{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T12:31:25Z","timestamp":1773405085434,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T00:00:00Z","timestamp":1730678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100009601","name":"Beijing Municipal Administration of Hospitals\u2019 Ascent Plan","doi-asserted-by":"crossref","award":["DFL20191802"],"award-info":[{"award-number":["DFL20191802"]}],"id":[{"id":"10.13039\/501100009601","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009331","name":"Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support","doi-asserted-by":"publisher","award":["ZYLX202126"],"award-info":[{"award-number":["ZYLX202126"]}],"id":[{"id":"10.13039\/501100009331","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Capital\u2019 s Funds for Health Improvement and Research","award":["2020-2-2174"],"award-info":[{"award-number":["2020-2-2174"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-78540-x","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T18:02:54Z","timestamp":1730743374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploration of common pathogenesis and candidate hub genes between HIV and monkeypox co-infection using bioinformatics and machine learning"],"prefix":"10.1038","volume":"14","author":[{"given":"Jialu","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyuan","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sa","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujiao","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjing","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Di","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiju","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,4]]},"reference":[{"key":"78540_CR1","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.3390\/v12111257","volume":"12","author":"E Alakunle","year":"2020","unstructured":"Alakunle, E., Moens, U., Nchinda, G. & Okeke, M. I. Monkeypox virus in Nigeria: infection biology, epidemiology, and evolution. Viruses. 12, 1257 (2020).","journal-title":"Viruses"},{"key":"78540_CR2","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1056\/NEJMoa2207323","volume":"387","author":"JP Thornhill","year":"2022","unstructured":"Thornhill, J. P. et al. Monkeypox virus infection in humans across 16 countries - April-June 2022. N Engl. J. Med. 387, 679\u2013691 (2022).","journal-title":"N Engl. J. Med."},{"key":"78540_CR3","unstructured":"World Health Organization. Clinical Management and Infection Prevention and Control for Monkeypox: Interim Rapid Response Guidance 1\u201376. (2022)."},{"key":"78540_CR4","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S0140-6736(23)00273-8","volume":"401","author":"O Mitj\u00e0","year":"2023","unstructured":"Mitj\u00e0, O. et al. Mpox in people with advanced HIV infection: a global case series. Lancet. 401, 939\u2013949 (2023).","journal-title":"Lancet"},{"key":"78540_CR5","unstructured":"http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hiv-aids"},{"key":"78540_CR6","doi-asserted-by":"publisher","first-page":"e1001538","DOI":"10.1371\/journal.pmed.1001538","volume":"10","author":"M Kaforou","year":"2013","unstructured":"Kaforou, M. et al. Detection of tuberculosis in HIV-infected and -uninfected African adults using whole blood RNA expression signatures: A case-control study. PLOS Med. 10, e1001538 (2013).","journal-title":"PLOS Med."},{"key":"78540_CR7","doi-asserted-by":"publisher","first-page":"e15615","DOI":"10.1371\/journal.pone.0015615","volume":"6","author":"KH Rubins","year":"2011","unstructured":"Rubins, K. H., Hensley, L. E., Relman, D. A. & Brown, P. O. Stunned silence: Gene expression programs in human cells infected with monkeypox or vaccinia virus. PLOS ONE. 6, e15615 (2011).","journal-title":"PLOS ONE"},{"key":"78540_CR8","doi-asserted-by":"publisher","first-page":"Article17","DOI":"10.2202\/1544-6115.1128","volume":"4","author":"B Zhang","year":"2005","unstructured":"Zhang, B. & Horvath, S. A general for weighted gene co-expression network analysis. Stat. Appl. Genet. Mol. Biol. 4, Article17 (2005).","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"78540_CR9","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1186\/1471-2105-9-559","volume":"9","author":"P Langfelder","year":"2008","unstructured":"Langfelder, P. & Horvath, S. W. G. C. N. A. An R package for weighted correlation network analysis. BMC Bioinform. 9, 559 (2008).","journal-title":"BMC Bioinform."},{"key":"78540_CR10","doi-asserted-by":"crossref","unstructured":"Li, Z. et al. Identification and validation of prognostic markers for lung squamous cell carcinoma associated with chronic obstructive pulmonary disease. J. Oncol. 4254195 (2022). (2022).","DOI":"10.1155\/2022\/4254195"},{"key":"78540_CR11","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330 (2000).","journal-title":"Nucleic Acids Res."},{"key":"78540_CR12","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951 (2019).","journal-title":"Protein Sci."},{"key":"78540_CR13","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013D592 (2023).","journal-title":"Nucleic Acids Res."},{"key":"78540_CR14","doi-asserted-by":"crossref","unstructured":"Lobo, J. M., Jim\u00e9nez-Valverde, A. & Real, R. A. U. C. A misleading measure of the performance of predictive distribution models. Glob. Ecol. Biogeogr. (John Wiley & Sons, Ltd, 17, 145\u2013151. (2008).","DOI":"10.1111\/j.1466-8238.2007.00358.x"},{"key":"78540_CR15","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1093\/ije\/dyz274","volume":"49","author":"ACJW Janssens","year":"2020","unstructured":"Janssens, A. C. J. W. & Martens, F. K. Reflection on modern methods: Revisiting the area under the ROC curve. Int. J. Epidemiol. 49, 1397\u20131403 (2020).","journal-title":"Int. J. Epidemiol."},{"key":"78540_CR16","first-page":"469","volume":"14","author":"W Cui","year":"2023","unstructured":"Cui, W. et al. Crystal structure of monkeypox H1 phosphatase, an antiviral drug target. Protein Cell. 14, 469\u2013472 (2023).","journal-title":"Protein Cell."},{"key":"78540_CR17","doi-asserted-by":"publisher","first-page":"1159389","DOI":"10.3389\/fcimb.2023.1159389","volume":"13","author":"A Ajmal","year":"2023","unstructured":"Ajmal, A. et al. Computer-assisted drug repurposing for thymidylate kinase drug target in monkeypox virus. Front. Cell. Infect. Microbiol. 13, 1159389 (2023).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"78540_CR18","doi-asserted-by":"crossref","unstructured":"Srivastava, V. et al. Identification of FDA-approved drugs with triple targeting mode of action for the treatment of monkeypox: A high throughput virtual screening study. Mol. Divers., 1\u201315 (2023).","DOI":"10.21203\/rs.3.rs-2183507\/v1"},{"key":"78540_CR19","doi-asserted-by":"publisher","first-page":"e0056623","DOI":"10.1128\/spectrum.00566-23","volume":"11","author":"T Hishiki","year":"2023","unstructured":"Hishiki, T. et al. Identification of IMP dehydrogenase as a potential target for anti-mpox virus agents. Microbiol. Spectr. 11, e0056623 (2023).","journal-title":"Microbiol. Spectr."},{"key":"78540_CR20","doi-asserted-by":"crossref","unstructured":"Bhattacharjee, A. et al. Proteome-based investigation identified potential drug Repurposable small molecules against monkeypox disease. Mol. Biotechnol., 1\u201315 (2022).","DOI":"10.1007\/s12033-022-00595-w"},{"key":"78540_CR21","doi-asserted-by":"publisher","first-page":"1020826","DOI":"10.3389\/fcell.2022.1020826","volume":"10","author":"OM Rusiecka","year":"2022","unstructured":"Rusiecka, O. M., Tournier, M., Molica, F. & Kwak, B. R. Pannexin1 channels-a potential therapeutic target in inflammation. Front. Cell. Dev. Biol. 10, 1020826 (2022).","journal-title":"Front. Cell. Dev. Biol."},{"key":"78540_CR22","doi-asserted-by":"publisher","first-page":"e75915","DOI":"10.1371\/journal.pone.0075915","volume":"8","author":"J Xiao","year":"2013","unstructured":"Xiao, J. et al. Spectrums of opportunistic infections and malignancies in HIV-infected patients in tertiary care hospital, China. PLOS ONE. 8, e75915 (2013).","journal-title":"PLOS ONE"},{"key":"78540_CR23","doi-asserted-by":"publisher","first-page":"101326","DOI":"10.1016\/j.coviro.2023.101326","volume":"60","author":"J Ratcliff","year":"2023","unstructured":"Ratcliff, J. & Simmonds, P. The roles of nucleic acid editing in adaptation of zoonotic viruses to humans. Curr. Opin. Virol. 60, 101326 (2023).","journal-title":"Curr. Opin. Virol."},{"key":"78540_CR24","doi-asserted-by":"publisher","first-page":"3386","DOI":"10.3390\/ijms24043386","volume":"24","author":"L Qiu","year":"2023","unstructured":"Qiu, L., Chao, W., Zhong, S. & Ren, A. J. Eukaryotic ribosomal protein S5 of the 40S subunit: Structure and function. Int. J. Mol. Sci. 24, 3386 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"78540_CR25","doi-asserted-by":"publisher","first-page":"503","DOI":"10.3390\/v10090503","volume":"10","author":"SD Dissanayaka Mudiyanselage","year":"2018","unstructured":"Dissanayaka Mudiyanselage, S. D., Qu, J., Tian, N., Jiang, J. & Wang, Y. Potato spindle tuber viroid RNA-templated transcription: Factors and regulation. Viruses. 10, 503 (2018).","journal-title":"Viruses"},{"key":"78540_CR26","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1038\/ni.1932","volume":"11","author":"L Unterholzner","year":"2010","unstructured":"Unterholzner, L. et al. IFI16 is an innate immune sensor for intracellular DNA. Nat. Immunol. 11, 997\u20131004 (2010).","journal-title":"Nat. Immunol."},{"key":"78540_CR27","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1089\/jir.2012.0159","volume":"33","author":"NC Reich","year":"2013","unstructured":"Reich, N. C. A death-promoting role for ISG54\/IFIT2. J. Interferon Cytokine Res. 33, 199\u2013205 (2013).","journal-title":"J. Interferon Cytokine Res."},{"key":"78540_CR28","doi-asserted-by":"publisher","first-page":"930","DOI":"10.3390\/vaccines11050930","volume":"11","author":"G Betancor","year":"2023","unstructured":"Betancor, G. You shall not pass: MX2 proteins are versatile viral inhibitors. Vaccines (Basel). 11, 930 (2023).","journal-title":"Vaccines (Basel)"},{"key":"78540_CR29","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1038\/s41564-021-00907-x","volume":"6","author":"Z Jiang","year":"2021","unstructured":"Jiang, Z. et al. IFI16 directly senses viral RNA and enhances RIG-I transcription and activation to restrict influenza virus infection. Nat. Microbiol. 6, 932\u2013945 (2021).","journal-title":"Nat. Microbiol."},{"key":"78540_CR30","doi-asserted-by":"publisher","first-page":"1354410","DOI":"10.3389\/fcimb.2024.1354410","volume":"14","author":"Y Wang","year":"2024","unstructured":"Wang, Y. et al. Transcriptome and proteomic analysis of mpox virus F3L-expressing cells. Front. Cell. Infect. Microbiol. 14, 1354410 (2024).","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"78540_CR31","doi-asserted-by":"publisher","first-page":"e1003712","DOI":"10.1371\/journal.ppat.1003712","volume":"9","author":"JW Bruce","year":"2013","unstructured":"Bruce, J. W. et al. ZASC1 stimulates HIV-1 transcription elongation by recruiting P-TEFb and TAT to the LTR promoter. PLOS Pathog. 9, e1003712 (2013).","journal-title":"PLOS Pathog"},{"key":"78540_CR32","doi-asserted-by":"publisher","first-page":"e1009364","DOI":"10.1371\/journal.ppat.1009364","volume":"17","author":"JW Bruce","year":"2021","unstructured":"Bruce, J. W., Bracken, M., Evans, E., Sherer, N. & Ahlquist, P. ZBTB2 represses HIV-1 transcription and is regulated by HIV-1 vpr and cellular DNA damage responses. PLOS Pathog. 17, e1009364 (2021).","journal-title":"PLOS Pathog"},{"key":"78540_CR33","doi-asserted-by":"publisher","first-page":"3712","DOI":"10.4238\/2011.December.8.6","volume":"10","author":"RL Sun","year":"2011","unstructured":"Sun, R. L. et al. Resistance to lipopolysaccharide-induced endotoxic shock in heterozygous Zfp191 gene-knockout mice. Genet. Mol. Res. 10, 3712\u20133721 (2011).","journal-title":"Genet. Mol. Res."},{"key":"78540_CR34","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1164\/rccm.201306-1181OC","volume":"189","author":"G Chen","year":"2014","unstructured":"Chen, G. et al. Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. Am. J. Respir Crit. Care Med. 189, 301\u2013313 (2014).","journal-title":"Am. J. Respir Crit. Care Med."},{"key":"78540_CR35","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1089\/aid.2011.0358","volume":"28","author":"N Dziuba","year":"2012","unstructured":"Dziuba, N. et al. Identification of cellular proteins required for replication of human immunodeficiency virus type 1. AIDS Res. Hum. Retrovir. 28, 1329\u20131339 (2012).","journal-title":"AIDS Res. Hum. Retrovir"},{"key":"78540_CR36","doi-asserted-by":"publisher","first-page":"4794","DOI":"10.1038\/s41467-021-25033-4","volume":"12","author":"Y Qin","year":"2021","unstructured":"Qin, Y. et al. TRIM28 SUMOylates and stabilizes NLRP3 to facilitate inflammasome activation. Nat. Commun. 12, 4794 (2021).","journal-title":"Nat. Commun."},{"key":"78540_CR37","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1742-4690-4-37","volume":"4","author":"D Rakotobe","year":"2007","unstructured":"Rakotobe, D. et al. Human polycomb group EED protein negatively affects HIV-1 assembly and release. Retrovirology. 4, 37 (2007).","journal-title":"Retrovirology"},{"key":"78540_CR38","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.5604\/17322693.1221384","volume":"70","author":"K Miko\u0142ajczyk","year":"2016","unstructured":"Miko\u0142ajczyk, K., Kaczmarek, R. & Czerwi\u0144ski, M. Can mutations in the gene encoding transcription factor EKLF (erythroid Kr\u00fcppel-Like factor) protect us against infectious and parasitic diseases? Postepy Hig Med. Dosw (Online). 70, 1068\u20131086 (2016).","journal-title":"Postepy Hig Med. Dosw (Online)"},{"key":"78540_CR39","doi-asserted-by":"crossref","unstructured":"Rai, K. R. et al. MIR155HG plays a bivalent role in regulating innate antiviral immunity by encoding long noncoding RNA-155 and microRNA-155-5p. mBio 13, e0251022 (2022).","DOI":"10.1128\/mbio.02510-22"},{"key":"78540_CR40","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.21037\/atm-21-4939","volume":"9","author":"B Li","year":"2021","unstructured":"Li, B., Zhang, Z. & Fu, Y. Anti-inflammatory effects of artesunate on atherosclerosis via mir-16-5p and TXNIP regulation of the NLRP3 inflammasome. Ann. Transl Med. 9, 1558 (2021).","journal-title":"Ann. Transl Med."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78540-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78540-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78540-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T22:02:58Z","timestamp":1731016978000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78540-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,4]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["78540"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-78540-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,4]]},"assertion":[{"value":"29 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study involving human participants was reviewed and approved by the Human Science Ethical Committee of Beijing Ditan Hospital, Capital Medical University. Written informed consent for participation was not required for this study in accordance with institutional requirements owing to the retrospective nature of the study. And all methods in the study were carried out in accordance with relevant guidelines and regulations.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}],"article-number":"26701"}}