{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T22:01:37Z","timestamp":1773525697894,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T00:00:00Z","timestamp":1731110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY014801"],"award-info":[{"award-number":["P30 EY014801"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30 EY014801"],"award-info":[{"award-number":["P30 EY014801"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["GR004596-1"],"award-info":[{"award-number":["GR004596-1"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["GR004596-1"],"award-info":[{"award-number":["GR004596-1"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-79296-0","type":"journal-article","created":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T09:24:30Z","timestamp":1731144270000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration"],"prefix":"10.1038","volume":"14","author":[{"given":"Chloe","family":"Moulin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina","family":"Dvoriantchikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloufar","family":"Bineshfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Swingle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaby","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Groso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Ivanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Pelaez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,9]]},"reference":[{"key":"79296_CR1","unstructured":"Ling-Ping Cen, K. K. P., Kowk-Fai & So Optic Nerve Diseases and Regeneration: How far are we from the Promised land? (Clinical and Experimental Opthalmology, 2023)."},{"issue":"6342","key":"79296_CR2","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1126\/science.aal5060","volume":"356","author":"B Laha","year":"2017","unstructured":"Laha, B., Stafford, B. K. & Huberman, A. D. Regenerating optic pathways from the eye to the brain. Science. 356 (6342), 1031\u20131034 (2017).","journal-title":"Science"},{"key":"79296_CR3","first-page":"2","volume":"3","author":"EL Singman","year":"2016","unstructured":"Singman, E. L. et al. Indirect traumatic optic neuropathy. Mil Med. Res. 3, 2 (2016).","journal-title":"Mil Med. Res."},{"issue":"18","key":"79296_CR4","doi-asserted-by":"publisher","first-page":"R749","DOI":"10.1016\/j.cub.2005.09.008","volume":"15","author":"LC Case","year":"2005","unstructured":"Case, L. C. & Tessier-Lavigne, M. Regeneration of the adult central nervous system. Curr. Biol. 15 (18), R749\u2013R753 (2005).","journal-title":"Curr. Biol."},{"key":"79296_CR5","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3389\/fphys.2019.00502","volume":"10","author":"CX Kha","year":"2019","unstructured":"Kha, C. X., Guerin, D. J. & Tseng, K. A. Using the Xenopus Developmental Eye Regrowth System to Distinguish the Role of Developmental Versus Regenerative mechanisms. Front. Physiol. 10, 502 (2019).","journal-title":"Front. Physiol."},{"issue":"1","key":"79296_CR6","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/BF00710404","volume":"186","author":"MA Wilson","year":"1992","unstructured":"Wilson, M. A. et al. Regeneration in the Xenopus tadpole optic nerve is preceded by a massive macrophage\/microglial response. Anat. Embryol. (Berl). 186 (1), 75\u201389 (1992).","journal-title":"Anat. Embryol. (Berl)"},{"issue":"5","key":"79296_CR7","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1002\/dneu.22665","volume":"79","author":"K Lust","year":"2019","unstructured":"Lust, K. & Tanaka, E. M. A comparative perspective on Brain Regeneration in amphibians and Teleost Fish. Dev. Neurobiol. 79 (5), 424\u2013436 (2019).","journal-title":"Dev. Neurobiol."},{"issue":"5","key":"79296_CR8","doi-asserted-by":"publisher","first-page":"pgad109","DOI":"10.1093\/pnasnexus\/pgad109","volume":"2","author":"L Fague","year":"2023","unstructured":"Fague, L. & Marsh-Armstrong, N. Dual leucine zipper kinase is necessary for retinal ganglion cell axonal regeneration in Xenopus laevis. PNAS Nexus. 2 (5), pgad109 (2023).","journal-title":"PNAS Nexus"},{"issue":"2","key":"79296_CR9","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.ydbio.2016.06.003","volume":"426","author":"GB Whitworth","year":"2017","unstructured":"Whitworth, G. B. et al. Translational profiling of retinal ganglion cell optic nerve regeneration in Xenopus laevis. Dev. Biol. 426 (2), 360\u2013373 (2017).","journal-title":"Dev. Biol."},{"key":"79296_CR10","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.expneurol.2013.03.001","volume":"247","author":"X Luo","year":"2013","unstructured":"Luo, X. et al. Three-dimensional evaluation of retinal ganglion cell axon regeneration and pathfinding in whole mouse tissue after injury. Exp. Neurol. 247, 653\u2013662 (2013).","journal-title":"Exp. Neurol."},{"issue":"11","key":"79296_CR11","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1111\/ejn.13383","volume":"44","author":"G Dvoriantchikova","year":"2016","unstructured":"Dvoriantchikova, G. et al. Virally delivered, constitutively active NFkappaB improves survival of injured retinal ganglion cells. Eur. J. Neurosci. 44 (11), 2935\u20132943 (2016).","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"79296_CR12","doi-asserted-by":"publisher","first-page":"11779","DOI":"10.1038\/s41598-017-12225-6","volume":"7","author":"W Tao","year":"2017","unstructured":"Tao, W. et al. A Novel Mouse Model of Traumatic Optic Neuropathy using external Ultrasound Energy to Achieve Focal, Indirect Optic nerve Injury. Sci. Rep. 7 (1), 11779 (2017).","journal-title":"Sci. Rep."},{"issue":"7","key":"79296_CR13","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1167\/iovs.18-24431","volume":"59","author":"BC Tse","year":"2018","unstructured":"Tse, B. C. et al. Tumor necrosis factor inhibition in the Acute Management of Traumatic Optic Neuropathy. Invest. Ophthalmol. Vis. Sci. 59 (7), 2905\u20132912 (2018).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"8","key":"79296_CR14","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1002\/glia.23165","volume":"65","author":"R Langhe","year":"2017","unstructured":"Langhe, R. et al. Muller glial cell reactivation in Xenopus models of retinal degeneration. Glia. 65 (8), 1333\u20131349 (2017).","journal-title":"Glia"},{"issue":"1","key":"79296_CR15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ydbio.2006.11.024","volume":"303","author":"C Yoshii","year":"2007","unstructured":"Yoshii, C. et al. Neural retinal regeneration in the anuran amphibian Xenopus laevis post-metamorphosis: transdifferentiation of retinal pigmented epithelium regenerates the neural retina. Dev. Biol. 303 (1), 45\u201356 (2007).","journal-title":"Dev. Biol."},{"key":"79296_CR16","doi-asserted-by":"crossref","unstructured":"Viczian, A. S. & Zuber, M. E. A simple behavioral assay for testing visual function in Xenopus laevis. J. Vis. Exp., 2014(88) (2014).","DOI":"10.3791\/51726-v"},{"key":"79296_CR17","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.exer.2018.02.010","volume":"170","author":"MC Sanchez-Migallon","year":"2018","unstructured":"Sanchez-Migallon, M. C. et al. Nerve fibre layer degeneration and retinal ganglion cell loss long term after optic nerve crush or transection in adult mice. Exp. Eye Res. 170, 40\u201350 (2018).","journal-title":"Exp. Eye Res."},{"issue":"4","key":"79296_CR18","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1167\/iovs.64.4.17","volume":"64","author":"S Pi","year":"2023","unstructured":"Pi, S. et al. Longitudinal Observation of Retinal Response to Optic nerve transection in rats using visible light Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 64 (4), 17 (2023).","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"23","key":"79296_CR19","doi-asserted-by":"publisher","first-page":"2808","DOI":"10.1016\/j.visres.2009.08.020","volume":"49","author":"G Parrilla-Reverter","year":"2009","unstructured":"Parrilla-Reverter, G. et al. Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study. Vis. Res. 49 (23), 2808\u20132825 (2009).","journal-title":"Vis. Res."},{"issue":"6","key":"79296_CR20","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1017\/S095252389815616X","volume":"15","author":"DJ Oh","year":"1998","unstructured":"Oh, D. J. & Northmore, D. P. Functional properties of retinal ganglion cells during optic nerve regeneration in the goldfish. Vis. Neurosci. 15 (6), 1145\u20131155 (1998).","journal-title":"Vis. Neurosci."},{"issue":"3","key":"79296_CR21","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/BF02842939","volume":"5","author":"DJ Stelzner","year":"1986","unstructured":"Stelzner, D. J., Bohn, R. C. & Strauss, J. A. Regeneration of the frog optic nerve. Comparisons with development. Neurochem Pathol. 5 (3), 255\u2013288 (1986).","journal-title":"Neurochem Pathol."},{"issue":"2","key":"79296_CR22","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/cne.901890205","volume":"189","author":"RL Meyer","year":"1980","unstructured":"Meyer, R. L. Mapping the normal and regenerating retinotectal projection of goldfish with autoradiographic methods. J. Comp. Neurol. 189 (2), 273\u2013289 (1980).","journal-title":"J. Comp. Neurol."},{"issue":"Pt 3","key":"79296_CR23","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.expneurol.2016.02.022","volume":"287","author":"JP Rasmussen","year":"2017","unstructured":"Rasmussen, J. P. & Sagasti, A. Learning to swim, again: Axon regeneration in fish. Exp. Neurol. 287 (Pt 3), 318\u2013330 (2017).","journal-title":"Exp. Neurol."},{"issue":"15","key":"79296_CR24","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.21037\/atm-20-5351","volume":"9","author":"L Fague","year":"2021","unstructured":"Fague, L., Liu, Y. A. & Marsh-Armstrong, N. The basic science of optic nerve regeneration. Ann. Transl Med. 9 (15), 1276 (2021).","journal-title":"Ann. Transl Med."},{"issue":"4","key":"79296_CR25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/sj.sc.3101674","volume":"43","author":"W Xu","year":"2005","unstructured":"Xu, W. et al. Increased production of reactive oxygen species contributes to motor neuron death in a compression mouse model of spinal cord injury. Spinal Cord. 43 (4), 204\u2013213 (2005).","journal-title":"Spinal Cord"},{"key":"79296_CR26","doi-asserted-by":"crossref","unstructured":"Shu, D. Y. et al. Role of oxidative stress in Ocular diseases: a Balancing Act. Metabolites, 13(2), 1\u201340. (2023).","DOI":"10.3390\/metabo13020187"},{"issue":"7\u20138","key":"79296_CR27","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/dneu.22780","volume":"80","author":"C Kiyoshi","year":"2020","unstructured":"Kiyoshi, C. & Tedeschi, A. Axon growth and synaptic function: a balancing act for axonal regeneration and neuronal circuit formation in CNS trauma and disease. Dev. Neurobiol. 80 (7\u20138), 277\u2013301 (2020).","journal-title":"Dev. Neurobiol."},{"issue":"38","key":"79296_CR28","doi-asserted-by":"publisher","first-page":"15132","DOI":"10.1073\/pnas.0707001104","volume":"104","author":"Z Wu","year":"2007","unstructured":"Wu, Z. et al. Caenorhabditis elegans neuronal regeneration is influenced by life stage, ephrin signaling, and synaptic branching. Proc. Natl. Acad. Sci. U S A. 104 (38), 15132\u201315137 (2007).","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"2","key":"79296_CR29","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.neuron.2016.09.026","volume":"92","author":"A Tedeschi","year":"2016","unstructured":"Tedeschi, A. et al. The Calcium Channel Subunit Alpha2delta2 suppresses Axon Regeneration in the adult CNS. Neuron. 92 (2), 419\u2013434 (2016).","journal-title":"Neuron"},{"issue":"2","key":"79296_CR30","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.neuron.2016.10.012","volume":"92","author":"JM Meves","year":"2016","unstructured":"Meves, J. M. & Zheng, B. Synaptic suppression of Axon Regeneration. Neuron. 92 (2), 267\u2013269 (2016).","journal-title":"Neuron"},{"key":"79296_CR31","doi-asserted-by":"crossref","unstructured":"Zahn, N. et al. Normal table of Xenopus development: a new graphical resource. Development, 149(14), 1\u201316. (2022).","DOI":"10.1242\/dev.200356"},{"issue":"1","key":"79296_CR32","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/S0165-4608(03)00126-2","volume":"146","author":"WJ van Everdink","year":"2003","unstructured":"van Everdink, W. J. et al. RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene candidates for B-cell chronic lymphocytic leukemia. Cancer Genet. Cytogenet. 146 (1), 48\u201357 (2003).","journal-title":"Cancer Genet. Cytogenet."},{"issue":"1","key":"79296_CR33","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin, A. et al. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 29 (1), 15\u201321 (2013).","journal-title":"Bioinformatics"},{"issue":"2","key":"79296_CR34","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","volume":"31","author":"S Anders","year":"2015","unstructured":"Anders, S., Pyl, P. T. & Huber, W. HTSeq\u2013a Python framework to work with high-throughput sequencing data. Bioinformatics. 31 (2), 166\u2013169 (2015).","journal-title":"Bioinformatics"},{"issue":"1","key":"79296_CR35","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson, M. D., McCarthy, D. J. & Smyth, G. K. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 26 (1), 139\u2013140 (2010).","journal-title":"Bioinformatics"},{"issue":"8","key":"79296_CR36","doi-asserted-by":"publisher","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","volume":"36","author":"SX Ge","year":"2020","unstructured":"Ge, S. X., Jung, D. & Yao, R. ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics. 36 (8), 2628\u20132629 (2020).","journal-title":"Bioinformatics"}],"updated-by":[{"DOI":"10.1038\/s41598-024-80215-6","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000}}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79296-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79296-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79296-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T05:03:53Z","timestamp":1734498233000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79296-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,9]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["79296"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-79296-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-5085599\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,9]]},"assertion":[{"value":"13 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1038\/s41598-024-80215-6","URL":"https:\/\/doi.org\/10.1038\/s41598-024-80215-6","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"27412"}}