{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:33:57Z","timestamp":1772688837170,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Science and Technology Department of Sichuan Province","award":["2022YFS0632"],"award-info":[{"award-number":["2022YFS0632"]}]},{"name":"the Science and Technology Department of Sichuan Province","award":["2023YFS0143"],"award-info":[{"award-number":["2023YFS0143"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-79236-y","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:05:40Z","timestamp":1732032340000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects and mechanisms of dexmedetomidine preconditioning on isoproterenol-induced ventricular arrhythmias"],"prefix":"10.1038","volume":"14","author":[{"given":"Shengji","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueru","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tangting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"issue":"1","key":"79236_CR1","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1093\/bja\/aeh166","volume":"93","author":"A Thompson","year":"2004","unstructured":"Thompson, A. & Balser, J. R. Perioperative cardiac arrhythmias. Br. J. Anaesth[J]. 93 (1), 86\u201394 (2004).","journal-title":"Br. J. Anaesth[J]"},{"issue":"Suppl 1","key":"79236_CR2","doi-asserted-by":"publisher","first-page":"S10","DOI":"10.1016\/j.ihj.2014.01.005","volume":"66","author":"CW Israel","year":"2014","unstructured":"Israel, C. W. Mechanisms of sudden cardiac death[J]. Indian Heart J. 66 (Suppl 1), S10\u2013S17 (2014).","journal-title":"Indian Heart J."},{"issue":"6","key":"79236_CR3","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.bja.2019.07.027","volume":"123","author":"K Wang","year":"2019","unstructured":"Wang, K. et al. Effects of dexmedetomidine on perioperative stress, inflammation, and immune function: systematic review and meta-analysis[J]. Br. J. Anaesth. 123 (6), 777\u2013794 (2019).","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"79236_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.4103\/0971-9784.58829","volume":"13","author":"F Menda","year":"2010","unstructured":"Menda, F. et al. Dexmedetomidine as an adjunct to anesthetic induction to attenuate hemodynamic response to endotracheal intubation in patients undergoing fast-track CABG[J]. Ann. Card Anaesth. 13 (1), 16\u201321 (2010).","journal-title":"Ann. Card Anaesth."},{"issue":"10","key":"79236_CR5","doi-asserted-by":"publisher","first-page":"5578","DOI":"10.19082\/5578","volume":"9","author":"G Soltani","year":"2017","unstructured":"Soltani, G., Jahanbakhsh, S. & Tashnizi, M. A. Etc. Effects of dexmedetomidine on heart arrhythmia prevention in off-pump coronary artery bypass surgery: a randomized clinical trial[J]. Electron. Physician. 9 (10), 5578\u20135587 (2017).","journal-title":"Electron. Physician"},{"issue":"3","key":"79236_CR6","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.athoracsur.2011.04.099","volume":"92","author":"C Chrysostomou","year":"2011","unstructured":"Chrysostomou, C., Sanchez-de-Toledo, J. & Wearden, P. Etc. Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations[J]. Ann. Thorac. Surg. 92 (3), 964\u2013972 (2011). discussion 972.","journal-title":"Ann. Thorac. Surg."},{"issue":"3","key":"79236_CR7","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00210-015-1195-1","volume":"389","author":"C Stoetzer","year":"2016","unstructured":"Stoetzer, C. et al. Inhibition of the cardiac Na\u207a channel \u03b1-subunit Nav1.5 by propofol and dexmedetomidine[J]. Naunyn Schmiedebergs Arch. Pharmacol. 389 (3), 315\u2013325 (2016).","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"79236_CR8","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.pbiomolbio.2020.02.008","volume":"157","author":"H Sutanto","year":"2020","unstructured":"Sutanto, H. et al. Cardiomyocyte calcium handling in health and disease: insights from in vitro and in silico studies[J]. Prog Biophys. Mol. Biol. 157, 54\u201375 (2020).","journal-title":"Prog Biophys. Mol. Biol."},{"issue":"7","key":"79236_CR9","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.3390\/cells11071090","volume":"11","author":"H Sutanto","year":"2022","unstructured":"Sutanto, H. & Heijman, J. Integrative Computational Modeling of Cardiomyocyte Calcium Handling and Cardiac arrhythmias: current Status and Future Challenges[J]. Cells. 11 (7), 1090 (2022).","journal-title":"Cells"},{"issue":"3","key":"79236_CR10","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1152\/physrev.00024.2019","volume":"101","author":"A Varr\u00f3","year":"2021","unstructured":"Varr\u00f3, A. et al. Cardiac transmembrane ion channels and action potentials: cellular physiology and arrhythmogenic behavior[J]. Physiol. Rev. 101 (3), 1083\u20131176 (2021).","journal-title":"Physiol. Rev."},{"issue":"Pt 1","key":"79236_CR11","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbrc.2022.10.036","volume":"636","author":"Z Liu","year":"2022","unstructured":"Liu, Z. et al. Pinocembrin alleviates the susceptibility to atrial fibrillation in isoproterenol-induced rats[J]. Biochem. Biophys. Res. Commun. 636 (Pt 1), 33\u201340 (2022).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"79236_CR12","doi-asserted-by":"publisher","first-page":"8538296","DOI":"10.1155\/2022\/8538296","volume":"2022","author":"X Luo","year":"2022","unstructured":"Luo, X. et al. Ageing increases Cardiac Electrical remodelling in rats and mice via NOX4\/ROS\/CaMKII-Mediated calcium signalling. Oxid. Med. Cell. Longev. 2022, 8538296 (2022).","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"6","key":"79236_CR13","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1007\/s00424-018-2121-4","volume":"470","author":"K Suita","year":"2018","unstructured":"Suita, K. et al. Vidarabine, an anti-herpesvirus agent, prevents catecholamine-induced arrhythmias without adverse effect on heart function in mice[J]. Pflugers Arch. 470 (6), 923\u2013935 (2018).","journal-title":"Pflugers Arch."},{"issue":"1","key":"79236_CR14","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12871-020-01025-7","volume":"20","author":"R Kang","year":"2020","unstructured":"Kang, R. et al. Intraoperative dexmedetomidine attenuates norepinephrine levels in patients undergoing transsphenoidal surgery: a randomized, placebo-controlled trial[J]. BMC Anesthesiol. 20 (1), 100 (2020).","journal-title":"BMC Anesthesiol"},{"issue":"5","key":"79236_CR15","doi-asserted-by":"publisher","first-page":"468","DOI":"10.23736\/S0375-9393.18.12992-0","volume":"85","author":"MH Kim","year":"2019","unstructured":"Kim, M. H. et al. Intraoperative dexmedetomidine attenuates stress responses in patients undergoing major spine surgery[J]. Minerva Anestesiol. 85 (5), 468\u2013477 (2019).","journal-title":"Minerva Anestesiol"},{"issue":"4","key":"79236_CR16","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1007\/s00246-013-0659-7","volume":"34","author":"JD Tobias","year":"2013","unstructured":"Tobias, J. D. & Chrysostomou, C. Dexmedetomidine: antiarrhythmic effects in the pediatric cardiac patient[J]. Pediatr. Cardiol. 34 (4), 779\u2013785 (2013).","journal-title":"Pediatr. Cardiol."},{"issue":"5","key":"79236_CR17","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1097\/00000542-200611000-00010","volume":"105","author":"A Snapir","year":"2006","unstructured":"Snapir, A., Posti, J. & Kentala, E. Etc. Effects of low and high plasma concentrations of dexmedetomidine on myocardial perfusion and cardiac function in healthy male subjects[J]. Anesthesiology. 105 (5), 902\u2013910 (2006). quiz 1069-70.","journal-title":"Anesthesiology"},{"issue":"4","key":"79236_CR18","first-page":"293","volume":"46","author":"LI Yangpeng","year":"2023","unstructured":"Yangpeng, L. I. et al. Application of optical mapping in cardiac electrophysiology and arrhythmias. J. Southwest. Med. Univ. [J]. 46 (4), 293\u2013297319 (2023).","journal-title":"J. Southwest. Med. Univ. [J]"},{"issue":"1","key":"79236_CR19","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/s41597-021-01085-5","volume":"8","author":"S He","year":"2021","unstructured":"He, S. et al. A dataset of dual calcium and voltage optical mapping in healthy and hypertrophied murine hearts[J]. Sci. Data. 8 (1), 314 (2021).","journal-title":"Sci. Data"},{"issue":"10","key":"79236_CR20","first-page":"1247","volume":"37","author":"T Zhang Wenjie","year":"2017","unstructured":"Zhang Wenjie, T. et al. Effect of dexmedetomidine on action potential duration of rat ventricular myocytes and the role of \u03b12 receptors[J]. Chin. J. Anesthesiology. 37 (10), 1247\u20131249 (2017).","journal-title":"Chin. J. Anesthesiology"},{"issue":"5","key":"79236_CR21","doi-asserted-by":"publisher","first-page":"399","DOI":"10.21037\/atm-20-5898","volume":"9","author":"L Yang","year":"2021","unstructured":"Yang, L. et al. Dexmedetomidine exhibits antiarrhythmic effects on human-induced pluripotent stem cell-derived cardiomyocytes through a Na\/Ca channel-mediated mechanism[J]. Ann. Transl Med. 9 (5), 399 (2021).","journal-title":"Ann. Transl Med."},{"key":"79236_CR22","doi-asserted-by":"publisher","first-page":"20032","DOI":"10.1038\/s41598-020-77014-0","volume":"10","author":"CC Chou","year":"2020","unstructured":"Chou, C. C. et al. Mechanisms of ranolazine pretreatment in preventing ventricular tachyarrhythmias in diabetic db\/db mice with acute regional ischemia-reperfusion injury[J]. Sci. Rep. 10, 20032 (2020).","journal-title":"Sci. Rep."},{"issue":"1","key":"79236_CR23","doi-asserted-by":"publisher","first-page":"23940","DOI":"10.1038\/s41598-021-03364-y","volume":"11","author":"C Ellermann","year":"2021","unstructured":"Ellermann, C. et al. Safe electrophysiologic profile of dexmedetomidine in different experimental arrhythmia models[J]. Sci. Rep. 11 (1), 23940 (2021).","journal-title":"Sci. Rep."},{"key":"79236_CR24","doi-asserted-by":"publisher","first-page":"H1388","DOI":"10.1152\/ajpheart.00665.2015","volume":"310","author":"R Jaimes 3rd","year":"2016","unstructured":"Jaimes, R. 3rd et al. W. A technical review of optical mapping of intracellular calcium within myocardial tissue. Am. J. Physiol. Heart Circ. Physiol. 310, H1388\u2013H1401 (2016).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"79236_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1161\/01.RES.0000159387.00749.3c","volume":"96","author":"RP Katra","year":"2005","unstructured":"Katra, R. P. & Laurita, K. R. Cellular mechanism of calcium-mediated triggered activity in the heart. Circ. Res. 96, 535\u2013542 (2005).","journal-title":"Circ. Res."},{"issue":"4","key":"79236_CR26","doi-asserted-by":"publisher","first-page":"H2054","DOI":"10.1152\/ajpheart.00830.2007","volume":"293","author":"Z Qu","year":"2007","unstructured":"Qu, Z. & Weiss, J. N. The chicken or the egg? Voltage and calcium dynamics in the heart[J]. Am. J. Physiol. Heart Circ. Physiol. 293 (4), H2054\u2013H2055 (2007).","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"79236_CR27","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/S0008-6363(02)00737-X","volume":"57","author":"ML Walker","year":"2003","unstructured":"Walker, M. L. & Rosenbaum, D. S. Repolarization alternans: implications for the mechanism and prevention of sudden cardiac death[J]. Cardiovasc. Res. 57 (3), 599\u2013614 (2003).","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"79236_CR28","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1161\/CIRCRESAHA.116.305404","volume":"116","author":"G Kanaporis","year":"2015","unstructured":"Kanaporis, G. & Blatter, L. A. The mechanisms of calcium cycling and action potential dynamics in cardiac alternans[J]. Circ. Res. 116 (5), 846\u2013856 (2015).","journal-title":"Circ. Res."},{"issue":"1","key":"79236_CR29","doi-asserted-by":"publisher","first-page":"16652","DOI":"10.1038\/s41598-021-95299-7","volume":"11","author":"N T\u00f3th","year":"2021","unstructured":"T\u00f3th, N. et al. The development of L-type Ca2\u2009+\u2009current mediated alternans does not depend on the restitution slope in canine ventricular myocardium[J]. Sci. Rep. 11 (1), 16652 (2021).","journal-title":"Sci. Rep."},{"issue":"1","key":"79236_CR30","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1161\/CIRCRESAHA.122.321668","volume":"132","author":"Z Qu","year":"2023","unstructured":"Qu, Z. & Weiss, J. N. Cardiac alternans: from Bedside to Bench and Back[J]. Circ. Res. 132 (1), 127\u2013149 (2023).","journal-title":"Circ. Res."},{"issue":"4","key":"79236_CR31","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/j.jaccao.2020.08.012","volume":"2","author":"B Du","year":"2020","unstructured":"Du, B. et al. Acute effects of Ibrutinib on ventricular arrhythmia in spontaneously hypertensive Rats[J]. JACC CardioOncol. 2 (4), 614\u2013629 (2020).","journal-title":"JACC CardioOncol"},{"issue":"2","key":"79236_CR32","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.hrthm.2018.08.033","volume":"16","author":"H Fukaya","year":"2019","unstructured":"Fukaya, H. et al. Arrhythmogenic cardiac alternans in heart failure is suppressed by late sodium current blockade by ranolazine[J]. Heart Rhythm. 16 (2), 281\u2013289 (2019).","journal-title":"Heart Rhythm"},{"issue":"7","key":"79236_CR33","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1093\/cvr\/cvaa162","volume":"117","author":"FE Fakuade","year":"2021","unstructured":"Fakuade, F. E. et al. Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation[J]. Cardiovasc. Res. 117 (7), 1790\u20131801 (2021).","journal-title":"Cardiovasc. Res."},{"key":"79236_CR34","doi-asserted-by":"publisher","first-page":"758157","DOI":"10.3389\/fimmu.2021.758157","volume":"12","author":"J Liao","year":"2021","unstructured":"Liao, J. et al. Interleukin-6-mediated-ca handling abnormalities contributes to Atrial Fibrillation in sterile pericarditis Rats[J]. Front. Immunol. 12, 758157 (2021).","journal-title":"Front. Immunol."},{"issue":"1","key":"79236_CR35","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1213\/01.ane.0000297421.92857.4e","volume":"106","author":"GB Hammer","year":"2008","unstructured":"Hammer, G. B. et al. The effects of dexmedetomidine on cardiac electrophysiology in children[J]. Anesth. Analg. 106 (1), 79\u201383 (2008).","journal-title":"Anesth. Analg"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79236-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79236-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79236-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T16:18:18Z","timestamp":1732033098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79236-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,19]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["79236"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-79236-y","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,19]]},"assertion":[{"value":"3 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"28662"}}