{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:47:23Z","timestamp":1787312843379,"version":"build-2736575974"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]},{"name":"the China Agriculture Research System of MOF and MARA","award":["CARS-38"],"award-info":[{"award-number":["CARS-38"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-79062-2","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T02:17:10Z","timestamp":1731118630000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bio-characteristics, tissue expression of miR-375 in hypothalamic-pituitary-ovarian axis and its regulation in reproduction-related diseases"],"prefix":"10.1038","volume":"14","author":[{"given":"Saiyi","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binglei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiqiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiujue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"key":"79062_CR1","doi-asserted-by":"publisher","unstructured":"Sun, H. Z., Chen, Y. & Guan, L. L. MicroRNA expression profiles across blood and different tissues in cattle. Sci. Data. 6 https:\/\/doi.org\/10.1038\/sdata.2019.13 (2019).","DOI":"10.1038\/sdata.2019.13"},{"key":"79062_CR2","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1016\/0092-8674(93)90529-y","volume":"75","author":"RC Lee","year":"1993","unstructured":"Lee, R. C., Feinbaum, R. L. & Ambros, V. The C. Elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75, 843\u2013854. https:\/\/doi.org\/10.1016\/0092-8674(93)90529-y (1993).","journal-title":"Cell"},{"key":"79062_CR3","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1146\/annurev.cellbio.23.090506.123406","volume":"23","author":"N Bushati","year":"2007","unstructured":"Bushati, N. & Cohen, S. M. microRNA functions. Annu. Rev. Cell Dev. Biol. 23, 175\u2013205. https:\/\/doi.org\/10.1146\/annurev.cellbio.23.090506.123406 (2007).","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"79062_CR4","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1080\/15476286.2021.1899491","volume":"18","author":"M Li","year":"2021","unstructured":"Li, M. & Yu, B. Recent advances in the regulation of plant miRNA biogenesis. RNA Biol. 18, 2087\u20132096. https:\/\/doi.org\/10.1080\/15476286.2021.1899491 (2021).","journal-title":"RNA Biol."},{"key":"79062_CR5","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1007\/s11033-021-06290-4","volume":"48","author":"AA Mengistu","year":"2021","unstructured":"Mengistu, A. A. & Tenkegna, T. A. The role of miRNA in plant\u2013virus interaction: a review. Mol. Biol. Rep. 48, 2853\u20132861. https:\/\/doi.org\/10.1007\/s11033-021-06290-4 (2021).","journal-title":"Mol. Biol. Rep."},{"key":"79062_CR6","doi-asserted-by":"publisher","unstructured":"He, J. et al. The role of miR-7 as a potential switch in the mouse hypothalamus-pituitary-ovary axis through regulation of gonadotropins. Mol. Cell. Endocrinol. 518 https:\/\/doi.org\/10.1016\/j.mce.2020.110969 (2020).","DOI":"10.1016\/j.mce.2020.110969"},{"key":"79062_CR7","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/ng1914","volume":"38","author":"E Berezikov","year":"2006","unstructured":"Berezikov, E. et al. Diversity of microRNAs in human and chimpanzee brain. Nat. Genet. 38, 1375\u20131377. https:\/\/doi.org\/10.1038\/ng1914 (2006).","journal-title":"Nat. Genet."},{"key":"79062_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.14670\/hh-11-798","volume":"32","author":"DY Kim","year":"2017","unstructured":"Kim, D. Y. & Sung, J. H. Regulatory role of microRNAs in the proliferation and differentiation of adipose-derived stem cells. Histol. Histopathol. 32, 1\u201310. https:\/\/doi.org\/10.14670\/hh-11-798 (2017).","journal-title":"Histol. Histopathol."},{"key":"79062_CR9","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1038\/ng1725","volume":"38","author":"JF Chen","year":"2006","unstructured":"Chen, J. F. et al. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat. Genet. 38, 228\u2013233. https:\/\/doi.org\/10.1038\/ng1725 (2006).","journal-title":"Nat. Genet."},{"key":"79062_CR10","doi-asserted-by":"publisher","first-page":"4023","DOI":"10.2147\/ijn.S377317","volume":"17","author":"W Zhao","year":"2022","unstructured":"Zhao, W. et al. Exosome Derived from mesenchymal stem cells alleviates pathological scars by inhibiting the Proliferation, Migration and protein expression of fibroblasts via delivering mir-138-5p to Target SIRT1. Int. J. Nanomed. 17, 4023\u20134038. https:\/\/doi.org\/10.2147\/ijn.S377317 (2022).","journal-title":"Int. J. Nanomed."},{"key":"79062_CR11","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/s12015-018-9808-y","volume":"14","author":"MMJ Mens","year":"2018","unstructured":"Mens, M. M. J. & Ghanbari, M. Cell cycle regulation of stem cells by microRNAs. Stem cell. Reviews Rep. 14, 309\u2013322. https:\/\/doi.org\/10.1007\/s12015-018-9808-y (2018).","journal-title":"Stem cell. Reviews Rep."},{"key":"79062_CR12","doi-asserted-by":"publisher","unstructured":"Liu, Q. et al. Screening of differentially expressed genes and miRNAs in Hypothalamus and Pituitary Gland of Sheep under different photoperiods. Genes. 13 https:\/\/doi.org\/10.3390\/genes13061091 (2022).","DOI":"10.3390\/genes13061091"},{"key":"79062_CR13","doi-asserted-by":"publisher","first-page":"103642","DOI":"10.1016\/j.msard.2022.103642","volume":"59","author":"B Erkal","year":"2022","unstructured":"Erkal, B. & Vural Korkut, S. Identification of miRNAs and their potential effects on multiple sclerosis related pathways using \u0131n silico analysis. Multiple Scler. Relat. Disorders. 59, 103642. https:\/\/doi.org\/10.1016\/j.msard.2022.103642 (2022).","journal-title":"Multiple Scler. Relat. Disorders"},{"key":"79062_CR14","doi-asserted-by":"publisher","unstructured":"Joseph, D. N. & Whirledge, S. Stress and the HPA Axis: balancing Homeostasis and Fertility. Int. J. Mol. Sci. 18 https:\/\/doi.org\/10.3390\/ijms18102224 (2017).","DOI":"10.3390\/ijms18102224"},{"key":"79062_CR15","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1038\/s42003-024-06488-9","volume":"7","author":"Z Yang","year":"2024","unstructured":"Yang, Z. et al. Integrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma. Commun. Biology. 7, 824. https:\/\/doi.org\/10.1038\/s42003-024-06488-9 (2024).","journal-title":"Commun. Biology"},{"key":"79062_CR16","doi-asserted-by":"publisher","first-page":"16884","DOI":"10.1039\/c9ra01523j","volume":"9","author":"F Kong","year":"2019","unstructured":"Kong, F. et al. Identification and characterization of differentially expressed miRNAs in HepG2 cells under normoxic and hypoxic conditions. RSC Adv. 9, 16884\u201316891. https:\/\/doi.org\/10.1039\/c9ra01523j (2019).","journal-title":"RSC Adv."},{"key":"79062_CR17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1051\/rnd:19990308","volume":"39","author":"B Malpaux","year":"1999","unstructured":"Malpaux, B., Thi\u00e9ry, J. C. & Chemineau, P. Melatonin and the seasonal control of reproduction. Reprod. Nutr. Dev. 39, 355\u2013366. https:\/\/doi.org\/10.1051\/rnd:19990308 (1999).","journal-title":"Reprod. Nutr. Dev."},{"key":"79062_CR18","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1051\/rnd:19880303","volume":"28","author":"JE Robinson","year":"1988","unstructured":"Robinson, J. E. (ed Karsch, F. J.) Timing the breeding season of the ewe: what is the role of daylength? Reprod. Nutr. Developpement 28 365\u2013374 https:\/\/doi.org\/10.1051\/rnd:19880303 (1988).","journal-title":"Reprod. Nutr. Developpement"},{"key":"79062_CR19","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12864-021-07536-y","volume":"22","author":"R Di","year":"2021","unstructured":"Di, R. et al. Expression characteristics of pineal miRNAs at ovine different reproductive stages and the identification of miRNAs targeting the AANAT gene. BMC Genom. 22, 217. https:\/\/doi.org\/10.1186\/s12864-021-07536-y (2021).","journal-title":"BMC Genom."},{"key":"79062_CR20","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.7150\/ijms.51743","volume":"18","author":"Y Zheng","year":"2021","unstructured":"Zheng, Y. et al. Identifying daily changes in circRNAs and circRNA-associated-ceRNA networks in the rat pineal gland. Int. J. Med. Sci. 18, 1225\u20131239. https:\/\/doi.org\/10.7150\/ijms.51743 (2021).","journal-title":"Int. J. Med. Sci."},{"key":"79062_CR21","doi-asserted-by":"publisher","first-page":"e12552","DOI":"10.1111\/jpi.12552","volume":"66","author":"J Qiu","year":"2019","unstructured":"Qiu, J. et al. MicroRNA-7 inhibits melatonin synthesis by acting as a linking molecule between leptin and norepinephrine signaling pathways in pig pineal gland. J. Pineal Res. 66, e12552. https:\/\/doi.org\/10.1111\/jpi.12552 (2019).","journal-title":"J. Pineal Res."},{"key":"79062_CR22","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s11626-020-00447-4","volume":"57","author":"H Li","year":"2021","unstructured":"Li, H., Li, X., Zhang, D., Li, J. & Cui, S. MiR-375 potentially enhances GnRH expression by targeting Sp1 in GT1-7 cells. Vitro Cell. Dev. Biology - Anim. 57, 438\u2013447. https:\/\/doi.org\/10.1007\/s11626-020-00447-4 (2021).","journal-title":"Vitro Cell. Dev. Biology - Anim."},{"key":"79062_CR23","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1159\/000456597","volume":"41","author":"H Chen","year":"2017","unstructured":"Chen, H. et al. Regulatory Role of miRNA-375 in expression of BMP15\/GDF9 receptors and its Effect on Proliferation and apoptosis of bovine cumulus cells. Cell. Physiol. Biochem. 41, 439\u2013450. https:\/\/doi.org\/10.1159\/000456597 (2017).","journal-title":"Cell. Physiol. Biochem."},{"key":"79062_CR24","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1530\/rep-16-0323","volume":"153","author":"C Yu","year":"2017","unstructured":"Yu, C. et al. miR-375 mediates CRH signaling pathway in inhibiting E2 synthesis in porcine ovary. Reproduction. 153, 63\u201373. https:\/\/doi.org\/10.1530\/rep-16-0323 (2017).","journal-title":"Reproduction"},{"key":"79062_CR25","doi-asserted-by":"publisher","unstructured":"Zhang, J., Guan, Y., Shen, C., Zhang, L. & Wang, X. MicroRNA-375 regulates oocyte in vitro maturation by targeting ADAMTS1 and PGR in bovine cumulus cells. Biomed. Pharmacother. 118 https:\/\/doi.org\/10.1016\/j.biopha.2019.109350 (2019).","DOI":"10.1016\/j.biopha.2019.109350"},{"key":"79062_CR26","doi-asserted-by":"publisher","first-page":"5859","DOI":"10.1016\/j.cell.2023.11.008","volume":"186","author":"Y Wei","year":"2023","unstructured":"Wei, Y. et al. Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture. Cell. 186, 5859\u20135875. .e5824 (2023).","journal-title":"Cell"},{"key":"79062_CR27","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1210\/endrev\/bnac013","volume":"43","author":"KL Clark","year":"2022","unstructured":"Clark, K. L. et al. Hippo Signaling in the Ovary: emerging roles in Development, Fertility, and Disease. Endocr. Rev. 43, 1074\u20131096. https:\/\/doi.org\/10.1210\/endrev\/bnac013 (2022).","journal-title":"Endocr. Rev."},{"key":"79062_CR28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-1-59745-528-2_2","volume":"402","author":"W Rychlik","year":"2007","unstructured":"Rychlik, W. OLIGO 7 primer analysis software. Methods Mol. Biol. 402, 35\u201360. https:\/\/doi.org\/10.1007\/978-1-59745-528-2_2 (2007).","journal-title":"Methods Mol. Biol."},{"key":"79062_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","volume":"28","author":"M Kanehisa","year":"2000","unstructured":"Kanehisa, M. & Goto, S. KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28, 27\u201330. https:\/\/doi.org\/10.1093\/nar\/28.1.27 (2000).","journal-title":"Nucleic Acids Res."},{"key":"79062_CR30","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa, M. Toward understanding the origin and evolution of cellular organisms. Protein Sci. 28, 1947\u20131951. https:\/\/doi.org\/10.1002\/pro.3715 (2019).","journal-title":"Protein Sci."},{"key":"79062_CR31","doi-asserted-by":"publisher","first-page":"D587","DOI":"10.1093\/nar\/gkac963","volume":"51","author":"M Kanehisa","year":"2023","unstructured":"Kanehisa, M., Furumichi, M., Sato, Y., Kawashima, M. & Ishiguro-Watanabe, M. KEGG for taxonomy-based analysis of pathways and genomes. Nucleic Acids Res. 51, D587\u2013d592. https:\/\/doi.org\/10.1093\/nar\/gkac963 (2023).","journal-title":"Nucleic Acids Res."},{"key":"79062_CR32","doi-asserted-by":"publisher","first-page":"e0294236","DOI":"10.1371\/journal.pone.0294236","volume":"18","author":"D Tang","year":"2023","unstructured":"Tang, D. et al. SRplot: a free online platform for data visualization and graphing. PLoS ONE. 18, e0294236. https:\/\/doi.org\/10.1371\/journal.pone.0294236 (2023).","journal-title":"PLoS ONE"},{"key":"79062_CR33","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon, P. et al. Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res. 13, 2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303 (2003).","journal-title":"Genome Res."},{"key":"79062_CR34","doi-asserted-by":"publisher","DOI":"10.2174\/1566524023666230417103201","author":"R Shao","year":"2023","unstructured":"Shao, R., Wang, Y., He, C. & Chen, L. Melatonin and its emerging physiological role in reproduction: a review and update. Curr. Mol. Med. https:\/\/doi.org\/10.2174\/1566524023666230417103201 (2023).","journal-title":"Curr. Mol. Med."},{"key":"79062_CR35","doi-asserted-by":"publisher","first-page":"113814","DOI":"10.1016\/j.expneurol.2021.113814","volume":"344","author":"L Xu","year":"2021","unstructured":"Xu, L. et al. MiR-375-3p mediates reduced pineal function in hypoxia-ischemia brain damage. Exp. Neurol. 344, 113814. https:\/\/doi.org\/10.1016\/j.expneurol.2021.113814 (2021).","journal-title":"Exp. Neurol."},{"key":"79062_CR36","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/s12276-022-00837-6","volume":"54","author":"J Gan","year":"2022","unstructured":"Gan, J. et al. MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4\/STAT3 axis. Exp. Mol. Med. 54, 1290\u20131305. https:\/\/doi.org\/10.1038\/s12276-022-00837-6 (2022).","journal-title":"Exp. Mol. Med."},{"key":"79062_CR37","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1530\/joe-20-0001","volume":"250","author":"J Zhang","year":"2021","unstructured":"Zhang, J. et al. miR-375 acts as a novel factor modulating pituitary prolactin synthesis through Rasd1 and Esr1. J. Endocrinol. 250, 25\u201335. https:\/\/doi.org\/10.1530\/joe-20-0001 (2021).","journal-title":"J. Endocrinol."},{"key":"79062_CR38","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/s0092-8674(03)00549-x","volume":"114","author":"S Wu","year":"2003","unstructured":"Wu, S., Huang, J., Dong, J. & Pan, D. Hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell. 114, 445\u2013456. https:\/\/doi.org\/10.1016\/s0092-8674(03)00549-x (2003).","journal-title":"Cell"},{"key":"79062_CR39","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1016\/j.cub.2007.09.062","volume":"17","author":"C Meignin","year":"2007","unstructured":"Meignin, C., Alvarez-Garcia, I., Davis, I. & Palacios, I. M. The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr. Biology: CB. 17, 1871\u20131878. https:\/\/doi.org\/10.1016\/j.cub.2007.09.062 (2007).","journal-title":"Curr. Biology: CB"},{"key":"79062_CR40","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.1016\/j.cub.2007.09.049","volume":"17","author":"C Polesello","year":"2007","unstructured":"Polesello, C. & Tapon, N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr. Biology: CB. 17, 1864\u20131870. https:\/\/doi.org\/10.1016\/j.cub.2007.09.049 (2007).","journal-title":"Curr. Biology: CB"},{"key":"79062_CR41","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1083\/jcb.201309141","volume":"205","author":"J Huang","year":"2014","unstructured":"Huang, J. & Kalderon, D. Coupling of hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation. J. Cell Biol. 205, 325\u2013338. https:\/\/doi.org\/10.1083\/jcb.201309141 (2014).","journal-title":"J. Cell Biol."},{"key":"79062_CR42","doi-asserted-by":"publisher","first-page":"e1004962","DOI":"10.1371\/journal.pgen.1004962","volume":"11","author":"DP Sarikaya","year":"2015","unstructured":"Sarikaya, D. P. & Extavour, C. G. The Hippo pathway regulates homeostatic growth of stem cell niche precursors in the Drosophila ovary. PLoS Genet. 11, e1004962. https:\/\/doi.org\/10.1371\/journal.pgen.1004962 (2015).","journal-title":"PLoS Genet."},{"key":"79062_CR43","doi-asserted-by":"publisher","first-page":"4480","DOI":"10.1038\/s41598-017-04052-6","volume":"7","author":"TH Hsu","year":"2017","unstructured":"Hsu, T. H. et al. The Hippo pathway acts downstream of the hedgehog signaling to regulate follicle stem cell maintenance in the Drosophila ovary. Sci. Rep. 7, 4480. https:\/\/doi.org\/10.1038\/s41598-017-04052-6 (2017).","journal-title":"Sci. Rep."},{"key":"79062_CR44","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.tibs.2020.08.008","volume":"46","author":"Z Wu","year":"2021","unstructured":"Wu, Z. & Guan, K. L. Hippo signaling in embryogenesis and development. Trends Biochem. Sci. 46, 51\u201363. https:\/\/doi.org\/10.1016\/j.tibs.2020.08.008 (2021).","journal-title":"Trends Biochem. Sci."},{"key":"79062_CR45","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1262\/jrd.2011-012","volume":"58","author":"F Matsuda","year":"2012","unstructured":"Matsuda, F., Inoue, N., Manabe, N. & Ohkura, S. Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells. J. Reprod. Dev. 58, 44\u201350. https:\/\/doi.org\/10.1262\/jrd.2011-012 (2012).","journal-title":"J. Reprod. Dev."},{"key":"79062_CR46","doi-asserted-by":"publisher","first-page":"244","DOI":"10.3389\/fendo.2020.00244","volume":"11","author":"J Vanselow","year":"2020","unstructured":"Vanselow, J., Christenson, L. K., Pate, J. L. & Editorial Regulation of dynamic changes and remodeling events during the formation, rescue and regression of the Corpus Luteum. Front. Endocrinol. 11, 244. https:\/\/doi.org\/10.3389\/fendo.2020.00244 (2020).","journal-title":"Front. Endocrinol."},{"key":"79062_CR47","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/humupd\/dmt049","volume":"20","author":"HM Brown","year":"2014","unstructured":"Brown, H. M. & Russell, D. L. Blood and lymphatic vasculature in the ovary: development, function and disease. Hum. Reprod. Update. 20, 29\u201339. https:\/\/doi.org\/10.1093\/humupd\/dmt049 (2014).","journal-title":"Hum. Reprod. Update"},{"key":"79062_CR48","doi-asserted-by":"publisher","unstructured":"Liu, X. et al. Targeting the Hippo Pathway in Gastric Cancer and other malignancies in the Digestive System: from bench to Bedside. Biomedicines. 10 https:\/\/doi.org\/10.3390\/biomedicines10102512 (2022).","DOI":"10.3390\/biomedicines10102512"},{"key":"79062_CR49","doi-asserted-by":"publisher","first-page":"7357","DOI":"10.18632\/aging.102214","volume":"11","author":"X Xu","year":"2019","unstructured":"Xu, X. et al. Mir-375-3p suppresses tumorigenesis and partially reverses chemoresistance by targeting YAP1 and SP1 in colorectal cancer cells. Aging. 11, 7357\u20137385. https:\/\/doi.org\/10.18632\/aging.102214 (2019).","journal-title":"Aging"},{"key":"79062_CR50","doi-asserted-by":"publisher","first-page":"1173491","DOI":"10.3389\/fcell.2023.1173491","volume":"11","author":"X Yang","year":"2023","unstructured":"Yang, X. et al. Gene SH3BGRL3 regulates acute myeloid leukemia progression through circRNA_0010984 based on competitive endogenous RNA mechanism. Front. cell. Dev. Biology. 11, 1173491. https:\/\/doi.org\/10.3389\/fcell.2023.1173491 (2023).","journal-title":"Front. cell. Dev. Biology"},{"key":"79062_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.imlet.2015.01.003","volume":"164","author":"CG Miao","year":"2015","unstructured":"Miao, C. G. et al. miR-375 regulates the canonical wnt pathway through FZD8 silencing in arthritis synovial fibroblasts. Immunol. Lett. 164, 1\u201310. https:\/\/doi.org\/10.1016\/j.imlet.2015.01.003 (2015).","journal-title":"Immunol. Lett."},{"key":"79062_CR52","doi-asserted-by":"publisher","first-page":"78989","DOI":"10.18632\/oncotarget.20742","volume":"8","author":"Q Yang","year":"2017","unstructured":"Yang, Q. et al. Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma. Oncotarget. 8, 78989\u201379002. https:\/\/doi.org\/10.18632\/oncotarget.20742 (2017).","journal-title":"Oncotarget"},{"key":"79062_CR53","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/nrm3470","volume":"13","author":"C Niehrs","year":"2012","unstructured":"Niehrs, C. The complex world of WNT receptor signalling. Nat. Rev. Mol. Cell. Bio. 13, 767\u2013779. https:\/\/doi.org\/10.1038\/nrm3470 (2012).","journal-title":"Nat. Rev. Mol. Cell. Bio"},{"key":"79062_CR54","doi-asserted-by":"publisher","first-page":"957","DOI":"10.5713\/ajas.20.0392","volume":"34","author":"W Wang","year":"2021","unstructured":"Wang, W. et al. miR-458b-5p regulates ovarian granulosa cells proliferation through Wnt\/\u03b2-catenin signaling pathway by targeting catenin beta-1. Anim. Bioscience. 34, 957\u2013966. https:\/\/doi.org\/10.5713\/ajas.20.0392 (2021).","journal-title":"Anim. Bioscience"},{"key":"79062_CR55","doi-asserted-by":"publisher","first-page":"E1524","DOI":"10.1210\/jc.2012-1427","volume":"97","author":"JV Jeppesen","year":"2012","unstructured":"Jeppesen, J. V. et al. LH-Receptor gene expression in human granulosa and cumulus cells from antral and preovulatory follicles. J. Clin. Endocrinol. Metab. 97, E1524\u2013E1531. https:\/\/doi.org\/10.1210\/jc.2012-1427 (2012).","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"79062_CR56","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1093\/toxsci\/kft175","volume":"136","author":"AM Sanchez","year":"2013","unstructured":"Sanchez, A. M. et al. Treatment with anticancer agents induces dysregulation of specific wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol. Sci. 136, 183\u2013192. https:\/\/doi.org\/10.1093\/toxsci\/kft175 (2013).","journal-title":"Toxicol. Sci."},{"key":"79062_CR57","first-page":"1507","volume":"12","author":"X Sun","year":"2019","unstructured":"Sun, X. et al. Knockdown of lncRNA XIST suppresses osteosarcoma progression by inactivating AKT\/mTOR signaling pathway by sponging miR-375-3p. Int. J. Clin. Exp. Pathol. 12, 1507\u20131517 (2019).","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"79062_CR58","doi-asserted-by":"publisher","first-page":"153303381880649","DOI":"10.1177\/1533033818806499","volume":"17","author":"KT Yuan","year":"2018","unstructured":"Yuan, K. T. et al. Deregulation of MicroRNA-375 inhibits Proliferation and Migration in Gastric Cancer in Association with autophagy-mediated AKT\/mTOR signaling pathways. Technol. Cancer Res. Treat. 17, 1533033818806499. https:\/\/doi.org\/10.1177\/1533033818806499 (2018).","journal-title":"Technol. Cancer Res. Treat."},{"key":"79062_CR59","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1006\/bbrc.1999.1612","volume":"264","author":"H Kirikoshi","year":"1999","unstructured":"Kirikoshi, H. et al. Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Biochem. Biophys. Res. Commun. 264, 955\u2013961. https:\/\/doi.org\/10.1006\/bbrc.1999.1612 (1999).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"79062_CR60","doi-asserted-by":"publisher","first-page":"212","DOI":"10.14715\/cmb\/2024.70.3.32","volume":"70","author":"M Goztepe","year":"2024","unstructured":"Goztepe, M. & Eroglu, O. Research of the unrecognised functions of miR-375 in prostate cancer cells. Cell. Mol. Biol. (Noisy-Le-Grand). 70, 212\u2013218. https:\/\/doi.org\/10.14715\/cmb\/2024.70.3.32 (2024).","journal-title":"Cell. Mol. Biol. (Noisy-Le-Grand)"},{"key":"79062_CR61","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1073\/pnas.0133792100","volume":"100","author":"T Fujino","year":"2003","unstructured":"Fujino, T. et al. Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc. Natl. Acad. Sci. U S A. 100, 229\u2013234. https:\/\/doi.org\/10.1073\/pnas.0133792100 (2003).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"79062_CR62","doi-asserted-by":"publisher","first-page":"38276","DOI":"10.1074\/jbc.M609509200","volume":"281","author":"MV Semenov","year":"2006","unstructured":"Semenov, M. V. & He, X. LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. J. Biol. Chem. 281, 38276\u201338284. https:\/\/doi.org\/10.1074\/jbc.M609509200 (2006).","journal-title":"J. Biol. Chem."},{"key":"79062_CR63","doi-asserted-by":"publisher","first-page":"3653","DOI":"10.7150\/thno.92676","volume":"14","author":"Y Zhao","year":"2024","unstructured":"Zhao, Y. et al. Chronic stress dysregulates the Hippo\/YAP\/14-3-3\u03b7 pathway and induces mitochondrial damage in basolateral amygdala in a mouse model of depression. Theranostics. 14, 3653\u20133673. https:\/\/doi.org\/10.7150\/thno.92676 (2024).","journal-title":"Theranostics"},{"key":"79062_CR64","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41392-022-01191-9","volume":"7","author":"M Fu","year":"2022","unstructured":"Fu, M. et al. The Hippo signalling pathway and its implications in human health and diseases. Signal. Transduct. Target. Therapy. 7, 376. https:\/\/doi.org\/10.1038\/s41392-022-01191-9 (2022).","journal-title":"Signal. Transduct. Target. Therapy"},{"key":"79062_CR65","doi-asserted-by":"publisher","unstructured":"Li, Z., Lin, J., Wu, J., Suo, J. & Wang, Z. The Hippo signalling pathway in bone homeostasis: under the regulation of mechanics and aging. Cell. Prolif. e13652. https:\/\/doi.org\/10.1111\/cpr.13652 (2024).","DOI":"10.1111\/cpr.13652"},{"key":"79062_CR66","doi-asserted-by":"publisher","DOI":"10.1101\/2024.07.09.602788","author":"P Zhou","year":"2024","unstructured":"Zhou, P. et al. Vestigial like 4 regulates the adipogenesis of classical brown adipose tissue. bioRxiv: Preprint Serv. Biology. https:\/\/doi.org\/10.1101\/2024.07.09.602788 (2024).","journal-title":"bioRxiv: Preprint Serv. Biology"},{"key":"79062_CR67","doi-asserted-by":"publisher","first-page":"104602","DOI":"10.1016\/j.phrs.2019.104602","volume":"152","author":"K Aamir","year":"2020","unstructured":"Aamir, K., Khan, H. U., Sethi, G., Hossain, M. A. & Arya, A. Wnt signaling mediates TLR pathway and promote unrestrained adipogenesis and metaflammation: therapeutic targets for obesity and type 2 diabetes. Pharmacol. Res. 152, 104602. https:\/\/doi.org\/10.1016\/j.phrs.2019.104602 (2020).","journal-title":"Pharmacol. Res."},{"key":"79062_CR68","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.ydbio.2018.07.021","volume":"442","author":"EA Newman","year":"2018","unstructured":"Newman, E. A., Wu, D., Taketo, M. M., Zhang, J. & Blackshaw, S. Canonical wnt signaling regulates patterning, differentiation and nucleogenesis in mouse hypothalamus and prethalamus. Dev. Biol. 442, 236\u2013248. https:\/\/doi.org\/10.1016\/j.ydbio.2018.07.021 (2018).","journal-title":"Dev. Biol."},{"key":"79062_CR69","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1089\/zeb.2008.0570","volume":"6","author":"X Wang","year":"2009","unstructured":"Wang, X., Lee, J. E. & Dorsky, R. I. Identification of wnt-responsive cells in the zebrafish hypothalamus. Zebrafish. 6, 49\u201358. https:\/\/doi.org\/10.1089\/zeb.2008.0570 (2009).","journal-title":"Zebrafish"},{"key":"79062_CR70","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1242\/dev.139055","volume":"144","author":"Y Xie","year":"2017","unstructured":"Xie, Y. & Dorsky, R. I. Development of the hypothalamus: conservation, modification and innovation. Development. 144, 1588\u20131599. https:\/\/doi.org\/10.1242\/dev.139055 (2017).","journal-title":"Development"},{"key":"79062_CR71","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.devcel.2012.07.012","volume":"23","author":"X Wang","year":"2012","unstructured":"Wang, X. et al. Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Dev. Cell. 23, 624\u2013636. https:\/\/doi.org\/10.1016\/j.devcel.2012.07.012 (2012).","journal-title":"Dev. Cell."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79062-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79062-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79062-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T07:05:50Z","timestamp":1731395150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79062-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,9]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["79062"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-79062-2","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,9]]},"assertion":[{"value":"25 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"The animal study protocol was approved by the Henan University of Science and Technology Animal Welfare and Use Committee (protocol code 2019HkDDk1201).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Institutional review board statement"}},{"value":"The authors declare no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"27353"}}