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It is hypothesized that the inappropriate filtering of sensory stimuli, including olfaction, can lead to aberrant social behavior in FXS. However, previous studies investigating olfaction in animal models of FXS have shown inconsistent results. Here, we found that <jats:italic>Fmr1<\/jats:italic> knock-out (KO) mice, a mouse model of FXS, showed increased sniffing duration for non-social odors during their first exposure. Additionally, while wild-type (WT) males demonstrated differences in behavioral patterns between non-social odors while <jats:italic>Fmr1<\/jats:italic> KO males did not show such distinction. We also showed that <jats:italic>Fmr1<\/jats:italic> KO males spent significantly less time sniffing female urine odor compared to WT males. Moreover, we found an increased volume of the olfactory bulb in <jats:italic>Fmr1<\/jats:italic> KO males. Overall, our findings suggest that the <jats:italic>Fmr1<\/jats:italic> KO mice demonstrate atypical olfactory behaviors as well as structural changes in the olfactory bulb.<\/jats:p>","DOI":"10.1038\/s41598-024-80000-5","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T12:27:20Z","timestamp":1737635240000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Altered olfactory responses in Fmr1 KO mice"],"prefix":"10.1038","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7197-8482","authenticated-orcid":false,"given":"Jan","family":"Tuma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1537-5377","authenticated-orcid":false,"given":"Amtul-Noor","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0031-6921","authenticated-orcid":false,"given":"Teena","family":"Philip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9947-4932","authenticated-orcid":false,"given":"Jeong Ben","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3150-6886","authenticated-orcid":false,"given":"Hye Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"80000_CR1","doi-asserted-by":"publisher","first-page":"722378","DOI":"10.3389\/fpsyt.2021.722378","volume":"12","author":"E Verdura","year":"2021","unstructured":"Verdura, E. et al. 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