1073\/pnas.83.12.4576","volume":"83","author":"B Jemiolo","year":"1986","unstructured":"Jemiolo, B., Harvey, S. & Novotny, M. Promotion of the Whitten effect in female mice by synthetic analogs of male urinary constituents. Proc. Natl. Acad. Sci. U S A. 83, 4576\u20134579. https:\/\/doi.org\/10.1073\/pnas.83.12.4576 (1986).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"77983_CR8","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/184105a0","volume":"184","author":"HM Bruce","year":"1959","unstructured":"Bruce, H. M. An exteroceptive block to pregnancy in the mouse. Nature. 184, 105. https:\/\/doi.org\/10.1038\/184105a0 (1959).","journal-title":"Nature"},{"key":"77983_CR9","first-page":"213","volume":"5","author":"S Van Der Lee","year":"1956","unstructured":"Van Der Lee, S. & Boot, L. M. Spontaneous pseudopregnancy in mice. II. Acta Physiol. Pharmacol. Neerl. 5, 213\u2013215 (1956).","journal-title":"Acta Physiol. Pharmacol. Neerl"},{"key":"77983_CR10","doi-asserted-by":"publisher","first-page":"107154","DOI":"10.1016\/j.anireprosci.2022.107154","volume":"248","author":"AJ Landaeta-Hernandez","year":"2023","unstructured":"Landaeta-Hernandez, A. J., Ungerfeld, R. & Chenoweth, P. J. Biostimulation and pheromones in livestock: a review. Anim. Reprod. Sci. 248, 107154. https:\/\/doi.org\/10.1016\/j.anireprosci.2022.107154 (2023).","journal-title":"Anim. Reprod. Sci."},{"key":"77983_CR11","doi-asserted-by":"publisher","first-page":"116590","DOI":"10.1016\/j.jenvman.2022.116590","volume":"325","author":"D Klassen","year":"2023","unstructured":"Klassen, D., Lennox, M. D., Dumont, M. J., Chouinard, G. & Tavares, J. R. Dispensers for pheromonal pest control. J. Environ. Manage. 325, 116590. https:\/\/doi.org\/10.1016\/j.jenvman.2022.116590 (2023).","journal-title":"J. Environ. Manage."},{"key":"77983_CR12","doi-asserted-by":"publisher","unstructured":"Roberts, S. A. et al. Darcin: a male pheromone that stimulates female memory and sexual attraction to an individual male\u2019s odour. BMC Biol. 8 https:\/\/doi.org\/10.1186\/1741-7007-8-75 (2010).","DOI":"10.1186\/1741-7007-8-75"},{"key":"77983_CR13","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1073\/pnas.82.7.2059","volume":"82","author":"M Novotny","year":"1985","unstructured":"Novotny, M., Harvey, S., Jemiolo, B. & Alberts, J. Synthetic pheromones that promote inter-male aggression in mice. Proc. Natl. Acad. Sci. U S A. 82, 2059\u20132061. https:\/\/doi.org\/10.1073\/pnas.82.7.2059 (1985).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"77983_CR14","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1093\/chemse\/24.3.289","volume":"24","author":"W Ma","year":"1999","unstructured":"Ma, W., Miao, Z. & Novotny, M. V. Induction of estrus in grouped female mice (Mus domesticus) by synthetic analogues of preputial gland constituents. Chem. Senses. 24, 289\u2013293. https:\/\/doi.org\/10.1093\/chemse\/24.3.289 (1999).","journal-title":"Chem. Senses"},{"key":"77983_CR15","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3389\/fncel.2019.00455","volume":"13","author":"Q Liu","year":"2019","unstructured":"Liu, Q. et al. Two Preputial Gland-secreted pheromones evoke sexually dimorphic neural pathways in the mouse vomeronasal system. Front. Cell. Neurosci. 13, 455. https:\/\/doi.org\/10.3389\/fncel.2019.00455 (2019).","journal-title":"Front. Cell. Neurosci."},{"key":"77983_CR16","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1677\/joe.0.0670283","volume":"67","author":"AM Gawienowski","year":"1975","unstructured":"Gawienowski, A. M., Orsulak, P. J., Stacewicz-Sapuntzakis, M. & Joseph, B. M. Presence of sex pheromone in preputial glands of male rats. J. Endocrinol. 67, 283\u2013288. https:\/\/doi.org\/10.1677\/joe.0.0670283 (1975).","journal-title":"J. Endocrinol."},{"key":"77983_CR17","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1097\/GME.0000000000001609","volume":"27","author":"NGSMPSEP The","year":"2020","unstructured":"The, N. G. S. M. P. S. E. P. The 2020 genitourinary syndrome of menopause position statement of the North American Menopause Society. Menopause. 27, 976\u2013992. https:\/\/doi.org\/10.1097\/GME.0000000000001609 (2020).","journal-title":"Menopause"},{"key":"77983_CR18","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.sxmr.2017.05.002","volume":"5","author":"Y Reisman","year":"2017","unstructured":"Reisman, Y. Sexual consequences of Post-SSRI syndrome. Sex. Med. Rev. 5, 429\u2013433. https:\/\/doi.org\/10.1016\/j.sxmr.2017.05.002 (2017).","journal-title":"Sex. Med. Rev."},{"key":"77983_CR19","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1002\/nau.23256","volume":"36","author":"LL Lua","year":"2017","unstructured":"Lua, L. L., Pathak, P. & Dandolu, V. Comparing anticholinergic persistence and adherence profiles in overactive bladder patients based on gender, obesity, and major anticholinergic agents. Neurourol. Urodyn. 36, 2123\u20132131. https:\/\/doi.org\/10.1002\/nau.23256 (2017).","journal-title":"Neurourol. Urodyn."},{"key":"77983_CR20","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1080\/13697137.2019.1604655","volume":"22","author":"AK Shea","year":"2019","unstructured":"Shea, A. K., Meschino, D. & Wolfman, W. The effect of serotonin reuptake inhibitors on the vaginal epithelium in postmenopausal women. Climacteric. 22, 507\u2013510. https:\/\/doi.org\/10.1080\/13697137.2019.1604655 (2019).","journal-title":"Climacteric"},{"key":"77983_CR21","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/jsm.12032","volume":"10","author":"SJ Dawson","year":"2013","unstructured":"Dawson, S. J., Suschinsky, K. D. & Lalumiere, M. L. Habituation of sexual responses in men and women: a test of the preparation hypothesis of women\u2019s genital responses. J. Sex. Med. 10, 990\u20131000. https:\/\/doi.org\/10.1111\/jsm.12032 (2013).","journal-title":"J. Sex. Med."},{"key":"77983_CR22","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1098\/rspb.2008.0302","volume":"275","author":"SA Ramm","year":"2008","unstructured":"Ramm, S. A., Cheetham, S. A. & Hurst, J. L. Encoding choosiness: female attraction requires prior physical contact with individual male scents in mice. Proc. Biol. Sci. 275, 1727\u20131735. https:\/\/doi.org\/10.1098\/rspb.2008.0302 (2008).","journal-title":"Proc. Biol. Sci."},{"key":"77983_CR23","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/0196-9781(87)90061-1","volume":"8","author":"B Ottesen","year":"1987","unstructured":"Ottesen, B. et al. Vasoactive intestinal polypeptide (VIP) provokes vaginal lubrication in normal women. Peptides. 8, 797\u2013800. https:\/\/doi.org\/10.1016\/0196-9781(87)90061-1 (1987).","journal-title":"Peptides"},{"key":"77983_CR24","first-page":"281","volume":"9","author":"H Hamano","year":"1983","unstructured":"Hamano, H. et al. A new method for measuring tears. CLAO J. 9, 281\u2013289 (1983).","journal-title":"CLAO J."},{"key":"77983_CR25","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/0031-9384(91)90570-e","volume":"50","author":"B Jemiolo","year":"1991","unstructured":"Jemiolo, B., Xie, T. M. & Novotny, M. Socio-sexual olfactory preference in female mice: attractiveness of synthetic chemosignals. Physiol. Behav. 50, 1119\u20131122. https:\/\/doi.org\/10.1016\/0031-9384(91)90570-e (1991).","journal-title":"Physiol. Behav."},{"key":"77983_CR26","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1167\/iovs.61.10.48","volume":"61","author":"A Thayer","year":"2020","unstructured":"Thayer, A. et al. THC regulates tearing via cannabinoid CB1 receptors. Invest. Ophthalmol. Vis. Sci. 61, 48. https:\/\/doi.org\/10.1167\/iovs.61.10.48 (2020).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"77983_CR27","doi-asserted-by":"publisher","first-page":"14182","DOI":"10.1038\/s41598-022-17987-2","volume":"12","author":"K Andreis","year":"2022","unstructured":"Andreis, K. et al. Cannabinoid CB1 receptors regulate salivation. Sci. Rep. 12, 14182. https:\/\/doi.org\/10.1038\/s41598-022-17987-2 (2022).","journal-title":"Sci. Rep."},{"key":"77983_CR28","doi-asserted-by":"publisher","unstructured":"Boswald, L. F., Matzek, D., Kienzle, E. & Popper, B. Influence of strain and Diet on urinary pH in Laboratory mice. Anim. (Basel). 11 https:\/\/doi.org\/10.3390\/ani11030702 (2021).","DOI":"10.3390\/ani11030702"},{"key":"77983_CR29","doi-asserted-by":"publisher","first-page":"e35538","DOI":"10.1371\/journal.pone.0035538","volume":"7","author":"SL Byers","year":"2012","unstructured":"Byers, S. L., Wiles, M. V., Dunn, S. L. & Taft, R. A. Mouse estrous cycle identification tool and images. PLoS ONE. 7, e35538. https:\/\/doi.org\/10.1371\/journal.pone.0035538 (2012).","journal-title":"PLoS ONE"},{"key":"77983_CR30","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00441-002-0583-2","volume":"309","author":"JH Stehle","year":"2002","unstructured":"Stehle, J. H., von Gall, C. & Korf, H. W. Organisation of the circadian system in melatonin-proficient C3H and melatonin-deficient C57BL mice: a comparative investigation. Cell. Tissue Res. 309, 173\u2013182. https:\/\/doi.org\/10.1007\/s00441-002-0583-2 (2002).","journal-title":"Cell. Tissue Res."},{"key":"77983_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.3389\/fnbeh.2020.00113","volume":"14","author":"T Chari","year":"2020","unstructured":"Chari, T., Griswold, S., Andrews, N. A. & Fagiolini, M. The stage of the Estrus cycle is critical for interpretation of female mouse Social Interaction Behavior. Front. Behav. Neurosci. 14, 113. https:\/\/doi.org\/10.3389\/fnbeh.2020.00113 (2020).","journal-title":"Front. Behav. Neurosci."},{"key":"77983_CR32","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1007\/BF01207438","volume":"15","author":"S Harvey","year":"1989","unstructured":"Harvey, S., Jemiolo, B. & Novotny, M. Pattern of volatile compounds in dominant and subordinate male mouse urine. J. Chem. Ecol. 15, 2061\u20132072. https:\/\/doi.org\/10.1007\/BF01207438 (1989).","journal-title":"J. Chem. Ecol."},{"key":"77983_CR33","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/BF01955433","volume":"46","author":"M Novotny","year":"1990","unstructured":"Novotny, M., Harvey, S. & Jemiolo, B. Chemistry of male dominance in the house mouse, Mus domesticus. Experientia. 46, 109\u2013113. https:\/\/doi.org\/10.1007\/BF01955433 (1990).","journal-title":"Experientia"},{"key":"77983_CR34","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1530\/jrf.0.0430515","volume":"43","author":"JG Vandenbergh","year":"1975","unstructured":"Vandenbergh, J. G., Whitsett, J. M. & Lombardi, J. R. Partial isolation of a pheromone accelerating puberty in female mice. J. Reprod. Fertil. 43, 515\u2013523. https:\/\/doi.org\/10.1530\/jrf.0.0430515 (1975).","journal-title":"J. Reprod. Fertil."},{"key":"77983_CR35","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1210\/endo-84-3-658","volume":"84","author":"JG Vandenbergh","year":"1969","unstructured":"Vandenbergh, J. G. Male odor accelerates female sexual maturation in mice. Endocrinology. 84, 658\u2013660. https:\/\/doi.org\/10.1210\/endo-84-3-658 (1969).","journal-title":"Endocrinology"},{"key":"77983_CR36","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/j.dcn.2011.07.007","volume":"1","author":"I Gordon","year":"2011","unstructured":"Gordon, I., Martin, C., Feldman, R. & Leckman, J. F. Oxytocin and social motivation. Dev. Cogn. Neurosci. 1, 471\u2013493. https:\/\/doi.org\/10.1016\/j.dcn.2011.07.007 (2011).","journal-title":"Dev. Cogn. Neurosci."},{"key":"77983_CR37","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1111\/j.1467-7687.2010.01021.x","volume":"14","author":"R Feldman","year":"2011","unstructured":"Feldman, R., Gordon, I. & Zagoory-Sharon, O. Maternal and paternal plasma, salivary, and urinary oxytocin and parent-infant synchrony: considering stress and affiliation components of human bonding. Dev. Sci. 14, 752\u2013761. https:\/\/doi.org\/10.1111\/j.1467-7687.2010.01021.x (2011).","journal-title":"Dev. Sci."},{"key":"77983_CR38","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/s0031-9384(01)00537-6","volume":"74","author":"S Jacob","year":"2001","unstructured":"Jacob, S., Hayreh, D. J. & McClintock, M. K. Context-dependent effects of steroid chemosignals on human physiology and mood. Physiol. Behav. 74, 15\u201327. https:\/\/doi.org\/10.1016\/s0031-9384(01)00537-6 (2001).","journal-title":"Physiol. Behav."},{"key":"77983_CR39","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1523\/JNEUROSCI.4430-06.2007","volume":"27","author":"C Wyart","year":"2007","unstructured":"Wyart, C. et al. Smelling a single component of male sweat alters levels of cortisol in women. J. Neurosci. 27, 1261\u20131265. https:\/\/doi.org\/10.1523\/JNEUROSCI.4430-06.2007 (2007).","journal-title":"J. Neurosci."},{"key":"77983_CR40","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.yhbeh.2004.06.002","volume":"46","author":"NA Spencer","year":"2004","unstructured":"Spencer, N. A. et al. Social chemosignals from breastfeeding women increase sexual motivation. Horm. Behav. 46, 362\u2013370. https:\/\/doi.org\/10.1016\/j.yhbeh.2004.06.002 (2004).","journal-title":"Horm. Behav."},{"key":"77983_CR41","doi-asserted-by":"publisher","first-page":"20142994","DOI":"10.1098\/rspb.2014.2994","volume":"282","author":"TD Wyatt","year":"2015","unstructured":"Wyatt, T. D. The search for human pheromones: the lost decades and the necessity of returning to first principles. Proc. Biol. Sci. 282, 20142994. https:\/\/doi.org\/10.1098\/rspb.2014.2994 (2015).","journal-title":"Proc. Biol. Sci."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77983-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77983-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77983-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T14:07:15Z","timestamp":1731420435000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-77983-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,12]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["77983"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-77983-6","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2024,11,12]]},"assertion":[{"value":"10 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27707"}}