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Logistic analysis was conducted to compare general data in MP asthma and MP non-asthma groups. The level of 25-(OH)-D, IL-4, and IFN-\u03b3 were detected and compared between groups. Moreover, the receiver operating characteristic curve (ROC) was applied to test the predictive value of each variable. The results of logistic regression analysis demonstrated that recurrent upper respiratory tract infections and collective living are related to the incidence of MP infection whether with asthma or without asthma. IL-4 and IFN-\u03b3 in MP asthma group were significantly higher than those in MP non-asthma group and control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090. 05), whilst 25-(OH)-D and IFN-\u03b3\/IL-4 in MP asthma group were significantly lower than those in MP non-asthma group and control group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090. 05). ROC curves indicated that the area under the curve (AUC) of 25-(OH)-D, IL-4, IFN-\u03b3, IFN-\u03b3\/IL-4, and joint detection are 0.765, 0.780, 0.853, 0.638, and 0.912 in diagnosis of MP infection-related asthma, and sensitivity and specificity of joint detection are both greater than 95%. For children with MP infection-related asthma, the level of IL-4 and IFN-\u03b3 is upregulated, while 25-(OH)-D is downregulated. The joint detection of 25-(OH)-D, IL-4, IFN-\u03b3, and IFN-\u03b3\/IL-4 may improve diagnostic capabilities of MP infection-related asthma.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-80322-4","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T06:34:23Z","timestamp":1732170863000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between 25-hydroxy vitamin D, interleukin-4, and interferon-\u03b3 levels and asthma in children with Mycoplasma pneumonia infection"],"prefix":"10.1038","volume":"14","author":[{"given":"Tao","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,21]]},"reference":[{"key":"80322_CR1","doi-asserted-by":"publisher","first-page":"1329516","DOI":"10.3389\/fphar.2024.1329516","volume":"15","author":"S Yang","year":"2024","unstructured":"Yang, S. et al. 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