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All research was performed in accordance with relevant guidelines and regulations in accordance with the Declaration of Helsinki. The specimens were collected during autopsy for routine histological examination and preserved in the Biobank Borealis of Northern Finland. The use of myocardial tissue obtained from the medicolegal autopsies as case control samples was approved by the Finnish Institute for Health and Welfare (THL\/873\/5.05.00\/2023; THL\/697\/5.05.00\/2017). Consent from next of kin or from the donor was waived by the Ethics Committee since according to the Finnish law, during post-mortem examinations, samples removed can also be used for medical research other than that related to investigation of the cause of death.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29476"}}