{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:21:39Z","timestamp":1787242899579,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-78702-x","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T04:06:14Z","timestamp":1730952374000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Enhancing fixation stability in proximal humerus fractures: screw orientation optimization in PHILOS plates through finite element analysis and biomechanical testing"],"prefix":"10.1038","volume":"14","author":[{"given":"Jichao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengdong","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"key":"78702_CR1","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.injury.2006.04.130","volume":"37","author":"CM Court-Brown","year":"2006","unstructured":"Court-Brown, C. M. & Caesar, B. Epidemiology of adult fractures: A review. Injury 37, 691\u2013697. https:\/\/doi.org\/10.1016\/j.injury.2006.04.130 (2006).","journal-title":"Injury"},{"key":"78702_CR2","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.otsr.2012.05.013","volume":"98","author":"A Roux","year":"2012","unstructured":"Roux, A. et al. Epidemiology of proximal humerus fractures managed in a trauma center. Orthop. Traumatol.: Surg. Res. 98, 715\u2013719. https:\/\/doi.org\/10.1016\/j.otsr.2012.05.013 (2012).","journal-title":"Orthop. Traumatol.: Surg. Res."},{"key":"78702_CR3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jseint.2021.08.006","volume":"6","author":"AH Patel","year":"2022","unstructured":"Patel, A. H. et al. Trending a decade of proximal humerus fracture management in older adults. JSES Int. 6, 137\u2013143. https:\/\/doi.org\/10.1016\/j.jseint.2021.08.006 (2022).","journal-title":"JSES Int."},{"key":"78702_CR4","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1093\/aje\/kwh224","volume":"160","author":"SP Chu","year":"2004","unstructured":"Chu, S. P. et al. Risk factors for proximal humerus fracture. Am. J. Epidemiol. 160, 360\u2013367. https:\/\/doi.org\/10.1093\/aje\/kwh224 (2004).","journal-title":"Am. J. Epidemiol."},{"key":"78702_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/life12020311","author":"LM Oldrini","year":"2022","unstructured":"Oldrini, L. M. et al. PHILOS synthesis for proximal humerus fractures has high complications and reintervention rates: A systematic review and meta-analysis. Life https:\/\/doi.org\/10.3390\/life12020311 (2022).","journal-title":"Life"},{"key":"78702_CR6","doi-asserted-by":"publisher","DOI":"10.3390\/met8040279","author":"F Hamandi","year":"2018","unstructured":"Hamandi, F., Laughlin, R. & Goswami, T. Failure analysis of PHILOS plate construct used for pantalar arthrodesis paper II\u2014screws and FEM simulations. Metals https:\/\/doi.org\/10.3390\/met8040279 (2018).","journal-title":"Metals"},{"key":"78702_CR7","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.2106\/jbjs.H.00006","volume":"91","author":"N S\u00fcdkamp","year":"2009","unstructured":"S\u00fcdkamp, N. et al. Open reduction and internal fixation of proximal humeral fractures with use of the locking proximal humerus plate. Results of a prospective, multicenter, observational study. J. Bone Joint Surg. Am. 91, 1320\u20131328. https:\/\/doi.org\/10.2106\/jbjs.H.00006 (2009).","journal-title":"J. Bone Joint Surg. Am."},{"key":"78702_CR8","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.2106\/jbjs.M.00028","volume":"96","author":"F Kralinger","year":"2014","unstructured":"Kralinger, F. et al. The influence of local bone density on the outcome of one hundred and fifty proximal humeral fractures treated with a locking plate. J. Bone Joint Surg. Am. 96, 1026\u20131032. https:\/\/doi.org\/10.2106\/jbjs.M.00028 (2014).","journal-title":"J. Bone Joint Surg. Am."},{"key":"78702_CR9","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s00402-019-03142-6","volume":"139","author":"C Hengg","year":"2019","unstructured":"Hengg, C. et al. Cement augmentation of the proximal humerus internal locking system in elderly patients: A multicenter randomized controlled trial. Arch. Orthop. Trauma Surg. 139, 927\u2013942. https:\/\/doi.org\/10.1007\/s00402-019-03142-6 (2019).","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"78702_CR10","doi-asserted-by":"publisher","first-page":"2176","DOI":"10.1016\/j.injury.2019.11.002","volume":"50","author":"VC Panagiotopoulou","year":"2019","unstructured":"Panagiotopoulou, V. C., Varga, P., Richards, R. G., Gueorguiev, B. & Giannoudis, P. V. Late screw-related complications in locking plating of proximal humerus fractures: A systematic review. Injury 50, 2176\u20132195. https:\/\/doi.org\/10.1016\/j.injury.2019.11.002 (2019).","journal-title":"Injury"},{"key":"78702_CR11","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s10439-018-02160-6","volume":"47","author":"A Jabran","year":"2019","unstructured":"Jabran, A., Peach, C., Zou, Z. & Ren, L. Parametric design optimisation of proximal humerus plates based on finite element method. Ann. Biomed. Eng. 47, 601\u2013614. https:\/\/doi.org\/10.1007\/s10439-018-02160-6 (2019).","journal-title":"Ann. Biomed. Eng."},{"key":"78702_CR12","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.jse.2021.06.012","volume":"31","author":"JF Schader","year":"2022","unstructured":"Schader, J. F. et al. One size may not fit all: patient-specific computational optimization of locking plates for improved proximal humerus fracture fixation. J. Shoulder Elb. Surg. 31, 192\u2013200. https:\/\/doi.org\/10.1016\/j.jse.2021.06.012 (2022).","journal-title":"J. Shoulder Elb. Surg."},{"key":"78702_CR13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.jot.2020.02.007","volume":"25","author":"D Mischler","year":"2020","unstructured":"Mischler, D., Windolf, M., Gueorguiev, B., Nijs, S. & Varga, P. Computational optimisation of screw orientations for improved locking plate fixation of proximal humerus fractures. J. Orthop. Trans. 25, 96\u2013104. https:\/\/doi.org\/10.1016\/j.jot.2020.02.007 (2020).","journal-title":"J. Orthop. Trans."},{"key":"78702_CR14","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.medengphy.2018.04.011","volume":"57","author":"P Varga","year":"2018","unstructured":"Varga, P., Inzana, J. A., Gueorguiev, B., S\u00fcdkamp, N. P. & Windolf, M. Validated computational framework for efficient systematic evaluation of osteoporotic fracture fixation in the proximal humerus. Med. Eng. Phys. 57, 29\u201339. https:\/\/doi.org\/10.1016\/j.medengphy.2018.04.011 (2018).","journal-title":"Med. Eng. Phys."},{"key":"78702_CR15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.medengphy.2018.12.004","volume":"63","author":"L Le","year":"2019","unstructured":"Le, L., Jabran, A., Peach, C. & Ren, L. Effect of screw thread length on stiffness of proximal humerus locking plate constructs: A finite element study. Med. Eng. Phys. 63, 79\u201387. https:\/\/doi.org\/10.1016\/j.medengphy.2018.12.004 (2019).","journal-title":"Med. Eng. Phys."},{"key":"78702_CR16","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.jmbbm.2017.07.004","volume":"75","author":"P Varga","year":"2017","unstructured":"Varga, P., Gr\u00fcnwald, L., Inzana, J. A. & Windolf, M. Fatigue failure of plated osteoporotic proximal humerus fractures is predicted by the strain around the proximal screws. J. Mech. Behav. Biomed. Mater. 75, 68\u201374. https:\/\/doi.org\/10.1016\/j.jmbbm.2017.07.004 (2017).","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"78702_CR17","doi-asserted-by":"publisher","first-page":"4650405","DOI":"10.1155\/2019\/4650405","volume":"2019","author":"F Mo","year":"2019","unstructured":"Mo, F., Zhang, H., Zhao, S., Xiao, Z. & Liu, T. Coupling musculoskeletal dynamics and subject-specific finite element analysis of femoral cortical bone failure after endoprosthetic knee replacement. Appl. Bion. Biomech. 2019, 4650405. https:\/\/doi.org\/10.1155\/2019\/4650405 (2019).","journal-title":"Appl. Bion. Biomech."},{"key":"78702_CR18","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1007\/s10439-016-1714-3","volume":"45","author":"H Wee","year":"2017","unstructured":"Wee, H., Reid, J. S., Chinchilli, V. M. & Lewis, G. S. Finite element-derived surrogate models of locked plate fracture fixation biomechanics. Ann. Biomed. Eng. 45, 668\u2013680. https:\/\/doi.org\/10.1007\/s10439-016-1714-3 (2017).","journal-title":"Ann. Biomed. Eng."},{"key":"78702_CR19","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.919721","volume":"10","author":"D Mischler","year":"2022","unstructured":"Mischler, D. et al. Locking plates with computationally enhanced screw trajectories provide superior biomechanical fixation stability of complex proximal humerus fractures. Front. Bioeng. Biotechnol. 10, 919721. https:\/\/doi.org\/10.3389\/fbioe.2022.919721 (2022).","journal-title":"Front. Bioeng. Biotechnol."},{"key":"78702_CR20","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering7010027","author":"F Hamandi","year":"2020","unstructured":"Hamandi, F., Simon, G., Laughlin, R. & Goswami, T. Biomechanical behavior of a variable angle locked tibiotalocalcaneal construct. Bioengineering https:\/\/doi.org\/10.3390\/bioengineering7010027 (2020).","journal-title":"Bioengineering"},{"key":"78702_CR21","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1016\/j.jse.2019.02.013","volume":"28","author":"JWA Fletcher","year":"2019","unstructured":"Fletcher, J. W. A., Windolf, M., Richards, R. G., Gueorguiev, B. & Varga, P. Screw configuration in proximal humerus plating has a significant impact on fixation failure risk predicted by finite element models. J. Shoulder Elb. Surg. 28, 1816\u20131823. https:\/\/doi.org\/10.1016\/j.jse.2019.02.013 (2019).","journal-title":"J. Shoulder Elb. Surg."},{"key":"78702_CR22","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23879","author":"P Varga","year":"2018","unstructured":"Varga, P., Gr\u00fcnwald, L. & Windolf, M. The prediction of cyclic proximal humerus fracture fixation failure by various bone density measures. J. Orthop. Res.: Off. Publ. Orthop. Res. Soc. https:\/\/doi.org\/10.1002\/jor.23879 (2018).","journal-title":"J. Orthop. Res.: Off. Publ. Orthop. Res. Soc."},{"key":"78702_CR23","doi-asserted-by":"publisher","first-page":"4116","DOI":"10.1016\/j.jbiomech.2015.10.012","volume":"48","author":"A Synek","year":"2015","unstructured":"Synek, A., Chevalier, Y., Baumbach, S. F. & Pahr, D. H. The influence of bone density and anisotropy in finite element models of distal radius fracture osteosynthesis: Evaluations and comparison to experiments. J. Biomech. 48, 4116\u20134123. https:\/\/doi.org\/10.1016\/j.jbiomech.2015.10.012 (2015).","journal-title":"J. Biomech."},{"key":"78702_CR24","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1155\/2022\/1268774","volume":"1\u20139","author":"J-S Lee","year":"2022","unstructured":"Lee, J.-S., Kim, J. H., Kim, K. G., Yoon, Y.-C. & Gas, P. Effect of calcar screw in locking compression plate system for osteoporotic proximal humerus fracture: A finite element analysis study. BioMed Res. Int. 1\u20139, 2022. https:\/\/doi.org\/10.1155\/2022\/1268774 (2022).","journal-title":"BioMed Res. Int."},{"key":"78702_CR25","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1007\/s00402-020-03627-9","volume":"141","author":"MJ Shin","year":"2021","unstructured":"Shin, M. J. et al. Role of inferomedial supporting screws for secondary varus deformity in non-osteoporotic proximal humerus fracture: A biomechanical study. Arch. Orthop. Trauma Surg. 141, 1517\u20131523. https:\/\/doi.org\/10.1007\/s00402-020-03627-9 (2021).","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"78702_CR26","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.injury.2016.02.028","volume":"47","author":"YK Zhang","year":"2016","unstructured":"Zhang, Y. K. et al. Biomechanical effect of the configuration of screw hole style on locking plate fixation in proximal humerus fracture with a simulated gap: A finite element analysis. Injury 47, 1191\u20131195. https:\/\/doi.org\/10.1016\/j.injury.2016.02.028 (2016).","journal-title":"Injury"},{"key":"78702_CR27","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1097\/TA.0b013e3181beed96","volume":"69","author":"J Lescheid","year":"2010","unstructured":"Lescheid, J., Zdero, R., Shah, S., Kuzyk, P. R. & Schemitsch, E. H. The biomechanics of locked plating for repairing proximal humerus fractures with or without medial cortical support. J. Trauma 69, 1235\u20131242. https:\/\/doi.org\/10.1097\/TA.0b013e3181beed96 (2010).","journal-title":"J. Trauma"},{"key":"78702_CR28","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.clinbiomech.2014.06.008","volume":"29","author":"JC Katthagen","year":"2014","unstructured":"Katthagen, J. C. et al. Biomechanical effects of calcar screws and bone block augmentation on medial support in locked plating of proximal humeral fractures. Clin. Biomech. (Bristol, Avon) 29, 735\u2013741. https:\/\/doi.org\/10.1016\/j.clinbiomech.2014.06.008 (2014).","journal-title":"Clin. Biomech. (Bristol, Avon)"},{"key":"78702_CR29","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.jbiomech.2011.02.142","volume":"44","author":"G Bergmann","year":"2011","unstructured":"Bergmann, G. et al. In vivo gleno-humeral joint loads during forward flexion and abduction. J. Biomech. 44, 1543\u20131552. https:\/\/doi.org\/10.1016\/j.jbiomech.2011.02.142 (2011).","journal-title":"J. Biomech."},{"key":"78702_CR30","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1016\/j.jbiomech.2009.05.035","volume":"42","author":"P Westerhoff","year":"2009","unstructured":"Westerhoff, P. et al. In vivo measurement of shoulder joint loads during activities of daily living. J. Biomech. 42, 1840\u20131849. https:\/\/doi.org\/10.1016\/j.jbiomech.2009.05.035 (2009).","journal-title":"J. Biomech."},{"key":"78702_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103297","volume":"9","author":"W Zhang","year":"2014","unstructured":"Zhang, W. et al. The mechanical benefit of medial support screws in locking plating of proximal humerus fractures. PLoS One 9, e103297. https:\/\/doi.org\/10.1371\/journal.pone.0103297 (2014).","journal-title":"PLoS One"},{"key":"78702_CR32","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/j.injury.2016.01.004","volume":"47","author":"JC Katthagen","year":"2016","unstructured":"Katthagen, J. C. et al. Influence of plate material and screw design on stiffness and ultimate load of locked plating in osteoporotic proximal humeral fractures. Injury 47, 617\u2013624. https:\/\/doi.org\/10.1016\/j.injury.2016.01.004 (2016).","journal-title":"Injury"},{"key":"78702_CR33","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.injury.2011.08.012","volume":"43","author":"G Gradl","year":"2012","unstructured":"Gradl, G. et al. Locking plate fixation of humeral head fractures with a telescoping screw. A comparative biomechanical study versus a standard plate. Injury 43, 734\u2013738. https:\/\/doi.org\/10.1016\/j.injury.2011.08.012 (2012).","journal-title":"Injury"},{"key":"78702_CR34","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s41779-017-0169-9","volume":"54","author":"SK Tumulu","year":"2017","unstructured":"Tumulu, S. K. & Sarkar, D. Computer-aided design, finite element analysis and material-model optimisation of knee prosthesis. J. Aust. Ceram. Soc. 54, 429\u2013438. https:\/\/doi.org\/10.1007\/s41779-017-0169-9 (2017).","journal-title":"J. Aust. Ceram. Soc."},{"key":"78702_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/life12020311","author":"LM Oldrini","year":"2022","unstructured":"Oldrini, L. M. et al. PHILOS synthesis for proximal humerus fractures has high complications and reintervention rates: A systematic review and meta-analysis. Life (Basel, Switzerland) https:\/\/doi.org\/10.3390\/life12020311 (2022).","journal-title":"Life (Basel, Switzerland)"},{"key":"78702_CR36","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.jbiomech.2014.12.008","volume":"48","author":"JA Steiner","year":"2015","unstructured":"Steiner, J. A., Ferguson, S. J. & van Lenthe, G. H. Computational analysis of primary implant stability in trabecular bone. J. Biomech. 48, 807\u2013815. https:\/\/doi.org\/10.1016\/j.jbiomech.2014.12.008 (2015).","journal-title":"J. Biomech."},{"key":"78702_CR37","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1097\/BOT.0b013e318206eb46","volume":"25","author":"C Voigt","year":"2011","unstructured":"Voigt, C., Geisler, A., Hepp, P., Schulz, A. P. & Lill, H. Are polyaxially locked screws advantageous in the plate osteosynthesis of proximal humeral fractures in the elderly? A prospective randomized clinical observational study. J. Orthop. Trauma 25, 596\u2013602. https:\/\/doi.org\/10.1097\/BOT.0b013e318206eb46 (2011).","journal-title":"J. Orthop. Trauma"},{"key":"78702_CR38","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1097\/TA.0b013e3181c9b8a7","volume":"69","author":"B Ockert","year":"2010","unstructured":"Ockert, B. et al. Monoaxial versus polyaxial screw insertion in angular stable plate fixation of proximal humeral fractures: Radiographic analysis of a prospective randomized study. J. Trauma 69, 1545\u20131551. https:\/\/doi.org\/10.1097\/TA.0b013e3181c9b8a7 (2010).","journal-title":"J. Trauma"},{"key":"78702_CR39","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s10439-019-02365-3","volume":"48","author":"M Tilton","year":"2020","unstructured":"Tilton, M. et al. Biomechanical testing of additive manufactured proximal humerus fracture fixation plates. Ann. Biomed. Eng. 48, 463\u2013476. https:\/\/doi.org\/10.1007\/s10439-019-02365-3 (2020).","journal-title":"Ann. Biomed. Eng."},{"key":"78702_CR40","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12893-022-01557-4","volume":"22","author":"D Li","year":"2022","unstructured":"Li, D. et al. Application of a lateral intertubercular sulcus plate in the treatment of proximal humeral fractures: A finite element analysis. BMC Surg. 22, 98. https:\/\/doi.org\/10.1186\/s12893-022-01557-4 (2022).","journal-title":"BMC Surg."},{"key":"78702_CR41","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.clinbiomech.2010.03.003","volume":"25","author":"T Wehner","year":"2010","unstructured":"Wehner, T., Claes, L., Niemeyer, F., Nolte, D. & Simon, U. Influence of the fixation stability on the healing time\u2014a numerical study of a patient-specific fracture healing process. Clin. Biomech. 25, 606\u2013612. https:\/\/doi.org\/10.1016\/j.clinbiomech.2010.03.003 (2010).","journal-title":"Clin. Biomech."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78702-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78702-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78702-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T04:19:19Z","timestamp":1730953159000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-78702-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["78702"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-78702-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"23 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27064"}}