{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:35:19Z","timestamp":1788784519008,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T00:00:00Z","timestamp":1732665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["National High Level Hospital Clinical Research Funding"],"award-info":[{"award-number":["National High Level Hospital Clinical Research Funding"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFC2504401"],"award-info":[{"award-number":["2022YFC2504401"]}]},{"name":"National High Level Hospital Clinical Research Funding-Elite Medical Professionals Project of China-Japan Friendship Hospital","award":["ZRJY2023-GG21"],"award-info":[{"award-number":["ZRJY2023-GG21"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82270108"],"award-info":[{"award-number":["82270108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-80985-z","type":"journal-article","created":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T15:49:32Z","timestamp":1732722572000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Causal relationship between lipidome and acute respiratory distress syndrome"],"prefix":"10.1038","volume":"14","author":[{"given":"Ruoyi","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijiang","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingen","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyuan","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,27]]},"reference":[{"key":"80985_CR1","doi-asserted-by":"crossref","unstructured":"Lieuwe, D. J. & Lorraine, B. B. W. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet 400 (2022).","DOI":"10.1016\/S0140-6736(22)01485-4"},{"key":"80985_CR2","unstructured":"Fang, Q., Willem, B. & Kay Choong, S. The new global definition of acute respiratory distress syndrome: insights from the MIMIC-IV database. Intensive Care Med. (2024)."},{"key":"80985_CR3","doi-asserted-by":"crossref","unstructured":"Nuala, J., Luciano, M. & Carolyn, S. G. C. Acute respiratory distress syndrome. Lancet 398 (2021).","DOI":"10.1016\/S0140-6736(21)00439-6"},{"key":"80985_CR4","doi-asserted-by":"crossref","unstructured":"Qianrui, H., Yue, L., Shusheng, L. & Yi, B. Signaling pathways and potential therapeutic targets in acute respiratory distress syndrome (ARDS). Respir. Res. 25 (2024).","DOI":"10.1186\/s12931-024-02678-5"},{"key":"80985_CR5","doi-asserted-by":"crossref","unstructured":"Jes\u00fas, V., Tamas, S., Giacomo, G. & Luigi, C. Redefining ARDS: a paradigm shift. Crit. Care 27 (2023).","DOI":"10.1186\/s13054-023-04699-w"},{"key":"80985_CR6","doi-asserted-by":"crossref","unstructured":"Charles, N. S. Pro-resolving lipid mediators are leads for resolution physiology. Nature 510 (2014).","DOI":"10.1038\/nature13479"},{"key":"80985_CR7","doi-asserted-by":"crossref","unstructured":"Edward, A. D. & Paul C, N. Eicosanoid storm in infection and inflammation. Nat. Rev. Immunol. 15 (2015).","DOI":"10.1038\/nri3859"},{"key":"80985_CR8","doi-asserted-by":"crossref","unstructured":"Carl, N. & Aihao, D. Nonresolving inflammation. Cell 140 (2010).","DOI":"10.1016\/j.cell.2010.02.029"},{"key":"80985_CR9","doi-asserted-by":"crossref","unstructured":"Luca, C., Nora, L. & Mojgan, M. Lipid mediators in critically ill patients: a step towards precision medicine. Front. Immunol. 11 (2020).","DOI":"10.3389\/fimmu.2020.599853"},{"key":"80985_CR10","doi-asserted-by":"crossref","unstructured":"Linda, O. et al. Genome-wide association analysis of plasma lipidome identifies 495 genetic associations. Nat. Commun. 14 (2023).","DOI":"10.1038\/s41467-023-42532-8"},{"key":"80985_CR11","doi-asserted-by":"crossref","unstructured":"Annelise, M. P. et al. Machine learning reveals serum sphingolipids as cholesterol-independent biomarkers of coronary artery disease. J. Clin. Investig. 130 (2019).","DOI":"10.1172\/JCI131838"},{"key":"80985_CR12","doi-asserted-by":"crossref","unstructured":"Rubina, T. & Samuli, R. Integrating lipidomics and genomics: emerging tools to understand cardiovascular diseases. Cell. Mol. Life Sci. 78 (2021).","DOI":"10.1007\/s00018-020-03715-4"},{"key":"80985_CR13","unstructured":"Mika, H. et al. Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients. Eur. Heart J. (2019)."},{"key":"80985_CR14","doi-asserted-by":"crossref","unstructured":"Stephen, B. et al. Guidelines for performing mendelian randomization investigations: update for summer 2023. Wellcome Open. Res. 4 (2020).","DOI":"10.12688\/wellcomeopenres.15555.2"},{"key":"80985_CR15","doi-asserted-by":"crossref","unstructured":"George, D. S. & Gibran, H. Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum. Mol. Genet. 23 (2014).","DOI":"10.1093\/hmg\/ddu328"},{"key":"80985_CR16","doi-asserted-by":"crossref","unstructured":"Gon\u00e7alo, R. A. et al. A map of human genome variation from population-scale sequencing. Nature 467 (2010).","DOI":"10.1038\/nature09534"},{"key":"80985_CR17","doi-asserted-by":"crossref","unstructured":"Gibran, H. et al. The MR-Base platform supports systematic causal inference across the human phenome. Elife 7 (2018).","DOI":"10.7554\/eLife.34408"},{"key":"80985_CR18","doi-asserted-by":"crossref","unstructured":"Stephen, B. & Simon, G. T. Avoiding bias from weak instruments in mendelian randomization studies. Int. J. Epidemiol. 40 (2011).","DOI":"10.1093\/ije\/dyr036"},{"key":"80985_CR19","doi-asserted-by":"crossref","unstructured":"Jim, R. B. et al. MendelianRandomization v0.5.0: updates to an R package for performing mendelian randomization analyses using summarized data. Wellcome Open. Res. 5 (2021).","DOI":"10.12688\/wellcomeopenres.16374.2"},{"key":"80985_CR20","doi-asserted-by":"crossref","unstructured":"Stephen, B., Adam, B. & Simon, G. T. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet. Epidemiol. 37 (2013).","DOI":"10.1002\/gepi.21758"},{"key":"80985_CR21","doi-asserted-by":"crossref","unstructured":"Stephen, B. & Simon, G. T. Interpreting findings from mendelian randomization using the MR-Egger method. Eur. J. Epidemiol. 32 (2017).","DOI":"10.1007\/s10654-017-0255-x"},{"key":"80985_CR22","doi-asserted-by":"crossref","unstructured":"Jack, B., George, D. S., Philip, C. & Stephen, B. H. Consistent estimation in mendelian randomization with some Invalid instruments using a weighted median estimator. Genet. Epidemiol. 40 (2016).","DOI":"10.1002\/gepi.21965"},{"key":"80985_CR23","doi-asserted-by":"crossref","unstructured":"Yang, Z., Zhipeng, L., Tasnim, C., Marilyn, C. & Wanqing, L. C. Habitual coffee intake and risk for nonalcoholic fatty liver disease: a two-sample mendelian randomization study. Eur. J. Nutr. 60 (2020).","DOI":"10.1007\/s00394-020-02369-z"},{"key":"80985_CR24","doi-asserted-by":"crossref","unstructured":"Alice, R. C. et al. Mendelian randomisation for mediation analysis: current methods and challenges for implementation. Eur. J. Epidemiol. 36 (2021).","DOI":"10.1007\/s10654-021-00757-1"},{"key":"80985_CR25","doi-asserted-by":"crossref","unstructured":"Jiaqin, Y. et al. Genetically predicted C-reactive protein mediates the association between rheumatoid arthritis and atlantoaxial subluxation. Front. Endocrinol. (Lausanne) 13 (2023).","DOI":"10.3389\/fendo.2022.1054206"},{"key":"80985_CR26","doi-asserted-by":"crossref","unstructured":"Gibran, H., Kate, T. & George, D. S. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet. 13 (2017).","DOI":"10.1371\/journal.pgen.1007149"},{"key":"80985_CR27","doi-asserted-by":"crossref","unstructured":"Jiang-Shan, T., Ning-Ning, L., Ting-Ting, G., Song, H. & Lu, H. Genetically predicted obesity and risk of deep vein thrombosis. Thromb. Res. 207 (2021).","DOI":"10.1016\/j.thromres.2021.08.026"},{"key":"80985_CR28","doi-asserted-by":"crossref","unstructured":"Marie, V., Chia-Yen, C., Benjamin, N. & Ron, D. Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases. Nat. Genet. 50 (2018).","DOI":"10.1038\/s41588-018-0099-7"},{"key":"80985_CR29","doi-asserted-by":"crossref","unstructured":"I, K. et al. HDL is the major source of vitamin E for type II pneumocytes. Free Radic. Biol. Med. 27 (1999).","DOI":"10.1016\/S0891-5849(99)00139-2"},{"key":"80985_CR30","doi-asserted-by":"crossref","unstructured":"M S, P. & L G, D. Lipoprotein-stimulated surfactant secretion in alveolar type II cells: mediation by heterotrimeric G proteins. Am. J. Physiol. 273 (1997).","DOI":"10.1152\/ajplung.1997.273.3.L634"},{"key":"80985_CR31","doi-asserted-by":"crossref","unstructured":"Shaun, M. P. et al. Effect of total cholesterol and statin therapy on mortality in ARDS patients: a secondary analysis of the SAILS and HARP-2 trials. Crit. Care 27 (2023).","DOI":"10.1186\/s13054-023-04387-9"},{"key":"80985_CR32","doi-asserted-by":"crossref","unstructured":"Ahilanandan, D., Rebecca, C. & Michael, P. W. G. & Anthony D, P. abnormal liver phosphatidylcholine synthesis revealed in patients with acute respiratory distress syndrome. J. Lipid Res. 59 (2018).","DOI":"10.1194\/jlr.P085050"},{"key":"80985_CR33","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","volume":"400","author":"LDJ Bos","year":"2022","unstructured":"Bos, L. D. J. & Ware, L. B. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet (London England). 400, 1145\u20131156 (2022).","journal-title":"Lancet (London England)"},{"key":"80985_CR34","doi-asserted-by":"publisher","first-page":"e1440","DOI":"10.1002\/ctm2.1440","volume":"13","author":"H Meng","year":"2023","unstructured":"Meng, H. et al. Deep phenotyping of the lipidomic response in COVID-19 and non-COVID-19 sepsis. Clin. Transl. Med. 13, e1440 (2023).","journal-title":"Clin. Transl. Med."},{"key":"80985_CR35","doi-asserted-by":"crossref","unstructured":"Tingting, H. et al. Phosphatidylethanolamine alleviates OX-LDL-induced macrophage inflammation by upregulating autophagy and inhibiting NLRP1 inflammasome activation. Free Radic. Biol. Med. 208 (2023).","DOI":"10.1016\/j.freeradbiomed.2023.08.031"},{"key":"80985_CR36","doi-asserted-by":"crossref","unstructured":"Xanthe, A. M. et al. Triglyceride breakdown from lipid droplets regulates the inflammatory response in macrophages. Proc. Natl. Acad. Sci. USA. 119 (2022).","DOI":"10.1073\/pnas.2114739119"},{"key":"80985_CR37","doi-asserted-by":"publisher","first-page":"L720","DOI":"10.1152\/ajplung.00396.2002","volume":"284","author":"T Nagase","year":"2003","unstructured":"Nagase, T. et al. A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 284, L720\u2013L726 (2003).","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"80985_CR38","doi-asserted-by":"publisher","first-page":"109637","DOI":"10.1016\/j.intimp.2022.109637","volume":"116","author":"Y Chen","year":"2023","unstructured":"Chen, Y. et al. Fexofenadine protects against lipopolysaccharide-induced acute lung injury by targeting cytosolic phospholipase A2. Int. Immunopharmacol. 116, 109637 (2023).","journal-title":"Int. Immunopharmacol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80985-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80985-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80985-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T16:19:04Z","timestamp":1732724344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80985-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,27]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["80985"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-80985-z","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,27]]},"assertion":[{"value":"25 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The information used in the current Mendelian randomization study is publically accessible. All original investigations had received ethical approval. The studies involving human participants were reviewed and approved by Ethics Committee of the China-Japan Friendship Hospital (NO.2023-ky-152). All methods were performed in accordance with the relevant guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29523"}}