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Y.K. received research grants from MSD life foundation and personal fees from GSK, Novartis Pharma, AstraZeneca, Sanofi, and Kyorin. K.F. received research grants from Novartis Pharma and GSK. S.F. received personal fees from AstraZeneca and Eli Lilly. H.O. received a research grant from Boehringer Ingelheim. A.N. reports personal fees from Astellas, AstraZeneca, Kyorin, GSK, MSD, Shionogi, Bayer, Sanofi, Taiho, and Boehringer Ingelheim, and research grants from Astellas, Kyorin, Boehringer Ingelheim, Novartis, MSD, Daiichi Sankyo, Taiho, Teijin, Ono, Takeda, and Sanofi Pharmaceutical. R.K., T. A., Y.I., Y. A., T. S., K.I., Y. M., T. U., T.T., or T.S. did not receive any grants or personal fees.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the ethics committee of Nagoya City University (60-18-0012) and registered in the UMIN Clinical Trials Registry (Registry ID UMIN000032497). 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