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Materials used in this study included, Self-adhesive hybrid composite (group A), Ion releasing flowable composite liner (group B), and alkasite restorative material (group C). Twenty-two discs were fabricated from each material for short-term fluoride release test, conducted on days 1, 7, and 14. For assessing secondary caries inhibition, sixty-six sound molar teeth were used and standardized class V cavities were prepared. Teeth were divided into three groups according to each material, followed by 800 cycles of thermocycling. Subsequently, teeth were immersed in a solution containing cariogenic bacteria for 30 days. After that, teeth were sectioned bucco-lingually and analyzed using a polarized light microscope to measure inhibition area, outer lesion depth, and extension. Data was statistically analyzed using different tests. The study results revealed a statistically significant differences in fluoride release existed among materials. Self-adhesive hybrid composite exhibited the highest fluoride release. Lesion extension and depth were statistically significantly greater next to Ion-releasing flowable composite liner. The inhibition areas next to the Self-adhesive hybrid composite were statistically significantly larger than the other two materials. In conclusion, all tested ion-releasing restorative materials displayed fluoride release and the potential to inhibit secondary caries formation. Self-adhesive hybrid composite demonstrated the highest fluoride-releasing potential and the greatest ability to inhibit secondary caries. Conversely, Ion-releasing flowable composite liner exhibited the least fluoride release with minimal secondary caries inhibition. Increasing fluoride release correlated with larger inhibition areas and reduced outer lesion depth and extension.<\/jats:p>","DOI":"10.1038\/s41598-024-78918-x","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T13:17:02Z","timestamp":1736515022000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparative measurement of short-term fluoride release and inhibition of caries around restoration by ion releasing restorative materials: an in vitro study"],"prefix":"10.1038","volume":"15","author":[{"given":"Eman T.","family":"El-Adl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M.","family":"Ebaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El-Sayed E.","family":"Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia M.","family":"Zaghloul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"78918_CR1","doi-asserted-by":"publisher","first-page":"557","DOI":"10.4012\/dmj.2013-023","volume":"32","author":"M Unal","year":"2013","unstructured":"Unal, M., Hubbezoglu, I., Zan, R., Kapdan, A. & Hurmuzlu, F. 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