{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:35:36Z","timestamp":1790566536085,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-80992-0","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T13:49:19Z","timestamp":1735566559000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Factors affecting fatigue progression in multiple sclerosis patients"],"prefix":"10.1038","volume":"14","author":[{"given":"Dima","family":"Machtoub","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Callie","family":"Fares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Sinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moustafa","family":"Al Hariri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rim","family":"Nehme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Chami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronny","family":"Joukhdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raya","family":"Tcheroyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim","family":"Adib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia J.","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"issue":"5","key":"80992_CR1","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1191\/1352458503ms943oa","volume":"9","author":"A Lerdal","year":"2003","unstructured":"Lerdal, A., Celius, E. G. & Moum, T. Fatigue and its association with sociodemographic variables among multiple sclerosis patients. Mult. Scler. 9(5), 509\u2013514 (2003).","journal-title":"Mult. Scler."},{"key":"80992_CR2","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.msard.2019.01.011","volume":"28","author":"S Rooney","year":"2019","unstructured":"Rooney, S., Wood, L., Moffat, F. & Paul, L. Prevalence of fatigue and its association with clinical features in progressive and non-progressive forms of multiple sclerosis. Mult. Scler. Relat. Disord. 28, 276\u2013282 (2019).","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"6","key":"80992_CR3","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1136\/jnnp-2018-320050","volume":"90","author":"ZM Manjaly","year":"2019","unstructured":"Manjaly, Z. M. et al. Pathophysiological and cognitive mechanisms of fatigue in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 90(6), 642\u2013651 (2019).","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"80992_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102585","volume":"46","author":"I Kister","year":"2020","unstructured":"Kister, I., Bacon, T. & Cutter, G. R. A longitudinal study of symptom botheration in multiple sclerosis. Mult. Scler. Relat. Disord. 46, 102585 (2020).","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"4","key":"80992_CR5","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s13760-013-0198-2","volume":"113","author":"M Ghajarzadeh","year":"2013","unstructured":"Ghajarzadeh, M. et al. Fatigue in multiple sclerosis: Relationship with disease duration, physical disability, disease pattern, age and sex. Acta neurologica Belgica 113(4), 411\u2013414 (2013).","journal-title":"Acta neurologica Belgica"},{"issue":"2","key":"80992_CR6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.7224\/1537-2073.2015-070","volume":"18","author":"KM Fiest","year":"2016","unstructured":"Fiest, K. M. et al. Fatigue and comorbidities in multiple sclerosis. Int. J. MS Care 18(2), 96\u2013104 (2016).","journal-title":"Int. J. MS Care"},{"issue":"1","key":"80992_CR7","doi-asserted-by":"publisher","first-page":"14","DOI":"10.7224\/1537-2073-10.1.14","volume":"10","author":"SJ Forwell","year":"2008","unstructured":"Forwell, S. J. et al. Primary and nonprimary fatigue in multiple sclerosis. Int. J. MS Care 10(1), 14\u201320 (2008).","journal-title":"Int. J. MS Care"},{"issue":"5","key":"80992_CR8","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3109\/00207454.2013.833198","volume":"124","author":"B Yamout","year":"2014","unstructured":"Yamout, B. et al. Multiple sclerosis in the Levant: A regional consensus statement. Int. J. Neurosci. 124(5), 377\u2013382 (2014).","journal-title":"Int. J. Neurosci."},{"key":"80992_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102963","volume":"52","author":"M Zeineddine","year":"2021","unstructured":"Zeineddine, M. et al. Epidemiology of multiple sclerosis in Lebanon: A rising prevalence in the middle east. Mult. Scler. Relat. Disord. 52, 102963 (2021).","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"4","key":"80992_CR10","first-page":"205521731988798","volume":"5","author":"V Meca-Lallana","year":"2019","unstructured":"Meca-Lallana, V. et al. Assessing fatigue in multiple sclerosis: Psychometric properties of the five-item Modified Fatigue Impact Scale (MFIS-5). Mult. Scler. J. Exp. Transl. Clin. 5(4), 2055217319887987 (2019).","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"key":"80992_CR11","volume":"49","author":"F Tustumi","year":"2022","unstructured":"Tustumi, F. Choosing the most appropriate cut-point for continuous variables. Rev. Col. Bras. Cir. 49, e20223346 (2022).","journal-title":"Rev. Col. Bras. Cir."},{"issue":"2","key":"80992_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.5127\/jep.008310","volume":"2","author":"J DeCoster","year":"2011","unstructured":"DeCoster, J., Gallucci, M. & Iselin, A.-M.R. Best practices for using median splits, artificial categorization, and their continuous alternatives. J. Exp. Psychopathol. 2(2), 197\u2013209 (2011).","journal-title":"J. Exp. Psychopathol."},{"issue":"1","key":"80992_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/bs.3830190102","volume":"19","author":"LR Derogatis","year":"1974","unstructured":"Derogatis, L. R. et al. The Hopkins symptom checklist (HSCL): A self-report symptom inventory. Behav. Sci. 19(1), 1\u201315 (1974).","journal-title":"Behav. Sci."},{"issue":"4","key":"80992_CR14","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1177\/13524585211023352","volume":"28","author":"TR Valentine","year":"2022","unstructured":"Valentine, T. R., Alschuler, K. N., Ehde, D. M. & Kratz, A. L. Prevalence, co-occurrence, and trajectories of pain, fatigue, depression, and anxiety in the year following multiple sclerosis diagnosis. Mult. Sclerosis J. 28(4), 620\u2013631 (2022).","journal-title":"Mult. Sclerosis J."},{"issue":"11","key":"80992_CR15","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1007\/s00415-006-0247-3","volume":"253","author":"N T\u00e9llez","year":"2006","unstructured":"T\u00e9llez, N. et al. Fatigue in multiple sclerosis persists over time: A longitudinal study. J. Neurol. 253(11), 1466\u20131470 (2006).","journal-title":"J. Neurol."},{"key":"80992_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101401","volume":"36","author":"K Hanken","year":"2019","unstructured":"Hanken, K. et al. Fatigue in Multiple Sclerosis is related to relapses, autonomic dysfunctions and introversion: A quasi-experimental study. Mult. Sclerosis Relat. Disord. 36, 101401 (2019).","journal-title":"Mult. Sclerosis Relat. Disord."},{"key":"80992_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.817256","volume":"12","author":"J Tarasiuk","year":"2021","unstructured":"Tarasiuk, J. et al. Co-occurrence of fatigue and depression in people with multiple sclerosis: A mini-review. Front. Neurol. 12, 817256 (2021).","journal-title":"Front. Neurol."},{"key":"80992_CR18","doi-asserted-by":"crossref","unstructured":"Stamoula, E., et al. Antidepressants on multiple sclerosis: A review of in vitro and in vivo models. Front. Immunol. 12 (2021).","DOI":"10.3389\/fimmu.2021.677879"},{"key":"80992_CR19","first-page":"cd007295","volume":"2","author":"MW Koch","year":"2011","unstructured":"Koch, M. W. et al. Pharmacologic treatment of depression in multiple sclerosis. Cochrane Database Syst. Rev. 2, cd007295 (2011).","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"80992_CR20","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/S1474-4422(20)30354-9","volume":"20","author":"B Nourbakhsh","year":"2021","unstructured":"Nourbakhsh, B. et al. Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial. Lancet Neurol. 20(1), 38\u201348 (2021).","journal-title":"Lancet Neurol."},{"issue":"1","key":"80992_CR21","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1037\/rep0000027","volume":"60","author":"D Amtmann","year":"2015","unstructured":"Amtmann, D. et al. Pain affects depression through anxiety, fatigue, and sleep in multiple sclerosis. Rehabil. Psychol. 60(1), 81\u201390 (2015).","journal-title":"Rehabil. Psychol."},{"issue":"2","key":"80992_CR22","first-page":"205521732311670","volume":"9","author":"A Salter","year":"2023","unstructured":"Salter, A. et al. Severity and worsening of fatigue among individuals with multiple sclerosis. Mult. Scler. J. Exp. Transl. Clin. 9(2), 20552173231167080 (2023).","journal-title":"Mult. Scler. J. Exp. Transl. Clin."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80992-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80992-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80992-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T02:03:28Z","timestamp":1735610608000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-80992-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["80992"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-80992-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3428873\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"10 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31682"}}