{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T16:40:44Z","timestamp":1793724044371,"version":"4.6.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-79979-8","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:47:20Z","timestamp":1732171640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["OCT analysis and MPOD assessment in patients affected by retinitis pigmentosa"],"prefix":"10.1038","volume":"14","author":[{"given":"Maria Ludovica","family":"Ruggeri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca Belloni","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Passamonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Quarta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Lorenzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Formenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Giansante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Porreca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Di Nicola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Toto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liborio","family":"Stuppia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Mastropasqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"issue":"9549","key":"79979_CR1","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1016\/S0140-6736(06)69740-7","volume":"368","author":"DT Hartong","year":"2006","unstructured":"Hartong, D. T., Berson, E. L. & Dryja, T. P. Retinitis pigmentosa. Lancet. 368 (9549), 1795\u20131809 (2006).","journal-title":"Lancet"},{"key":"79979_CR2","doi-asserted-by":"crossref","unstructured":"Poornachandra, B. et al. Quantifying microstructural changes in retinitis pigmentosa using spectral domain\u2014optical coherence tomography. Eye Vis. ;6(1). (2019).","DOI":"10.1186\/s40662-019-0139-0"},{"issue":"4","key":"79979_CR3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.4103\/aam.aam_181_22","volume":"22","author":"O Okonkwo","year":"2023","unstructured":"Okonkwo, O., Hassan, A., ChinezeThelma Agweye, Victor, U. & Akanbi, T. Clinical presentation and macular morphology in retinitis pigmentosa patients. Ann. Afr. Med. 22 (4), 451\u2013455 (2023).","journal-title":"Ann. Afr. Med."},{"key":"79979_CR4","unstructured":"Giusti, C., Forte, R. & Vingolo, E. M. Clinical pathogenesis of macular holes in patients affected by retinitis pigmentosa. Eur. Rev. Med. Pharmacol. Sci. 6(2\u20133), 45\u201348.  (2002)."},{"key":"79979_CR5","doi-asserted-by":"crossref","unstructured":"Kamde, S. P. & Anil, A. Retinitis pigmentosa: Pathogenesis, diagnostic findings, and treatment. Cureus.  (2023).","DOI":"10.7759\/cureus.48006"},{"key":"79979_CR6","doi-asserted-by":"crossref","unstructured":"D\u2019Esposito, F. et al. RP1 Dominant p.Ser740* pathogenic variant in 20 knowingly unrelated families affected by rod\u2013cone dystrophy: Potential founder effect in Western Sicily. Medicina 60(2), 254 (2024).","DOI":"10.3390\/medicina60020254"},{"key":"79979_CR7","doi-asserted-by":"crossref","unstructured":"Smirnov, V. M. et al. Large Benefit from simple things: High-dose vitamin A improves RBP4-related retinal dystrophy. Int. J. Mol. Sci. 23(12), 6590  (2022).","DOI":"10.3390\/ijms23126590"},{"key":"79979_CR8","doi-asserted-by":"crossref","unstructured":"Wu, K. Y. et al. Retinitis pigmentosa: Novel therapeutic targets and drug development. Pharmaceutics 15(2), 685 (2023).","DOI":"10.3390\/pharmaceutics15020685"},{"issue":"1","key":"79979_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1600-0420.2005.00627.x","volume":"84","author":"PV Algvere","year":"2006","unstructured":"Algvere, P. V., Marshall, J. & Seregard, S. Age-related maculopathy and the impact of blue light hazard. Acta Ophthalmol. Scand. 84 (1), 4\u201315 (2006).","journal-title":"Acta Ophthalmol. Scand."},{"issue":"21","key":"79979_CR10","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.1016\/S0042-6989(97)00457-4","volume":"38","author":"LT Sharpe","year":"1998","unstructured":"Sharpe, L. T., Stockman, A., Knau, H. & J\u00e4gle, H. Macular pigment densities derived from central and peripheral spectral sensitivity differences. Vis. Res. 38 (21), 3233\u20133239 (1998).","journal-title":"Vision. Res."},{"issue":"1","key":"79979_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/eye.2010.164","volume":"25","author":"R de Kinkelder","year":"2010","unstructured":"de Kinkelder, R. et al. Macular pigment optical density measurements: evaluation of a device using heterochromatic flicker photometry. Eye. 25 (1), 105\u2013112 (2010).","journal-title":"Eye"},{"key":"79979_CR12","doi-asserted-by":"crossref","unstructured":"Quarta, A. et al. Analysis of macular pigment optical density in macular holes with different border phenotypes. Ophthalmol. Ther. (2024).","DOI":"10.1007\/s40123-023-00874-y"},{"issue":"2","key":"79979_CR13","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1167\/iovs.09-3396","volume":"51","author":"MA Sandberg","year":"2010","unstructured":"Sandberg, M. A., Johnson, E. J. & Berson, E. L. The relationship of macular pigment optical density to serum lutein in retinitis pigmentosa. Investig. Opthalmol. Visual Sci. 51 (2), 1086 (2010).","journal-title":"Invest. Opthalmology Visual Sci."},{"key":"79979_CR14","doi-asserted-by":"crossref","unstructured":"Bayat, K. et al. Choroidal structure investigated by choroidal vascularity index in patients with inherited retinal diseases. Int. J. Retina Vitreous. 9(1). (2023).","DOI":"10.1186\/s40942-023-00457-w"},{"key":"79979_CR15","doi-asserted-by":"crossref","unstructured":"Hamel, C. Retinitis pigmentosa. Orphanet J. Rare Dis. 1, 40 (2006).","DOI":"10.1186\/1750-1172-1-40"},{"issue":"1","key":"79979_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-011-9296-8","volume":"124","author":"DC Hood","year":"2011","unstructured":"Hood, D. C. et al. ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Doc. Ophthalmol. 124 (1), 1\u201313 (2011).","journal-title":"Doc. Ophthalmol."},{"issue":"1","key":"79979_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s10633-012-9353-y","volume":"126","author":"M Bach","year":"2012","unstructured":"Bach, M. et al. ISCEV standard for clinical pattern electroretinography (PERG): 2012 update. Doc. Ophthalmol. 126 (1), 1\u20137 (2012).","journal-title":"Doc. Ophthalmol."},{"key":"79979_CR18","doi-asserted-by":"crossref","unstructured":"Ruggeri, M. L. et al. Long term follow up of brolucizumab in macular neovascularization. Ophthalmic Res. (2023).","DOI":"10.1159\/000534894"},{"issue":"3","key":"79979_CR19","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.3390\/jcm12031140","volume":"12","author":"L Toto","year":"2023","unstructured":"Toto, L. et al. Choroidal and retinal imaging biomarkers in different types of macular neovascularization. J. Clin. Med. 12 (3), 1140 (2023).","journal-title":"J. Clin. Med."},{"key":"79979_CR20","doi-asserted-by":"crossref","unstructured":"Cerino, L., Aharrh-Gnama, A., Ruggeri, M. L. & Carpineto, P. Macular pigment optical density assessed by heterochromatic flicker photometry in eyes affected by primary epiretinal membrane. Retina.  (2021).","DOI":"10.1097\/IAE.0000000000003387"},{"issue":"14","key":"79979_CR21","doi-asserted-by":"publisher","first-page":"6360","DOI":"10.1167\/iovs.16-20544","volume":"57","author":"L Toto","year":"2016","unstructured":"Toto, L. et al. Macular features in retinitis pigmentosa: correlations among ganglion cell complex thickness, capillary density, and macular function. Investig. Opthalmol. Visual Sci. 57 (14), 6360 (2016).","journal-title":"Investig. Opthalmol. Visual Sci."},{"issue":"11","key":"79979_CR22","doi-asserted-by":"publisher","first-page":"8425","DOI":"10.1167\/iovs.11-7780","volume":"52","author":"R V\u00e1mos","year":"2011","unstructured":"V\u00e1mos, R., T\u00e1trai, E., N\u00e9meth, J., Holder, D. E., DeBuc, D.C., Somfai, G.M. The structure and function of the macula in patients with advanced retinitis pigmentosa. Investig. Ophthalmol. Vis. Sci. 52 (11), 8425\u20138425 (2011).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"issue":"5","key":"79979_CR23","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/S0161-6420(95)30953-0","volume":"102","author":"ZY Li","year":"1995","unstructured":"Li, Z. Y., Possin, D. E. & Milam, A. H. Histopathology of bone spicule pigmentation in retinitis pigmentosa. Ophthalmology. 102 (5), 805\u2013816 (1995).","journal-title":"Ophthalmology"},{"key":"79979_CR24","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.exer.2016.03.018","volume":"150","author":"BW Jones","year":"2016","unstructured":"Jones, B. W. et al. Retinal remodeling in human retinitis pigmentosa. Exp. Eye Res. 150, 149\u2013165 (2016).","journal-title":"Exp. Eye Res."},{"key":"79979_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2016.04.032","volume":"329","author":"S Saha","year":"2016","unstructured":"Saha, S. et al. Changes in ganglion cells during retinal degeneration. Neuroscience. 329, 1\u201311 (2016).","journal-title":"Neuroscience"},{"key":"79979_CR26","doi-asserted-by":"crossref","unstructured":"Zhao, T. T., Tian, C. Y. & Zheng, Q.Y. Activation of M\u00fcller cells occurs during retinal degeneration in RCS rats. Adv. Exp. Med. Biol. 575\u2013583 (2009).","DOI":"10.1007\/978-1-4419-1399-9_66"},{"key":"79979_CR27","unstructured":"Heravi, M. & Rasoulinejad, S. A. Potential of M\u00fcller glial cells in regeneration of retina; clinical and molecular approach. Int. J. Organ Transplant. Med. 13(1), 50\u201359 (2022)."},{"issue":"8","key":"79979_CR28","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.1172\/JCI85193","volume":"126","author":"D Sanges","year":"2016","unstructured":"Sanges, D. et al. Reprogramming M\u00fcller glia via in vivo cell fusion regenerates murine photoreceptors. J. Clin. Investig. 126 (8), 3104\u20133116 (2016).","journal-title":"J. Clin. Investig."},{"key":"79979_CR29","unstructured":"Roesch, K., Stadler, M. B. & Cepko, C. L. Gene expression changes within M\u00fcller glial cells in retinitis pigmentosa. Mol. Vis. 18, 1197\u20131214 (2012)."},{"key":"79979_CR30","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.trsl.2018.12.006","volume":"207","author":"X Li","year":"2019","unstructured":"Li, X., Liu, J., Hoh, J. & Liu, J. M\u00fcller cells in pathological retinal angiogenesis. Transl. Res. 207, 96\u2013106 (2019).","journal-title":"Transl. Res."},{"key":"79979_CR31","doi-asserted-by":"crossref","unstructured":"Bringmann, A. et al. The primate fovea: Structure, function and development. Prog. Retin. Eye Res. 66, 49\u201384 (2018).","DOI":"10.1016\/j.preteyeres.2018.03.006"},{"key":"79979_CR32","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.exer.2017.12.004","volume":"167","author":"S Syrbe","year":"2018","unstructured":"Syrbe, S. et al. M\u00fcller glial cells of the primate foveola: an electron microscopical study. Exp. Eye Res. 167, 110\u2013117 (2018).","journal-title":"Exp. Eye Res."},{"issue":"4","key":"79979_CR33","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","volume":"25","author":"A Bringmann","year":"2006","unstructured":"Bringmann, A. et al. M\u00fcller cells in the healthy and diseased retina. Prog. Retin. Eye Res. 25 (4), 397\u2013424 (2006).","journal-title":"Prog. Retin. Eye Res."},{"issue":"5","key":"79979_CR34","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1136\/bjo.79.5.407","volume":"79","author":"A von R\u00fcckmann","year":"1995","unstructured":"von R\u00fcckmann, A., Fitzke, F. W. & Bird, A. C. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br. J. Ophthalmol. 79 (5), 407\u2013412 (1995).","journal-title":"Br. J. Ophthalmol."},{"issue":"5","key":"79979_CR35","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.optm.2007.03.017","volume":"79","author":"IYF Leung","year":"2008","unstructured":"Leung, I. Y. F. Macular pigment: New clinical methods of detection and the role of carotenoids in age-related macular degeneration. Optometry J. Am. Optom. Assoc.. 79 (5), 266\u2013272 (2008).","journal-title":"Optometry J. Am. Optom. Assoc."},{"issue":"2","key":"79979_CR36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S1350-9462(97)00012-8","volume":"17","author":"A Milam","year":"1998","unstructured":"Milam, A., Li, Z. & Fariss, R. Histopathology of the human retina in retinitis pigmentosa. Prog. Retin. Eye Res. 17 (2), 175\u2013205 (1998).","journal-title":"Prog. Retin. Eye Res."},{"key":"79979_CR37","doi-asserted-by":"crossref","unstructured":"Konieczka, K., Flammer, A. J., Todorova, M., Meyer, P. & Flammer, J. Retinitis pigmentosa and ocular blood flow. EPMA J. ;3(1). (2012).","DOI":"10.1186\/1878-5085-3-17"},{"key":"79979_CR38","doi-asserted-by":"crossref","unstructured":"Mastropasqua, R. et al. Radial peripapillary capillary network in patients with retinitis pigmentosa: an optical coherence tomography angiography study. Front. Neurol. ;8. (2017).","DOI":"10.3389\/fneur.2017.00572"},{"issue":"4","key":"79979_CR39","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1111\/j.1442-9071.2012.02867.x","volume":"41","author":"LN Ayton","year":"2012","unstructured":"Ayton, L. N., Guymer, R. H. & Luu, C. D. Choroidal thickness profiles in retinitis pigmentosa. Clin. Exp. Ophthalmol. 41 (4), 396\u2013403 (2012).","journal-title":"Clin. Exp. Ophthalmol."},{"issue":"1","key":"79979_CR40","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1136\/bjophthalmol-2012-301917","volume":"97","author":"DS Dhoot","year":"2012","unstructured":"Dhoot, D. S. et al. Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography. Br. J. Ophthalmol. 97 (1), 66\u201369 (2012).","journal-title":"Br. J. Ophthalmol."},{"issue":"1","key":"79979_CR41","doi-asserted-by":"publisher","first-page":"52","DOI":"10.5301\/ejo.5000961","volume":"28","author":"A Sodi","year":"2017","unstructured":"Sodi, A. et al. EDI-OCT evaluation of choroidal thickness in retinitis pigmentosa. Eur. J. Ophthalmol. 28 (1), 52\u201357 (2017).","journal-title":"Eur. J. Ophthalmol."},{"key":"79979_CR42","doi-asserted-by":"crossref","unstructured":"Akay, F., Akmaz, B. & G\u00fcven, Y. Z. Optical coherence tomography detection of changes in inner retinal and choroidal thicknesses in patients with early retinitis pigmentosa. Arquivos Brasileiros De Oftalmologia 83(5). (2020).","DOI":"10.5935\/0004-2749.20200080"},{"issue":"10","key":"79979_CR43","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.jfo.2018.04.013","volume":"41","author":"I Aknin","year":"2018","unstructured":"Aknin, I. & Pradat, P. Choroidal thickness in healthy eyes using enhanced depth imaging optical coherence tomography and comparison with cases of retinitis pigmentosa. J. Fran\u00e7ais d\u2019Ophtalmologie. 41 (10), 933\u2013938 (2018).","journal-title":"J. Fran\u00e7ais d\u2019Ophtalmologie"},{"issue":"1","key":"79979_CR44","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.sjopt.2015.09.003","volume":"30","author":"J Chhablani","year":"2016","unstructured":"Chhablani, J., Jonnadula, G. B., Srinivasa Rao, P., Venkata, A. & Jalali, S. Choroidal thickness profile in Retinitis Pigmentosa\u2014correlation with outer retinal structures. Saudi J. Ophthalmol. 30 (1), 9\u201313 (2016).","journal-title":"Saudi J. Ophthalmol."},{"issue":"3","key":"79979_CR45","doi-asserted-by":"publisher","first-page":"191","DOI":"10.3928\/23258160-20180221-07","volume":"49","author":"R Tan","year":"2018","unstructured":"Tan, R. et al. Choroidal vascularity index in retinitis pigmentosa: an OCT study. Ophthalmic surgery. Lasers Imaging Retina. 49 (3), 191\u2013197 (2018).","journal-title":"Lasers Imaging Retina"},{"key":"79979_CR46","doi-asserted-by":"crossref","unstructured":"Toto, L. et al. Choroidal modifications assessed by means of choroidal vascularity index after oral eplerenone treatment in chronic central serous chorioretinopathy. Eye (2022).","DOI":"10.1038\/s41433-022-02091-6"},{"key":"79979_CR47","doi-asserted-by":"crossref","unstructured":"Shen, C. et al. Choroidal vascular changes in retinitis pigmentosa patients detected by optical coherence tomography angiography. BMC Ophthalmol. ;20(1). (2020).","DOI":"10.1186\/s12886-020-01640-5"},{"issue":"15","key":"79979_CR48","doi-asserted-by":"publisher","first-page":"5000","DOI":"10.1167\/iovs.19-27300","volume":"60","author":"C Iovino","year":"2019","unstructured":"Iovino, C. et al. Evaluation of the choroid in eyes with retinitis pigmentosa and cystoid macular edema. Investig. Ophthalmol. Vis. Sci. 60 (15), 5000\u20135000 (2019).","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"79979_CR49","doi-asserted-by":"publisher","first-page":"33921","DOI":"10.1038\/srep33921","volume":"6","author":"Y Nagasaka","year":"2016","unstructured":"Nagasaka, Y. et al. Increased aqueous flare is associated with thickening of inner retinal layers in eyes with retinitis pigmentosa. Sci. Rep. 6, 33921. https:\/\/doi.org\/10.1038\/srep33921 (2016).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79979-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79979-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79979-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T07:10:09Z","timestamp":1732173009000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-79979-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,21]]},"references-count":49,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["79979"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-79979-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,21]]},"assertion":[{"value":"15 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the University \u201cG. d\u2019Annunzio\u201dof Chieti- Pescara. Informed consent was obtained from all subjects involved in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent was obtained from all subjects involved in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"28830"}}