{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T16:53:08Z","timestamp":1793379188893,"version":"4.5.0"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"European Union MSCA Doctoral Networks","award":["101167421"],"award-info":[{"award-number":["101167421"]}]},{"DOI":"10.13039\/501100003770","name":"Banca d\u2019Italia","doi-asserted-by":"publisher","award":["30166604"],"award-info":[{"award-number":["30166604"]}],"id":[{"id":"10.13039\/501100003770","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Associazione Italiana Sindrome Fibromialgica"},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["Bando Ricerca Corrente (2024)"],"award-info":[{"award-number":["Bando Ricerca Corrente (2024)"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-81298-x","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T11:05:09Z","timestamp":1733310309000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mitochondrial function in patients affected with fibromyalgia syndrome is impaired and correlates with disease severity"],"prefix":"10.1038","volume":"14","author":[{"given":"Chiara","family":"Macchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Giachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Fichtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Pedretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piercarlo","family":"Sarzi-Puttini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Mitro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Corsini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Ruscica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Gualtierotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"issue":"15","key":"81298_CR1","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1001\/jama.2014.3266","volume":"311","author":"DJ Clauw","year":"2014","unstructured":"Clauw, D. J. Fibromyalgia: A clinical review. JAMA. 311(15), 1547\u20131555 (2014).","journal-title":"JAMA."},{"issue":"2","key":"81298_CR2","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1002\/art.1780330203","volume":"33","author":"F Wolfe","year":"1990","unstructured":"Wolfe, F. et al. The American college of rheumatology 1990 criteria for the classification of fibromyalgia. Report of the multicenter criteria committee. Arthritis Rheum. 33(2), 160\u2013172 (1990).","journal-title":"Arthritis Rheum."},{"issue":"3","key":"81298_CR3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","volume":"46","author":"F Wolfe","year":"2016","unstructured":"Wolfe, F. et al. 2016 Revisions to the 2010\/2011 fibromyalgia diagnostic criteria. Semin. Arthritis Rheum. 46(3), 319\u2013329 (2016).","journal-title":"Semin. Arthritis Rheum."},{"issue":"5","key":"81298_CR4","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1002\/acr.21896","volume":"65","author":"A Vincent","year":"2013","unstructured":"Vincent, A. et al. Prevalence of fibromyalgia: A population-based study in Olmsted county, Minnesota, utilizing the rochester epidemiology project. Arthritis Care Res. (Hoboken). 65(5), 786\u2013792 (2013).","journal-title":"Arthritis Care Res. (Hoboken)."},{"issue":"3","key":"81298_CR5","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.berh.2007.03.003","volume":"21","author":"J McBeth","year":"2007","unstructured":"McBeth, J. & Jones, K. Epidemiology of chronic musculoskeletal pain. Best Pract. Res. Clin. Rheumatol. 21(3), 403\u2013425 (2007).","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"7","key":"81298_CR6","first-page":"1570","volume":"26","author":"KP White","year":"1999","unstructured":"White, K. P., Speechley, M., Harth, M. & Ostbye, T. The London fibromyalgia epidemiology study: the prevalence of fibromyalgia syndrome in London. Ontario. J. Rheumatol. 26(7), 1570\u20131576 (1999).","journal-title":"Ontario. J. Rheumatol."},{"key":"81298_CR7","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1186\/1472-6963-10-102","volume":"10","author":"E Choy","year":"2010","unstructured":"Choy, E. et al. A patient survey of the impact of fibromyalgia and the journey to diagnosis. BMC Health Serv. Res. 10, 102 (2010).","journal-title":"BMC Health Serv. Res."},{"issue":"11","key":"81298_CR8","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1038\/s41584-020-00506-w","volume":"16","author":"P Sarzi-Puttini","year":"2020","unstructured":"Sarzi-Puttini, P., Giorgi, V., Marotto, D. & Atzeni, F. Fibromyalgia: An update on clinical characteristics, aetiopathogenesis and treatment. Nat. Rev. Rheumatol. 16(11), 645\u2013660 (2020).","journal-title":"Nat. Rev. Rheumatol."},{"issue":"12","key":"81298_CR9","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1007\/s10067-023-06778-3","volume":"42","author":"B Ghavidel-Parsa","year":"2023","unstructured":"Ghavidel-Parsa, B. & Bidari, A. The crosstalk of the pathophysiologic models in fibromyalgia. Clin. Rheumatol. 42(12), 3177\u20133187 (2023).","journal-title":"Clin. Rheumatol."},{"issue":"3 Suppl","key":"81298_CR10","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","volume":"152","author":"CJ Woolf","year":"2011","unstructured":"Woolf, C. J. Central sensitization: implications for the diagnosis and treatment of pain. Pain 152(3 Suppl), S2-s15 (2011).","journal-title":"Pain"},{"issue":"11","key":"81298_CR11","volume":"13","author":"F Wolfe","year":"2021","unstructured":"Wolfe, F. & Rasker, J. J. The evolution of fibromyalgia, its concepts, and criteria. Cureus. 13(11), e20010 (2021).","journal-title":"Cureus."},{"issue":"4","key":"81298_CR12","doi-asserted-by":"publisher","first-page":"2349","DOI":"10.1152\/physrev.00058.2021","volume":"103","author":"JS Harrington","year":"2023","unstructured":"Harrington, J. S., Ryter, S. W., Plataki, M., Price, D. R. & Choi, A. M. K. Mitochondria in health, disease, and aging. Physiol. Rev. 103(4), 2349\u20132422 (2023).","journal-title":"Physiol. Rev."},{"issue":"10","key":"81298_CR13","doi-asserted-by":"publisher","first-page":"4202","DOI":"10.1007\/s12035-020-01996-1","volume":"57","author":"EDS Brum","year":"2020","unstructured":"Brum, E. D. S. et al. Relevance of mitochondrial dysfunction in the reserpine-induced experimental fibromyalgia model. Mol. Neurobiol. 57(10), 4202\u20134217 (2020).","journal-title":"Mol. Neurobiol."},{"key":"81298_CR14","doi-asserted-by":"crossref","unstructured":"Favero, G., Bonomini, F., Franco, C., Rezzani, R. Mitochondrial dysfunction in skeletal muscle of a fibromyalgia model: The potential benefits of melatonin. Int. J. Mol. Sci. 20(3), (2019).","DOI":"10.3390\/ijms20030765"},{"issue":"8","key":"81298_CR15","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1002\/j.1532-2149.2013.00284.x","volume":"17","author":"B Gerdle","year":"2013","unstructured":"Gerdle, B. et al. Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients\u2013a 31P-MRS study. Eur. J. Pain. 17(8), 1205\u20131215 (2013).","journal-title":"Eur. J. Pain."},{"key":"81298_CR16","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.121440","volume":"321","author":"PC Da Rosa","year":"2023","unstructured":"Da Rosa, P. C., Bertomeu, J. B., Royes, L. F. F. & Osiecki, R. The physical exercise-induced oxidative\/inflammatory response in peripheral blood mononuclear cells: Signaling cellular energetic stress situations. Life Sci. 321, 121440 (2023).","journal-title":"Life Sci."},{"issue":"2","key":"81298_CR17","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1152\/japplphysiol.00777.2018","volume":"126","author":"CP Hedges","year":"2019","unstructured":"Hedges, C. P. et al. Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men. J. Appl. Physiol. 126(2), 454\u2013461 (2019).","journal-title":"J. Appl. Physiol."},{"issue":"7","key":"81298_CR18","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.nmd.2015.03.001","volume":"25","author":"GS Gorman","year":"2015","unstructured":"Gorman, G. S. et al. Perceived fatigue is highly prevalent and debilitating in patients with mitochondrial disease. Neuromuscul. Disord. 25(7), 563\u2013566 (2015).","journal-title":"Neuromuscul. Disord."},{"issue":"6","key":"81298_CR19","first-page":"1215","volume":"42","author":"L Israel","year":"2024","unstructured":"Israel, L. et al. Mitochondrial structural alterations in fibromyalgia: A pilot electron microscopy study. Clin. Exp. Rheumatol. 42(6), 1215\u20131223 (2024).","journal-title":"Clin. Exp. Rheumatol."},{"issue":"2","key":"81298_CR20","first-page":"369","volume":"30","author":"F Wolfe","year":"2003","unstructured":"Wolfe, F. Pain extent and diagnosis: development and validation of the regional pain scale in 12,799 patients with rheumatic disease. J. Rheumatol. 30(2), 369\u2013378 (2003).","journal-title":"J. Rheumatol."},{"key":"81298_CR21","doi-asserted-by":"crossref","unstructured":"Audano, M., Pedretti, S., Cermenati, G., Brioschi, E., Diaferia, G. R., Ghisletti, S., et al. Zc3h10 is a novel mitochondrial regulator. EMBO Rep. 19(4), (2018).","DOI":"10.15252\/embr.201745531"},{"issue":"6","key":"81298_CR22","doi-asserted-by":"publisher","first-page":"104435","DOI":"10.1016\/j.isci.2022.104435","volume":"25","author":"C Macchi","year":"2022","unstructured":"Macchi, C. et al. Monocarboxylate transporter 1 deficiency impacts CD8(+) T lymphocytes proliferation and recruitment to adipose tissue during obesity. iScience 25(6), 104435 (2022).","journal-title":"iScience"},{"issue":"1","key":"81298_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1038\/s41514-023-00130-4","volume":"10","author":"JK Ehinger","year":"2024","unstructured":"Ehinger, J. K. et al. Mitochondrial function in peripheral blood cells across the human lifespan. NPJ Aging. 10(1), 10 (2024).","journal-title":"NPJ Aging."},{"key":"81298_CR24","doi-asserted-by":"crossref","unstructured":"Greco, M. F., Rizzuto, A. S., Zar\u00e0, M., Cafora, M., Favero, C., Solazzo, G., et al. PCSK9 confers inflammatory properties to extracellular vesicles released by vascular smooth muscle cells. Int J Mol Sci. 23(21), (2022).","DOI":"10.3390\/ijms232113065"},{"issue":"6","key":"81298_CR25","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1042\/CS20140101","volume":"127","author":"BK Chacko","year":"2014","unstructured":"Chacko, B. K. et al. The bioenergetic health index: A new concept in mitochondrial translational research. Clin Sci (Lond). 127(6), 367\u2013373 (2014).","journal-title":"Clin Sci (Lond)."},{"key":"81298_CR26","unstructured":"Rosner, B. Fundamentals of biostatistics. 7th ed. Boston: Brooks\/Cole, Cengage Learning; (2011)."},{"issue":"8","key":"81298_CR27","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.3899\/jrheum.141519","volume":"42","author":"F Wolfe","year":"2015","unstructured":"Wolfe, F., Walitt, B. T., Rasker, J. J., Katz, R. S. & H\u00e4user, W. The use of polysymptomatic distress categories in the evaluation of fibromyalgia (FM) and FM severity. J. Rheumatol. 42(8), 1494\u20131501 (2015).","journal-title":"J. Rheumatol."},{"issue":"11","key":"81298_CR28","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1093\/gerona\/glu096","volume":"70","author":"DJ Tyrrell","year":"2015","unstructured":"Tyrrell, D. J. et al. Respirometric profiling of muscle mitochondria and blood cells are associated with differences in gait speed among community-dwelling older adults. J. Gerontol. A Biol. Sci. Med. Sci. 70(11), 1394\u20131399 (2015).","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"81298_CR29","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.redox.2016.09.009","volume":"10","author":"DJ Tyrrell","year":"2016","unstructured":"Tyrrell, D. J., Bharadwaj, M. S., Jorgensen, M. J., Register, T. C. & Molina, A. J. Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health. Redox. Biol. 10, 65\u201377 (2016).","journal-title":"Redox. Biol."},{"issue":"10","key":"81298_CR30","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1007\/s00421-017-3684-z","volume":"117","author":"C Busquets-Cort\u00e9s","year":"2017","unstructured":"Busquets-Cort\u00e9s, C. et al. Training and acute exercise modulates mitochondrial dynamics in football players\u2019 blood mononuclear cells. Eur. J. Appl. Physiol. 117(10), 1977\u20131987 (2017).","journal-title":"Eur. J. Appl. Physiol."},{"issue":"1","key":"81298_CR31","doi-asserted-by":"publisher","first-page":"R17","DOI":"10.1186\/ar2918","volume":"12","author":"MD Cordero","year":"2010","unstructured":"Cordero, M. D. et al. Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: Implications in the pathogenesis of the disease. Arthritis. Res. Ther. 12(1), R17 (2010).","journal-title":"Arthritis. Res. Ther."},{"issue":"13\u201314","key":"81298_CR32","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1016\/j.clinbiochem.2010.06.013","volume":"43","author":"MD Cordero","year":"2010","unstructured":"Cordero, M. D. et al. Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients. Clin. Biochem. 43(13\u201314), 1174\u20131176 (2010).","journal-title":"Clin. Biochem."},{"issue":"10","key":"81298_CR33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026915","volume":"6","author":"MD Cordero","year":"2011","unstructured":"Cordero, M. D. et al. Clinical symptoms in fibromyalgia are better associated to lipid peroxidation levels in blood mononuclear cells rather than in plasma. PLoS One. 6(10), e26915 (2011).","journal-title":"PLoS One."},{"issue":"5","key":"81298_CR34","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.nmd.2020.02.017","volume":"30","author":"J van den Ameele","year":"2020","unstructured":"van den Ameele, J. et al. Chronic pain is common in mitochondrial disease. Neuromuscul. Disord. 30(5), 413\u2013419 (2020).","journal-title":"Neuromuscul. Disord."},{"key":"81298_CR35","doi-asserted-by":"publisher","first-page":"6627864","DOI":"10.1155\/2021\/6627864","volume":"2021","author":"G Chelimsky","year":"2021","unstructured":"Chelimsky, G. et al. Impaired mitochondrial bioenergetics function in pediatric chronic overlapping pain conditions with functional gastrointestinal disorders. Pain Res. Manag. 2021, 6627864 (2021).","journal-title":"Pain Res. Manag."},{"issue":"4","key":"81298_CR36","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1016\/j.neuron.2021.11.020","volume":"110","author":"M van der Vlist","year":"2022","unstructured":"van der Vlist, M. et al. Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain. Neuron. 110(4), 613\u201326.e9 (2022).","journal-title":"Neuron."},{"key":"81298_CR37","doi-asserted-by":"crossref","unstructured":"van Eeden, C., Redmond, D., Mohazab, N., Larch\u00e9, M. J., Mason, A. L., Cohen Tervaert, J. W., et al. Evidence of a Novel Mitochondrial Signature in Systemic Sclerosis Patients with Chronic Fatigue Syndrome. Int. J. Mol. Sci. 24(15), (2023).","DOI":"10.3390\/ijms241512057"},{"key":"81298_CR38","doi-asserted-by":"publisher","first-page":"9577874","DOI":"10.1155\/2021\/9577874","volume":"2021","author":"J Sun","year":"2021","unstructured":"Sun, J. et al. Nrf2 activation attenuates chronic constriction injury-induced neuropathic pain via Induction of PGC-1\u03b1-mediated mitochondrial biogenesis in the spinal cord. Oxid. Med. Cell Longev. 2021, 9577874 (2021).","journal-title":"Oxid. Med. Cell Longev."},{"issue":"1","key":"81298_CR39","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s12031-012-9848-8","volume":"49","author":"MV Ivannikov","year":"2013","unstructured":"Ivannikov, M. V., Sugimori, M. & Llin\u00e1s, R. R. Synaptic vesicle exocytosis in hippocampal synaptosomes correlates directly with total mitochondrial volume. J. Mol. Neurosci. 49(1), 223\u2013230 (2013).","journal-title":"J. Mol. Neurosci."},{"issue":"6","key":"81298_CR40","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/s00018-023-04814-8","volume":"80","author":"FV Duarte","year":"2023","unstructured":"Duarte, F. V., Ciampi, D. & Duarte, C. B. Mitochondria as central hubs in synaptic modulation. Cell Mol. Life Sci. 80(6), 173 (2023).","journal-title":"Cell Mol. Life Sci."},{"key":"81298_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2024.110083","volume":"758","author":"F Inferrera","year":"2024","unstructured":"Inferrera, F. et al. Impaired mitochondrial quality control in fibromyalgia: Mechanisms involved in skeletal muscle alteration. Arch Biochem Biophys. 758, 110083 (2024).","journal-title":"Arch Biochem Biophys."},{"issue":"7","key":"81298_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2024.167301","volume":"1870","author":"Y Marino","year":"2024","unstructured":"Marino, Y. et al. Role of mitochondrial dysfunction and biogenesis in fibromyalgia syndrome: Molecular mechanism in central nervous system. Biochim. Biophys. Acta Mol. Basis. Dis. 1870(7), 167301 (2024).","journal-title":"Biochim. Biophys. Acta Mol. Basis. Dis."},{"key":"81298_CR43","doi-asserted-by":"crossref","unstructured":"Qiao, Y. S., Santanasto, A. J., Coen, P. M., Cawthon, P. M., Cummings, S. R., Forman, D. E., et al. Associations between skeletal muscle energetics and accelerometry-based performance fatigability: Study of muscle, mobility and aging. Aging Cell. e14015, (2023).","DOI":"10.1111\/acel.14015"},{"key":"81298_CR44","doi-asserted-by":"crossref","unstructured":"Lavorato, M., Loro, E., Debattisti, V., Khurana, T. S., Franzini-Armstrong, C. Elongated mitochondrial constrictions and fission in muscle fatigue. J. Cell Sci. 131(23), (2018).","DOI":"10.1242\/jcs.221028"},{"issue":"2","key":"81298_CR45","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s13167-022-00281-6","volume":"13","author":"L Koklesova","year":"2022","unstructured":"Koklesova, L. et al. Mitochondrial health quality control: Measurements and interpretation in the framework of predictive, preventive, and personalized medicine. EPMA J. 13(2), 177\u2013193 (2022).","journal-title":"EPMA J."},{"issue":"10","key":"81298_CR46","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1038\/s41588-023-01505-9","volume":"55","author":"W Lee","year":"2023","unstructured":"Lee, W. et al. Molecular basis for maternal inheritance of human mitochondrial DNA. Nat Genet. 55(10), 1632\u20131639 (2023).","journal-title":"Nat Genet."},{"key":"81298_CR47","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2147\/OARRR.S257470","volume":"12","author":"A Mart\u00ednez-Lara","year":"2020","unstructured":"Mart\u00ednez-Lara, A. et al. Mitochondrial imbalance as a new approach to the study of fibromyalgia. Open Access Rheumatol. 12, 175\u2013185 (2020).","journal-title":"Open Access Rheumatol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81298-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81298-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81298-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T12:13:46Z","timestamp":1737980026000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81298-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,4]]},"references-count":47,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["81298"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-81298-x","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-4654793\/v1","asserted-by":"object"}]},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,4]]},"assertion":[{"value":"28 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2025","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Update","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The original online version of this Article was revised: In the original version of this Article, the author name P. Sarzi-Puttini was incorrectly indexed. The original Article has been corrected.","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"30247"}}