{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T05:10:21Z","timestamp":1731129021327,"version":"3.28.0"},"reference-count":104,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:00:00Z","timestamp":1730764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-78150-7","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T06:02:09Z","timestamp":1730786529000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies"],"prefix":"10.1038","volume":"14","author":[{"given":"Michael","family":"Agrez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristofer J.","family":"Thurecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas L.","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gayathri","family":"Subramaniam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher B.","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Parker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darryl","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Rzepecka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavin","family":"Knox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anastasia","family":"Nika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew M.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayley","family":"Gooding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,5]]},"reference":[{"key":"78150_CR1","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1038\/s41392-023-01557-7","volume":"8","author":"T Zhao","year":"2023","unstructured":"Zhao, T. et al. Vaccine adjuvants: mechanisms and platforms. Signal. Transduct. Target. Ther. 8, 283 (2023).","journal-title":"Signal. Transduct. Target. Ther."},{"key":"78150_CR2","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1189\/jlb.72.5.932","volume":"72","author":"M Fogel","year":"2002","unstructured":"Fogel, M., Long, J. A., Thompson, P. J. & Upham, J. W. Dendritic cell maturation and IL-12 synthesis induced by the synthetic immune-response modifier S-28463. J. Leukoc. Biol. 72, 932\u2013938 (2002).","journal-title":"J. Leukoc. Biol."},{"key":"78150_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1097\/CJI.0b013e318165f5d2","volume":"31","author":"AS Kaka","year":"2008","unstructured":"Kaka, A. S., Foster, A. E., Weiss, H. E., Rooney, C. M. & Leen, A. M. Using dendritic cell maturation and IL-12 producing capacity as markers of function: a cautionary tale. J. Immunother. 31, 359\u2013369 (2008).","journal-title":"J. Immunother"},{"key":"78150_CR4","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1586\/14760584.2014.863715","volume":"13","author":"H Shirota","year":"2014","unstructured":"Shirota, H. & Klinman, D. M. Recent progress concerning CpG DNA and its use as a vaccine adjuvant. Expert Rev. Vaccines. 13, 299\u2013312 (2014).","journal-title":"Expert Rev. Vaccines"},{"key":"78150_CR5","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1038\/ni1210","volume":"6","author":"G Shakhar","year":"2005","unstructured":"Shakhar, G. et al. Stable T cell\u2013dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat. Immunol. 6, 707\u2013714 (2005).","journal-title":"Nat. Immunol."},{"key":"78150_CR6","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1111\/j.1600-0625.2007.00668.x","volume":"17","author":"H Haenssle","year":"2008","unstructured":"Haenssle, H. et al. CD40 ligation during dendritic cell maturation reduces cell death and prevents interleukin-10\u2010induced regression to macrophage\u2010like monocytes. Exp. Dermatol. 17, 177\u2013187 (2008).","journal-title":"Exp. Dermatol."},{"key":"78150_CR7","doi-asserted-by":"crossref","unstructured":"Lion, E., Smits, E. L., Berneman, Z. N. & Van Tendeloo V. F. NK cells: Key to success of DC-based cancer vaccines? Oncologist. 17, 1256\u20131270 (2012).","DOI":"10.1634\/theoncologist.2011-0122"},{"key":"78150_CR8","doi-asserted-by":"publisher","first-page":"18994","DOI":"10.1038\/s41598-023-45412-9","volume":"13","author":"A Alrubayyi","year":"2023","unstructured":"Alrubayyi, A. et al. Natural killer cell responses during SARS-CoV-2 infection and vaccination in people living with HIV-1. Sci. Rep. 13, 18994 (2023).","journal-title":"Sci. Rep."},{"key":"78150_CR9","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.4049\/jimmunol.1000844","volume":"185","author":"A Horowitz","year":"2010","unstructured":"Horowitz, A., Behrens, R. H., Okell, L., Fooks, A. R. & Riley, E. M. NK cells as effectors of acquired immune responses: Effector CD4\u2009+\u2009T cell-dependent activation of NK cells following vaccination. J. Immunol. 185, 2808\u20132818 (2010).","journal-title":"J. Immunol."},{"key":"78150_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijid.2013.09.023","volume":"19","author":"C Qu","year":"2014","unstructured":"Qu, C., Brinck-Jensen, N. S., Zang, M. & Chen, K. Monocyte-derived dendritic cells: Targets as potent antigen-presenting cells for the design of vaccines against infectious diseases. Int. J. Infect. Dis. 19, 1\u20135 (2014).","journal-title":"Int. J. Infect. Dis."},{"key":"78150_CR11","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1189\/jlb.0106011","volume":"80","author":"V Hoene","year":"2006","unstructured":"Hoene, V., Peiser, M. & Wanner, R. Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19. J. Leukoc. Biol. 80, 1328\u20131336 (2006).","journal-title":"J. Leukoc. Biol."},{"key":"78150_CR12","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.3389\/fimmu.2020.01513","volume":"11","author":"JA Soto","year":"2020","unstructured":"Soto, J. A. et al. The role of dendritic cells during infections caused by highly prevalent viruses. Front. Immunol. 11, 1513 (2020).","journal-title":"Front. Immunol."},{"key":"78150_CR13","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1084\/jem.20060401","volume":"203","author":"C Guiducci","year":"2006","unstructured":"Guiducci, C. et al. Properties regulating the nature of the plasmacytoid dendritic cell response to toll-like receptor 9 activation. J. Exp. Med. 203, 1999\u20132008 (2006).","journal-title":"J. Exp. Med."},{"key":"78150_CR14","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1159\/000163628","volume":"59","author":"JH Peters","year":"1991","unstructured":"Peters, J. H., Ruppert, J., Gieseler, R. K. H., Najar, H. M. & Xu, H. Differentiation of human monocytes into CD14 negative accessory cells: Do dendritic cells derive from the monocytic lineage? Pathobiology. 59, 122\u2013126 (1991).","journal-title":"Pathobiology"},{"key":"78150_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2172-13-22","volume":"13","author":"AM Gerlach","year":"2012","unstructured":"Gerlach, A. M. et al. Role of CD40 ligation in dendritic cell semimaturation. BMC Immunol. 13, 1\u201311 (2012).","journal-title":"BMC Immunol."},{"key":"78150_CR16","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.4049\/jimmunol.170.8.4069","volume":"170","author":"M Dauer","year":"2003","unstructured":"Dauer, M. et al. Mature dendritic cells derived from human monocytes within 48 hours: A novel strategy for dendritic cell differentiation from blood precursors. J. Immunol. 170, 4069\u20134076 (2003).","journal-title":"J. Immunol."},{"key":"78150_CR17","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.1002\/1521-4141(200209)32:9<2617::AID-IMMU2617>3.0.CO;2-F","volume":"32","author":"M Gursel","year":"2002","unstructured":"Gursel, M., Verthelyi, D. & Klinman, D. M. CpG oligodeoxynucleotides induce human monocytes to mature into functional dendritic cells. Eur. J. Immunol. 32, 2617\u20132622 (2002).","journal-title":"Eur. J. Immunol."},{"key":"78150_CR18","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/j.1600-065X.2009.00782.x","volume":"229","author":"R Elgueta","year":"2009","unstructured":"Elgueta, R. et al. Molecular mechanism and function of CD40\/CD40L engagement in the immune system. Immunol. Rev. 229, 152\u2013172 (2009).","journal-title":"Immunol. Rev."},{"key":"78150_CR19","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12865-023-00547-2","volume":"24","author":"H Choi","year":"2023","unstructured":"Choi, H., Lee, H. J., Sohn, H. J. & Kim, T. G. CD40 ligand stimulation affects the number and memory phenotypes of human peripheral CD8\u2009+\u2009T cells. BMC Immunol. 24, 15 (2023).","journal-title":"BMC Immunol."},{"key":"78150_CR20","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3390\/vaccines8040617","volume":"8","author":"C Lapenta","year":"2020","unstructured":"Lapenta, C., Gabriele, L. & Santini, S. M. IFN-alpha-mediated differentiation of dendritic cells for cancer immunotherapy: Advances and perspectives. Vaccines. 8, 617 (2020).","journal-title":"Vaccines"},{"key":"78150_CR21","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1172\/JCI68395","volume":"123","author":"BM Carreno","year":"2013","unstructured":"Carreno, B. M. et al. IL-12p70\u2013producing patient DC vaccine elicits Tc1-polarized immunity. J. Clin. Invest. 123, 3383\u20133394 (2013).","journal-title":"J. Clin. Invest."},{"key":"78150_CR22","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1128\/JVI.01262-19","volume":"93","author":"L Ye","year":"2019","unstructured":"Ye, L. et al. Type I and type III interferons differ in their adjuvant activities for influenza vaccines. J. Virol. 93, 10\u20131128 (2019).","journal-title":"J. Virol."},{"key":"78150_CR23","doi-asserted-by":"publisher","first-page":"eadm845123","DOI":"10.1126\/scitranslmed.adm8451","volume":"16","author":"B Brook","year":"2024","unstructured":"Brook, B. et al. Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70. Sci. Transl Med. 16, eadm845123 (2024).","journal-title":"Sci. Transl Med."},{"key":"78150_CR24","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1016\/j.jaci.2009.02.011","volume":"123","author":"S L\u00e9tourneau","year":"2009","unstructured":"L\u00e9tourneau, S., Krieg, C., Pantaleo, G. & Boyman, O. IL-2- and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets. J. Allergy Clin. Immunol. 123, 758\u2013762 (2009).","journal-title":"J. Allergy Clin. Immunol."},{"key":"78150_CR25","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1038\/sj.embor.7401099","volume":"8","author":"MF Bachmann","year":"2007","unstructured":"Bachmann, M. F. & Oxenius, A. Interleukin 2: From immunostimulation to immunoregulation and back again. EMBO Rep. 8, 1142\u20131148 (2007).","journal-title":"EMBO Rep."},{"key":"78150_CR26","doi-asserted-by":"publisher","first-page":"294","DOI":"10.4049\/jimmunol.140.1.294","volume":"140","author":"A Weinberg","year":"1988","unstructured":"Weinberg, A. & Merigan, T. C. Recombinant interleukin 2 as an adjuvant for vaccine-induced protection. Immunization of guinea pigs with herpes simplex virus subunit vaccines. J. Immunol. 140, 294\u2013299 (1988).","journal-title":"J. Immunol."},{"key":"78150_CR27","doi-asserted-by":"publisher","first-page":"4240","DOI":"10.1073\/pnas.86.11.4240","volume":"86","author":"JH Nunberg","year":"1989","unstructured":"Nunberg, J. H., Doyle, M. V., York, S. M. & York, C. J. Interleukin 2 acts as an adjuvant to increase the potency of inactivated rabies virus vaccine. Proc. Natl. Acad. Sci. U S A. 86, 4240\u20134243 (1989).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"78150_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40425-016-0160-y","volume":"4","author":"H Khong","year":"2016","unstructured":"Khong, H. & Overwijk, W. W. Adjuvants for peptide-based cancer vaccines. J. Immunother. Cancer. 4, 1\u201311 (2016).","journal-title":"J. Immunother. Cancer"},{"key":"78150_CR29","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s11094-020-02111-3","volume":"53","author":"NA Alpatova","year":"2020","unstructured":"Alpatova, N. A., Avdeeva, Z. I., Nikitina, T. N. & Medunitsyn, N. V. Adjuvant properties of cytokines in vaccination. Pharm. Chem. J. 53, 991\u2013996 (2020).","journal-title":"Pharm. Chem. J."},{"key":"78150_CR30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.3390\/pharmaceutics13020142","volume":"13","author":"M Luchner","year":"2021","unstructured":"Luchner, M., Reinke, S. & Milicic, A. TLR agonists as vaccine adjuvants targeting cancer and infectious diseases. Pharmaceutics. 13, 142 (2021).","journal-title":"Pharmaceutics"},{"key":"78150_CR31","doi-asserted-by":"publisher","first-page":"3752","DOI":"10.1016\/j.vaccine.2007.01.111","volume":"25","author":"JC Aguilar","year":"2007","unstructured":"Aguilar, J. C. & Rodriguez, E. G. Vaccine adjuvants revisited. Vaccine. 25, 3752\u20133762 (2007).","journal-title":"Vaccine"},{"key":"78150_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12862-017-0901-7","volume":"17","author":"E Ishengoma","year":"2017","unstructured":"Ishengoma, E. & Agaba, M. Evolution of toll-like receptors in the context of terrestrial ungulates and cetaceans diversification. BMC Evol. Biol. 17, 1\u201313 (2017).","journal-title":"BMC Evol. Biol."},{"key":"78150_CR33","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1038\/cmi.2012.38","volume":"9","author":"JL Cervantes","year":"2012","unstructured":"Cervantes, J. L., Weinerman, B., Basole, C. & Salazar, J. C. TLR8: The forgotten relative revindicated. Cell. Mol. Immunol. 9, 434\u2013438 (2012).","journal-title":"Cell. Mol. Immunol."},{"key":"78150_CR34","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.immuni.2011.05.006","volume":"34","author":"T Kawai","year":"2011","unstructured":"Kawai, T. & Akira, S. Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity. 34, 637\u2013650 (2011).","journal-title":"Immunity"},{"key":"78150_CR35","doi-asserted-by":"publisher","first-page":"C2","DOI":"10.1016\/j.vaccine.2010.07.022","volume":"28","author":"M Moser","year":"2010","unstructured":"Moser, M. & Leo, O. Key concepts in immunology. Vaccine. 28, C2\u2013C13 (2010).","journal-title":"Vaccine"},{"key":"78150_CR36","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.addr.2008.12.008","volume":"61","author":"J Vollmer","year":"2009","unstructured":"Vollmer, J. & Krieg, A. M. Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists. Adv. Drug Deliv Rev. 61, 195\u2013204 (2009).","journal-title":"Adv. Drug Deliv Rev."},{"key":"78150_CR37","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.7150\/ijbs.81210","volume":"19","author":"JX Yang","year":"2023","unstructured":"Yang, J. X. et al. TLR9 and STING agonists cooperatively boost the immune response to SARS-CoV-2 RBD vaccine through an increased germinal center B cell response and reshaped T helper responses. Int. J. Biol. Sci. 19, 2897\u20132913 (2023).","journal-title":"Int. J. Biol. Sci."},{"key":"78150_CR38","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3389\/fnut.2019.00140","volume":"6","author":"S Nigar","year":"2019","unstructured":"Nigar, S. & Shimosato, T. Cooperation of oligodeoxynucleotides and synthetic molecules as enhanced immune modulators. Front. Nutr. 6, 140 (2019).","journal-title":"Front. Nutr."},{"key":"78150_CR39","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1586\/erv.10.174","volume":"10","author":"C Bode","year":"2011","unstructured":"Bode, C., Zhao, G., Steinhagen, F., Kinjo, T. & Klinman, D. M. CpG DNA as a vaccine adjuvant. Expert Rev. Vaccines. 10, 499\u2013511 (2011).","journal-title":"Expert Rev. Vaccines"},{"key":"78150_CR40","doi-asserted-by":"crossref","unstructured":"Miga, A. J. et al. Dendritic cell longevity and T cell persistence is controlled by CD154-CD40 interactions. Eur. J. Immunol. 31, 959\u2013965 (2001). (2001).","DOI":"10.1002\/1521-4141(200103)31:3<959::AID-IMMU959>3.0.CO;2-A"},{"key":"78150_CR41","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1093\/intimm\/14.4.367","volume":"14","author":"T Luft","year":"2002","unstructured":"Luft, T. et al. IFN-\u03b1 enhances CD40 ligand\u2010mediated activation of immature monocyte\u2010derived dendritic cells. Int. Immunol. 14, 367\u2013380 (2002).","journal-title":"Int. Immunol."},{"key":"78150_CR42","doi-asserted-by":"publisher","first-page":"11185","DOI":"10.1038\/s41598-022-15455-5","volume":"12","author":"M Agrez","year":"2022","unstructured":"Agrez, M. et al. A novel lipidic peptide with potential to promote balanced effector-regulatory T cell responses. Sci. Rep. 12, 11185 (2022).","journal-title":"Sci. Rep."},{"key":"78150_CR43","doi-asserted-by":"publisher","first-page":"7137","DOI":"10.4049\/jimmunol.179.10.7137","volume":"179","author":"E Kakazu","year":"2007","unstructured":"Kakazu, E., Kanno, N., Ueno, Y. & Shimosegawa, T. Extracellular branched-chain amino acids, especially valine, regulate maturation and function of monocyte-derived dendritic cells. J. Immunol. 179, 7137\u20137146 (2007).","journal-title":"J. Immunol."},{"key":"78150_CR44","doi-asserted-by":"publisher","first-page":"5836","DOI":"10.1074\/jbc.M007540200","volume":"276","author":"S Futaki","year":"2001","unstructured":"Futaki, S. et al. Arginine-rich peptides: An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery. J. Biol. Chem. 276, 5836\u20135840 (2001).","journal-title":"J. Biol. Chem."},{"key":"78150_CR45","doi-asserted-by":"publisher","first-page":"13003","DOI":"10.1073\/pnas.97.24.13003","volume":"97","author":"PA Wender","year":"2000","unstructured":"Wender, P. A. et al. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters. Proc. Natl. Acad. Sci. U S A. 97, 13003\u201313008 (2000).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"78150_CR46","doi-asserted-by":"publisher","first-page":"11702","DOI":"10.1038\/s41598-023-38890-4","volume":"13","author":"M Agrez","year":"2023","unstructured":"Agrez, M. et al. An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage. Sci. Rep. 13, 11702 (2023).","journal-title":"Sci. Rep."},{"key":"78150_CR47","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/JLB.5MIR0420-055R","volume":"108","author":"K Bendickova","year":"2020","unstructured":"Bendickova, K. & Fric, J. Roles of IL-2 in bridging adaptive and innate immunity, and as a tool for cellular immunotherapy. J. Leucoc Biol. 108, 427\u2013437 (2020).","journal-title":"J. Leucoc Biol."},{"key":"78150_CR48","doi-asserted-by":"publisher","first-page":"3058","DOI":"10.1073\/pnas.0812851107","volume":"107","author":"D Busse","year":"2010","unstructured":"Busse, D. et al. Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc. Natl. Acad. Sci. U S A. 107, 3058\u20133063 (2010).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"78150_CR49","doi-asserted-by":"publisher","first-page":"e0167215","DOI":"10.1371\/journal.pone.0167215","volume":"11","author":"AN Shatrova","year":"2016","unstructured":"Shatrova, A. N. et al. Time-dependent regulation of IL-2R \u03b1-chain (CD25) expression by TCR signal strength and IL-2-induced STAT5 signaling in activated human blood T lymphocytes. PLoS ONE. 11, e0167215 (2016).","journal-title":"PLoS ONEs"},{"key":"78150_CR50","doi-asserted-by":"publisher","first-page":"3183","DOI":"10.1182\/blood.V95.10.3183","volume":"95","author":"KS Wang","year":"2000","unstructured":"Wang, K. S., Frank, D. A. & Ritz, J. Interleukin-2 enhances the response of natural killer cells to interleukin-12 through up-regulation of the interleukin-12 receptor and STAT4. Blood. 95, 3183\u20133190 (2000).","journal-title":"Blood"},{"key":"78150_CR51","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1084\/jem.20122462","volume":"210","author":"G Gasteiger","year":"2013","unstructured":"Gasteiger, G. et al. IL-2\u2013dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells. J. Exp. Med. 210, 1167\u20131178 (2013).","journal-title":"J. Exp. Med."},{"key":"78150_CR52","doi-asserted-by":"crossref","unstructured":"Noelle, R. J. et al. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc. Natl. Acad. Sci. U. S. A. 89, 6550\u20136554 (1992).","DOI":"10.1073\/pnas.89.14.6550"},{"key":"78150_CR53","first-page":"69","volume":"73","author":"T Kawabe","year":"2011","unstructured":"Kawabe, T., Matsushima, M., Hashimoto, N., Imaizumi, K. & Hasegawa, Y. CD40\/CD40 ligand interactions in immune responses and pulmonary immunity. Nagoya J. Med. Sci. 73, 69 (2011).","journal-title":"Nagoya J. Med. Sci."},{"key":"78150_CR54","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.4049\/jimmunol.163.5.2517","volume":"163","author":"R Bianchi","year":"1999","unstructured":"Bianchi, R. et al. Autocrine IL-12 is involved in dendritic cell modulation via CD40 ligation. J. Immunol. 163, 2517\u20132521 (1999).","journal-title":"J. Immunol."},{"key":"78150_CR55","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.4049\/jimmunol.160.4.1701","volume":"160","author":"JF McDyer","year":"1998","unstructured":"McDyer, J. F., Goletz, T. J., Thomas, E., June, C. H. & Seder, R. A. CD40 ligand\/CD40 stimulation regulates the production of IFN-gamma from human peripheral blood mononuclear cells in an IL-12- and\/or CD28-dependent manner. J. Immunol. 160, 1701\u20131707 (1998).","journal-title":"J. Immunol."},{"key":"78150_CR56","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.addr.2018.12.005","volume":"141","author":"JL Karnell","year":"2019","unstructured":"Karnell, J. L., Rieder, S. A., Ettinger, R. & Kolbeck, R. Targeting the CD40-CD40L pathway in autoimmune diseases: Humoral immunity and beyond. Adv. Drug Deliv Rev. 141, 92\u2013103 (2019).","journal-title":"Adv. Drug Deliv Rev."},{"key":"78150_CR57","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3389\/fimmu.2012.00161","volume":"3","author":"T Zelante","year":"2012","unstructured":"Zelante, T., Fric, J., Wong Yoke Wei, A. & Ricciardi-Castagnoli, P. Interleukin-2 production by dendritic cells and its immuno-regulatory functions. Front. Immunol. 3, 161 (2012).","journal-title":"Front. Immunol."},{"key":"78150_CR58","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.actbio.2021.05.003","volume":"133","author":"CL O\u2019Neill","year":"2021","unstructured":"O\u2019Neill, C. L., Shrimali, P. C., Clapacs, Z. E., Files, M. A. & Rudra, J. S. Peptide-based supramolecular vaccine systems. Acta Biomater. 133, 153\u2013167 (2021).","journal-title":"Acta Biomater."},{"key":"78150_CR59","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1096\/fasebj.11.6.9194525","volume":"11","author":"M Seia","year":"1997","unstructured":"Seia, M. & Zisman, E. Different roles of D-amino acids in immune phenomena. FASEB J. 11, 449\u2013456 (1997).","journal-title":"FASEB J."},{"key":"78150_CR60","doi-asserted-by":"publisher","first-page":"5281","DOI":"10.2147\/IJN.S317626","volume":"16","author":"W Chen","year":"2021","unstructured":"Chen, W. et al. CpG-based nanovaccines for cancer immunotherapy. Int. J. Nanomed. 16, 5281\u20135299 (2021).","journal-title":"Int. J. Nanomed."},{"key":"78150_CR61","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3390\/cells13010097","volume":"13","author":"MA Miles","year":"2024","unstructured":"Miles, M. A. et al. TLR9 monotherapy in immune-competent mice suppresses orthotopic prostate tumor development. Cells. 13, 97 (2024).","journal-title":"Cells"},{"key":"78150_CR62","doi-asserted-by":"publisher","first-page":"154","DOI":"10.7150\/ijbs.62424","volume":"18","author":"H Zhao","year":"2022","unstructured":"Zhao, H. et al. CpG-C ODN M362 as an immunoadjuvant for HBV therapeutic vaccine reverses the systemic tolerance against HBV. Int. J. Biol. Sci. 18, 154 (2022).","journal-title":"Int. J. Biol. Sci."},{"key":"78150_CR63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12985-018-1089-1","volume":"15","author":"P Yu","year":"2018","unstructured":"Yu, P. et al. A CpG oligodeoxynucleotide enhances the immune response to rabies vaccination in mice. Virol. J. 15, 1\u20138 (2018).","journal-title":"Virol. J."},{"key":"78150_CR64","doi-asserted-by":"publisher","first-page":"649","DOI":"10.3390\/vaccines11030649","volume":"11","author":"Y Li","year":"2023","unstructured":"Li, Y. & Chen, X. CpG 1018 is an effective adjuvant for influenza nucleoprotein. Vaccines. 11, 649 (2023).","journal-title":"Vaccines"},{"key":"78150_CR65","doi-asserted-by":"publisher","first-page":"33","DOI":"10.4110\/in.2016.16.1.33","volume":"16","author":"S Lim","year":"2016","unstructured":"Lim, S., Koo, J. H. & Choi, J. M. Use of cell-penetrating peptides in dendritic cell-based vaccination. Immune Netw. 16, 33\u201343 (2016).","journal-title":"Immune Netw."},{"key":"78150_CR66","first-page":"1477","volume":"62","author":"F Mattner","year":"2002","unstructured":"Mattner, F. et al. Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: Induction of potent and long-lasting T-cell responses against cancer antigens. Cancer Res. 62, 1477\u20131480 (2002).","journal-title":"Cancer Res."},{"key":"78150_CR67","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S0958-1669(98)80011-6","volume":"9","author":"MH Van Regenmortel","year":"1998","unstructured":"Van Regenmortel, M. H. & Muller, S. D-peptides as immunogens and diagnostic reagents. Curr. Opin. Biotechnol. 9, 377\u2013382 (1998).","journal-title":"Curr. Opin. Biotechnol."},{"key":"78150_CR68","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1038\/s41423-021-00734-4","volume":"19","author":"TN Bullock","year":"2022","unstructured":"Bullock, T. N. CD40 stimulation as a molecular adjuvant for cancer vaccines and other immunotherapies. Cell. Mol. Immunol. 19, 14\u201322 (2022).","journal-title":"Cell. Mol. Immunol."},{"key":"78150_CR69","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/ni1223","volume":"6","author":"G Napolitani","year":"2005","unstructured":"Napolitani, G., Rinaldi, A., Bertoni, F., Sallusto, F. & Lanzavecchia, A. Selected toll-like receptor agonist combinations synergistically trigger a T helper type 1\u2013polarizing program in dendritic cells. Nat. Immunol. 6, 769\u2013776 (2005).","journal-title":"Nat. Immunol."},{"key":"78150_CR70","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1007\/s00262-005-0089-3","volume":"55","author":"T Osada","year":"2006","unstructured":"Osada, T., Clay, T., Hobeika, A., Lyerly, H. K. & Morse, M. A. NK cell activation by dendritic cell vaccine: A mechanism of action for clinical activity. Cancer Immunol. Immunother. 55, 1122\u20131131 (2006).","journal-title":"Cancer Immunol. Immunother"},{"key":"78150_CR71","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1158\/1078-0432.CCR-13-2302","volume":"20","author":"CH Van Elssen","year":"2014","unstructured":"Van Elssen, C. H., Oth, T., Germeraad, W. T., Bos, G. M. & Vanderlocht, J. Natural killer cells: The secret weapon in dendritic cell vaccination strategies. Clin. Cancer Res. 20, 1095\u20131103 (2014).","journal-title":"Clin. Cancer Res."},{"key":"78150_CR72","doi-asserted-by":"crossref","unstructured":"Pampena, M. B. & Levy, E. M. Natural killer cells as helper cells in dendritic cell cancer vaccines. Front. Immunol. 6, 13 (2015). (2015).","DOI":"10.3389\/fimmu.2015.00013"},{"key":"78150_CR73","doi-asserted-by":"publisher","first-page":"e29585","DOI":"10.1002\/jmv.29585","volume":"96","author":"D Mele","year":"2024","unstructured":"Mele, D. et al. Long-term dynamics of natural killer cells in response to SARS\u2010CoV\u20102 vaccination: Persistently enhanced activity postvaccination. J. Med. Virol. 96, e29585 (2024).","journal-title":"J. Med. Virol."},{"key":"78150_CR74","doi-asserted-by":"publisher","first-page":"113712","DOI":"10.1016\/j.ejmech.2021.113712","volume":"224","author":"J Zhou","year":"2021","unstructured":"Zhou, J., Li, Y., Huang, W., Shi, W. & Qian, H. Source and exploration of the peptides used to construct peptide-drug conjugates. Eur. J. Med. Chem. 224, 113712 (2021).","journal-title":"Eur. J. Med. Chem."},{"key":"78150_CR75","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1189\/jlb.72.6.1180","volume":"72","author":"M Rosenzwajg","year":"2002","unstructured":"Rosenzwajg, M., Jourquin, F., Tailleux, L. & Gluckman, J. C. CD40 ligation and phagocytosis differently affect the differentiation of monocytes into dendritic cells. J. Leukoc. Biol. 72, 1180\u20131189 (2002).","journal-title":"J. Leukoc. Biol."},{"key":"78150_CR76","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1093\/intimm\/8.2.275","volume":"8","author":"AI Jaiswal","year":"1996","unstructured":"Jaiswal, A. I., Dubey, C., Swain, S. L. & Croft, M. Regulation of CD40 ligand expression on naive CD4 T cells: A role for TCR but not co-stimulatory signals. Int. Immunol. 8, 275\u2013285 (1996).","journal-title":"Int. Immunol."},{"key":"78150_CR77","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.intimp.2008.12.012","volume":"9","author":"ER Secor Jr","year":"2009","unstructured":"Secor, E. R. Jr et al. Bromelain treatment reduces CD25 expression on activated CD4\u2009+\u2009T cells in vitro. Int. Immunopharmacol. 9, 340\u2013346 (2009).","journal-title":"Int. Immunopharmacol."},{"key":"78150_CR78","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.4049\/jimmunol.169.5.2736","volume":"169","author":"JF McDyer","year":"2002","unstructured":"McDyer, J. F. et al. IL-2 receptor blockade inhibits late, but not early, IFN-\u03b3 and CD40 ligand expression in human T cells: Disruption of both IL-12-dependent and-independent pathways of IFN-\u03b3 production. J. Immunol. 169, 2736\u20132746 (2002).","journal-title":"J. Immunol."},{"key":"78150_CR79","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1084\/jem.20020845","volume":"196","author":"BO Lee","year":"2002","unstructured":"Lee, B. O., Haynes, L., Eaton, S. M., Swain, S. L. & Randall, T. D. The biological outcome of CD40 signaling is dependent on the duration of CD40 ligand expression: Reciprocal regulation by interleukin (IL)-4 and IL-12. J. Exp. Med. 196, 693\u2013704 (2002).","journal-title":"J. Exp. Med."},{"key":"78150_CR80","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1016\/j.ajpath.2020.05.007","volume":"190","author":"AK Abbas","year":"2020","unstructured":"Abbas, A. K. The surprising story of IL-2: From experimental models to clinical application. Am. J. Pathol. 190, 1776\u20131781 (2020).","journal-title":"Am. J. Pathol."},{"key":"78150_CR81","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1158\/2326-6066.CIR-17-0549","volume":"6","author":"H Sultan","year":"2018","unstructured":"Sultan, H. et al. Sustained persistence of IL-2 signaling enhances the antitumor effect of peptide vaccines through T-cell expansion and preventing PD-1 inhibition. Cancer Immunol. Res. 6, 617\u2013627 (2018).","journal-title":"Cancer Immunol. Res."},{"key":"78150_CR82","doi-asserted-by":"crossref","unstructured":"Cox, A. et al. Targeting natural killer cells to enhance vaccine responses. Trends Pharmacol. Sci. 42, 789\u2013801 (2021). (2021).","DOI":"10.1016\/j.tips.2021.06.004"},{"key":"78150_CR83","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.bbmt.2014.01.006","volume":"20","author":"JW Leong","year":"2014","unstructured":"Leong, J. W. et al. Preactivation with IL-12, IL-15, and IL-18 induces CD25 and a functional high-affinity IL-2 receptor on human cytokine-induced memory-like natural killer cells. Biol. Blood Marrow Tr. 20, 463\u2013473 (2014).","journal-title":"Biol. Blood Marrow Tr."},{"key":"78150_CR84","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1182\/blood-2005-07-2709","volume":"107","author":"T Ito","year":"2006","unstructured":"Ito, T., Kanzler, H., Duramad, O., Cao, W. & Liu, Y. J. Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. Blood. 107, 2423\u20132431 (2006).","journal-title":"Blood"},{"key":"78150_CR85","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/nature03547","volume":"434","author":"K Honda","year":"2005","unstructured":"Honda, K. et al. Spatiotemporal regulation of MyD88\u2013IRF-7 signalling for robust type-I interferon induction. Nature. 434, 1035\u20131040 (2005).","journal-title":"Nature"},{"key":"78150_CR86","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1016\/S0264-410X(02)00343-2","volume":"20","author":"K Lingnau","year":"2002","unstructured":"Lingnau, K. et al. Poly-L-arginine synergizes with oligodeoxynucleotides containing CpG-motifs (CpG-ODN) for enhanced and prolonged immune responses and prevents the CpG-ODN-induced systemic release of pro-inflammatory cytokines. Vaccine. 20, 3498\u20133508 (2002).","journal-title":"Vaccine"},{"key":"78150_CR87","first-page":"101573","volume":"36","author":"M Matsuda","year":"2023","unstructured":"Matsuda, M. & Mochizuki, S. Control of A\/D type CpG-ODN aggregates to a suitable size for induction of strong immunostimulant activity. Biochem. Biophys. Rep. 36, 101573 (2023).","journal-title":"Biochem. Biophys. Rep."},{"key":"78150_CR88","doi-asserted-by":"crossref","unstructured":"M\u00e9ndez-Ardoy, A., Lostal\u00e9\u2010Seijo, I. & Montenegro, J. Where in the cell is our cargo? Methods currently used to study intracellular cytosolic localisation. Chembiochem. 20, 488\u2013498 (2019).","DOI":"10.1002\/cbic.201800390"},{"key":"78150_CR89","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000142731","volume":"1","author":"AK Kiemer","year":"2008","unstructured":"Kiemer, A. K. et al. Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. J. Innate Immun. 1, 29\u201345 (2008).","journal-title":"J. Innate Immun."},{"key":"78150_CR90","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1002\/eji.200324032","volume":"34","author":"J Vollmer","year":"2004","unstructured":"Vollmer, J. et al. Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities. Eur. J. Immunol. 34, 251\u2013262 (2004).","journal-title":"Eur. J. Immunol."},{"key":"78150_CR91","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.immuni.2008.09.002","volume":"29","author":"JA Villadangos","year":"2008","unstructured":"Villadangos, J. A. & Young, L. Antigen-presentation properties of plasmacytoid dendritic cells. Immunity. 29, 352\u2013361 (2008).","journal-title":"Immunity"},{"key":"78150_CR92","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.4049\/jimmunol.178.3.1534","volume":"178","author":"Y Lou","year":"2007","unstructured":"Lou, Y. et al. Plasmacytoid dendritic cells synergize with myeloid dendritic cells in the induction of antigen-specific antitumor immune responses. J. Immunol. 178, 1534\u20131541 (2007).","journal-title":"J. Immunol."},{"key":"78150_CR93","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/S1471-4906(02)02214-7","volume":"23","author":"M Lechmann","year":"2002","unstructured":"Lechmann, M., Berchtold, S., Steinkasserer, A. & Hauber, J. CD83 on dendritic cells: More than just a marker for maturation. Trends Immunol. 23, 273\u2013275 (2002).","journal-title":"Trends Immunol."},{"key":"78150_CR94","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.humimm.2003.11.002","volume":"65","author":"Y Jin","year":"2004","unstructured":"Jin, Y. & ET, A. L. Antigen presentation and immune regulatory capacity of immature and mature-enriched antigen presenting (dendritic) cells derived from human bone marrow. Hum. Immunol. 65, 93\u2013103 (2004).","journal-title":"Hum. Immunol."},{"key":"78150_CR95","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.yexcr.2017.01.020","volume":"352","author":"X Fang","year":"2017","unstructured":"Fang, X. et al. Rapid de novo generation of antigen specific human B cells with expression of Blimp-1 and AID by in vitro immunization. Exp. Cell. Res. 352, 53\u201362 (2017).","journal-title":"Exp. Cell. Res."},{"key":"78150_CR96","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.coi.2019.04.003","volume":"58","author":"WR Heath","year":"2019","unstructured":"Heath, W. R., Kato, Y., Steiner, T. M. & Caminschi, I. Antigen presentation by dendritic cells for B cell activation. Curr. Opin. Immunol. 58, 44\u201352 (2019).","journal-title":"Curr. Opin. Immunol."},{"key":"78150_CR97","first-page":"728","volume":"20","author":"L Yang","year":"2023","unstructured":"Yang, L., Li, S., Chen, L. & Zhang, Y. Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity. Cancer Biol. Med. 20, 728 (2023).","journal-title":"Cancer Biol. Med."},{"key":"78150_CR98","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/cei\/uxac104","volume":"210","author":"RL Velounias","year":"2022","unstructured":"Velounias, R. L. & Tull, T. J. Human B-cell subset identification and changes in inflammatory diseases. Clin. Exp. Immunol. 210, 201\u2013216 (2022).","journal-title":"Clin. Exp. Immunol."},{"key":"78150_CR99","doi-asserted-by":"publisher","first-page":"4500","DOI":"10.1182\/blood-2002-11-3569","volume":"101","author":"NL Bernasconi","year":"2003","unstructured":"Bernasconi, N. L. et al. A role for toll-like receptors in acquired immunity: Up-regulation of TLR9 by BCR triggering in naive B cells and constitutive expression in memory B cells. Blood. 101, 4500\u20134504 (2003).","journal-title":"Blood"},{"key":"78150_CR100","doi-asserted-by":"publisher","first-page":"514","DOI":"10.4049\/jimmunol.127.2.514","volume":"127","author":"C Morimoto","year":"1981","unstructured":"Morimoto, C. et al. Primary in vitro anti-KLH antibody formation by peripheral blood lymphocytes in man: Detection with a radioimmunoassay. J. Immunol. 127, 514\u2013517 (1981).","journal-title":"J. Immunol."},{"key":"78150_CR101","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1016\/j.molimm.2007.07.020","volume":"45","author":"P Presicce","year":"2008","unstructured":"Presicce, P., Taddeo, A., Conti, A., Villa, M. L. & Della Bella, S. Keyhole limpet hemocyanin induces the activation and maturation of human dendritic cells through the involvement of mannose receptor. Molec Immunol. 45, 1136\u20131145 (2008).","journal-title":"Molec Immunol."},{"key":"78150_CR102","doi-asserted-by":"publisher","first-page":"9038","DOI":"10.3390\/ijms23169038","volume":"23","author":"M Hao","year":"2022","unstructured":"Hao, M., Zhang, L. & Chen, P. Membrane internalization mechanisms and design strategies of arginine-rich cell-penetrating peptides. Int. J. Mol. Sci. 23, 9038 (2022).","journal-title":"Int. J. Mol. Sci."},{"key":"78150_CR103","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1021\/acscentsci.5b00308","volume":"1","author":"AE Rabideau","year":"2015","unstructured":"Rabideau, A. E. & Pentelute, B. L. A d-amino acid at the N-terminus of a protein abrogates its degradation by the N-end rule pathway. ACS Cent. Sci. 1, 423\u2013430 (2015).","journal-title":"ACS Cent. Sci."},{"key":"78150_CR104","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1469-0691.2012.03971.x","volume":"18","author":"P Ljungman","year":"2012","unstructured":"Ljungman, P. Vaccination of immunocompromised patients. Clin. Microbiol. Infect. 18, 93\u201399 (2012).","journal-title":"Clin. Microbiol. Infect."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78150-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78150-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78150-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T10:05:15Z","timestamp":1731060315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78150-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,5]]},"references-count":104,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["78150"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-78150-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"type":"electronic","value":"2045-2322"}],"subject":[],"published":{"date-parts":[[2024,11,5]]},"assertion":[{"value":"27 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors M.A. and S.P. declare competing financial interest as Executive Directors of InterK Peptide Therapeutics Limited. The remaining authors do not have any competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"26737"}}