{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:03:29Z","timestamp":1791925409305,"version":"4.3.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFC1704500-2018YFC1704503"],"award-info":[{"award-number":["2018YFC1704500-2018YFC1704503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFC1704500-2018YFC1704503"],"award-info":[{"award-number":["2018YFC1704500-2018YFC1704503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFC1704500-2018YFC1704503"],"award-info":[{"award-number":["2018YFC1704500-2018YFC1704503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFC1704500-2018YFC1704503"],"award-info":[{"award-number":["2018YFC1704500-2018YFC1704503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2018YFC1704500-2018YFC1704503"],"award-info":[{"award-number":["2018YFC1704500-2018YFC1704503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-78364-9","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T17:01:56Z","timestamp":1730912516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Network pharmacology and transcriptomics explore the therapeutic effects of Ermiao Wan categorized formulas for diabetes in mice"],"prefix":"10.1038","volume":"14","author":[{"given":"Yuping","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"78364_CR1","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","volume":"126","author":"ME Piche","year":"2020","unstructured":"Piche, M. E., Tchernof, A. & Despres, J. P. Obesity phenotypes, diabetes, and cardiovascular diseases. Circ. Res. 126, 1477\u20131500. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.316101 (2020).","journal-title":"Circ. Res."},{"key":"78364_CR2","doi-asserted-by":"publisher","first-page":"115567","DOI":"10.1016\/j.jep.2022.115567","volume":"297","author":"Q Zhao","year":"2022","unstructured":"Zhao, Q. et al. An optimized herbal combination for the treatment of liver fibrosis: Hub genes, bioactive ingredients, and molecular mechanisms. J. Ethnopharmacol. 297, 115567. https:\/\/doi.org\/10.1016\/j.jep.2022.115567 (2022).","journal-title":"J. Ethnopharmacol."},{"key":"78364_CR3","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13195-021-00951-z","volume":"14","author":"J Fang","year":"2022","unstructured":"Fang, J. et al. Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer\u2019s disease. Alzheimers Res. Ther. 14, 7. https:\/\/doi.org\/10.1186\/s13195-021-00951-z (2022).","journal-title":"Alzheimers Res. Ther."},{"key":"78364_CR4","doi-asserted-by":"publisher","first-page":"10331","DOI":"10.1038\/ncomms10331","volume":"7","author":"E Guney","year":"2016","unstructured":"Guney, E., Menche, J., Vidal, M. & Barabasi, A. L. Network-based in silico drug efficacy screening. Nat. Commun. 7, 10331. https:\/\/doi.org\/10.1038\/ncomms10331 (2016).","journal-title":"Nat. Commun."},{"key":"78364_CR5","doi-asserted-by":"publisher","first-page":"113350","DOI":"10.1016\/j.biopha.2022.113350","volume":"153","author":"F Ahmed","year":"2022","unstructured":"Ahmed, F. et al. A comprehensive review of artificial intelligence and network based approaches to drug repurposing in Covid-19. Biomed. Pharmacother. 153, 113350. https:\/\/doi.org\/10.1016\/j.biopha.2022.113350 (2022).","journal-title":"Biomed. Pharmacother"},{"key":"78364_CR6","doi-asserted-by":"publisher","first-page":"154934","DOI":"10.1016\/j.phymed.2023.154934","volume":"118","author":"Y Yuan","year":"2023","unstructured":"Yuan, Y. et al. Elucidation of the mechanism of Yiqi Tongluo Granule against cerebral ischemia\/reperfusion injury based on a combined strategy of network pharmacology, multi-omics and molecular biology. Phytomedicine. 118, 154934. https:\/\/doi.org\/10.1016\/j.phymed.2023.154934 (2023).","journal-title":"Phytomedicine"},{"key":"78364_CR7","doi-asserted-by":"publisher","first-page":"154384","DOI":"10.1016\/j.phymed.2022.154384","volume":"105","author":"X Hu","year":"2022","unstructured":"Hu, X. et al. Combining network pharmacology, RNA-seq, and metabolomics strategies to reveal the mechanism of Cimicifugae Rhizoma - Smilax Glabra Roxb herb pair for the treatment of psoriasis. Phytomedicine. 105, 154384. https:\/\/doi.org\/10.1016\/j.phymed.2022.154384 (2022).","journal-title":"Phytomedicine"},{"key":"78364_CR8","doi-asserted-by":"publisher","unstructured":"Chen, Y. et al. Simiao Wan modulates the gut microbiota and bile acid metabolism during improving type 2 diabetes mellitus in mice. Phytomedicine 104. 154264. https:\/\/doi.org\/10.1016\/j.phymed.2022.154264 (2022).","DOI":"10.1016\/j.phymed.2022.154264"},{"key":"78364_CR9","doi-asserted-by":"publisher","first-page":"1012961","DOI":"10.3389\/fnut.2022.1012961","volume":"9","author":"T Xia","year":"2022","unstructured":"Xia, T. et al. Simiao Wan and its ingredients alleviate type 2 diabetes mellitus via IRS1\/AKT2\/FOXO1\/GLUT2 signaling. Front. Nutr. 9, 1012961. https:\/\/doi.org\/10.3389\/fnut.2022.1012961 (2022).","journal-title":"Front. Nutr."},{"key":"78364_CR10","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.jep.2014.04.042","volume":"154","author":"G Chen","year":"2014","unstructured":"Chen, G. et al. Er-Miao-San, a traditional herbal formula containing Rhizoma atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-kappaB pathway and MAPKs activation. J. Ethnopharmacol. 154, 711\u2013718. https:\/\/doi.org\/10.1016\/j.jep.2014.04.042 (2014).","journal-title":"J. Ethnopharmacol."},{"key":"78364_CR11","doi-asserted-by":"publisher","unstructured":"Oh, S. D. et al. Effect of Achyranthes bidentata Blume on 3T3-L1 Adipogenesis and Rats Fed with a High-Fat Diet. Evid Based Complement Alternat Med 158018. https:\/\/doi.org\/10.1155\/2014\/158018 (2014).","DOI":"10.1155\/2014\/158018"},{"key":"78364_CR12","doi-asserted-by":"publisher","first-page":"109319","DOI":"10.1016\/j.intimp.2022.109319","volume":"113","author":"Y Zhao","year":"2022","unstructured":"Zhao, Y. et al. Demethyleneberberine blocked the maturation of IL-1beta in inflammation by inhibiting TLR4-mitochondria signaling. Int. Immunopharmacol. 113, 109319. https:\/\/doi.org\/10.1016\/j.intimp.2022.109319 (2022).","journal-title":"Int. Immunopharmacol."},{"key":"78364_CR13","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.2174\/1568026620666201022144405","volume":"21","author":"A Baska","year":"2021","unstructured":"Baska, A., Leis, K. & Ga\u0142\u0105zka, P. Berberine in the treatment of diabetes mellitus: A review. Endocr. Metab. Immune Disord Drug Targets. 21, 1379\u20131386. https:\/\/doi.org\/10.2174\/1568026620666201022144405 (2021).","journal-title":"Endocr. Metab. Immune Disord Drug Targets"},{"key":"78364_CR14","doi-asserted-by":"publisher","first-page":"155903","DOI":"10.1016\/j.phymed.2024.155903","volume":"132","author":"H Liu","year":"2024","unstructured":"Liu, H. et al. Efficacy and mechanism of the Ermiao San series of formulas for rheumatoid arthritis based on Chinmedomics strategy. Phytomedicine. 132, 155903. https:\/\/doi.org\/10.1016\/j.phymed.2024.155903 (2024).","journal-title":"Phytomedicine"},{"key":"78364_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"78364_CR16","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"78364_CR17","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013D592. https:\/\/doi.org\/10.1093\/nar\/gkac963 (2023).","journal-title":"Nucleic Acids Res."},{"key":"78364_CR18","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1016\/S0140-6736(22)01655-5","volume":"400","author":"E Ahmad","year":"2022","unstructured":"Ahmad, E., Lim, S., Lamptey, R., Webb, D. R. & Davies, M. J. Type 2 diabetes. Lancet. 400, 1803\u20131820. https:\/\/doi.org\/10.1016\/S0140-6736(22)01655-5 (2022).","journal-title":"Lancet"},{"key":"78364_CR19","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.jphs.2020.04.008","volume":"143","author":"L Surbala","year":"2020","unstructured":"Surbala, L., Singh, C. B., Devi, R. V. & Singh, O. J. Rutaecarpine exhibits anti-diabetic potential in high fat diet-multiple low dose streptozotocin induced type 2 diabetic mice and in vitro by modulating hepatic glucose homeostasis. J. Pharmacol. Sci. 143, 307\u2013314. https:\/\/doi.org\/10.1016\/j.jphs.2020.04.008 (2020).","journal-title":"J. Pharmacol. Sci."},{"key":"78364_CR20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.4155\/ppa-2021-0027","volume":"11","author":"S Gupta","year":"2022","unstructured":"Gupta, S., Buttar, H. S., Kaur, G. & Tuli, H. S. Baicalein: Promising therapeutic applications with special reference to published patents. Pharm. Pat. Anal. 11, 23\u201332. https:\/\/doi.org\/10.4155\/ppa-2021-0027 (2022).","journal-title":"Pharm. Pat. Anal."},{"key":"78364_CR21","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.2174\/1381612825666190722115410","volume":"25","author":"S Khan","year":"2019","unstructured":"Khan, S. & Kamal, M. A. Wogonin alleviates hyperglycemia through increased glucose entry into cells Via AKT\/GLUT4 pathway. Curr. Pharm. Des. 25, 2602\u20132606. https:\/\/doi.org\/10.2174\/1381612825666190722115410 (2019).","journal-title":"Curr. Pharm. Des."},{"key":"78364_CR22","doi-asserted-by":"publisher","first-page":"112560","DOI":"10.1016\/j.biopha.2021.112560","volume":"146","author":"R Dhanya","year":"2022","unstructured":"Dhanya, R. Quercetin for managing type 2 diabetes and its complications, an insight into multitarget therapy. Biomed. Pharmacother. 146, 112560. https:\/\/doi.org\/10.1016\/j.biopha.2021.112560 (2022).","journal-title":"Biomed. Pharmacother"},{"key":"78364_CR23","doi-asserted-by":"publisher","first-page":"3417","DOI":"10.1002\/ptr.8217","volume":"38","author":"M Zhu","year":"2024","unstructured":"Zhu, M. et al. Luteolin: A promising multifunctional natural flavonoid for human diseases. Phytother Res. 38, 3417\u20133443. https:\/\/doi.org\/10.1002\/ptr.8217 (2024). Luteolin.","journal-title":"Phytother Res."},{"key":"78364_CR24","doi-asserted-by":"publisher","first-page":"990299","DOI":"10.3389\/fendo.2022.990299","volume":"13","author":"Y Yang","year":"2022","unstructured":"Yang, Y. et al. Mechanisms of Kaempferol in the treatment of diabetes: A comprehensive and latest review. Front. Endocrinol. 13, 990299. https:\/\/doi.org\/10.3389\/fendo.2022.990299 (2022).","journal-title":"Front. Endocrinol."},{"key":"78364_CR25","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.2337\/dc21-0438","volume":"44","author":"SM Mousavi","year":"2021","unstructured":"Mousavi, S. M. et al. Dietary intake of linoleic acid, its concentrations, and the risk of type 2 diabetes: A systematic review and dose-response meta-analysis of prospective cohort studies. Diabetes Care. 44, 2173\u20132181. https:\/\/doi.org\/10.2337\/dc21-0438 (2021).","journal-title":"Diabetes Care"},{"key":"78364_CR26","doi-asserted-by":"publisher","first-page":"e372","DOI":"10.1038\/emm.2017.125","volume":"49","author":"J Kim","year":"2017","unstructured":"Kim, J. et al. Cadmium-induced ER stress and inflammation are mediated through C\/EBP-DDIT3 signaling in human bronchial epithelial cells. Exp. Mol. Med. 49, e372. https:\/\/doi.org\/10.1038\/emm.2017.125 (2017).","journal-title":"Exp. Mol. Med."},{"key":"78364_CR27","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1038\/s42255-019-0146-4","volume":"1","author":"EA Day","year":"2019","unstructured":"Day, E. A. et al. Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss. Nat. Metab. 1, 1202\u20131208. https:\/\/doi.org\/10.1038\/s42255-019-0146-4 (2019).","journal-title":"Nat. Metab."},{"key":"78364_CR28","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13024-021-00437-4","volume":"16","author":"H Li","year":"2021","unstructured":"Li, H. et al. High dose expression of heme oxigenase-1 induces retinal degeneration through ER stress-related DDIT3. Mol. Neurodegener. 16, 16. https:\/\/doi.org\/10.1186\/s13024-021-00437-4 (2021).","journal-title":"Mol. Neurodegener"},{"key":"78364_CR29","doi-asserted-by":"publisher","first-page":"20003","DOI":"10.1073\/pnas.1013754107","volume":"107","author":"M Namdar","year":"2010","unstructured":"Namdar, M., Perez, G., Ngo, L. & Marks, P. A. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc. Natl. Acad. Sci. U S A. 107, 20003\u201320008. https:\/\/doi.org\/10.1073\/pnas.1013754107 (2010).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"78364_CR30","doi-asserted-by":"publisher","first-page":"155023","DOI":"10.1016\/j.phymed.2023.155023","volume":"119","author":"J Liu","year":"2023","unstructured":"Liu, J. et al. Modulating endoplasmic reticulum stress in APP\/PS1 mice by Gomisin B and Osthole in Bushen-Yizhi formula: Synergistic effects and therapeutic implications for Alzheimer\u2019s disease. Phytomedicine. 119, 155023. https:\/\/doi.org\/10.1016\/j.phymed.2023.155023 (2023).","journal-title":"Phytomedicine"},{"key":"78364_CR31","doi-asserted-by":"publisher","first-page":"7213","DOI":"10.1038\/s41467-021-27539-3","volume":"12","author":"X Li","year":"2021","unstructured":"Li, X. et al. The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression. Nat. Commun. 12, 7213. https:\/\/doi.org\/10.1038\/s41467-021-27539-3 (2021).","journal-title":"Nat. Commun."},{"key":"78364_CR32","doi-asserted-by":"publisher","first-page":"3877","DOI":"10.1172\/JCI123374","volume":"129","author":"J He","year":"2019","unstructured":"He, J. et al. Fbxw7 increases CCL2\/7 in CX3CR1hi macrophages to promote intestinal inflammation. J. Clin. Invest. 129, 3877\u20133893. https:\/\/doi.org\/10.1172\/JCI123374 (2019).","journal-title":"J. Clin. Invest."},{"key":"78364_CR33","doi-asserted-by":"publisher","first-page":"1799","DOI":"10.1093\/eurheartj\/ehac094","volume":"43","author":"MK Georgakis","year":"2022","unstructured":"Georgakis, M. K., Bernhagen, J., Heitman, L. H., Weber, C. & Dichgans, M. Targeting the CCL2-CCR2 axis for atheroprotection. Eur. Heart J. 43, 1799\u20131808. https:\/\/doi.org\/10.1093\/eurheartj\/ehac094 (2022).","journal-title":"Eur. Heart J."},{"key":"78364_CR34","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1161\/CIRCRESAHA.111.243212","volume":"110","author":"PE Kolattukudy","year":"2012","unstructured":"Kolattukudy, P. E. & Niu, J. Inflammation, endoplasmic reticulum stress, autophagy, and the monocyte chemoattractant protein-1\/CCR2 pathway. Circ. Res. 110, 174\u2013189. https:\/\/doi.org\/10.1161\/CIRCRESAHA.111.243212 (2012).","journal-title":"Circ. Res."},{"key":"78364_CR35","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1038\/s41586-020-2040-3","volume":"579","author":"A Vasanthakumar","year":"2020","unstructured":"Vasanthakumar, A. et al. Sex-specific adipose tissue imprinting of regulatory T cells. Nature. 579, 581\u2013585. https:\/\/doi.org\/10.1038\/s41586-020-2040-3 (2020).","journal-title":"Nature"},{"key":"78364_CR36","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1055\/a-0620-8553","volume":"50","author":"J Yang","year":"2018","unstructured":"Yang, J. Associations of estrogen receptor alpha gene polymorphisms with type 2 diabetes mellitus and metabolic syndrome: A systematic review and meta-analysis. Horm. Metab. Res. 50, 469\u2013477. https:\/\/doi.org\/10.1055\/a-0620-8553 (2018).","journal-title":"Horm. Metab. Res."},{"key":"78364_CR37","doi-asserted-by":"publisher","unstructured":"Xu, X. et al. Study on the mechanism of Gegen Qinlian Decoction for treating type II diabetes mellitus by integrating network pharmacology and pharmacological evaluation. J. Ethnopharmacol. 262 https:\/\/doi.org\/10.1016\/j.jep.2020.113129 (2020).","DOI":"10.1016\/j.jep.2020.113129"},{"key":"78364_CR38","doi-asserted-by":"publisher","unstructured":"Dai, W. et al. Alleviation of Fufang Fanshiliu decoction on type II diabetes mellitus by reducing insulin resistance: A comprehensive network prediction and experimental validation. J. Ethnopharmacol. 294 https:\/\/doi.org\/10.1016\/j.jep.2022.115338 (2022).","DOI":"10.1016\/j.jep.2022.115338"},{"key":"78364_CR39","doi-asserted-by":"publisher","first-page":"154703","DOI":"10.1016\/j.phymed.2023.154703","volume":"113","author":"T Yang","year":"2023","unstructured":"Yang, T. et al. Targeting mTOR\/YY1 signaling pathway by quercetin through CYP7A1-mediated cholesterol-to-bile acids conversion alleviated type 2 diabetes mellitus induced hepatic lipid accumulation. Phytomedicine. 113, 154703. https:\/\/doi.org\/10.1016\/j.phymed.2023.154703 (2023).","journal-title":"Phytomedicine"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78364-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78364-9","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78364-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T17:02:58Z","timestamp":1730912578000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78364-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["78364"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-78364-9","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,6]]},"assertion":[{"value":"2 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27014"}}