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Written informed consent for publication of their details was obtained from the patients or their next of kin. This study was conducted in accordance with the Declaration of Helsinki. The mouse experiments were approved by the Laboratory Animal Ethics Committee of Xiangya Hospital of Central South University (Ethics no. 202409156). This study is reported in accordance with ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent for participation in this study and publication of their details was obtained from the patients or their next of kin.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}],"article-number":"27744"}}