{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T16:17:37Z","timestamp":1779293857765,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH120514"],"award-info":[{"award-number":["R01MH120514"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01MH051399"],"award-info":[{"award-number":["R01MH051399"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation","award":["29699 (CM)"],"award-info":[{"award-number":["29699 (CM)"]}]},{"name":"NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation","award":["31194 (LFP)"],"award-info":[{"award-number":["31194 (LFP)"]}]},{"DOI":"10.13039\/100000957","name":"Alzheimer\u2019s Association","doi-asserted-by":"publisher","award":["24AARG-NTF-1198746"],"award-info":[{"award-number":["24AARG-NTF-1198746"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007027","name":"Leon Levy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["P01DA047233"],"award-info":[{"award-number":["P01DA047233"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021ZD0202900"],"award-info":[{"award-number":["2021ZD0202900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021ZD0202902"],"award-info":[{"award-number":["2021ZD0202902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Fund for International Senior Scientists","award":["T2250710685"],"award-info":[{"award-number":["T2250710685"]}]},{"DOI":"10.13039\/100016804","name":"Shenzhen Natural Science Foundation","doi-asserted-by":"crossref","award":["J20220127"],"award-info":[{"award-number":["J20220127"]}],"id":[{"id":"10.13039\/100016804","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Medical Research Fund","award":["B2303012"],"award-info":[{"award-number":["B2303012"]}]},{"name":"Shenzhen Key Laboratory of Precision Diagnosis and Treatment of Depression","award":["ZDSYS20220606100606014"],"award-info":[{"award-number":["ZDSYS20220606100606014"]}]},{"name":"Science and Technology Research and Development Foundation of Shenzhen","award":["KQTD20221101093608028"],"award-info":[{"award-number":["KQTD20221101093608028"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-80767-7","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T01:15:04Z","timestamp":1735348504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Male and female behavioral variability and morphine response in C57BL\/6J, DBA\/2J, and their BXD progeny following chronic stress exposure"],"prefix":"10.1038","volume":"14","author":[{"given":"Carole","family":"Morel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyonna F.","family":"Parise","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yentl Y.","family":"Van der Zee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orna","family":"Issler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caleb J.","family":"Browne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Blando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine B.","family":"LeClair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio V.","family":"Aubry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherod","family":"Haynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert W.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan K.","family":"Mulligan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott J.","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Nestler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Hu","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"issue":"Pt B","key":"80767_CR1","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.neuropharm.2013.08.020","volume":"76","author":"D Shurtleff","year":"2014","unstructured":"Shurtleff, D., Sasek, C. & Kautz, M. Sponsor\u2019s foreword: NIDA at forty. Neuropharmacology 76(Pt B), 195\u2013197 (2014).","journal-title":"Neuropharmacology"},{"key":"80767_CR2","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1001\/archpsyc.57.3.261","volume":"57","author":"KS Kendler","year":"2000","unstructured":"Kendler, K. S., Karkowski, L. M., Neale, M. C. & Prescott, C. A. Illicit psychoactive substance use, heavy use, abuse, and dependence in a US population-based sample of male twins. Arch. Gen. Psychiatry 57, 261\u2013269 (2000).","journal-title":"Arch. Gen. Psychiatry"},{"key":"80767_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1080\/10673220127912","volume":"9","author":"MT Tsuang","year":"2001","unstructured":"Tsuang, M. T., Bar, J. L., Harley, R. M. & Lyons, M. J. The harvard twin study of substance abuse: what we have learned. Harv. Rev. Psychiatry 9, 267\u2013279 (2001).","journal-title":"Harv. Rev. Psychiatry"},{"key":"80767_CR4","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.tins.2005.06.005","volume":"28","author":"WAJ Carlezon","year":"2005","unstructured":"Carlezon, W. A. J., Duman, R. S. & Nestler, E. J. The many faces of CREB. Trends Neurosci. 28, 436\u2013445 (2005).","journal-title":"Trends Neurosci."},{"key":"80767_CR5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1196\/annals.1441.030","volume":"1141","author":"R Sinha","year":"2008","unstructured":"Sinha, R. Chronic stress, drug use, and vulnerability to addiction. Ann. N. Y. Acad. Sci. 1141, 105\u2013130 (2008).","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"80767_CR6","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.biopsych.2015.05.022","volume":"79","author":"LA Khibnik","year":"2016","unstructured":"Khibnik, L. A. et al. Stress and cocaine trigger divergent and cell type-specific regulation of synaptic transmission at single spines in nucleus accumbens. Biol. Psychiatry 79, 898\u2013905 (2016).","journal-title":"Biol. Psychiatry"},{"key":"80767_CR7","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1038\/mp.2017.145","volume":"23","author":"C Morel","year":"2018","unstructured":"Morel, C. et al. Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells\u2019 activity. Mol. Psychiatry 23, 1597\u20131605 (2018).","journal-title":"Mol. Psychiatry"},{"key":"80767_CR8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2018.100140","volume":"10","author":"SL Andersen","year":"2019","unstructured":"Andersen, S. L. Stress, sensitive periods, and substance abuse. Neurobiol. Stress 10, 100140 (2019).","journal-title":"Neurobiol. Stress"},{"key":"80767_CR9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1172\/JCI113875","volume":"83","author":"DW Crabb","year":"1989","unstructured":"Crabb, D. W., Edenberg, H. J., Bosron, W. F. & Li, T. K. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. J. Clin. Investig. 83, 314\u2013316 (1989).","journal-title":"J. Clin. Investig."},{"key":"80767_CR10","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/S0140-6736(05)67322-9","volume":"366","author":"PR Burton","year":"2005","unstructured":"Burton, P. R., Tobin, M. D. & Hopper, J. L. Key concepts in genetic epidemiology. Lancet (London, England) 366, 941\u2013951 (2005).","journal-title":"Lancet (London, England)"},{"key":"80767_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1385\/NMM:5:1:085","volume":"5","author":"MJ Kreek","year":"2004","unstructured":"Kreek, M. J., Nielsen, D. A. & LaForge, K. S. Genes associated with addiction: alcoholism, opiate, and cocaine addiction. Neuromol. Med. 5, 85\u2013108 (2004).","journal-title":"Neuromol. Med."},{"key":"80767_CR12","doi-asserted-by":"publisher","first-page":"3970","DOI":"10.1038\/s41380-022-01709-1","volume":"27","author":"JD Deak","year":"2022","unstructured":"Deak, J. D. et al. Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci. Mol. Psychiatry 27, 3970\u20133979 (2022).","journal-title":"Mol. Psychiatry"},{"key":"80767_CR13","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/s44220-023-00034-y","volume":"1","author":"AS Hatoum","year":"2023","unstructured":"Hatoum, A. S. et al. Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. Nat. Ment. Health 1, 210\u2013223 (2023).","journal-title":"Nat. Ment. Health"},{"key":"80767_CR14","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1097\/00002508-200207001-00003","volume":"18","author":"EC Strain","year":"2002","unstructured":"Strain, E. C. Assessment and treatment of comorbid psychiatric disorders in opioid-dependent patients. Clin. J. Pain 18, S14-27 (2002).","journal-title":"Clin. J. Pain"},{"key":"80767_CR15","doi-asserted-by":"publisher","first-page":"247","DOI":"10.4088\/JCP.v67n0211","volume":"67","author":"KP Conway","year":"2006","unstructured":"Conway, K. P., Compton, W., Stinson, F. S. & Grant, B. F. Lifetime comorbidity of DSM-IV mood and anxiety disorders and specific drug use disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. J. Clin. Psychiatry 67, 247\u2013257 (2006).","journal-title":"J. Clin. Psychiatry"},{"key":"80767_CR16","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/add.15594","volume":"117","author":"Y-I Hser","year":"2022","unstructured":"Hser, Y.-I. et al. Long-term follow-up assessment of opioid use outcomes among individuals with comorbid mental disorders and opioid use disorder treated with buprenorphine or methadone in a randomized clinical trial. Addiction 117, 151\u2013161 (2022).","journal-title":"Addiction"},{"key":"80767_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsiml.2020.100009","volume":"1","author":"S Schenk","year":"2020","unstructured":"Schenk, S., Eisenbarth, H. & Dixon, L. Treating opioid use disorders in the criminal justice system with pharmacotherapy. Forensic Sci. Int. Mind Law 1, 100009 (2020).","journal-title":"Forensic Sci. Int. Mind Law"},{"key":"80767_CR18","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cels.2020.12.002","volume":"12","author":"DG Ashbrook","year":"2021","unstructured":"Ashbrook, D. G. et al. A platform for experimental precision medicine: The extended BXD mouse family. Cell Syst. 12, 235-247.e9 (2021).","journal-title":"Cell Syst."},{"key":"80767_CR19","doi-asserted-by":"publisher","first-page":"7193","DOI":"10.1523\/JNEUROSCI.16-22-07193.1996","volume":"16","author":"RW Williams","year":"1996","unstructured":"Williams, R. W., Strom, R. C., Rice, D. S. & Goldowitz, D. Genetic and environmental control of variation in retinal ganglion cell number in mice. J. Neurosci. Off. J. Soc. Neurosci. 16, 7193\u20137205 (1996).","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"80767_CR20","doi-asserted-by":"publisher","first-page":"RESEARCH0046","DOI":"10.1186\/gb-2001-2-11-research0046","volume":"2","author":"RW Williams","year":"2001","unstructured":"Williams, R. W., Gu, J., Qi, S. & Lu, L. The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis. Genome Biol. 2, RESEARCH0046 (2001).","journal-title":"Genome Biol."},{"key":"80767_CR21","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/j.cell.2012.08.012","volume":"150","author":"PA Andreux","year":"2012","unstructured":"Andreux, P. A. et al. Systems genetics of metabolism: the use of the BXD murine reference panel for multiscalar integration of traits. Cell 150, 1287\u20131299 (2012).","journal-title":"Cell"},{"key":"80767_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039191","volume":"7","author":"AM McKnite","year":"2012","unstructured":"McKnite, A. M. et al. Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits. PLoS One 7, e39191 (2012).","journal-title":"PLoS One"},{"key":"80767_CR23","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/ffj.2074","volume":"26","author":"AA Bachmanov","year":"2011","unstructured":"Bachmanov, A. A. et al. Genetics of sweet taste preferences. Flavour Fragr. J. 26, 286\u2013294 (2011).","journal-title":"Flavour Fragr. J."},{"key":"80767_CR24","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3389\/fnbeh.2015.00171","volume":"9","author":"DG Ashbrook","year":"2015","unstructured":"Ashbrook, D. G., Williams, R. W., Lu, L. & Hager, R. A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder. Front. Behav. Neurosci. 9, 171 (2015).","journal-title":"Front. Behav. Neurosci."},{"key":"80767_CR25","doi-asserted-by":"publisher","first-page":"614","DOI":"10.3390\/genes13040614","volume":"13","author":"A Chunduri","year":"2022","unstructured":"Chunduri, A., Watson, P. M. & Ashbrook, D. G. New insights on gene by environmental effects of drugs of abuse in animal models using GeneNetwork. Genes (Basel) 13, 614 (2022).","journal-title":"Genes (Basel)"},{"key":"80767_CR26","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1523\/JNEUROSCI.17-02-00745.1997","volume":"17","author":"JE Grisel","year":"1997","unstructured":"Grisel, J. E. et al. Quantitative trait loci affecting methamphetamine responses in BXD recombinant inbred mouse strains. J. Neurosci. Off. J. Soc. Neurosci. 17, 745\u2013754 (1997).","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"80767_CR27","first-page":"181","volume":"5","author":"JC Crabbe","year":"1983","unstructured":"Crabbe, J. C., Kosobud, A., Young, E. R. & Janowsky, J. S. Polygenic and single-gene determination of responses to ethanol in BXD\/Ty recombinant inbred mouse strains. Neurobehav. Toxicol. Teratol. 5, 181\u2013187 (1983).","journal-title":"Neurobehav. Toxicol. Teratol."},{"key":"80767_CR28","first-page":"1230","volume":"270","author":"BK Tolliver","year":"1994","unstructured":"Tolliver, B. K., Belknap, J. K., Woods, W. E. & Carney, J. M. Genetic analysis of sensitization and tolerance to cocaine. J. Pharmacol. Exp. Ther. 270, 1230\u20131238 (1994).","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"80767_CR29","first-page":"603","volume":"75","author":"A Wahlstr\u00f6m","year":"1986","unstructured":"Wahlstr\u00f6m, A., Hammar, L., Lundin, L. G. & Rane, A. Morphine metabolism in mouse brain. NIDA Res. Monogr. 75, 603\u2013606 (1986).","journal-title":"NIDA Res. Monogr."},{"key":"80767_CR30","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1300\/J069v10n01_06","volume":"10","author":"TJ Phillips","year":"1991","unstructured":"Phillips, T. J., Belknap, J. K. & Crabbe, J. C. Use of recombinant inbred strains to assess vulnerability to drug abuse at the genetic level. J. Addict. Dis. 10, 73\u201387 (1991).","journal-title":"J. Addict. Dis."},{"key":"80767_CR31","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1097\/WCO.0b013e32832d9b86","volume":"22","author":"A Badea","year":"2009","unstructured":"Badea, A., Johnson, G. A. & Williams, R. W. Genetic dissection of the mouse CNS using magnetic resonance microscopy. Curr. Opin. Neurol. 22, 379\u2013386 (2009).","journal-title":"Curr. Opin. Neurol."},{"key":"80767_CR32","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1038\/s41467-022-29155-1","volume":"13","author":"C Morel","year":"2022","unstructured":"Morel, C. et al. Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors. Nat. Commun. 13, 1532 (2022).","journal-title":"Nat. Commun."},{"key":"80767_CR33","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/nprot.2011.361","volume":"6","author":"SA Golden","year":"2011","unstructured":"Golden, S. A., Covington, H. E., Berton, O. & Russo, S. J. A standardized protocol for repeated social defeat stress in mice. Nat. Protoc. 6, 1183\u20131191 (2011).","journal-title":"Nat. Protoc."},{"key":"80767_CR34","doi-asserted-by":"publisher","first-page":"16362","DOI":"10.1523\/JNEUROSCI.1392-15.2015","volume":"35","author":"GE Hodes","year":"2015","unstructured":"Hodes, G. E. et al. Sex differences in nucleus accumbens transcriptome profiles associated with susceptibility versus resilience to subchronic variable stress. J. Neurosci. 35, 16362\u201316376 (2015).","journal-title":"J. Neurosci."},{"key":"80767_CR35","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1126\/science.1226767","volume":"339","author":"J Barik","year":"2013","unstructured":"Barik, J. et al. Chronic stress triggers social aversion via glucococorticoid receptor in dopaminoceptive neurons. Science 339, 332\u2013335 (2013).","journal-title":"Science"},{"key":"80767_CR36","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s002130100917","volume":"158","author":"R Sinha","year":"2001","unstructured":"Sinha, R. How does stress increase risk of drug abuse and relapse?. Psychopharmacology (Berl.) 158, 343\u2013359 (2001).","journal-title":"Psychopharmacology (Berl.)"},{"key":"80767_CR37","first-page":"477","volume":"2","author":"JC Crabbe","year":"1993","unstructured":"Crabbe, J. C. & Belknap, J. K. Behavior genetic analyses of drug withdrawal. Alcohol Alcohol Suppl. 2, 477\u2013482 (1993).","journal-title":"Alcohol Alcohol Suppl."},{"key":"80767_CR38","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.3390\/brainsci12121634","volume":"12","author":"JA Baker","year":"2022","unstructured":"Baker, J. A., Brettin, J. T., Mulligan, M. K. & Hamre, K. M. Effects of genetics and sex on acute gene expression changes in the hippocampus following neonatal ethanol exposure in BXD recombinant inbred mouse strains. Brain Sci. 12, 1634 (2022).","journal-title":"Brain Sci."},{"key":"80767_CR39","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/BF00428322","volume":"66","author":"K Kitahama","year":"1979","unstructured":"Kitahama, K. & Valatx, J. L. Strain differences in amphetamine sensitivity in mice. II. Overcompensation of paradoxical sleep after deprivation in two C57 strains. Psychopharmacology (Berl.) 66, 291\u2013295 (1979).","journal-title":"Psychopharmacology (Berl.)"},{"key":"80767_CR40","doi-asserted-by":"publisher","first-page":"PL117","DOI":"10.1016\/0024-3205(95)02040-P","volume":"57","author":"JK Belknap","year":"1995","unstructured":"Belknap, J. K. et al. Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL\/6 and DBA\/2 strains. Life Sci. 57, PL117-24 (1995).","journal-title":"Life Sci."},{"key":"80767_CR41","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/ijc.10606","volume":"101","author":"WE Grizzle","year":"2002","unstructured":"Grizzle, W. E. et al. BXD recombinant inbred mice represent a novel T cell-mediated immune response tumor model. Int. J. Cancer 101, 270\u2013279 (2002).","journal-title":"Int. J. Cancer"},{"key":"80767_CR42","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/978-1-4939-6427-7_4","volume":"1488","author":"MK Mulligan","year":"2017","unstructured":"Mulligan, M. K., Mozhui, K., Prins, P. & Williams, R. W. GeneNetwork: A toolbox for systems genetics. Methods Mol. Biol. 1488, 75\u2013120. https:\/\/doi.org\/10.1007\/978-1-4939-6427-7_4 (2017).","journal-title":"Methods Mol. Biol."},{"issue":"12","key":"80767_CR43","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12974-015-0297-5","volume":"18","author":"L Ma","year":"2015","unstructured":"Ma, L., Piirainen, S., Kulesskaya, N., Rauvala, H. & Tian, L. Association of brain immune genes with social behavior of inbred mouse strains. J. Neuroinflamm. 18(12), 75. https:\/\/doi.org\/10.1186\/s12974-015-0297-5 (2015).","journal-title":"J. Neuroinflamm."},{"issue":"5","key":"80767_CR44","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12431","volume":"17","author":"AT Knoll","year":"2018","unstructured":"Knoll, A. T., Jiang, K. & Levitt, P. Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co-occurring traits. Genes Brain Behav. 17(5), e12431. https:\/\/doi.org\/10.1111\/gbb.12431 (2018).","journal-title":"Genes Brain Behav."},{"issue":"7","key":"80767_CR45","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12469","volume":"17","author":"A Delprato","year":"2018","unstructured":"Delprato, A. et al. A quantitative trait locus on chromosome 1 modulates intermale aggression in mice. Genes Brain Behav. 17(7), e12469. https:\/\/doi.org\/10.1111\/gbb.12469 (2018).","journal-title":"Genes Brain Behav."},{"issue":"8","key":"80767_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044236","volume":"7","author":"A Talishinsky","year":"2012","unstructured":"Talishinsky, A. & Rosen, G. D. Systems genetics of the lateral septal nucleus in mouse: heritability, genetic control, and covariation with behavioral and morphological traits. PLoS One 7(8), e44236. https:\/\/doi.org\/10.1371\/journal.pone.0044236 (2012).","journal-title":"PLoS One"},{"issue":"284","key":"80767_CR47","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.neuroscience.2014.09.069","volume":"22","author":"B Zi\u00f3\u0141kowska","year":"2015","unstructured":"Zi\u00f3\u0141kowska, B., Gieryk, A., Solecki, W. & Przew\u0141ocki, R. Temporal and anatomic patterns of immediate-early gene expression in the forebrain of C57BL\/6 and DBA\/2 mice after morphine administration. Neuroscience 22(284), 107\u2013124. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.09.069 (2015).","journal-title":"Neuroscience"},{"key":"80767_CR48","doi-asserted-by":"publisher","DOI":"10.1126\/science.1249240","author":"AK Friedman","year":"2014","unstructured":"Friedman, A. K. et al. Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science https:\/\/doi.org\/10.1126\/science.1249240 (2014).","journal-title":"Science"},{"key":"80767_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.02.021","author":"S Zhang","year":"2018","unstructured":"Zhang, S. et al. Sex Differences in the neuroadaptations of reward-related circuits in response to subchronic variable stress. Neuroscience https:\/\/doi.org\/10.1016\/j.neuroscience.2018.02.021 (2018).","journal-title":"Neuroscience"},{"issue":"2","key":"80767_CR50","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/FBP.0b013e32830c368c","volume":"20","author":"JL Brigman","year":"2009","unstructured":"Brigman, J. L., Mathur, P., Lu, L., Williams, R. W. & Holmes, A. Genetic relationship between anxiety-related and fear-related behaviors in BXD recombinant inbred mice. Behav. Pharmacol. 20(2), 204\u2013209. https:\/\/doi.org\/10.1097\/FBP.0b013e32830c368c (2009).","journal-title":"Behav. Pharmacol."},{"key":"80767_CR51","doi-asserted-by":"publisher","first-page":"696","DOI":"10.1038\/s41586-022-05484-5","volume":"613","author":"L Li","year":"2023","unstructured":"Li, L. et al. Social trauma engages lateral septum circuitry to occlude social reward. Nature 613, 696\u2013703 (2023).","journal-title":"Nature"},{"key":"80767_CR52","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.cpr.2017.10.012","volume":"66","author":"RK McHugh","year":"2018","unstructured":"McHugh, R. K., Votaw, V. R., Sugarman, D. E. & Greenfield, S. F. Sex and gender differences in substance use disorders. Clin. Psychol. Rev. 66, 12\u201323 (2018).","journal-title":"Clin. Psychol. Rev."},{"key":"80767_CR53","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.jpain.2009.07.016","volume":"11","author":"RN Jamison","year":"2010","unstructured":"Jamison, R. N., Butler, S. F., Budman, S. H., Edwards, R. R. & Wasan, A. D. Gender differences in risk factors for aberrant prescription opioid use. J. Pain 11, 312\u2013320 (2010).","journal-title":"J. Pain"},{"key":"80767_CR54","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.drugalcdep.2014.10.003","volume":"145","author":"B Lewis","year":"2014","unstructured":"Lewis, B., Hoffman, L. A. & Nixon, S. J. Sex differences in drug use among polysubstance users. Drug Alcohol Depend. 145, 127\u2013133 (2014).","journal-title":"Drug Alcohol Depend."},{"key":"80767_CR55","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bbr.2006.02.009","volume":"170","author":"F Papaleo","year":"2006","unstructured":"Papaleo, F. & Contarino, A. Gender- and morphine dose-linked expression of spontaneous somatic opiate withdrawal in mice. Behav. Brain Res. 170, 110\u2013118 (2006).","journal-title":"Behav. Brain Res."},{"key":"80767_CR56","doi-asserted-by":"publisher","first-page":"35455","DOI":"10.1038\/srep35455","volume":"6","author":"DD Kiraly","year":"2016","unstructured":"Kiraly, D. D. et al. Alterations of the host microbiome affect behavioral responses to cocaine. Sci. Rep. 6, 35455 (2016).","journal-title":"Sci. Rep."},{"key":"80767_CR57","doi-asserted-by":"publisher","first-page":"eabn9494","DOI":"10.1126\/sciadv.abn9494","volume":"8","author":"O Issler","year":"2022","unstructured":"Issler, O. et al. The long noncoding RNA FEDORA is a cell type- and sex-specific regulator of depression. Sci. Adv. 8, eabn9494 (2022).","journal-title":"Sci. Adv."},{"key":"80767_CR58","doi-asserted-by":"publisher","first-page":"13877","DOI":"10.1038\/ncomms13877","volume":"8","author":"ES Calipari","year":"2017","unstructured":"Calipari, E. S. et al. Dopaminergic dynamics underlying sex-specific cocaine reward. Nat. Commun. 8, 13877 (2017).","journal-title":"Nat. Commun."},{"key":"80767_CR59","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1093\/hmg\/ddg078","volume":"12","author":"RD Emes","year":"2003","unstructured":"Emes, R. D., Goodstadt, L., Winter, E. E. & Ponting, C. P. Comparison of the genomes of human and mouse lays the foundation of genome zoology. Hum. Mol. Genet. 12, 701\u2013709 (2003).","journal-title":"Hum. Mol. Genet."},{"key":"80767_CR60","doi-asserted-by":"publisher","first-page":"12838","DOI":"10.1038\/s41598-017-12811-8","volume":"7","author":"A Takahashi","year":"2017","unstructured":"Takahashi, A. et al. Establishment of a repeated social defeat stress model in female mice. Sci. Rep. 7, 12838 (2017).","journal-title":"Sci. Rep."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80767-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80767-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80767-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T02:03:03Z","timestamp":1735351383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80767-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":60,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["80767"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-80767-7","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"23 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30785"}}