{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:33:34Z","timestamp":1789184014570,"version":"build-2803163510"},"reference-count":98,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/07618-6"],"award-info":[{"award-number":["2019\/07618-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/26015-8"],"award-info":[{"award-number":["2018\/26015-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/16935-7"],"award-info":[{"award-number":["2016\/16935-7"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/00715-0"],"award-info":[{"award-number":["2017\/00715-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/07467-1"],"award-info":[{"award-number":["2013\/07467-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/03657-8"],"award-info":[{"award-number":["2012\/03657-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/50411-5"],"award-info":[{"award-number":["2016\/50411-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["312469\/2018-7"],"award-info":[{"award-number":["312469\/2018-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302703\/2017-9"],"award-info":[{"award-number":["302703\/2017-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005942","name":"Funda\u00e7\u00e3o Butantan","doi-asserted-by":"publisher","award":["001\/0708\/000.223\/2024"],"award-info":[{"award-number":["001\/0708\/000.223\/2024"]}],"id":[{"id":"10.13039\/501100005942","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CONICET\/FAPESP","award":["2016"],"award-info":[{"award-number":["2016"]}]},{"name":"CONICET\/FAPESP","award":["2016"],"award-info":[{"award-number":["2016"]}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"Agencia I+D+i","doi-asserted-by":"crossref","award":["PICT-2020-SERIEA-02027"],"award-info":[{"award-number":["PICT-2020-SERIEA-02027"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-81851-8","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T14:22:47Z","timestamp":1735568567000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Jararaca GPIb-binding protein causes thrombocytopenia during Bothrops jararaca envenomation"],"prefix":"10.1038","volume":"14","author":[{"given":"Marcelo Larami","family":"Santoro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Teresa Azevedo","family":"Sachetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Gomes","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Jos\u00e9 Soares","family":"Torquato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Andrade-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilza","family":"Trevisan-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia Zaccanini","family":"de Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange M. T.","family":"Serrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e2nia Gomes","family":"de Moura Mattaraia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparecida Sadae","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elisa","family":"Peichoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,30]]},"reference":[{"key":"81851_CR1","doi-asserted-by":"publisher","first-page":"17063","DOI":"10.1038\/nrdp.2017.63","volume":"3","author":"JM Guti\u00e9rrez","year":"2017","unstructured":"Guti\u00e9rrez, J. M. et al. Snakebite envenoming. Nat. Rev. Dis. Primers 3, 17063 (2017).","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"8","key":"81851_CR2","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1016\/j.toxicon.2008.03.018","volume":"51","author":"ML Santoro","year":"2008","unstructured":"Santoro, M. L. et al. Haematological evaluation of patients bitten by the Jararaca, Bothrops jararaca, in Brazil. Toxicon 51(8), 1440\u20131448 (2008).","journal-title":"Toxicon"},{"key":"81851_CR3","first-page":"303","volume":"28","author":"IS Sano-Martins","year":"1995","unstructured":"Sano-Martins, I. S. et al. Hematological changes induced by Bothrops jararaca venom in dogs. Braz J. Med. Biol. Res. 28, 303\u2013312 (1995).","journal-title":"Braz J. Med. Biol. Res."},{"issue":"9","key":"81851_CR4","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1590\/S0100-736X2010000900003","volume":"30","author":"AP Arag\u00e3o","year":"2010","unstructured":"Arag\u00e3o, A. P. et al. Experimental poisoning by Bothropoides Jararaca and Bothrops jararacussu in sheep: clinic-pathological and laboratory aspects. Pesq Vet. Bras. 30(9), 717\u2013728 (2010).","journal-title":"Pesq Vet. Bras."},{"key":"81851_CR5","unstructured":"Da Costa, M. M. Envenenamento botr\u00f3pico Natural Fatal em Equinos no centro-oeste do Brasil: caracteriza\u00e7\u00e3o epidemiol\u00f3gica, cl\u00ednico-patol\u00f3gica e Ultraestrutural (Universidade de Bras\u00edlia, 2019)."},{"key":"81851_CR6","doi-asserted-by":"publisher","first-page":"107350","DOI":"10.1016\/j.toxicon.2023.107350","volume":"237","author":"AB Abad Ribeiro","year":"2024","unstructured":"Abad Ribeiro, A. B. et al. Hemoperitoneum after a Bothrops snakebite: Case report. Toxicon 237, 107350 (2024).","journal-title":"Toxicon"},{"issue":"11","key":"81851_CR7","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1177\/1535370215590818","volume":"240","author":"LV Senise","year":"2015","unstructured":"Senise, L. V., Yamashita, K. M. & Santoro, M. L. Bothrops jararaca envenomation: Pathogenesis of hemostatic disturbances and intravascular hemolysis. Exp. Biol. Med. (Maywood) 240(11), 1528\u20131536 (2015).","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"5","key":"81851_CR8","doi-asserted-by":"publisher","first-page":"e2814","DOI":"10.1371\/journal.pntd.0002814","volume":"8","author":"KM Yamashita","year":"2014","unstructured":"Yamashita, K. M., Alves, A. F., Barbaro, K. C. & Santoro, M. L. Bothrops jararaca venom metalloproteinases are essential for coagulopathy and increase plasma tissue factor levels during envenomation. PLoS Negl. Trop. Dis. 8(5), e2814 (2014).","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"10","key":"81851_CR9","doi-asserted-by":"publisher","first-page":"e0006774","DOI":"10.1371\/journal.pntd.0006774","volume":"12","author":"ATA Sachetto","year":"2018","unstructured":"Sachetto, A. T. A., Rosa, J. G. & Santoro, M. L. Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararaca snake venom in mice. PLoS Negl. Trop. Dis. 12(10), e0006774 (2018).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"81851_CR10","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.thromres.2019.01.018","volume":"175","author":"CM Thomazini","year":"2019","unstructured":"Thomazini, C. M., Soares, R. P. S., da Rocha, T. R. F., Sachetto, A. T. A. & Santoro, M. L. Optimization of Von Willebrand factor multimer analysis in vertical mini-gel electrophoresis systems: a rapid procedure. Thromb. Res. 175, 76\u201383 (2019).","journal-title":"Thromb. Res."},{"key":"81851_CR11","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jprot.2016.06.029","volume":"151","author":"CA Nicolau","year":"2017","unstructured":"Nicolau, C. A. et al. An in-depth snake venom proteopeptidome characterization: Benchmarking Bothrops jararaca. J. Proteom. 151, 214\u2013231 (2017).","journal-title":"J. Proteom."},{"issue":"9","key":"81851_CR12","doi-asserted-by":"publisher","first-page":"e0009715","DOI":"10.1371\/journal.pntd.0009715","volume":"15","author":"CM Thomazini","year":"2021","unstructured":"Thomazini, C. M. et al. Involvement of Von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom. PLoS Negl. Trop. Dis. 15(9), e0009715 (2021).","journal-title":"PLoS Negl. Trop. Dis."},{"key":"81851_CR13","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.toxicon.2019.01.003","volume":"159","author":"JG Rosa","year":"2019","unstructured":"Rosa, J. G., de Albuquerque, C. Z., Mattaraia, V. G. M. & Santoro, M. L. Comparative study of platelet aggregation and secretion induced by Bothrops jararaca snake venom and thrombin. Toxicon 159, 50\u201360 (2019).","journal-title":"Toxicon"},{"issue":"21","key":"81851_CR14","doi-asserted-by":"publisher","first-page":"7186","DOI":"10.1021\/bi00021a033","volume":"34","author":"SM Serrano","year":"1995","unstructured":"Serrano, S. M., Mentele, R., Sampaio, C. A. & Fink, E. Purification, characterization, and amino acid sequence of a serine proteinase, PA-BJ, with platelet-aggregating activity from the venom of Bothrops jararaca. Biochemistry 34(21), 7186\u20137193 (1995).","journal-title":"Biochemistry"},{"issue":"3","key":"81851_CR15","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S0014-5793(00)01803-2","volume":"477","author":"BF Santos","year":"2000","unstructured":"Santos, B. F., Serrano, S. M., Kuliopulos, A. & Niewiarowski, S. Interaction of viper venom serine peptidases with thrombin receptors on human platelets. FEBS Lett. 477(3), 199\u2013202 (2000).","journal-title":"FEBS Lett."},{"issue":"9","key":"81851_CR16","doi-asserted-by":"publisher","first-page":"4514","DOI":"10.1073\/pnas.75.9.4514","volume":"75","author":"MS Read","year":"1978","unstructured":"Read, M. S., Shermer, R. W. & Brinkhous, K. M. Venom coagglutinin: an activator of platelet aggregation dependent on Von Willebrand factor. Proc. Natl. Acad. Sci. USA 75(9), 4514\u20134518 (1978).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"81851_CR17","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1182\/blood.V55.3.517.517","volume":"55","author":"KM Brinkhous","year":"1980","unstructured":"Brinkhous, K. M. & Read, M. S. Use of venom coagglutinin and lyophilized platelets in testing for platelet-aggregating Von Willebrand factor. Blood 55(3), 517\u2013520 (1980).","journal-title":"Blood"},{"issue":"3","key":"81851_CR18","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1073\/pnas.90.3.928","volume":"90","author":"Y Usami","year":"1993","unstructured":"Usami, Y. et al. Primary structure of two-chain botrocetin, a Von Willebrand factor modulator purified from the venom of Bothrops jararaca. Proc. Natl. Acad. Sci. USA 90(3), 928\u2013932 (1993).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"81851_CR19","doi-asserted-by":"publisher","first-page":"3469","DOI":"10.1182\/blood-2002-03-0806","volume":"101","author":"Y Wu","year":"2003","unstructured":"Wu, Y. et al. Interaction between Von Willebrand factor and glycoprotein ib activates src kinase in human platelets: role of phosphoinositide 3-kinase. Blood 101(9), 3469\u20133476 (2003).","journal-title":"Blood"},{"issue":"3","key":"81851_CR20","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1016\/0304-4165(94)00178-Z","volume":"1243","author":"Y Ozaki","year":"1995","unstructured":"Ozaki, Y. et al. Protein tyrosine phosphorylation in human platelets induced by interaction between glycoprotein ib and von Willebrand factor. Biochim. Biophys. Acta 1243(3), 482\u2013488 (1995).","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"81851_CR21","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/S0969-2126(02)00787-6","volume":"10","author":"K Fukuda","year":"2002","unstructured":"Fukuda, K. et al. Structural basis of Von Willebrand factor activation by the snake toxin botrocetin. Structure 10(7), 943\u2013950 (2002).","journal-title":"Structure"},{"key":"81851_CR22","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/j.1749-6632.1981.tb29732.x","volume":"370","author":"KM Brinkhous","year":"1981","unstructured":"Brinkhous, K. M., Read, M. S., Reddick, R. L. & Griggs, T. R. Pathophysiology of platelet-aggregating Von Willebrand factor: applications of the venom coagglutinin vWF assay. Ann. N Y Acad. Sci. 370, 191\u2013204 (1981).","journal-title":"Ann. N Y Acad. Sci."},{"key":"81851_CR23","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1073\/pnas.78.5.3230","volume":"78","author":"KM Brinkhous","year":"1981","unstructured":"Brinkhous, K. M., Barnes, D. S., Potter, J. Y. & Read, M. S. Von Willebrand syndrome induced by a Bothrops venom factor: bioassayfor venom coagglutinin. Proc. Natl. Acad. Sci. USA 78, 3230\u20133234 (1981).","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"6","key":"81851_CR24","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1161\/01.ATV.15.6.793","volume":"15","author":"WE Sanders","year":"1995","unstructured":"Sanders, W. E., Reddick, R. L., Nichols, T. C., Brinkhous, K. M. & Read, M. S. Thrombotic thrombocytopenia induced in dogs and pigs. The role of plasma and platelet vWF in animal models of thrombotic thrombocytopenic purpura. Arterioscler. Thromb. Vasc Biol. 15(6), 793\u2013800 (1995).","journal-title":"Arterioscler. Thromb. Vasc Biol."},{"issue":"4","key":"81851_CR25","first-page":"443","volume":"59","author":"WE Sanders","year":"1988","unstructured":"Sanders, W. E., Read, M. S., Reddick, R. L., Garris, J. B. & Brinkhous, K. M. Thrombotic thrombocytopenia with Von Willebrand factor deficiency induced by botrocetin - an animal model. Lab. Invest. 59(4), 443\u2013452 (1988).","journal-title":"Lab. Invest."},{"issue":"26","key":"81851_CR26","doi-asserted-by":"publisher","first-page":"5329","DOI":"10.1021\/bi300442c","volume":"51","author":"Y Yamamoto-Suzuki","year":"2012","unstructured":"Yamamoto-Suzuki, Y. et al. Identification and recombinant analysis of botrocetin-2, a snake venom cofactor for Von Willebrand factor-induced platelet agglutination. Biochemistry 51(26), 5329\u20135338 (2012).","journal-title":"Biochemistry"},{"issue":"3","key":"81851_CR27","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/jth.13617","volume":"15","author":"T Matsui","year":"2017","unstructured":"Matsui, T. et al. Mutant botrocetin-2 inhibits Von Willebrand factor-induced platelet agglutination. J. Thromb. Haemost 15(3), 538\u2013548 (2017).","journal-title":"J. Thromb. Haemost"},{"issue":"2","key":"81851_CR28","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1016\/S0021-9258(18)54041-2","volume":"268","author":"RM Scarborough","year":"1993","unstructured":"Scarborough, R. M. et al. Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms. J. Biol. Chem. 268(2), 1058\u20131065 (1993).","journal-title":"J. Biol. Chem."},{"issue":"2","key":"81851_CR29","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1006\/excr.1999.4583","volume":"251","author":"AL Coelho","year":"1999","unstructured":"Coelho, A. L. et al. Effects of jarastatin, a novel snake venom disintegrin, on neutrophil migration and actin cytoskeleton dynamics. Exp. Cell. Res. 251(2), 379\u2013387 (1999).","journal-title":"Exp. Cell. Res."},{"issue":"2","key":"81851_CR30","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.bbrc.2005.01.148","volume":"329","author":"JH Fernandez","year":"2005","unstructured":"Fernandez, J. H., Silva, C. A., Assakura, M. T., Camargo, A. C. & Serrano, S. M. Molecular cloning, functional expression, and molecular modeling of bothrostatin, a new highly active disintegrin from Bothrops jararaca venom. Biochem. Biophys. Res. Commun. 329(2), 457\u2013464 (2005).","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"2","key":"81851_CR31","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1055\/s-0038-1649807","volume":"74","author":"Y Fujimura","year":"1995","unstructured":"Fujimura, Y. et al. Isolation and characterization of Jararaca GPIb-BP, a snake venom antagonist specific to platelet glycoprotein ib. Thromb. Haemost 74(2), 743\u2013750 (1995).","journal-title":"Thromb. Haemost"},{"issue":"18","key":"81851_CR32","doi-asserted-by":"publisher","first-page":"10635","DOI":"10.1074\/jbc.271.18.10635","volume":"271","author":"T Kawasaki","year":"1996","unstructured":"Kawasaki, T. et al. Complete amino acid sequence and identification of the platelet glycoprotein Ib-binding site of Jararaca GPIb-BP, a snake venom protein isolated from Bothrops jararaca. J. Biol. Chem. 271(18), 10635\u201310639 (1996).","journal-title":"J. Biol. Chem."},{"issue":"3","key":"81851_CR33","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/0049-3848(90)90100-Q","volume":"58","author":"RB Zingali","year":"1990","unstructured":"Zingali, R. B., Carlini, C. R., Francischetti, I. M. & Guimaraes, J. A. Bothrops jararaca snake venom: effects on platelet aggregation. Thromb. Res. 58(3), 303\u2013316 (1990).","journal-title":"Thromb. Res."},{"issue":"1","key":"81851_CR34","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1006\/abbi.1999.1230","volume":"367","author":"SM Serrano","year":"1999","unstructured":"Serrano, S. M. et al. A novel phospholipase A2, BJ-PLA2, from the venom of the snake Bothrops jararaca: purification, primary structure analysis, and its characterization as a platelet-aggregation-inhibiting factor. Arch. Biochem. Biophys. 367(1), 26\u201332 (1999).","journal-title":"Arch. Biochem. Biophys."},{"key":"81851_CR35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40409-018-0170-y","volume":"24","author":"RCA Cedro","year":"2018","unstructured":"Cedro, R. C. A. et al. Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom. J. Venom. Anim. Toxins Incl. Trop. Dis. 24, 33 (2018).","journal-title":"J. Venom. Anim. Toxins Incl. Trop. Dis."},{"key":"81851_CR36","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.toxicon.2009.05.016","volume":"54","author":"ML Santoro","year":"2009","unstructured":"Santoro, M. L., Vaquero, T. S., Paes Leme, A. F. & Serrano, S. M. NPP-BJ, a nucleotide pyrophosphatase\/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation. Toxicon 54, 499\u2013512 (2009).","journal-title":"Toxicon"},{"issue":"32","key":"81851_CR37","doi-asserted-by":"publisher","first-page":"22869","DOI":"10.1016\/S0021-9258(18)50027-2","volume":"267","author":"MJ Paine","year":"1992","unstructured":"Paine, M. J., Desmond, H. P., Theakston, R. D. & Crampton, J. M. Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family. J. Biol. Chem. 267(32), 22869\u201322876 (1992).","journal-title":"J. Biol. Chem."},{"issue":"1\u20132","key":"81851_CR38","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0304-4165(96)00140-7","volume":"1335","author":"AS Kamiguti","year":"1997","unstructured":"Kamiguti, A. S. et al. Collagen-induced secretion-dependent phase of platelet aggregation is inhibited by the snake venom metalloproteinase jararhagin. Biochim. Biophys. Acta 1335(1\u20132), 209\u2013217 (1997).","journal-title":"Biochim. Biophys. Acta"},{"issue":"51","key":"81851_CR39","doi-asserted-by":"publisher","first-page":"32599","DOI":"10.1074\/jbc.272.51.32599","volume":"272","author":"AS Kamiguti","year":"1997","unstructured":"Kamiguti, A. S. et al. Proteolytic cleavage of the b1 subunit of platelet a2b1 integrin by the metalloproteinase jararhagin compromises collagen-stimulated phosphorylation of pp72syk. J. Biol. Chem. 272(51), 32599\u201332605 (1997).","journal-title":"J. Biol. Chem."},{"issue":"1","key":"81851_CR40","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1006\/bbrc.1994.1706","volume":"201","author":"Y Usami","year":"1994","unstructured":"Usami, Y. et al. A 28\u00a0kDa-protein with disintegrin-like structure (jararhagin-C) purified from Bothrops jararaca venom inhibits collagen- and ADP-induced platelet aggregation. Biochem. Biophys. Res. Commun. 201(1), 331\u2013339 (1994).","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"81851_CR41","doi-asserted-by":"crossref","unstructured":"Ulloa-Fernandez, A., Escalante, T., Gutierrez, J. M. & Rucavado, A. Platelet depletion enhances lethal, hemorrhagic and myotoxic activities of Bothrops asper snake venom in a murine model. Toxicon 106936. (2022).","DOI":"10.1016\/j.toxicon.2022.106936"},{"key":"81851_CR42","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0076-6879(09)63008-1","volume":"463","author":"JE Noble","year":"2009","unstructured":"Noble, J. E. & Bailey, M. J. Quantitation of protein. Methods Enzymol. 463, 73\u201395 (2009).","journal-title":"Methods Enzymol."},{"issue":"5259","key":"81851_CR43","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","volume":"227","author":"UK Laemmli","year":"1970","unstructured":"Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227(5259), 680\u2013685 (1970).","journal-title":"Nature"},{"issue":"2","key":"81851_CR44","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/elps.1150080203","volume":"8","author":"H Blum","year":"1987","unstructured":"Blum, H., Beier, H. & Gross, H. J. Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels. Electrophoresis 8(2), 93\u201399 (1987).","journal-title":"Electrophoresis"},{"issue":"3","key":"81851_CR45","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1177\/0023677213516312","volume":"48","author":"Felasa working group on revision of guidelines for health monitoring of rodents and rabbits","year":"2014","unstructured":"Felasa working group on revision of guidelines for health monitoring of rodents and rabbits et al. FELASA recommendations for the health monitoring of mouse, rat, hamster, guinea pig and rabbit colonies in breeding and experimental units. Lab. Anim. 48(3), 178\u2013192 (2014).","journal-title":"Lab. Anim."},{"key":"81851_CR46","unstructured":"Brasil Minist\u00e9rio da Ci\u00eancia Tecnologia e Inova\u00e7\u00e3o. Conselho Nacional De Controle De Experimenta\u00e7\u00e3o Animal. Guia brasileiro de produ\u00e7\u00e3o, manuten\u00e7\u00e3o ou utiliza\u00e7\u00e3o de animais em atividades de ensino ou pesquisa cient\u00edfica. 1 ed: Bras\u00edlia: Minist\u00e9rio Da Ci\u00eancia1107 (Tecnologia e Inova\u00e7\u00e3o, 2023)."},{"issue":"7","key":"81851_CR47","doi-asserted-by":"publisher","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","volume":"18","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert, N. et al. The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. PLoS Biol. 18(7), e3000410 (2020).","journal-title":"PLoS Biol."},{"key":"81851_CR48","first-page":"167","volume":"14","author":"LC Taborda","year":"1940","unstructured":"Taborda, L. C. A influ\u00eancia da temperatura sobre os princ\u00edpios toxico, coagulante e proteol\u00edtico do veneno de Bothrops jararaca. Mem. Inst. Butantan 14, 167\u2013180 (1940).","journal-title":"Mem. Inst. Butantan"},{"issue":"2","key":"81851_CR49","first-page":"316","volume":"37","author":"OD Ratnoff","year":"1951","unstructured":"Ratnoff, O. D. & Menzie, C. A new method for the determination of fibrinogen in small samples of plasma. J. Lab. Clin. Med. 37(2), 316\u2013320 (1951).","journal-title":"J. Lab. Clin. Med."},{"issue":"8","key":"81851_CR50","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1016\/j.toxicon.2010.08.011","volume":"56","author":"TC Antunes","year":"2010","unstructured":"Antunes, T. C., Yamashita, K. M., Barbaro, K. C., Saiki, M. & Santoro, M. L. Comparative analysis of newborn and adult Bothrops jararaca snake venoms. Toxicon 56(8), 1443\u20131458 (2010).","journal-title":"Toxicon"},{"key":"81851_CR51","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/194927b0","volume":"194","author":"GV Born","year":"1962","unstructured":"Born, G. V. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature 194, 927\u2013929 (1962).","journal-title":"Nature"},{"issue":"2","key":"81851_CR52","first-page":"369","volume":"92","author":"ML Santoro","year":"2004","unstructured":"Santoro, M. L. & Sano-Martins, I. S. Platelet dysfunction during Bothrops jararaca snake envenomation in rabbits. Thromb. Haemost 92(2), 369\u2013383 (2004).","journal-title":"Thromb. Haemost"},{"issue":"5","key":"81851_CR53","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nmeth.1322","volume":"6","author":"JR Wisniewski","year":"2009","unstructured":"Wisniewski, J. R., Zougman, A., Nagaraj, N. & Mann, M. Universal sample preparation method for proteome analysis. Nat. Methods 6(5), 359\u2013362 (2009).","journal-title":"Nat. Methods"},{"issue":"22","key":"81851_CR54","doi-asserted-by":"publisher","first-page":"11361","DOI":"10.1021\/acs.analchem.5b02721","volume":"87","author":"L He","year":"2015","unstructured":"He, L., Diedrich, J., Chu, Y. Y. & Yates, J. R. 3rd. Extracting accurate precursor information for tandem mass spectra by RawConverter. Anal. Chem. 87(22), 11361\u201311367 (2015).","journal-title":"Anal. Chem."},{"issue":"3","key":"81851_CR55","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1093\/molbev\/msu337","volume":"32","author":"IL Junqueira-de-Azevedo","year":"2015","unstructured":"Junqueira-de-Azevedo, I. L. et al. Venom-related transcripts from Bothrops jararaca tissues provide novel molecular insights into the production and evolution of snake venom. Mol. Biol. Evol. 32(3), 754\u2013766 (2015).","journal-title":"Mol. Biol. Evol."},{"key":"81851_CR56","doi-asserted-by":"crossref","unstructured":"Hanna, S. L., Sherman, N. E., Kinter, M. T. & Goldberg, J. B. Comparison of proteins expressed by Pseudomonas aeruginosa strains representing initial and chronic isolates from a cystic fibrosis patient: an analysis by 2-D gel electrophoresis and capillary column liquid chromatography-tandem mass spectrometry. Microbiol. (Reading) 146 (Pt 10)((Pt 10)):2495\u2009\u2013\u2009508  (2000).","DOI":"10.1099\/00221287-146-10-2495"},{"issue":"8","key":"81851_CR57","doi-asserted-by":"publisher","first-page":"1896","DOI":"10.1038\/nprot.2007.261","volume":"2","author":"J Rappsilber","year":"2007","unstructured":"Rappsilber, J., Mann, M. & Ishihama, Y. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nat. Protoc. 2(8), 1896\u20131906 (2007).","journal-title":"Nat. Protoc."},{"issue":"12","key":"81851_CR58","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","volume":"26","author":"J Cox","year":"2008","unstructured":"Cox, J. & Mann, M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat. Biotechnol. 26(12), 1367\u20131372 (2008).","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"81851_CR59","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1021\/pr101065j","volume":"10","author":"J Cox","year":"2011","unstructured":"Cox, J. et al. Andromeda: a peptide search engine integrated into the MaxQuant environment. J. Proteome Res. 10(4), 1794\u20131805 (2011).","journal-title":"J. Proteome Res."},{"issue":"Pt 6","key":"81851_CR60","doi-asserted-by":"publisher","first-page":"127279","DOI":"10.1016\/j.ijbiomac.2023.127279","volume":"253","author":"D Trevisan-Silva","year":"2023","unstructured":"Trevisan-Silva, D. et al. Systemic toxicity of snake venom metalloproteinases: multi-omics analyses of kidney and blood plasma disturbances in a mouse model. Int. J. Biol. Macromol. 253(Pt 6), 127279 (2023).","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"81851_CR61","first-page":"589","volume":"386","author":"JC Modesto","year":"2005","unstructured":"Modesto, J. C. et al. Insularinase A, a prothrombin activator from Bothrops insularis venom, is a metalloprotease derived from a gene encoding protease and disintegrin domains. Biol. Chem. 386(6), 589\u2013600 (2005).","journal-title":"Biol. Chem."},{"issue":"1","key":"81851_CR62","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.toxicon.2007.08.005","volume":"51","author":"C Baldo","year":"2008","unstructured":"Baldo, C. BnP1, a novel P-I metalloproteinase from Bothrops neuwiedi venom: Biological effects benchmarking relatively to jararhagin, a P-III SVMP\u2606. Toxicon 51(1), 54\u201365 (2008).","journal-title":"Toxicon"},{"issue":"5","key":"81851_CR63","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1055\/s-0038-1650636","volume":"76","author":"Y Fujimura","year":"1996","unstructured":"Fujimura, Y., Kawasaki, T. & Titani, K. Snake venom proteins modulating the interaction between Von Willebrand factor and platelet glycoprotein ib. Thromb. Haemost 76(5), 633\u2013639 (1996).","journal-title":"Thromb. Haemost"},{"issue":"5","key":"81851_CR64","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0041-0101(95)00012-B","volume":"33","author":"LC Mancuso","year":"1995","unstructured":"Mancuso, L. C. et al. Fractionation of Bothrops pirajai snake venom: isolation and characterization of piratoxin-I, a new myotoxic protein. Toxicon 33(5), 615\u2013626 (1995).","journal-title":"Toxicon"},{"issue":"12","key":"81851_CR65","doi-asserted-by":"publisher","first-page":"e28521","DOI":"10.1371\/journal.pone.0028521","volume":"6","author":"JI Dos Santos","year":"2011","unstructured":"Dos Santos, J. I. et al. Structural and functional studies of a bothropic myotoxin complexed to rosmarinic acid: new insights into Lys49-PLA2 inhibition. PLoS One 6(12), e28521 (2011).","journal-title":"PLoS One"},{"issue":"2","key":"81851_CR66","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.biochi.2005.07.008","volume":"88","author":"CA Bello","year":"2006","unstructured":"Bello, C. A. et al. Isolation and biochemical characterization of a fibrinolytic proteinase from Bothrops leucurus (white-tailed jararaca) snake venom. Biochimie 88(2), 189\u2013200 (2006).","journal-title":"Biochimie"},{"issue":"4","key":"81851_CR67","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.toxicon.2007.11.026","volume":"51","author":"AL Oliveira-Carvalho","year":"2008","unstructured":"Oliveira-Carvalho, A. L. et al. Identification and characterization of a new member of snake venom thrombin inhibitors from Bothrops insularis using a proteomic approach. Toxicon 51(4), 659\u2013671 (2008).","journal-title":"Toxicon"},{"issue":"8","key":"81851_CR68","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/0041-0101(92)90383-G","volume":"30","author":"M Maruyama","year":"1992","unstructured":"Maruyama, M., Sugiki, M., Yoshida, E., Mihara, H. & Nakajima, N. Purification and characterization of two fibrinolytic enzymes from Bothrops jararaca (Jararaca) venom. Toxicon 30(8), 853\u2013864 (1992).","journal-title":"Toxicon"},{"issue":"8","key":"81851_CR69","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1021\/acs.jproteome.6b00217","volume":"15","author":"D Andrade-Silva","year":"2016","unstructured":"Andrade-Silva, D. et al. Proteomic and glycoproteomic profilings reveal that post-translational modifications of toxins contribute to venom phenotype in snakes. J. Proteome Res. 15(8), 2658\u20132675 (2016).","journal-title":"J. Proteome Res."},{"issue":"3","key":"81851_CR70","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/095371000403116","volume":"11","author":"K Satoh","year":"2000","unstructured":"Satoh, K. et al. Activation of protein-tyrosine kinase pathways in human platelets stimulated with the A1 domain of Von Willebrand factor. Platelets 11(3), 171\u2013176 (2000).","journal-title":"Platelets"},{"issue":"12","key":"81851_CR71","doi-asserted-by":"publisher","first-page":"3836","DOI":"10.1182\/blood.V97.12.3836","volume":"97","author":"Y Wu","year":"2001","unstructured":"Wu, Y. et al. Role of fc receptor g-chain in platelet glycoprotein Ib-mediated signaling. Blood 97(12), 3836\u20133845 (2001).","journal-title":"Blood"},{"issue":"9","key":"81851_CR72","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1182\/blood.V81.9.2321.2321","volume":"81","author":"M Peng","year":"1993","unstructured":"Peng, M., Lu, W., Beviglia, L., Niewiarowski, S. & Kirby, E. P. Echicetin: a snake venom protein that inhibits binding of Von Willebrand factor and alboaggregins to platelet glycoprotein ib. Blood 81(9), 2321\u20132328 (1993).","journal-title":"Blood"},{"issue":"Pt 3","key":"81851_CR73","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1042\/bj3080947","volume":"308","author":"T Kawasaki","year":"1995","unstructured":"Kawasaki, T. et al. Tokaracetin, a new platelet antagonist that binds to platelet glycoprotein ib and inhibits Von Willebrand factor-dependent shear-induced platelet aggregation. Biochem. J. 308(Pt 3), 947\u2013953 (1995).","journal-title":"Biochem. J."},{"issue":"4","key":"81851_CR74","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1038\/sj.bjp.0703865","volume":"132","author":"CH Yeh","year":"2001","unstructured":"Yeh, C. H., Chang, M. C., Peng, H. C. & Huang, T. F. Pharmacological characterization and antithrombotic effect of agkistin, a platelet glycoprotein ib antagonist. Br. J. Pharmacol. 132(4), 843\u2013850 (2001).","journal-title":"Br. J. Pharmacol."},{"issue":"5","key":"81851_CR75","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.toxicon.2004.11.017","volume":"45","author":"G Xu","year":"2005","unstructured":"Xu, G. et al. How does agkicetin-C bind on platelet glycoprotein ibalpha and achieve its platelet effects? Toxicon 45(5), 561\u2013570 (2005).","journal-title":"Toxicon"},{"issue":"6","key":"81851_CR76","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1055\/s-0037-1615040","volume":"79","author":"Y Sakurai","year":"1998","unstructured":"Sakurai, Y. et al. The cDNA cloning and molecular characterization of a snake venom platelet glycoprotein Ib-binding protein, mamushigin, from Agkistrodon halys blomhoffii venom. Thromb. Haemost 79(6), 1199\u20131207 (1998).","journal-title":"Thromb. Haemost"},{"issue":"2","key":"81851_CR77","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0049-3848(99)00143-7","volume":"97","author":"Y Taniuchi","year":"2000","unstructured":"Taniuchi, Y., Kawasaki, T. & Fujimura, Y. The high molecular mass, glycoprotein Ib-binding protein flavocetin-A induces only small platelet aggregates in vitro. Thromb. Res. 97(2), 69\u201375 (2000).","journal-title":"Thromb. Res."},{"issue":"1","key":"81851_CR78","first-page":"123","volume":"94","author":"A Rucavado","year":"2005","unstructured":"Rucavado, A. et al. Thrombocytopenia and platelet hypoaggregation induced by Bothrops asper snake venom. Toxins involved and their contribution to metalloproteinase-induced pulmonary hemorrhage. Thromb. Haemost 94(1), 123\u2013131 (2005).","journal-title":"Thromb. Haemost"},{"issue":"4","key":"81851_CR79","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1055\/s-0037-1615657","volume":"85","author":"A Rucavado","year":"2001","unstructured":"Rucavado, A. et al. Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage. Thromb. Haemost 85(4), 710\u2013715 (2001).","journal-title":"Thromb. Haemost"},{"issue":"8","key":"81851_CR80","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/j.toxicon.2005.02.023","volume":"45","author":"T Matsui","year":"2005","unstructured":"Matsui, T. & Hamako, J. Structure and function of snake venom toxins interacting with human von Willebrand factor. Toxicon 45(8), 1075\u20131087 (2005).","journal-title":"Toxicon"},{"key":"81851_CR81","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.toxicon.2012.10.023","volume":"63","author":"C Herrera","year":"2013","unstructured":"Herrera, C., Rucavado, A., Warrell, D. A. & Gutierrez, J. M. Systemic effects induced by the venom of the snake Bothrops caribbaeus in a murine model. Toxicon 63, 19\u201331 (2013).","journal-title":"Toxicon"},{"issue":"6","key":"81851_CR82","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1080\/09537104.2022.2071852","volume":"33","author":"Y Zhang","year":"2022","unstructured":"Zhang, Y., Ehrlich, S. M., Zhu, C. & Du, X. Signaling mechanisms of the platelet glycoprotein Ib-IX complex. Platelets 33(6), 823\u2013832 (2022).","journal-title":"Platelets"},{"issue":"9","key":"81851_CR83","doi-asserted-by":"publisher","first-page":"6478","DOI":"10.1016\/S0021-9258(17)37396-9","volume":"269","author":"L De Marco","year":"1994","unstructured":"De Marco, L., Mazzucato, M., Masotti, A. & Ruggeri, Z. M. Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein ib alpha. J. Biol. Chem. 269(9), 6478\u20136484 (1994).","journal-title":"J. Biol. Chem."},{"issue":"6","key":"81851_CR84","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/j.1538-7836.2008.02979.x","volume":"6","author":"TC White","year":"2008","unstructured":"White, T. C. et al. Protein C supports platelet binding and activation under flow: role of glycoprotein ib and apolipoprotein E receptor 2. J. Thromb. Haemost. 6(6), 995\u20131002 (2008).","journal-title":"J. Thromb. Haemost"},{"issue":"10","key":"81851_CR85","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1161\/CIRCULATIONAHA.118.036323","volume":"139","author":"J Li","year":"2019","unstructured":"Li, J. et al. Platelet protein disulfide isomerase promotes glycoprotein iba-mediated platelet-neutrophil interactions under thromboinflammatory conditions. Circulation 139(10), 1300\u20131319 (2019).","journal-title":"Circulation"},{"issue":"11","key":"81851_CR86","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1096\/fj.02-0830fje","volume":"17","author":"K Jurk","year":"2003","unstructured":"Jurk, K. et al. Thrombospondin-1 mediates platelet adhesion at high shear via glycoprotein ib (GPIb): an alternative\/backup mechanism to Von Willebrand factor. FASEB J. 17(11), 1490\u20131492 (2003).","journal-title":"FASEB J."},{"issue":"2","key":"81851_CR87","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1182\/blood-2014-06-581942","volume":"125","author":"P Prakash","year":"2015","unstructured":"Prakash, P., Kulkarni, P. P. & Chauhan, A. K. Thrombospondin 1 requires Von Willebrand factor to modulate arterial thrombosis in mice. Blood 125(2), 399\u2013406 (2015).","journal-title":"Blood"},{"issue":"1","key":"81851_CR88","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1038\/s41467-020-14958-x","volume":"11","author":"D Kohler","year":"2020","unstructured":"Kohler, D. et al. Red blood cell-derived semaphorin 7A promotes thrombo-inflammation in myocardial ischemia-reperfusion injury through platelet GPIb. Nat. Commun. 11(1), 1315 (2020).","journal-title":"Nat. Commun."},{"issue":"6","key":"81851_CR89","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1084\/jem.190.6.803","volume":"190","author":"GM Romo","year":"1999","unstructured":"Romo, G. M. et al. The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J. Exp. Med. 190 (6), 803\u2013813 (1999).","journal-title":"J. Exp. Med."},{"key":"81851_CR90","doi-asserted-by":"publisher","first-page":"15559","DOI":"10.1038\/ncomms15559","volume":"8","author":"Y Wang","year":"2017","unstructured":"Wang, Y., Gao, H., Shi, C., Erhardt, P. W. & Pavlovsky, A. Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbalpha. Nat. Commun. 8, 15559 (2017).","journal-title":"Nat. Commun."},{"key":"81851_CR91","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.cellsig.2017.09.016","volume":"40","author":"NS Gowert","year":"2017","unstructured":"Gowert, N. S. et al. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell. Signal. 40, 210\u2013221 (2017).","journal-title":"Cell. Signal."},{"issue":"4","key":"81851_CR92","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1182\/blood.V90.4.1508","volume":"90","author":"HN Bradford","year":"1997","unstructured":"Bradford, H. N. et al. Human kininogens regulate thrombin binding to platelets through the glycoprotein Ib-IX-V complex. Blood 90(4), 1508\u20131515 (1997).","journal-title":"Blood"},{"key":"81851_CR93","doi-asserted-by":"crossref","unstructured":"Kossmann, S. et al. Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci. Transl Med. 9(375). (2017).","DOI":"10.1126\/scitranslmed.aah4923"},{"issue":"30","key":"81851_CR94","doi-asserted-by":"publisher","first-page":"22756","DOI":"10.1074\/jbc.M002591200","volume":"275","author":"HN Bradford","year":"2000","unstructured":"Bradford, H. N., Pixley, R. A. & Colman, R. W. Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation. J. Biol. Chem. 275(30), 22756\u201322763 (2000).","journal-title":"J. Biol. Chem."},{"issue":"15","key":"81851_CR95","doi-asserted-by":"publisher","first-page":"3904","DOI":"10.1111\/bph.13178","volume":"172","author":"TT Li","year":"2015","unstructured":"Li, T. T. et al. A novel snake venom-derived GPIb antagonist, anfibatide, protects mice from acute experimental ischaemic stroke and reperfusion injury. Br. J. Pharmacol. 172(15), 3904\u20133916 (2015).","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"81851_CR96","doi-asserted-by":"publisher","first-page":"11663","DOI":"10.1038\/s41598-021-91165-8","volume":"11","author":"BX Li","year":"2021","unstructured":"Li, B. X. et al. In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbalpha. Sci. Rep. 11(1), 11663 (2021).","journal-title":"Sci. Rep."},{"issue":"2","key":"81851_CR97","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1160\/TH13-06-0490","volume":"111","author":"X Lei","year":"2014","unstructured":"Lei, X. et al. Anfibatide, a novel GPIb complex antagonist, inhibits platelet adhesion and thrombus formation in vitro and in vivo in murine models of thrombosis. Thromb. Haemost 111(2), 279\u2013289 (2014).","journal-title":"Thromb. Haemost"},{"key":"81851_CR98","doi-asserted-by":"publisher","first-page":"175032","DOI":"10.1016\/j.ejphar.2022.175032","volume":"926","author":"R Li","year":"2022","unstructured":"Li, R. et al. Anfibatide alleviates inflammation and apoptosis via inhibiting NF-kappaB\/NLRP3 axis in ischemic stroke. Eur. J. Pharmacol. 926, 175032 (2022).","journal-title":"Eur. J. Pharmacol."}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81851-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81851-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81851-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T08:02:50Z","timestamp":1735632170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81851-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":98,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["81851"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-81851-8","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]},"assertion":[{"value":"30 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"31769"}}