{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T12:51:54Z","timestamp":1777294314558,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T00:00:00Z","timestamp":1731283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82300884"],"award-info":[{"award-number":["82300884"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81902729"],"award-info":[{"award-number":["81902729"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2023JJ40990"],"award-info":[{"award-number":["2023JJ40990"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Special Funding for the Construction of Innovative Provinces in Hunan","award":["2020SK4003"],"award-info":[{"award-number":["2020SK4003"]}]},{"name":"Project Program of National Clinical Research Center for Geriatric Disorders","award":["2021KFJJ03"],"award-info":[{"award-number":["2021KFJJ03"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-78179-8","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T13:23:10Z","timestamp":1731331390000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predicting lymph node metastasis in papillary thyroid carcinoma with Hashimoto\u2019s thyroiditis using regression and network analysis"],"prefix":"10.1038","volume":"14","author":[{"given":"Lirong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5291-0151","authenticated-orcid":false,"given":"Shi","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,11]]},"reference":[{"key":"78179_CR1","doi-asserted-by":"publisher","first-page":"1273498","DOI":"10.3389\/fendo.2023.1273498","volume":"14","author":"L Janicki","year":"2023","unstructured":"Janicki, L., Patel, A., Jendrzejewski, J. & Hellmann, A. Prevalence and Impact of BRAF mutation in patients with concomitant papillary thyroid carcinoma and Hashimoto\u2019s thyroiditis: a systematic review with meta-analysis. Frontiers in endocrinology. 14, 1273498. https:\/\/doi.org\/10.3389\/fendo.2023.1273498 (2023).","journal-title":"Frontiers in endocrinology."},{"issue":"4","key":"78179_CR2","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/s2213-8587(22)00035-3","volume":"10","author":"M Pizzato","year":"2022","unstructured":"Pizzato, M. et al. The epidemiological landscape of thyroid cancer worldwide: GLOBOCAN estimates for incidence and mortality rates in 2020. The lancet Diabetes & endocrinology. 10(4), 264\u2013272. https:\/\/doi.org\/10.1016\/s2213-8587(22)00035-3 (2022).","journal-title":"The lancet Diabetes & endocrinology."},{"issue":"10","key":"78179_CR3","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1001\/jamainternmed.2021.4804","volume":"181","author":"K LeClair","year":"2021","unstructured":"LeClair, K. et al. Evaluation of Gender Inequity in Thyroid Cancer Diagnosis: Differences by Sex in US Thyroid Cancer Incidence Compared With a Meta-analysis of Subclinical Thyroid Cancer Rates at Autopsy. JAMA internal medicine. 181(10), 1351\u20131358. https:\/\/doi.org\/10.1001\/jamainternmed.2021.4804 (2021).","journal-title":"JAMA internal medicine."},{"issue":"1","key":"78179_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","volume":"26","author":"BR Haugen","year":"2016","unstructured":"Haugen, B. R. et al. 2015 American Thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the american thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid J Am Thyroid Assoc. 26(1), 1\u2013133. https:\/\/doi.org\/10.1089\/thy.2015.0020 (2016).","journal-title":"Thyroid J Am Thyroid Assoc."},{"issue":"10","key":"78179_CR5","doi-asserted-by":"publisher","first-page":"5723","DOI":"10.1210\/jc.2005-0285","volume":"90","author":"S Leboulleux","year":"2005","unstructured":"Leboulleux, S. et al. Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and\/or tumor extension beyond the thyroid capsule at initial diagnosis. The Journal of clinical endocrinology and metabolism. 90(10), 5723\u20139. https:\/\/doi.org\/10.1210\/jc.2005-0285 (2005).","journal-title":"The Journal of clinical endocrinology and metabolism."},{"key":"78179_CR6","doi-asserted-by":"publisher","first-page":"713475","DOI":"10.3389\/fendo.2021.713475","volume":"12","author":"Y Min","year":"2021","unstructured":"Min, Y. et al. Preoperatively Predicting the Central Lymph Node Metastasis for Papillary Thyroid Cancer Patients With Hashimoto\u2019s Thyroiditis. Frontiers in endocrinology. 12, 713475. https:\/\/doi.org\/10.3389\/fendo.2021.713475 (2021).","journal-title":"Frontiers in endocrinology."},{"key":"78179_CR7","doi-asserted-by":"publisher","first-page":"801925","DOI":"10.3389\/fendo.2022.801925","volume":"13","author":"J Xu","year":"2022","unstructured":"Xu, J. et al. Hashimoto\u2019s Thyroiditis: A \u201cDouble-Edged Sword\u201d in Thyroid Carcinoma. Front Endocrinol. 13, 801925. https:\/\/doi.org\/10.3389\/fendo.2022.801925 (2022).","journal-title":"Front Endocrinol."},{"issue":"12","key":"78179_CR8","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/j.tem.2014.09.001","volume":"25","author":"M Ehlers","year":"2014","unstructured":"Ehlers, M. & Schott, M. Hashimoto\u2019s thyroiditis and papillary thyroid cancer: are they immunologically linked?. Trends Endocrinol Metabol TEM. 25(12), 656\u201364. https:\/\/doi.org\/10.1016\/j.tem.2014.09.001 (2014).","journal-title":"Trends Endocrinol Metabol TEM."},{"issue":"6","key":"78179_CR9","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1007\/s00432-014-1629-z","volume":"140","author":"Y Zhang","year":"2014","unstructured":"Zhang, Y., Dai, J., Wu, T., Yang, N. & Yin, Z. The study of the coexistence of Hashimoto\u2019s thyroiditis with papillary thyroid carcinoma. J Cancer Res Clin Oncol. 140(6), 1021\u20136. https:\/\/doi.org\/10.1007\/s00432-014-1629-z (2014).","journal-title":"J Cancer Res Clin Oncol."},{"issue":"2","key":"78179_CR10","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1177\/106689690201000207","volume":"10","author":"DM Tamimi","year":"2002","unstructured":"Tamimi, D. M. The association between chronic lymphocytic thyroiditis and thyroid tumors. Int J Surg Pathol. 10(2), 141\u20136. https:\/\/doi.org\/10.1177\/106689690201000207 (2002).","journal-title":"Int J Surg Pathol."},{"issue":"6","key":"78179_CR11","doi-asserted-by":"publisher","first-page":"e0269995","DOI":"10.1371\/journal.pone.0269995","volume":"17","author":"Q Tang","year":"2022","unstructured":"Tang, Q., Pan, W. & Peng, L. Association between Hashimoto thyroiditis and clinical outcomes of papillary thyroid carcinoma: A meta-analysis. PloS one. 17(6), e0269995. https:\/\/doi.org\/10.1371\/journal.pone.0269995 (2022).","journal-title":"PloS one."},{"issue":"1","key":"78179_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12902-021-00923-2","volume":"22","author":"L Wang","year":"2022","unstructured":"Wang, L. et al. Lymph node metastasis of papillary thyroid carcinoma in the context of Hashimoto\u2019s thyroiditis. BMC Endocr Disord. 22(1), 12. https:\/\/doi.org\/10.1186\/s12902-021-00923-2 (2022).","journal-title":"BMC Endocr Disord."},{"issue":"7","key":"78179_CR13","doi-asserted-by":"publisher","first-page":"e2118526","DOI":"10.1001\/jamanetworkopen.2021.18526","volume":"4","author":"S Xu","year":"2021","unstructured":"Xu, S. et al. Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes. JAMA Netw Open. 4(7), e2118526. https:\/\/doi.org\/10.1001\/jamanetworkopen.2021.18526 (2021).","journal-title":"JAMA Netw Open."},{"issue":"1","key":"78179_CR14","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1186\/s12885-022-09655-5","volume":"22","author":"QW Luo","year":"2022","unstructured":"Luo, Q. W. et al. A novel tool for predicting the risk of central lymph node metastasis in patients with papillary thyroid microcarcinoma: a retrospective cohort study. BMC Cancer. 22(1), 606. https:\/\/doi.org\/10.1186\/s12885-022-09655-5 (2022).","journal-title":"BMC Cancer."},{"issue":"6","key":"78179_CR15","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.surg.2013.07.021","volume":"154","author":"SM Jara","year":"2013","unstructured":"Jara, S. M. et al. The relationship between chronic lymphocytic thyroiditis and central neck lymph node metastasis in North American patients with papillary thyroid carcinoma. Surgery. 154(6), 1272\u201380. https:\/\/doi.org\/10.1016\/j.surg.2013.07.021 (2013) (discussion 1280-2).","journal-title":"Surgery."},{"key":"78179_CR16","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3389\/fendo.2017.00337","volume":"8","author":"A Ieni","year":"2017","unstructured":"Ieni, A. et al. One-third of an Archivial Series of Papillary Thyroid Cancer (Years 2007\u20132015) Has Coexistent Chronic Lymphocytic Thyroiditis, Which Is Associated with a More Favorable Tumor-Node-Metastasis Staging. Front Endocrinol. 8, 337. https:\/\/doi.org\/10.3389\/fendo.2017.00337 (2017).","journal-title":"Front Endocrinol."},{"key":"78179_CR17","doi-asserted-by":"publisher","first-page":"868606","DOI":"10.3389\/fendo.2022.868606","volume":"13","author":"B Zeng","year":"2022","unstructured":"Zeng, B. et al. Hashimoto\u2019s Thyroiditis Is Associated With Central Lymph Node Metastasis in Classical Papillary Thyroid Cancer: Analysis from a High-Volume Single-Center Experience. Front Endocrinol. 13, 868606. https:\/\/doi.org\/10.3389\/fendo.2022.868606 (2022).","journal-title":"Front Endocrinol."},{"issue":"1","key":"78179_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s43046-020-0017-9","volume":"32","author":"O Hussein","year":"2020","unstructured":"Hussein, O. et al. Thyroid cancer associated with Hashimoto thyroiditis: similarities and differences in an endemic area. J Egypt Natl Cancer Inst. 32(1), 7. https:\/\/doi.org\/10.1186\/s43046-020-0017-9 (2020).","journal-title":"J Egypt Natl Cancer Inst."},{"key":"78179_CR19","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1186\/1471-2407-12-610","volume":"12","author":"L Zhang","year":"2012","unstructured":"Zhang, L. et al. The clinical features of papillary thyroid cancer in Hashimoto\u2019s thyroiditis patients from an area with a high prevalence of Hashimoto\u2019s disease. BMC Cancer. 12, 610. https:\/\/doi.org\/10.1186\/1471-2407-12-610 (2012).","journal-title":"BMC Cancer."},{"issue":"4","key":"78179_CR20","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/s11154-018-9474-z","volume":"19","author":"R Vita","year":"2018","unstructured":"Vita, R., Ieni, A., Tuccari, G. & Benvenga, S. The increasing prevalence of chronic lymphocytic thyroiditis in papillary microcarcinoma. Rev Endocrine Metabol Disord. 19(4), 301\u2013309. https:\/\/doi.org\/10.1007\/s11154-018-9474-z (2018).","journal-title":"Rev Endocrine Metabol Disord."},{"key":"78179_CR21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12874-016-0141-3","volume":"16","author":"BC Kahan","year":"2016","unstructured":"Kahan, B. C., Rushton, H., Morris, T. P. & Daniel, R. M. A comparison of methods to adjust for continuous covariates in the analysis of randomised trials. BMC Med Res Methodol. 16, 42. https:\/\/doi.org\/10.1186\/s12874-016-0141-3 (2016).","journal-title":"BMC Med Res Methodol."},{"issue":"3","key":"78179_CR22","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1093\/biostatistics\/kxm045","volume":"9","author":"J Friedman","year":"2008","unstructured":"Friedman, J., Hastie, T. & Tibshirani, R. Sparse inverse covariance estimation with the graphical lasso. Biostatistics (Oxford, England). 9(3), 432\u201341. https:\/\/doi.org\/10.1093\/biostatistics\/kxm045 (2008).","journal-title":"Biostatistics (Oxford, England)."},{"issue":"2","key":"78179_CR23","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3758\/s13428-017-0910-x","volume":"50","author":"JMB Haslbeck","year":"2018","unstructured":"Haslbeck, J. M. B. & Waldorp, L. J. How well do network models predict observations? On the importance of predictability in network models. Behav Res Methods. 50(2), 853\u2013861. https:\/\/doi.org\/10.3758\/s13428-017-0910-x (2018).","journal-title":"Behav Res Methods."},{"issue":"3","key":"78179_CR24","doi-asserted-by":"publisher","first-page":"L7","DOI":"10.1530\/erc-17-0453","volume":"25","author":"L Lamartina","year":"2018","unstructured":"Lamartina, L. et al. 8th edition of the AJCC\/TNM staging system of thyroid cancer: what to expect (ITCO#2). Endocr Relat Cancer. 25(3), L7-l11. https:\/\/doi.org\/10.1530\/erc-17-0453 (2018).","journal-title":"Endocr Relat Cancer."},{"key":"78179_CR25","doi-asserted-by":"publisher","first-page":"30750","DOI":"10.1038\/srep30750","volume":"6","author":"Z Yang","year":"2016","unstructured":"Yang, Z., Algesheimer, R. & Tessone, C. J. A Comparative Analysis of Community Detection Algorithms on Artificial Networks. Sci Rep. 6, 30750. https:\/\/doi.org\/10.1038\/srep30750 (2016).","journal-title":"Sci Rep."},{"issue":"1","key":"78179_CR26","doi-asserted-by":"publisher","first-page":"195","DOI":"10.3758\/s13428-017-0862-1","volume":"50","author":"S Epskamp","year":"2018","unstructured":"Epskamp, S., Borsboom, D. & Fried, E. I. Estimating psychological networks and their accuracy: A tutorial paper. Behav Res Methods. 50(1), 195\u2013212. https:\/\/doi.org\/10.3758\/s13428-017-0862-1 (2018).","journal-title":"Behav Res Methods."},{"key":"78179_CR27","doi-asserted-by":"publisher","first-page":"856278","DOI":"10.3389\/fendo.2022.856278","volume":"13","author":"Z Wang","year":"2022","unstructured":"Wang, Z. et al. A Clinical Predictive Model of Central Lymph Node Metastases in Papillary Thyroid Carcinoma. Front Endocrinol. 13, 856278. https:\/\/doi.org\/10.3389\/fendo.2022.856278 (2022).","journal-title":"Front Endocrinol."},{"issue":"4","key":"78179_CR28","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1111\/j.1365-2265.2011.04272.x","volume":"76","author":"S Diessl","year":"2012","unstructured":"Diessl, S. et al. Impact of moderate vs stringent TSH suppression on survival in advanced differentiated thyroid carcinoma. Clin Endocrinol. 76(4), 586\u201392. https:\/\/doi.org\/10.1111\/j.1365-2265.2011.04272.x (2012).","journal-title":"Clin Endocrinol."},{"issue":"16","key":"78179_CR29","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1038\/onc.2011.390","volume":"31","author":"C Lu","year":"2012","unstructured":"Lu, C., Zhu, X., Willingham, M. C. & Cheng, S. Y. Activation of tumor cell proliferation by thyroid hormone in a mouse model of follicular thyroid carcinoma. Oncogene. 31(16), 2007\u201316. https:\/\/doi.org\/10.1038\/onc.2011.390 (2012).","journal-title":"Oncogene."},{"key":"78179_CR30","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3389\/fendo.2020.00265","volume":"11","author":"J Mao","year":"2020","unstructured":"Mao, J. et al. Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Systematic Review and Meta-Analysis. Front Endocrinol. 11, 265. https:\/\/doi.org\/10.3389\/fendo.2020.00265 (2020).","journal-title":"Front Endocrinol."},{"issue":"4","key":"78179_CR31","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3109\/0284186x.2011.653438","volume":"51","author":"CM Hoff","year":"2012","unstructured":"Hoff, C. M. Importance of hemoglobin concentration and its modification for the outcome of head and neck cancer patients treated with radiotherapy. Acta oncologica (Stockholm, Sweden). 51(4), 419\u201332. https:\/\/doi.org\/10.3109\/0284186x.2011.653438 (2012).","journal-title":"Acta oncologica (Stockholm, Sweden)."},{"key":"78179_CR32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.18632\/oncotarget.28367","volume":"14","author":"CM Farag","year":"2023","unstructured":"Farag, C. M., Antar, R., Akosman, S., Ng, M. & Whalen, M. J. What is hemoglobin, albumin, lymphocyte, platelet (HALP) score A comprehensive literature review of HALP\u2019s prognostic ability in different cancer types. Oncotarget. 14, 153\u2013172. https:\/\/doi.org\/10.18632\/oncotarget.28367 (2023).","journal-title":"Oncotarget."},{"issue":"4","key":"78179_CR33","doi-asserted-by":"publisher","first-page":"e402","DOI":"10.1016\/j.clgc.2019.12.002","volume":"18","author":"K Mori","year":"2020","unstructured":"Mori, K. et al. Prognostic Value of Hemoglobin in Metastatic Hormone-sensitive Prostate Cancer: A Systematic Review and Meta-analysis. Clin Genitourinary Cancer. 18(4), e402\u2013e409. https:\/\/doi.org\/10.1016\/j.clgc.2019.12.002 (2020).","journal-title":"Clin Genitourinary Cancer."},{"issue":"28","key":"78179_CR34","doi-asserted-by":"publisher","first-page":"e34283","DOI":"10.1097\/md.0000000000034283","volume":"102","author":"M Shahrokh","year":"2023","unstructured":"Shahrokh, M., Alsultan, M. & Kabalan, Y. The relationship between papillary thyroid carcinoma and preoperative TSH level: A cross-sectional study from Syria. Medicine. 102(28), e34283. https:\/\/doi.org\/10.1097\/md.0000000000034283 (2023).","journal-title":"Medicine."},{"issue":"10","key":"78179_CR35","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1089\/thy.2023.0046","volume":"33","author":"M Yamamoto","year":"2023","unstructured":"Yamamoto, M. et al. Active Surveillance Outcomes of Patients with Low-Risk Papillary Thyroid Microcarcinoma According to Levothyroxine Treatment Status. Thyroid J Am Thyroid Assoc. 33(10), 1182\u20131189. https:\/\/doi.org\/10.1089\/thy.2023.0046 (2023).","journal-title":"Thyroid J Am Thyroid Assoc."},{"issue":"6","key":"78179_CR36","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1007\/s00268-012-1423-5","volume":"36","author":"Y Ito","year":"2012","unstructured":"Ito, Y. et al. Prognostic factors for recurrence of papillary thyroid carcinoma in the lymph nodes, lung, and bone: analysis of 5,768 patients with average 10-year follow-up. World J Surg. 36(6), 1274\u20138. https:\/\/doi.org\/10.1007\/s00268-012-1423-5 (2012).","journal-title":"World J Surg."},{"issue":"6","key":"78179_CR37","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","volume":"17","author":"SB Edge","year":"2010","unstructured":"Edge, S. B. & Compton, C. C. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 17(6), 1471\u20134. https:\/\/doi.org\/10.1245\/s10434-010-0985-4 (2010).","journal-title":"Ann Surg Oncol."},{"issue":"1","key":"78179_CR38","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12943-021-01428-1","volume":"20","author":"X Mao","year":"2021","unstructured":"Mao, X. et al. Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives. Mol Cancer. 20(1), 131. https:\/\/doi.org\/10.1186\/s12943-021-01428-1 (2021).","journal-title":"Mol Cancer."},{"issue":"1","key":"78179_CR39","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s13046-020-01709-5","volume":"39","author":"X Jiang","year":"2020","unstructured":"Jiang, X. et al. The role of microenvironment in tumor angiogenesis. J Exp Clin Cancer Res. 39(1), 204. https:\/\/doi.org\/10.1186\/s13046-020-01709-5 (2020).","journal-title":"J Exp Clin Cancer Res."},{"issue":"2","key":"78179_CR40","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/s10555-007-9055-1","volume":"26","author":"P Vaupel","year":"2007","unstructured":"Vaupel, P. & Mayer, A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 26(2), 225\u201339. https:\/\/doi.org\/10.1007\/s10555-007-9055-1 (2007).","journal-title":"Cancer Metastasis Rev."},{"issue":"4","key":"78179_CR41","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1210\/jc.2011-2735","volume":"97","author":"E Fiore","year":"2012","unstructured":"Fiore, E. & Vitti, P. Serum TSH and risk of papillary thyroid cancer in nodular thyroid disease. J Clin Endocrinol Metabol. 97(4), 1134\u201345. https:\/\/doi.org\/10.1210\/jc.2011-2735 (2012).","journal-title":"J Clin Endocrinol Metabol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78179-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78179-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78179-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T12:17:45Z","timestamp":1731673065000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78179-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,11]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["78179"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-78179-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,11]]},"assertion":[{"value":"1 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study is part of the \"Ultrasound and Clinical Big Data Research on Thyroid Diseases\" project conducted by the Department of General Surgery (Hepatic and Thyroid Surgery) at Xiangya Hospital, Central South University. The project has been approved by the Ethics Committee of Xiangya Hospital, Central South University, with approval number 202211733. All methods were performed in accordance with the relevant guidelines and regulations, including the Declaration of Helsinki.Written informed consent was obtained at the time of surgery for general use of clinical information in future studies. Given that minors typically do not possess the legal capacity and maturity to fully understand the nature, risks, and potential benefits of the study, the written informed consent for minors in this research will be confirmed by their parents or guardians to ensure the protection of their rights.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"I would like to declare on behalf of my co-authors that our paper is new and neither the entire manuscript nor any part of its content has been published or has been accepted elsewhere. It is not in submission at any other journal.All authors have approved of the final version of this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"<!--Emphasis Type='Bold' removed-->Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27585"}}