{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T20:09:01Z","timestamp":1793304541904,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-78679-7","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T13:06:54Z","timestamp":1730984814000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between glycated hemoglobin and the risk of neonatal respiratory distress syndrome in preterm premature rupture of membranes pregnancies"],"prefix":"10.1038","volume":"14","author":[{"given":"Hui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siya","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyi","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongna","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"issue":"22.e1-3","key":"78679_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.jpeds.2007.03.017","volume":"151","author":"SR Hintz","year":"2007","unstructured":"Hintz, S. R. et al. Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxide. J. Pediatr. 151 (22.e1-3), 16\u201322 (2007).","journal-title":"J. Pediatr."},{"key":"78679_CR2","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/AOG.0b013e318162688f","volume":"111","author":"X Qiu","year":"2008","unstructured":"Qiu, X., Lee, S. K., Tan, K., Piedboeuf, B. & Canning, R. Comparison of singleton and multiple-birth outcomes of infants born at or before 32 weeks of gestation. Obstet. Gynecol. 111, 365\u2013371 (2008).","journal-title":"Obstet. Gynecol."},{"key":"78679_CR3","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.ajog.2005.05.038","volume":"193","author":"KA Gerten","year":"2005","unstructured":"Gerten, K. A., Coonrod, D. V., Bay, R. C. & Chambliss, L. R. Cesarean delivery and respiratory distress syndrome: does labor make a difference? Am. J. Obstet. Gynecol. 193, 1061\u20131064 (2005).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"78679_CR4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.5152\/balkanmedj.2014.8733","volume":"31","author":"J Liu","year":"2014","unstructured":"Liu, J., Yang, N. & Liu, Y. High-risk factors of respiratory distress syndrome in term neonates: a retrospective case-control study. Balkan Med. J. 31, 64\u201368 (2014).","journal-title":"Balkan Med. J."},{"key":"78679_CR5","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.2337\/dc22-S002","volume":"45","author":"2","year":"2022","unstructured":"2. Classification and diagnosis of diabetes: standards of medical care in diabetes-2022. Diabetes Care. 45, S17\u2013s38 (2022).","journal-title":"Diabetes Care"},{"key":"78679_CR6","doi-asserted-by":"publisher","first-page":"e46986","DOI":"10.2196\/46986","volume":"9","author":"X Chen","year":"2023","unstructured":"Chen, X. et al. Association between serum glycated hemoglobin levels at early gestation and the risk of subsequent pregnancy loss in pregnant women without diabetes mellitus: prospective cohort study. JMIR Public. Health Surveill. 9, e46986 (2023).","journal-title":"JMIR Public. Health Surveill"},{"key":"78679_CR7","doi-asserted-by":"crossref","unstructured":"Ma\u00f1\u00e9, L. et al. Early HbA1c levels as a predictor of adverse obstetric outcomes: a systematic review and Meta-analysis. J. Clin. Med. 13 (2024).","DOI":"10.3390\/jcm13061732"},{"key":"78679_CR8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1365-3016.2010.01140.x","volume":"24","author":"MM Hedderson","year":"2010","unstructured":"Hedderson, M. M., Darbinian, J. A. & Ferrara, A. Disparities in the risk of gestational diabetes by race-ethnicity and country of birth. Paediatr. Perinat. Epidemiol. 24, 441\u2013448 (2010).","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"78679_CR9","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.gyobfe.2010.12.009","volume":"39","author":"H Legardeur","year":"2011","unstructured":"Legardeur, H., Girard, G. & Mandelbrot, L. Screening of gestational diabetes mellitus: a new consensus? Gynecol. Obstet. Fertil. 39, 174\u2013179 (2011).","journal-title":"Gynecol. Obstet. Fertil."},{"key":"78679_CR10","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1055\/s-0037-1604414","volume":"34","author":"T Kawakita","year":"2017","unstructured":"Kawakita, T. et al. Increased neonatal respiratory morbidity associated with gestational and pregestational diabetes: a retrospective study. Am. J. Perinatol. 34, 1160\u20131168 (2017).","journal-title":"Am. J. Perinatol."},{"key":"78679_CR11","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1007\/s00404-017-4505-7","volume":"296","author":"I Mortier","year":"2017","unstructured":"Mortier, I. et al. Is gestational diabetes an independent risk factor of neonatal severe respiratory distress syndrome after 34 weeks of gestation? A prospective study. Arch. Gynecol. Obstet. 296, 1071\u20131077 (2017).","journal-title":"Arch. Gynecol. Obstet."},{"key":"78679_CR12","doi-asserted-by":"publisher","first-page":"431e1","DOI":"10.1016\/j.ajog.2013.12.026","volume":"210","author":"NS Boghossian","year":"2014","unstructured":"Boghossian, N. S. et al. Changes in diabetes status between pregnancies and impact on subsequent newborn outcomes. Am. J. Obstet. Gynecol. 210, 431e1\u201343114 (2014).","journal-title":"Am. J. Obstet. Gynecol."},{"key":"78679_CR13","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1001\/jamapediatrics.2018.1811","volume":"172","author":"M Persson","year":"2018","unstructured":"Persson, M. et al. Association of maternal diabetes with neonatal outcomes of very preterm and very low-birth-weight infants: an International Cohort Study. JAMA Pediatr. 172, 867\u2013875 (2018).","journal-title":"JAMA Pediatr."},{"key":"78679_CR14","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3109\/14767058.2016.1174208","volume":"30","author":"K Bricelj","year":"2017","unstructured":"Bricelj, K. et al. Neonatal respiratory morbidity in late-preterm births in pregnancies with and without gestational diabetes mellitus. J. Matern Fetal Neonatal Med. 30, 377\u2013379 (2017).","journal-title":"J. Matern Fetal Neonatal Med."},{"key":"78679_CR15","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.earlhumdev.2014.04.006","volume":"90","author":"GP Fung","year":"2014","unstructured":"Fung, G. P. et al. Does gestational diabetes mellitus affect respiratory outcome in late-preterm infants? Early Hum. Dev. 90, 527\u2013530 (2014).","journal-title":"Early Hum. Dev."},{"key":"78679_CR16","doi-asserted-by":"publisher","first-page":"S20","DOI":"10.2337\/dc24-S002","volume":"47","author":"2","year":"2024","unstructured":"2. Diagnosis and classification of diabetes: standards of care in diabetes-2024. Diabetes Care. 47, S20\u2013s42 (2024).","journal-title":"Diabetes Care"},{"key":"78679_CR17","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1080\/jmf.12.6.428.432","volume":"12","author":"O Langer","year":"2002","unstructured":"Langer, O. The controversy surrounding fetal lung maturity in diabetes in pregnancy: a re-evaluation. J. Matern Fetal Neonatal Med. 12, 428\u2013432 (2002).","journal-title":"J. Matern Fetal Neonatal Med."},{"key":"78679_CR18","doi-asserted-by":"publisher","first-page":"245","DOI":"10.3109\/01902149709087370","volume":"23","author":"IH Gewolb","year":"1997","unstructured":"Gewolb, I. H. & O\u2019Brien, J. Surfactant secretion by type II pneumocytes is inhibited by high glucose concentrations. Exp. Lung Res. 23, 245\u2013255 (1997).","journal-title":"Exp. Lung Res."},{"key":"78679_CR19","doi-asserted-by":"crossref","unstructured":"Simmons, D. et al. Effect of treatment for early gestational diabetes mellitus on neonatal respiratory distress: a secondary analysis of the TOBOGM study. Bjog (2024).","DOI":"10.1111\/1471-0528.17938"},{"key":"78679_CR20","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0301-2115(98)90333-5","volume":"83","author":"JJ Piazze","year":"1999","unstructured":"Piazze, J. J. et al. Fetal lung maturity in pregnancies complicated by insulin-dependent and gestational diabetes: a matched cohort study. Eur. J. Obstet. Gynecol. Reprod. Biol. 83, 145\u2013150 (1999).","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"78679_CR21","first-page":"191","volume":"69","author":"F Mimouni","year":"1987","unstructured":"Mimouni, F. et al. Respiratory distress syndrome in infants of diabetic mothers in the 1980s: no direct adverse effect of maternal diabetes with modern management. Obstet. Gynecol. 69, 191\u2013195 (1987).","journal-title":"Obstet. Gynecol."},{"key":"78679_CR22","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1111\/j.1464-5491.1994.tb00335.x","volume":"11","author":"S Cnattingius","year":"1994","unstructured":"Cnattingius, S., Berne, C. & Nordstr\u00f6m, M. L. Pregnancy outcome and infant mortality in diabetic patients in Sweden. Diabet. Med. 11, 696\u2013700 (1994).","journal-title":"Diabet. Med."},{"key":"78679_CR23","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/S1701-2163(16)32068-0","volume":"28","author":"K Johns","year":"2006","unstructured":"Johns, K., Olynik, C., Mase, R., Kreisman, S. & Tildesley, H. Gestational diabetes mellitus outcome in 394 patients. J. Obstet. Gynaecol. Can. 28, 122\u2013127 (2006).","journal-title":"J. Obstet. Gynaecol. Can."},{"key":"78679_CR24","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.placenta.2019.07.008","volume":"86","author":"H Yu","year":"2019","unstructured":"Yu, H. et al. Importance of early elevated maternal HbA1c levels in identifying adverse fetal and neonatal events. Placenta. 86, 28\u201334 (2019).","journal-title":"Placenta"},{"key":"78679_CR25","doi-asserted-by":"publisher","first-page":"2953","DOI":"10.2337\/dc14-1312","volume":"37","author":"RC Hughes","year":"2014","unstructured":"Hughes, R. C., Moore, M. P., Gullam, J. E., Mohamed, K. & Rowan, J. An early pregnancy HbA1c\u2009\u2265\u20095.9% (41 mmol\/mol) is optimal for detecting diabetes and identifies women at increased risk of adverse pregnancy outcomes. Diabetes Care. 37, 2953\u20132959 (2014).","journal-title":"Diabetes Care"},{"key":"78679_CR26","doi-asserted-by":"publisher","first-page":"108187","DOI":"10.1016\/j.jdiacomp.2022.108187","volume":"36","author":"J Punnose","year":"2022","unstructured":"Punnose, J. et al. Is HbA1c in the first trimester associated with adverse outcomes among pregnant Asian Indian women without gestational diabetes? J. Diabetes Complications. 36, 108187 (2022).","journal-title":"J. Diabetes Complications"},{"key":"78679_CR27","doi-asserted-by":"publisher","first-page":"108377","DOI":"10.1016\/j.diabres.2020.108377","volume":"169","author":"N Iwama","year":"2020","unstructured":"Iwama, N. et al. Associations between glycosylated hemoglobin level at less than 24 weeks of gestation and adverse pregnancy outcomes in Japan: the Japan Environment and Children\u2019s study (JECS). Diabetes Res. Clin. Pract. 169, 108377 (2020).","journal-title":"Diabetes Res. Clin. Pract."},{"key":"78679_CR28","first-page":"390","volume":"102","author":"L Ma\u00f1\u00e9","year":"2017","unstructured":"Ma\u00f1\u00e9, L. et al. Role of first-trimester HbA1c as a predictor of adverse obstetric outcomes in a multiethnic cohort. J. Clin. Endocrinol. Metab. 102, 390\u2013397 (2017).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"78679_CR29","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1055\/s-0038-1675619","volume":"36","author":"L Chen","year":"2019","unstructured":"Chen, L. et al. Early pregnancy hemoglobin A1C and pregnancy outcomes: a population-based study. Am. J. Perinatol. 36, 1045\u20131053 (2019).","journal-title":"Am. J. Perinatol."},{"key":"78679_CR30","unstructured":"Clinical guidelines for prevention. And treatment of type 2 diabetes mellitus in the elderly in China (2022 edition). Zhonghua Nei Ke Za Zhi. 61, 12\u201350 (2022)."},{"key":"78679_CR31","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1007\/BF00279919","volume":"28","author":"R Worth","year":"1985","unstructured":"Worth, R., Potter, J. M., Drury, J., Fraser, R. B. & Cullen, D. R. Glycosylated haemoglobin in normal pregnancy: a longitudinal study with two independent methods. Diabetologia. 28, 76\u201379 (1985).","journal-title":"Diabetologia"},{"key":"78679_CR32","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.2337\/diacare.27.5.1200","volume":"27","author":"LR Nielsen","year":"2004","unstructured":"Nielsen, L. R. et al. HbA1c levels are significantly lower in early and late pregnancy. Diabetes Care. 27, 1200\u20131201 (2004).","journal-title":"Diabetes Care"},{"key":"78679_CR33","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1080\/00016340801908783","volume":"87","author":"G Daskalakis","year":"2008","unstructured":"Daskalakis, G. et al. Placental pathology in women with gestational diabetes. Acta Obstet. Gynecol. Scand. 87, 403\u2013407 (2008).","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"78679_CR34","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1007\/s00125-002-0958-7","volume":"45","author":"IM Evers","year":"2002","unstructured":"Evers, I. M., de Valk, H. W., Mol, B. W., ter Braak, E. W. & Visser, G. H. Macrosomia despite good glycaemic control in type I diabetic pregnancy; results of a nationwide study in the Netherlands. Diabetologia. 45, 1484\u20131489 (2002).","journal-title":"Diabetologia"},{"key":"78679_CR35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00592-010-0199-z","volume":"47","author":"A Lapolla","year":"2010","unstructured":"Lapolla, A., Dalfr\u00e0, M. G. & Fedele, D. Pregnancy complicated by diabetes: what is the best level of HbA1c for conception? Acta Diabetol. 47, 187\u2013192 (2010).","journal-title":"Acta Diabetol."},{"key":"78679_CR36","doi-asserted-by":"publisher","first-page":"2612","DOI":"10.2337\/dc06-0914","volume":"29","author":"GL Nielsen","year":"2006","unstructured":"Nielsen, G. L., M\u00f8ller, M. & S\u00f8rensen, H. T. HbA1c in early diabetic pregnancy and pregnancy outcomes: a Danish population-based cohort study of 573 pregnancies in women with type 1 diabetes. Diabetes Care. 29, 2612\u20132616 (2006).","journal-title":"Diabetes Care"},{"key":"78679_CR37","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.2337\/dc08-2061","volume":"32","author":"DM Jensen","year":"2009","unstructured":"Jensen, D. M. et al. Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes. Diabetes Care. 32, 1046\u20131048 (2009).","journal-title":"Diabetes Care"},{"key":"78679_CR38","doi-asserted-by":"publisher","first-page":"e184571","DOI":"10.1001\/jamanetworkopen.2018.4571","volume":"1","author":"JG Ray","year":"2018","unstructured":"Ray, J. G. et al. Prevalence of severe maternal morbidity and factors associated with maternal mortality in Ontario, Canada. JAMA Netw. Open. 1, e184571 (2018).","journal-title":"JAMA Netw. Open."},{"key":"78679_CR39","doi-asserted-by":"publisher","first-page":"e2030207","DOI":"10.1001\/jamanetworkopen.2020.30207","volume":"3","author":"AJF Davidson","year":"2020","unstructured":"Davidson, A. J. F. et al. Association of improved periconception Hemoglobin A1c with pregnancy outcomes in women with diabetes. JAMA Netw. Open. 3, e2030207 (2020).","journal-title":"JAMA Netw. Open."},{"key":"78679_CR40","doi-asserted-by":"publisher","first-page":"100069","DOI":"10.1016\/j.ajogmf.2019.100069","volume":"2","author":"MM Finneran","year":"2020","unstructured":"Finneran, M. M. et al. The use of longitudinal hemoglobin A1c values to predict adverse obstetric and neonatal outcomes in pregnancies complicated by pregestational diabetes. Am. J. Obstet. Gynecol. MFM. 2, 100069 (2020).","journal-title":"Am. J. Obstet. Gynecol. MFM"},{"key":"78679_CR41","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1159\/000528914","volume":"120","author":"DG Sweet","year":"2023","unstructured":"Sweet, D. G. et al. European consensus guidelines on the management of respiratory distress syndrome: 2022 update. Neonatology. 120, 3\u201323 (2023).","journal-title":"Neonatology"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78679-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78679-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78679-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T13:15:34Z","timestamp":1730985334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78679-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["78679"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-78679-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"18 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval for this study was obtained from the Clinical Research Ethics Committee of the Xiaolan People\u2019s Hospital of Zhongshan. We collected data from medical records; thus, the Ethics Committee of the Xiaolan People\u2019s Hospital of Zhongshan agreed that the informed consent of each participant was not necessary..","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27122"}}