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Its\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    ortholog, PfUCH37, is unusual in that it possesses both DUB and deneddylating activities. While PfUCH37 is enriched in proteasome preparations, its direct interaction and broader functions in\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    remain unclear, particularly given the absence of the chromatin remodeling complex INO80 homologs. This study utilizes transgenic parasites and proteomics to identify PfUCH37-associating proteins. We confirm a direct interaction with the proteasome and demonstrate that the interaction mechanism is evolutionarily conserved. Notably, we discover a divergence in localization compared to the human enzyme and identify novel interacting partners, suggesting alternative functions for PfUCH37 in\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    . These findings provide insights into the unique biology of this enzyme in malaria parasites, potentially opening avenues for targeted therapeutic interventions.\n                  <\/jats:p>","DOI":"10.1038\/s41598-024-80433-y","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T23:53:40Z","timestamp":1732665220000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Proteasome associated function of UCH37 is evolutionarily conserved in Plasmodium parasites"],"prefix":"10.1038","volume":"14","author":[{"given":"Mohsen","family":"Hajisadeghian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie M.","family":"Geiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Briggs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katerina","family":"Artavanis-Tsakonas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"80433_CR1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1016\/j.molcel.2016.01.014","volume":"61","author":"RT VanderLinden","year":"2016","unstructured":"VanderLinden, R. 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