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Flake holds multiple patents related to the EXTEND technology, and holds option rights and is a Paid Medical Consultant for Vitara Biomedical Inc. All other authors have declared that no conflicts of interest exist.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"These experiments were approved by the Institutional Animal Care and Use Committee of Children\u2019s Hospital of Philadelphia Research Institute (N\u00b0:19\u2013000984) and followed the \u2018Animal Research: Reporting of In Vivo Experiments\u2019 (ARRIVE) guidelines<sup>60<\/sup>. The animal vendors and facilities operated under the United States Department of Agriculture (USDA) national guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Study approval"}}],"article-number":"28840"}}