{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:13:43Z","timestamp":1783354423318,"version":"3.54.6"},"reference-count":59,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670742"],"award-info":[{"award-number":["81670742"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018916","name":"Suzhou Municipal Health Commission","doi-asserted-by":"publisher","award":["SKJY2021082"],"award-info":[{"award-number":["SKJY2021082"]}],"id":[{"id":"10.13039\/100018916","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Conversion Base - Endocrinology and Metabolism","award":["ML12301323"],"award-info":[{"award-number":["ML12301323"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Sci Rep"],"DOI":"10.1038\/s41598-024-81878-x","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T02:32:45Z","timestamp":1735353165000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["[Gly14]-Humanin ameliorates high glucose-induced endothelial senescence via SIRT6"],"prefix":"10.1038","volume":"14","author":[{"given":"Muqin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,28]]},"reference":[{"key":"81878_CR1","doi-asserted-by":"publisher","first-page":"ITC33","DOI":"10.7326\/AITC202203150","volume":"175","author":"FZ Syed","year":"2022","unstructured":"Syed, F. Z. Type 1 diabetes mellitus. Ann. Intern. Med. 175, ITC33\u2013ITC48 (2022).","journal-title":"Ann. Intern. Med."},{"key":"81878_CR2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41581-020-0278-5","volume":"16","author":"JB Cole","year":"2020","unstructured":"Cole, J. B. & Florez, J. C. Genetics of diabetes mellitus and diabetes complications. Nat. Rev. Nephrol. 16, 377\u2013390 (2020).","journal-title":"Nat. Rev. Nephrol."},{"key":"81878_CR3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1152\/physrev.00045.2011","volume":"93","author":"JM Forbes","year":"2013","unstructured":"Forbes, J. M. & Cooper, M. E. Mechanisms of diabetic complications. Physiol. Rev. 93, 137\u2013188 (2013).","journal-title":"Physiol. Rev."},{"key":"81878_CR4","doi-asserted-by":"publisher","first-page":"27","DOI":"10.5551\/jat.RV17014","volume":"25","author":"N Katakami","year":"2018","unstructured":"Katakami, N. Mechanism of development of atherosclerosis and cardiovascular disease in diabetes mellitus. J. Atheroscler Thromb. 25, 27\u201339 (2018).","journal-title":"J. Atheroscler Thromb."},{"key":"81878_CR5","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1161\/CIRCRESAHA.118.313816","volume":"123","author":"K Kobiyama","year":"2018","unstructured":"Kobiyama, K., Ley, K. & Atherosclerosis A chronic inflammatory disease with an autoimmune component. Circ. Res. 123, 1118\u20131120 (2018).","journal-title":"Circ. Res."},{"key":"81878_CR6","doi-asserted-by":"publisher","first-page":"S40","DOI":"10.1016\/j.amjmed.2017.04.010","volume":"130","author":"M Lehrke","year":"2017","unstructured":"Lehrke, M. & Marx, N. Diabetes mellitus and heart failure. Am. J. Med. 130, S40\u2013S50 (2017).","journal-title":"Am. J. Med."},{"key":"81878_CR7","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.coph.2021.08.013","volume":"61","author":"JP Kane","year":"2021","unstructured":"Kane, J. P., Pullinger, C. R., Goldfine, I. D. & Malloy, M. J. Dyslipidemia and diabetes mellitus: Role of lipoprotein species and interrelated pathways of lipid metabolism in diabetes mellitus. Curr. Opin. Pharmacol. 61, 21\u201327 (2021).","journal-title":"Curr. Opin. Pharmacol."},{"key":"81878_CR8","doi-asserted-by":"publisher","first-page":"900254","DOI":"10.3389\/fimmu.2022.900254","volume":"13","author":"J Ye","year":"2022","unstructured":"Ye, J. et al. Diabetes Mellitus promotes the development of atherosclerosis: the role of NLRP3. Front. Immunol. 13, 900254 (2022).","journal-title":"Front. Immunol."},{"key":"81878_CR9","doi-asserted-by":"publisher","first-page":"E1835","DOI":"10.3390\/ijms21051835","volume":"21","author":"A Poznyak","year":"2020","unstructured":"Poznyak, A. et al. The diabetes mellitus-atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation. Int. J. Mol. Sci. 21, E1835 (2020).","journal-title":"Int. J. Mol. Sci."},{"key":"81878_CR10","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1177\/2047487319878373","volume":"26","author":"L La Sala","year":"2019","unstructured":"La Sala, L., Prattichizzo, F. & Ceriello, A. The link between diabetes and atherosclerosis. Eur. J. Prev. Cardiol. 26, 15\u201324 (2019).","journal-title":"Eur. J. Prev. Cardiol."},{"key":"81878_CR11","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","volume":"118","author":"MA Gimbrone","year":"2016","unstructured":"Gimbrone, M. A. & Garc\u00eda-Carde\u00f1a, G. Endothelial cell dysfunction and the pathobiology of atherosclerosis. Circ. Res. 118, 620\u2013636 (2016).","journal-title":"Circ. Res."},{"key":"81878_CR12","doi-asserted-by":"publisher","first-page":"1802","DOI":"10.1016\/j.bbadis.2018.08.008","volume":"1865","author":"G Jia","year":"2019","unstructured":"Jia, G., Aroor, A. R., Jia, C. & Sowers, J. R. Endothelial cell senescence in aging-related vascular dysfunction. Biochim. Biophys. Acta Mol. Basis Dis. 1865, 1802\u20131809 (2019).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"81878_CR13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12933-018-0763-3","volume":"17","author":"R Kaur","year":"2018","unstructured":"Kaur, R., Kaur, M. & Singh, J. Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies. Cardiovasc. Diabetol. 17, 121 (2018).","journal-title":"Cardiovasc. Diabetol."},{"key":"81878_CR14","unstructured":"Capsaicin ameliorates intermittent high glucose-. mediated endothelial senescence via the TRPV1\/SIRT1 pathway - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/35405615\/"},{"key":"81878_CR15","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1111\/jcmm.14233","volume":"24","author":"S Khemais-Benkhiat","year":"2020","unstructured":"Khemais-Benkhiat, S. et al. Angiotensin II-induced redox-sensitive SGLT1 and 2 expression promotes high glucose-induced endothelial cell senescence. J. Cell. Mol. Med. 24, 2109\u20132122 (2020).","journal-title":"J. Cell. Mol. Med."},{"key":"81878_CR16","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.molimm.2018.07.008","volume":"101","author":"X Wang","year":"2018","unstructured":"Wang, X. et al. Humanin prevents high glucose-induced monocyte adhesion to endothelial cells by targeting KLF2. Mol. Immunol. 101, 245\u2013250 (2018).","journal-title":"Mol. Immunol."},{"key":"81878_CR17","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1161\/CIRCRESAHA.118.312563","volume":"123","author":"AJ Donato","year":"2018","unstructured":"Donato, A. J., Machin, D. R. & Lesniewski, L. A. Mechanisms of dysfunction in the aging vasculature and role in age-related disease. Circ. Res. 123, 825\u2013848 (2018).","journal-title":"Circ. Res."},{"key":"81878_CR18","unstructured":"The protective effects. Of metformin in an in vitro model of aging 3T3 fibroblast under the high glucose conditions - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/29512021\/"},{"key":"81878_CR19","unstructured":"Optineurin-mediated mitophagy. Protects renal tubular epithelial cells against accelerated senescence in diabetic nephropathy - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/29367621\/"},{"key":"81878_CR20","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.cmet.2019.05.006","volume":"30","author":"C Aguayo-Mazzucato","year":"2019","unstructured":"Aguayo-Mazzucato, C. et al. Acceleration of \u03b2 cell aging determines diabetes and senolysis improves disease outcomes. Cell. Metab. 30, 129\u2013142e4 (2019).","journal-title":"Cell. Metab."},{"key":"81878_CR21","doi-asserted-by":"publisher","first-page":"9121","DOI":"10.1002\/jcp.26956","volume":"233","author":"W Wei","year":"2018","unstructured":"Wei, W. & Ji, S. Cellular senescence: Molecular mechanisms and pathogenicity. J. Cell. Physiol. 233, 9121\u20139135 (2018).","journal-title":"J. Cell. Physiol."},{"key":"81878_CR22","doi-asserted-by":"crossref","unstructured":"Davalli, P., Mitic, T., Caporali, A., Lauriola, A. & D\u2019Arca, D. R. O. S. Cell senescence, and novel molecular mechanisms in aging and age-related diseases. Oxid Med Cell Longev 3565127 (2016).","DOI":"10.1155\/2016\/3565127"},{"key":"81878_CR23","doi-asserted-by":"publisher","first-page":"9796","DOI":"10.1074\/jbc.M206913200","volume":"278","author":"VP Bindokas","year":"2003","unstructured":"Bindokas, V. P. et al. Visualizing superoxide production in normal and diabetic rat islets of Langerhans. J. Biol. Chem. 278, 9796\u20139801 (2003).","journal-title":"J. Biol. Chem."},{"key":"81878_CR24","first-page":"1","volume":"50","author":"X Li","year":"2018","unstructured":"Li, X. et al. Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp. Mol. Med. 50, 1\u201314 (2018).","journal-title":"Exp. Mol. Med."},{"key":"81878_CR25","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.lfs.2012.11.021","volume":"92","author":"Y Li","year":"2013","unstructured":"Li, Y., Jia, Y., Zhou, J. & Huang, K. Effect of methionine sulfoxide reductase B1 silencing on high-glucose-induced apoptosis of human lens epithelial cells. Life Sci. 92, 193\u2013201 (2013).","journal-title":"Life Sci."},{"key":"81878_CR26","first-page":"558","volume":"12","author":"D Coradduzza","year":"2023","unstructured":"Coradduzza, D. et al. Humanin and its pathophysiological roles in aging: A systematic review. Biology (Basel). 12, 558 (2023).","journal-title":"Biology (Basel)"},{"key":"81878_CR27","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1089\/rej.2018.2114","volume":"21","author":"AR Mendelsohn","year":"2018","unstructured":"Mendelsohn, A. R. & Larrick, J. W. Mitochondrial-derived peptides exacerbate senescence. Rejuvenation Res. 21, 369\u2013373 (2018).","journal-title":"Rejuvenation Res."},{"key":"81878_CR28","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.diabres.2014.09.020","volume":"106","author":"Y Xie","year":"2014","unstructured":"Xie, Y. et al. Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res. Clin. Pract. 106, 560\u2013566 (2014).","journal-title":"Diabetes Res. Clin. Pract."},{"key":"81878_CR29","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1161\/01.CIR.0000109498.77895.6F","volume":"109","author":"M Federici","year":"2004","unstructured":"Federici, M. et al. G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. Circulation 109, 399\u2013405 (2004).","journal-title":"Circulation"},{"key":"81878_CR30","doi-asserted-by":"publisher","first-page":"4796","DOI":"10.1021\/jm500487d","volume":"57","author":"MD Parenti","year":"2014","unstructured":"Parenti, M. D. et al. Discovery of Novel and selective SIRT6 inhibitors. J. Med. Chem. 57, 4796\u20134804 (2014).","journal-title":"J. Med. Chem."},{"key":"81878_CR31","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1136\/gut.2005.083691","volume":"56","author":"CC Thompson","year":"2007","unstructured":"Thompson, C. C. et al. Pancreatic cancer cells overexpress gelsolin family-capping proteins, which contribute to their cell motility. Gut 56, 95\u2013106 (2007).","journal-title":"Gut"},{"key":"81878_CR32","doi-asserted-by":"publisher","first-page":"4394","DOI":"10.3390\/ijms24054394","volume":"24","author":"AG Rodr\u00edguez","year":"2023","unstructured":"Rodr\u00edguez, A. G. et al. Impact of acute high glucose on mitochondrial function in a model of endothelial cells: Role of PDGF-C. Int. J. Mol. Sci. 24, 4394 (2023).","journal-title":"Int. J. Mol. Sci."},{"key":"81878_CR33","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1111\/cas.14719","volume":"112","author":"U Thonsri","year":"2021","unstructured":"Thonsri, U. et al. High glucose-ROS conditions enhance the progression in cholangiocarcinoma via upregulation of MAN2A2 and CHD8. Cancer Sci. 112, 254\u2013264 (2021).","journal-title":"Cancer Sci."},{"key":"81878_CR34","doi-asserted-by":"publisher","first-page":"5893","DOI":"10.1172\/JCI136466","volume":"130","author":"Z Guo","year":"2020","unstructured":"Guo, Z. et al. DCAF1 regulates Treg senescence via the ROS axis during immunological aging. J. Clin. Invest. 130, 5893\u20135908 (2020).","journal-title":"J. Clin. Invest."},{"key":"81878_CR35","doi-asserted-by":"publisher","first-page":"e106048","DOI":"10.15252\/embj.2020106048","volume":"40","author":"A Lagnado","year":"2021","unstructured":"Lagnado, A. et al. Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner. EMBO J. 40, e106048 (2021).","journal-title":"EMBO J."},{"key":"81878_CR36","doi-asserted-by":"publisher","first-page":"101813","DOI":"10.1016\/j.redox.2020.101813","volume":"38","author":"HJ Sun","year":"2021","unstructured":"Sun, H. J. et al. Polysulfide-mediated sulfhydration of SIRT1 prevents diabetic nephropathy by suppressing phosphorylation and acetylation of p65 NF-\u03baB and STAT3. Redox Biol. 38, 101813 (2021).","journal-title":"Redox Biol."},{"key":"81878_CR37","doi-asserted-by":"publisher","first-page":"154271","DOI":"10.1016\/j.phymed.2022.154271","volume":"104","author":"Y Xue","year":"2022","unstructured":"Xue, Y. et al. Danshensu prevents thrombosis by inhibiting platelet activation via SIRT1\/ROS\/mtDNA pathways without increasing bleeding risk. Phytomedicine 104, 154271 (2022).","journal-title":"Phytomedicine"},{"key":"81878_CR38","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1001\/jama.2021.22208","volume":"326","author":"L Wang","year":"2021","unstructured":"Wang, L. et al. Prevalence and treatment of diabetes in China, 2013\u20132018. JAMA 326, 2498\u20132506 (2021).","journal-title":"JAMA"},{"key":"81878_CR39","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3904\/kjim.2015.075","volume":"31","author":"HJ Kim","year":"2016","unstructured":"Kim, H. J. et al. Association between blood glucose level derived using the oral glucose tolerance test and glycated hemoglobin level. Korean J. Intern. Med. 31, 535\u2013542 (2016).","journal-title":"Korean J. Intern. Med."},{"key":"81878_CR40","doi-asserted-by":"publisher","first-page":"e12895","DOI":"10.1111\/acel.12895","volume":"18","author":"E Seo","year":"2019","unstructured":"Seo, E., Kang, H., Choi, H., Choi, W. & Jun, H. S. Reactive oxygen species-induced changes in glucose and lipid metabolism contribute to the accumulation of cholesterol in the liver during aging. Aging Cell. 18, e12895 (2019).","journal-title":"Aging Cell."},{"key":"81878_CR41","doi-asserted-by":"publisher","first-page":"607","DOI":"10.3389\/fendo.2019.00607","volume":"10","author":"T Rharass","year":"2019","unstructured":"Rharass, T. & Lucas, S. High glucose level impairs human mature bone marrow adipocyte function through increased ROS production. Front. Endocrinol. (Lausanne). 10, 607 (2019).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"81878_CR42","unstructured":"Stachydrine ameliorates high-. glucose induced endothelial cell senescence and SIRT1 downregulation - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/23744621\/"},{"key":"81878_CR43","doi-asserted-by":"publisher","first-page":"118724","DOI":"10.1016\/j.lfs.2020.118724","volume":"264","author":"T Chen","year":"2021","unstructured":"Chen, T. et al. SIRT3 protects endothelial cells from high glucose-induced senescence and dysfunction via the p53 pathway. Life Sci. 264, 118724 (2021).","journal-title":"Life Sci."},{"key":"81878_CR44","doi-asserted-by":"publisher","first-page":"4579","DOI":"10.1093\/eurheartj\/ehac431","volume":"43","author":"C Chi","year":"2022","unstructured":"Chi, C. et al. Exerkine fibronectin type-III domain-containing protein 5\/irisin-enriched extracellular vesicles delay vascular ageing by increasing SIRT6 stability. Eur. Heart J. 43, 4579\u20134595 (2022).","journal-title":"Eur. Heart J."},{"key":"81878_CR45","doi-asserted-by":"publisher","first-page":"112659","DOI":"10.1016\/j.biopha.2022.112659","volume":"147","author":"Q Pu","year":"2022","unstructured":"Pu, Q. et al. Nicotinamide mononucleotide increases cell viability and restores tight junctions in high-glucose-treated human corneal epithelial cells via the SIRT1\/Nrf2\/HO-1 pathway. Biomed. Pharmacother. 147, 112659 (2022).","journal-title":"Biomed. Pharmacother"},{"key":"81878_CR46","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3389\/fphys.2018.00135","volume":"9","author":"J Kuang","year":"2018","unstructured":"Kuang, J. et al. The role of Sirt6 in obesity and diabetes. Front. Physiol. 9, 135 (2018).","journal-title":"Front. Physiol."},{"key":"81878_CR47","doi-asserted-by":"publisher","first-page":"166815","DOI":"10.1016\/j.bbadis.2023.166815","volume":"1869","author":"Y You","year":"2023","unstructured":"You, Y. & Liang, W. SIRT1 and SIRT6: The role in aging-related diseases. Biochim. Biophys. Acta Mol. Basis Dis. 1869, 166815 (2023).","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"81878_CR48","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.14336\/AD.2022.0413","volume":"13","author":"Z Guo","year":"2022","unstructured":"Guo, Z., Li, P., Ge, J. & Li, H. SIRT6 in aging, metabolism, inflammation and cardiovascular diseases. Aging Dis. 13, 1787\u20131822 (2022).","journal-title":"Aging Dis."},{"key":"81878_CR49","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1002\/jcp.30185","volume":"236","author":"L Scisciola","year":"2021","unstructured":"Scisciola, L. et al. New insight in molecular mechanisms regulating SIRT6 expression in diabetes: Hyperglycaemia effects on SIRT6 DNA methylation. J. Cell. Physiol. 236, 4604\u20134613 (2021).","journal-title":"J. Cell. Physiol."},{"key":"81878_CR50","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.1002\/jcb.25171","volume":"116","author":"M Choe","year":"2015","unstructured":"Choe, M. et al. The RUNX2 transcription factor negatively regulates SIRT6 expression to alter glucose metabolism in breast Cancer cells. J. Cell. Biochem. 116, 2210\u20132226 (2015).","journal-title":"J. Cell. Biochem."},{"key":"81878_CR51","first-page":"728","volume":"56","author":"Z Dong","year":"2020","unstructured":"Dong, Z. et al. FOXO3a\u2013SIRT6 axis suppresses aerobic glycolysis in melanoma. Int. J. Oncol. 56, 728\u2013742 (2020).","journal-title":"Int. J. Oncol."},{"key":"81878_CR52","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s00011-021-01485-8","volume":"70","author":"J Liu","year":"2021","unstructured":"Liu, J. et al. CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p\/SIRT6 axis. Inflamm. Res. 70, 835\u2013846 (2021).","journal-title":"Inflamm. Res."},{"key":"81878_CR53","doi-asserted-by":"publisher","first-page":"130024","DOI":"10.1016\/j.bbagen.2021.130024","volume":"1866","author":"T Niikura","year":"2022","unstructured":"Niikura, T. Humanin and Alzheimer\u2019s disease: The beginning of a new field. Biochim. Biophys. Acta Gen. Subj. 1866, 130024 (2022).","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"81878_CR54","doi-asserted-by":"publisher","first-page":"683151","DOI":"10.3389\/fendo.2021.683151","volume":"12","author":"H Cai","year":"2021","unstructured":"Cai, H., Liu, Y., Men, H. & Zheng, Y. Protective mechanism of humanin against oxidative stress in aging-related cardiovascular diseases. Front. Endocrinol. (Lausanne). 12, 683151 (2021).","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"81878_CR55","doi-asserted-by":"publisher","first-page":"213","DOI":"10.4239\/wjd.v13.i3.213","volume":"13","author":"C Boutari","year":"2022","unstructured":"Boutari, C., Pappas, P. D., Theodoridis, T. D. & Vavilis, D. Humanin and diabetes mellitus: A review of in vitro and in vivo studies. World J. Diabetes. 13, 213\u2013223 (2022).","journal-title":"World J. Diabetes"},{"key":"81878_CR56","doi-asserted-by":"publisher","first-page":"11185","DOI":"10.18632\/aging.103534","volume":"12","author":"K Yen","year":"2020","unstructured":"Yen, K. et al. The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. Aging (Albany NY). 12, 11185\u201311199 (2020).","journal-title":"Aging (Albany NY)"},{"key":"81878_CR57","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cmet.2015.02.009","volume":"21","author":"C Lee","year":"2015","unstructured":"Lee, C. et al. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell. Metab. 21, 443\u2013454 (2015).","journal-title":"Cell. Metab."},{"key":"81878_CR58","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.2147\/DMSO.S306026","volume":"14","author":"MY Shen","year":"2021","unstructured":"Shen, M. Y., Wang, M., Liu, Z., Wang, S. & Xie, Y. [Gly14]-Humanin ameliorates high glucose-induced apoptosis by inhibiting the expression of MicroRNA-155 in endothelial microparticles. Diabetes Metab. Syndr. Obes. 14, 2335\u20132347 (2021).","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"81878_CR59","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1080\/21655979.2021.2001911","volume":"13","author":"J Zhang","year":"2022","unstructured":"Zhang, J., Lei, H. & Li, X. The protective effects of S14G-humanin (HNG) against mono-sodium urate (MSU) crystals- induced gouty arthritis. Bioengineered 13, 345\u2013356 (2022).","journal-title":"Bioengineered"}],"container-title":["Scientific Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81878-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81878-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81878-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T16:05:16Z","timestamp":1735401916000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.nature.com\/articles\/s41598-024-81878-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,28]]},"references-count":59,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["81878"],"URL":"https:\/\/doi.org\/10.1038\/s41598-024-81878-x","relation":{},"ISSN":["2045-2322"],"issn-type":[{"value":"2045-2322","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,28]]},"assertion":[{"value":"2 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"This study was approved by the Ethics Committee of the Second Affiliated Hospital of Soochow University (JD-LK-2022-095-01, July 28, 2022).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All methods in this study were conducted according to the guidelines and regulations of the Declaration of Helsinki, and all informed consent was obtained from all subjects and\/or their legal guardian(s).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}],"article-number":"30924"}}